Biochemistry and Molecular Biology

Research Output

2020

A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors

Qiu, Z., Fa, P., Liu, T., Prasad, C. B., Ma, S., Hong, Z., Chan, E. R., Wang, H., Li, Z., He, K., Wang, Q. E., Williams, T. M., Yan, C., Sizemore, S. T., Narla, G. & Zhang, J., Aug 15 2020, In : Cancer Research. 80, 16, p. 3305-3318 14 p.

Research output: Contribution to journalArticle

Open Access

A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer

Lokeshwar, V. B., Morera, D. S., Hasanali, S. L., Yates, T. J., Hupe, M. C., Knapp, J., Lokeshwar, S. D., Wang, J., Hennig, M. J. P., Baskar, R., Escudero, D. O., Racine, R. R., Dhir, N., Jordan, A. R., Hoye, K., Azih, I., Manoharan, M., Klaassen, Z. W. A., Kavuri, S. K., Lopez, L. E. & 2 others, Ghosh, S. & Lokeshwar, B. L., Jul 1 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 13, p. 3455-3467 13 p.

Research output: Contribution to journalArticle

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

Wang, L., Liu, Y., Du, T., Yang, H., Lei, L., Guo, M., Ding, H., Zhang, J., Wang, H., Chen, X. & Yan, C., Feb 1 2020, In : Cell Death and Differentiation. 27, 2, p. 662-675 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells

Smith, A. D., Lu, C., Payne, D., Paschall, A. V., Klement, J. D., Redd, P. S., Ibrahim, M. L., Yang, D., Han, Q., Liu, Z., Shi, H., Hartney, T. J., Nayak-Kapoor, A. & Liu, K., Aug 1 2020, In : Cancer Research. 80, 15, p. 3145-3156 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium

Song, W., Sheng, L., Chen, F., Tian, Y., Li, L., Wang, G., Li, H. & Cai, Y., Mar 1 2020, In : Cell Stress and Chaperones. 25, 2, p. 223-233 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function

Upadhyay, K. K., Jadeja, R. N., Vyas, H. S., Pandya, B., Joshi, A., Vohra, A., Thounaojam, M. C., Martin, P. M., Bartoli, M. & Devkar, R. V., Jan 2020, In : Redox Biology. 28, 101314.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

Yu, M., Guo, G., Huang, L., Deng, L., Chang, C. S., Achyut, B. R., Canning, M., Xu, N., Arbab, A. S., Bollag, R. J., Rodriguez, P. C., Mellor, A. L., Shi, H., Munn, D. H. & Cui, Y., Dec 1 2020, In : Nature communications. 11, 1, 515.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

Bhutia, Y. D., Ogura, J., Grippo, P. J., Torres, C., Sato, T., Wachtel, M., Ramachandran, S., Babu, E., Sivaprakasam, S., Rajasekaran, D., Schniers, B., On, N., Smoot, L., Thangaraju, M., Gnana-Prakasam, J. P. & Ganapathy, V., Mar 2020, In : Asian Journal of Pharmaceutical Sciences. 15, 2, p. 237-251 15 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Clinical Parameters Outperform Molecular Subtypes for Predicting Outcome in Bladder Cancer: Results from Multiple Cohorts, Including TCGA

Morera, D. S., Hasanali, S. L., Belew, D., Ghosh, S., Klaassen, Z., Jordan, A. R., Wang, J., Terris, M. K., Bollag, R. J., Merseburger, A. S., Stenzl, A., Soloway, M. S. & Lokeshwar, V. B., Jan 1 2020, In : The Journal of urology. 203, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Competitive ubiquitination activates the tumor suppressor p53

Li, X., Guo, M., Cai, L., Du, T., Liu, Y., Ding, H. F., Wang, H., Zhang, J., Chen, X. & Yan, C., Jun 1 2020, In : Cell Death and Differentiation. 27, 6, p. 1807-1818 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In : International Journal of Cancer. 146, 8, p. 2243-2254 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Elashiry, M., Elashiry, M. M., Elsayed, R., Rajendran, M., Auersvald, C., Zeitoun, R., Rashid, M. H., Ara, R., Meghil, M. M., Liu, Y., Arbab, A. S., Arce, R. M., Hamrick, M., Elsalanty, M., Brendan, M., Pacholczyk, R. & Cutler, C. W., Jan 1 2020, In : Journal of Extracellular Vesicles. 9, 1, 1795362.

