Biochemistry and Molecular Biology

Research Output

Article

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

331 Scopus citations

Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to fas ligand-induced apoptosis in vitro and tumor suppression in vivo

Yang, D., Torres, C. M., Bardhan, K., Zimmerman, M., McGaha, T. L. & Liu, K., May 1 2012, In : Journal of Immunology. 188, 9, p. 4441-4449 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Defective antibody-mediated opsonisation of S. pneumoniae in high risk patients detected by flow cytometry

Obaro, S. K., Henderson, D. C. & Monteil, M. A., Jan 1996, In : Immunology Letters. 49, 1-2, p. 83-89 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Defective T-cell receptor-induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53-/- mice

Singh, N., Huang, L. & Qin, H., Feb 2010, In : European Journal of Immunology. 40, 2, p. 559-568 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study

Khodaverdian, V., Tapadar, S., MacDonald, I. A., Xu, Y., Ho, P. Y., Bridges, A., Rajpurohit, P., Sanghani, B. A., Fan, Y., Thangaraju, M., Hathaway, N. A. & Oyelere, A. K., Dec 1 2019, In : Scientific reports. 9, 1, 4802.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock

Subramani, K., Chu, X., Warren, M., Lee, M., Lu, S., Singh, N. & Raju, R. P., Mar 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 3, p. 688-695 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Degradation of Oxidized Insulin B Chain by the Multiproteinase Complex Macropain (Proteasome)

Dick, L. R., Moomaw, C. R., DeMartino, G. N. & Slaughter, C. A., Mar 1 1991, In : Biochemistry. 30, 10, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

84 Scopus citations
8 Scopus citations

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

Hong, Y., Manoharan, I., Suryawanshi, A., Shanmugam, A., Swafford, D., Ahmad, S., Chinnadurai, R., Manicassamy, B., He, Y., Mellor, A. L., Thangaraju, M., Munn, D. H. & Manicassamy, S., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

26 Scopus citations

Deletion of the amino acid transporter SLC6A14 suppresses tumour growth in spontaneous mouse models of breast cancer

Babu, E., Bhutia, Y. D., Ramachandran, S., Gnana-Prakasam, J. P., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Jul 1 2015, In : Biochemical Journal. 469, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Elashiry, M., Elashiry, M. M., Elsayed, R., Rajendran, M., Auersvald, C., Zeitoun, R., Rashid, M. H., Ara, R., Meghil, M. M., Liu, Y., Arbab, A. S., Arce, R. M., Hamrick, M., Elsalanty, M., Brendan, M., Pacholczyk, R. & Cutler, C. W., Jan 1 2020, In : Journal of Extracellular Vesicles. 9, 1, 1795362.

Research output: Contribution to journalArticle

Open Access

De novo design of selective antibiotic peptides by incorporation of unnatural amino acids

Hicks, R. P., Bhonsle, J. B., Venugopal, D., Koser, B. W. & Magill, A. J., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3026-3036 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

De novo identification of LTR retrotransposons in eukaryotic genomes

Rho, M., Choi, J. H., Kim, S., Lynch, M. & Tang, H., Apr 3 2007, In : BMC Genomics. 8, 90.

Research output: Contribution to journalArticle

48 Scopus citations

De novo transcriptome sequencing in a songbird, the dark-eyed junco (Junco hyemalis): genomic tools for an ecological model system

Peterson, M. P., Whittaker, D. J., Ambreth, S., Sureshchandra, S., Buechlein, A., Podicheti, R., Choi, J. H., Lai, Z., Mockatis, K., Colbourne, J., Tang, H. & Ketterson, E. D., Jul 9 2012, In : BMC Genomics. 13, 1, 305.

Research output: Contribution to journalArticle

28 Scopus citations

Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.