Research output: Contribution to journalArticle

Open Access

Diagnostic utility of axial imaging in the evaluation of hematuria: A systematic review and critical appraisal of the literature

Wallis, C. J. D., Sayyid, R. K., Manyevitch, R., Perlis, N., Lokeshwar, V. B., Fleshner, N. E., Terris, M. K., Nielsen, M. E. & Klaassen, Z. W. A., Jul 2020, In : Canadian Urological Association Journal. 15, 2

Research output: Contribution to journalReview article

Open Access

Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells

Ibrahim, M. L., Lu, C., Klement, J. D., Redd, P. S., Yang, D., Smith, A. D. & Liu, K., Jan 1 2020, (Accepted/In press) In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticle

First draft genome for the sand-hopper Trinorchestia longiramus

Patra, A. K., Chung, O., Yoo, J. Y., Kim, M. S., Yoon, M. G., Choi, J. H. & Yang, Y., Dec 1 2020, In : Scientific Data. 7, 1, 85.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Homocysteine induces inflammation in retina and brain

Elsherbiny, N. M., Sharma, I., Kira, D., Alhusban, S., Samra, Y. A., Jadeja, R., Martin, P., Al-Shabrawey, M. & Tawfik, A., Mar 2020, In : Biomolecules. 10, 3, 393.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Identifying Sialylation Linkages at the Glycopeptide Level by Glycosyltransferase Labeling Assisted Mass Spectrometry (GLAMS)

Zhu, H., Wang, S., Liu, D., Ding, L., Chen, C., Liu, Y., Wu, Z., Bollag, R., Liu, K., Alexander, W. M., Yin, J., Ma, C., Li, L. & Wang, P. G., May 5 2020, In : Analytical Chemistry. 92, 9, p. 6297-6303 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Inactivation of endothelial ADAM17 reduces retinal ischemia-reperfusion induced neuronal and vascular damage

Gutsaeva, D. R., Shalaby, L., Powell, F. L., Thounaojam, M. C., Abouhish, H., Wetzstein, S. A., Jadeja, R. N., Kwok, H. F., Martin, P. M. & Bartoli, M., Aug 1 2020, In : International journal of molecular sciences. 21, 15, p. 1-18 18 p., 5379.

Research output: Contribution to journalArticle

Open Access
Open Access
7 Scopus citations

Inhibition of HDAC6 attenuates diabetes-induced retinal redox imbalance and microangiopathy

Abouhish, H., Thounaojam, M., Jadeja, R. N., Gutsaeva, D. R., Powell, F. L., Khriza, M., Martin, P. M. & Bartoli, M., Jul 2020, In : Antioxidants. 9, 7, p. 1-19 19 p., 599.

Research output: Contribution to journalArticle

Open Access

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Yang, W., Yu, T., Huang, X., Bilotta, A. J., Xu, L., Lu, Y., Sun, J., Pan, F., Zhou, J., Zhang, W., Yao, S., Maynard, C. L., Singh, N., Dann, S. M., Liu, Z. & Cong, Y., Dec 1 2020, In : Nature communications. 11, 1, 4457.

Research output: Contribution to journalArticle

Open Access
Open Access

Investigation of the effect of dietary intake of omega-3 polyunsaturated fatty acids on trauma-induced white matter injury with quantitative diffusion MRI in mice

Reyes, L. D., Haight, T., Desai, A., Chen, H., Bosomtwi, A., Korotcov, A., Dardzinski, B., Kim, H. Y. & Pierpaoli, C., Nov 1 2020, In : Journal of Neuroscience Research. 98, 11, p. 2232-2244 13 p.

Research output: Contribution to journalArticle

Open Access

Label-free ferrohydrodynamic cell separation of circulating tumor cells

Zhao, W., Cheng, R., Jenkins, B. D., Davis, M. B., Kavuri, S. K., Hao, Z., Schroeder, C. & Mao, L., Jan 1 2020, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 868-869 2 p. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

LncRNA CDKN2B-AS1/miR-141/cyclin D network regulates tumor progression and metastasis of renal cell carcinoma

Dasgupta, P., Kulkarni, P., Majid, S., Hashimoto, Y., Shiina, M., Shahryari, V., Bhat, N. S., Tabatabai, L., Yamamura, S., Saini, S., Tanaka, Y. & Dahiya, R., Aug 1 2020, In : Cell Death and Disease. 11, 8, 660.

Research output: Contribution to journalArticle

Open Access

Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome

Patrick, A. T., He, W., Madu, J., Sripathi, S. R., Choi, S., Lee, K., Samson, F. P., Powell, F. L., Bartoli, M., Jee, D., Gutsaeva, D. R. & Jahng, W. J., 2020, (Accepted/In press) In : Journal of Diabetes and Metabolic Disorders.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular Bio-Imaging Probe for Non-Invasive Differentiation Between Human Leiomyoma Versus Leiomyosarcoma

Shalaby, S., Khater, M., Laknaur, A., Arbab, A. & Al-Hendy, A., Feb 1 2020, In : Reproductive Sciences. 27, 2, p. 644-654 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma

Dimri, M. & Satyanarayana, A., Feb 2020, In : Cancers. 12, 2, 491.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

Molecular targeting of renal cell carcinoma by an oral combination

Jordan, A. R., Wang, J., Yates, T. J., Hasanali, S. L., Lokeshwar, S. D., Morera, D. S., Shamaladevi, N., Li, C. S., Klaassen, Z., Terris, M. K., Thangaraju, M., Singh, A. B., Soloway, M. S. & Lokeshwar, V. B., May 1 2020, In : Oncogenesis. 9, 5, 52.

Research output: Contribution to journalArticle

Open Access

Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury

Vaibhav, K., Braun, M., Alverson, K., Khodadadi, H., Kutiyanawalla, A., Ward, A., Banerjee, C., Sparks, T., Malik, A., Rashid, M. H., Rashid, M. H., Khan, M. B., Waters, M. F., Hess, D. C., Arbab, A. S., Vender, J. R., Hoda, N., Hoda, N., Hoda, N., Baban, B. & 3 others, Baban, B., Baban, B. & Dhandapani, K. M., May 2020, In : Science Advances. 6, 22, EAAX8847.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Novel small-molecule LG1836 inhibits the in vivo growth of castration-resistant prostate cancer

Chen, Y., Li, X., Mamouni, K., Yang, Y., Danaher, A., White, J., Liu, H. Y., Kucuk, O., Gera, L. & Wu, D., Sep 1 2020, In : Prostate. 80, 12, p. 993-1005 13 p.

Research output: Contribution to journalArticle

NRF2 mediates γ-globin gene regulation through epigenetic modifications in a β-YAC transgenic mouse model

Zhu, X., Xi, C., Ward, A., Takezaki, M., Shi, H., Peterson, K. R. & Pace, B. S., Sep 1 2020, In : Experimental Biology and Medicine. 245, 15, p. 1308-1318 11 p.

Research output: Contribution to journalArticle

Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice

Achyut, B. R., Zhang, H., Angara, K., Mivechi, N. F., Arbab, A. S. & Ko, L., Apr 28 2020, In : Cancer Letters. 476, p. 57-66 10 p.

Research output: Contribution to journalArticle

Open Access

Pancreatic Adenocarcinoma: Unconventional Approaches for an Unconventional Disease

Gromisch, C., Qadan, M., Machado, M. A., Liu, K., Colson, Y. & Grinstaff, M. W., Aug 15 2020, In : Cancer Research. 80, 16, p. 3179-3192 14 p.