Corlazzoli, F., Rossetti, S., Bistulfi, G., Ren, M. & Sacchi, N., 2009, In : PloS one. 4, 1, p. e4305

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer

Hu, X., Bardhan, K., Paschall, A. V., Yang, D., Waller, J. L., Park, M. A., Nayak, A., Samuel, T. A., Abrams, S. I. & Liu, K., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 19103-19115 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Descriptive epidemiology of asthma in Trinidad, West Indies

Monteil, M. A., Juman, S., Hassanally, R., Williams, K. P., Pierre, L., Rahaman, M., Singh, H. & Trinidade, A., Jan 1 2000, In : Journal of Asthma. 37, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity

Manfredini, S., Pavan, B., Vertuani, S., Scaglianti, M., Compagnone, D., Biondi, C., Scatturin, A., Tanganelli, S., Ferraro, L., Prasad, P. & Dalpiaz, A., Jan 31 2002, In : Journal of Medicinal Chemistry. 45, 3, p. 559-562 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Zhang, J., Wang, N., Xie, X., Yan, C., Fu, F., Yao, J. & Wang, H., Jun 1 2017, In : Wuhan University Journal of Natural Sciences. 22, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules

Manfredini, S., Vertuani, S., Pavan, B., Vitali, F., Scaglianti, M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. & Dalpiaz, A., Oct 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 20, p. 5453-5463 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Detection of differentially methylated regions using bayes factor for ordinal group responses

Dunbar, F., Xu, H., Ryu, D., Ghosh, S., Shi, H. & George, V., Sep 2019, In : Genes. 10, 9, 721.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors

Li, N., Chen, M., Truong, S., Yan, C. & Buttyan, R., Oct 2014, In : Prostate. 74, 14, p. 1400-1410 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Determining the effect of the incorporation of unnatural amino acids into antimicrobial peptides on the interactions with zwitterionic and anionic membrane model systems

Russell, A. L., Kennedy, A. M., Spuches, A. M., Gibson, W. S., Venugopal, D., Klapper, D., Srouji, A. H., Bhonsle, J. B. & Hicks, R. P., Nov 1 2011, In : Chemistry and Physics of Lipids. 164, 8, p. 740-758 19 p.

Research output: Contribution to journalArticle

14 Scopus citations

Development of a novel animal model to differentiate radiation necrosis from tumor recurrence

Kumar, S., Arbab, A. S., Jain, R., Kim, J., DeCarvalho, A. C., Shankar, A., Mikkelsen, T. & Brown, S. L., Jul 2012, In : Journal of Neuro-Oncology. 108, 3, p. 411-420 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Development of a partial fibronectin knockout transgenic mouse model

Manshouri, T., Huang, S., Sundaresan, A., Chakravarthy, M., Chakrabarty, S. & Albitar, M., Jan 1 1997, In : Transgenics. 2, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In : International Journal of Cancer. 139, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Liu, X., Zou, H., Slaughter, C. & Wang, X., Apr 18 1997, In : Cell. 89, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

1566 Scopus citations

Diagnosis and characterization of acute erythroleukemia subsets by determining the percentages of myeloblasts and proerythroblasts in 69 cases

Ramchandran, R., Bengra, C., Whitney, B., Lanclos, K. & Tuan Lo, D., Sep 11 2000, In : American Journal of Hematology. 65, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: A RPE specific phenomenon

Ananth, S., Zhuang, L., Gopal, E., Itagaki, S., Ellappan, B., Smith, S. B., Ganapathy, V. & Martin, P., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 75-80 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
30 Scopus citations

Diet-induced obesity and mammary tumor development in MMTV-neu female mice

Cleary, M. P., Grande, J. P., Juneja, S. C. & Maihle, N. J., Dec 1 2004, In : Nutrition and Cancer. 50, 2, p. 174-180 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Differential biodistribution of intravenously administered endothelial progenitor and cytotoxic T-cells in rat bearing orthotopic human glioma

Varma, N. R. S., Shankar, A., Iskander, A., Janic, B., Borin, T. F., Ali, M. M. & Arbab, A. S., Jun 10 2013, In : BMC Medical Imaging. 13, 1, 17.