Research output: Contribution to journalReview article

1 Scopus citations

PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo

Li, F., Liu, Z., Sun, H., Li, C., Wang, W., Ye, L., Yan, C., Tian, J. & Wang, H., Feb 2020, In : Acta Pharmaceutica Sinica B. 10, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Poly-IC enhances the effectiveness of cancer immunotherapy by promoting T cell tumor infiltration

Sultan, H., Wu, J., Fesenkova, V. I., Fan, A. E., Addis, D., Salazar, A. M. & Celis, E., Sep 21 2020, In : Journal for ImmunoTherapy of Cancer. 8, 2, e001224.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Promotion of epithelial hyperplasia by interleukin-8—CXCR axis in human prostate

Smith, D. K., Hasanali, S. L., Wang, J., Kallifatidis, G., Morera, D. S., Jordan, A. R., Terris, M. K., Klaassen, Z., Bollag, R., Lokeshwar, V. B. & Lokeshwar, B. L., Sep 1 2020, In : Prostate. 80, 12, p. 938-949 12 p.

Research output: Contribution to journalArticle

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome

Hu, T., Chong, Y., Lu, S., McGuinness, M., Williams, D. A. & Cowell, J. K., Jan 31 2020, In : Haematologica. 105, 2, p. E68-E71

Research output: Contribution to journalLetter

Open Access

Role of G-Protein Coupled Receptors in Chemotaxis of Innate Lymphoid Cells

Bhatt, B., Zhu, H., Patel, N. & Singh, N., 2020, Methods in Molecular Biology. Humana Press Inc., p. 93-98 6 p. (Methods in Molecular Biology; vol. 2121).

Research output: Chapter in Book/Report/Conference proceedingChapter

Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice

Gunebakan, E., Yalcin, E., Dulger, E. C., Yigitbasi, A., Ates, N., Caglayan, A., Beker, M. C., Sahin, K., Korkaya, H. & Kilic, E., Feb 1 2020, In : Biomedicines. 8, 2, 23.

Research output: Contribution to journalArticle

Open Access

Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades

Huang, Y., Feng, G., Cai, J., Peng, Q., Yang, Z., Yan, C., Yang, L. & Wang, Z., May 1 2020, In : Life sciences. 248, 117449.

Research output: Contribution to journalArticle

SLC6A14, a Na+/Cl --coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling

Sikder, M. O. F., Sivaprakasam, S., Brown, T. P., Thangaraju, M., Bhutia, Y. D. & Ganapathy, V., Apr 2020, In : Biochemical Journal. 477, 8, p. 1409-1425 17 p.

Research output: Contribution to journalArticle

Open Access

SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth

Lu, C., Klement, J. D., Yang, D., Albers, T., Lebedyeva, I. O., Waller, J. L. & Liu, K., Apr 28 2020, In : Cancer Letters. 476, p. 87-96 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Emerging Role of Senescence in Ocular Disease

Sreekumar, P. G., Hinton, D. R., Kannan, R. & Martin, P. M., 2020, In : Oxidative medicine and cellular longevity. 2020, 2583601.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The role of melatonin on miRNAs modulation in triple-negative breast cancer cells

Ferreira, L. C., Orso, F., Dettori, D., Lacerda, J. Z., Borin, T. F., Taverna, D. & Zuccari, D. A. P. C., Feb 1 2020, In : PloS one. 15, 2, e0228062.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis

Wang, L., Xu, Y., Rogers, H., Saidi, L., Noguchi, C. T., Li, H., Yewdell, J. W., Guydosh, N. R. & Ye, Y., Jan 1 2020, In : Cell Research. 30, 1, p. 5-20 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity

Suryawanshi, A., Hussein, M. S., Prasad, P. D. & Manicassamy, S., Feb 17 2020, In : Frontiers in immunology. 11, 122.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2019

A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients

Mitchell, A., Hasanali, S. L., Morera, D. S., Baskar, R., Wang, X., Khan, R., Talukder, A., Li, C. S., Manoharan, M., Jordan, A. R., Wang, J., Bollag, R. J., Singh, N., Albo, D., Ghosh, S. & Lokeshwar, V. B., 2019, In : Cancer biomarkers : section A of Disease markers. 26, 3, p. 291-301 11 p.

Research output: Contribution to journalArticle

3 Scopus citations