Research output: Contribution to journalArticle

7 Scopus citations

Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer

Yan, P. S., Shi, H., Rahmatpanah, F., Hsiau, T. H. C., Hsiau, A. H. A., Leu, Y. W., Liu, J. C. & Huang, T. H. M., Oct 1 2003, In : Cancer Research. 63, 19, p. 6178-6186 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians

Shiina, M., Hashimoto, Y., Kato, T., Yamamura, S., Tanaka, Y., Majid, S., Saini, S., Varahram, S., Kulkarni, P., Dasgupta, P., Mitsui, Y., Sumida, M., Tabatabai, L., Deng, G., Kumar, D. & Dahiya, R., 2017, In : Oncotarget. 8, 5, p. 8356-8368 13 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Differential influence of the 4F2 heavy chain and the protein related to b0,+ amino acid transport on substrate affinity of the heteromeric b0,+ amino acid transporter

Rajan, D. P., Huang, W., Kekuda, R., George, R. L., Wang, J., Conway, S. J., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., May 12 2000, In : Journal of Biological Chemistry. 275, 19, p. 14331-14335 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Differential in vivo biodistribution of 131I-labeled exosomes from diverse cellular origins and its implication for theranostic application

Rashid, M. H., Borin, T. F., Ara, R., Angara, K., Cai, J., Achyut, B. R., Liu, Y. & Arbab, A. S., Oct 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 21, 102072.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Differential methylation tests of regulatory regions

Ryu, D., Xu, H., George, V., Su, S., Wang, X., Shi, H. & Podolsky, R. H., Jun 1 2016, In : Statistical Applications in Genetics and Molecular Biology. 15, 3, p. 237-251 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases

Bell, S. M., Connolly, D. C., Maihle, N. J. & Degen, J. L., Sep 1993, In : Molecular and Cellular Biology. 13, 9, p. 5888-5897 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids

Miyauchi, S., Gopal, E., Thakkar, S. V., Ichikawa, S., Prasad, P. D. & Ganapathy, V., Apr 2007, In : Journal of Pharmacology and Experimental Therapeutics. 321, 1, p. 257-264 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Differential PI3Kδ signaling in CD4+ T-cell subsets enables selective targeting of t regulatory cells to enhance cancer immunotherapy

Ahmad, S., Abu-Eid, R., Shrimali, R. K., Webb, M., Verma, V., Doroodchi, A., Berrong, Z., Samara, R., Rodriguez, P. C., Mkrtichyan, M. & Khleif, S. N., Apr 15 2017, In : Cancer Research. 77, 8, p. 1892-1904 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2

Ganapathy, M. E., Brandsch, M., Prasad, P. D., Ganapathy, V. & Leibach, F. H., Jan 1 1995, In : Journal of Biological Chemistry. 270, 43, p. 25672-25677 6 p.

Research output: Contribution to journalArticle

248 Scopus citations

Differential regulation of cell motility and invasion by FAK

Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., Huang, S., Li, E., Nemerow, G. R., Leng, J., Spencer, K. S. R., Cheresh, D. A. & Schlaepfer, D. D., Mar 3 2003, In : Journal of Cell Biology. 160, 5, p. 753-767 15 p.

Research output: Contribution to journalArticle

426 Scopus citations

Direct detection by 15N NMR of the tryptophan tryptophylquinone aminoquinol reaction intermediate of methylamine dehydrogenase

Bishop, G. R., Valente, E. J., Whitehead, T. L., Brown, K. L., Hicks, R. P. & Davidson, V. L., Dec 1 1996, In : Journal of the American Chemical Society. 118, 50, p. 12868-12869 2 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity

Pan, Y., Choi, J-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In : Scientific reports. 9, 1, 3433.

Research output: Contribution to journalArticle

2 Scopus citations

Disease tropism of c-erbB: Effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation

Pelley, R. J., Maihle, N. J., Boerkoel, C., Shu, H. K., Carter, T. H., Moscovici, C. & Kung, H. J., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 18, p. 7164-7168 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid

Somenzi, G., Sala, G., Rossetti, S., Ren, M. Q., Ghidoni, R. & Sacchi, N., Sep 5 2007, In : PloS one. 2, 9, e836.

Research output: Contribution to journalArticle

26 Scopus citations

Disruption of the escherichia coli outer membrane permeability barrier by immobilized polymyxin b

Rosenthal, K. S. & Storm, D. R., 1977, In : The Journal of Antibiotics. 30, 12, p. 1087-1092 6 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells

Salh, B., Assi, K., Huang, S., O'Brien, L., Steinbrecher, U. & Gómez-Muñoz, A., Oct 1 2002, In : Journal of Leukocyte Biology. 72, 4, p. 790-799 10 p.

Research output: Contribution to journalArticle

9 Scopus citations