Biochemistry and Molecular Biology

Research Output

2019

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Systemic antibiotic therapy reduces circulating inflammatory dendritic cells and Treg–Th17 plasticity in periodontitis

Rajendran, M., Looney, S., Singh, N., Elashiry, M., Meghil, M. M., El-Awady, A. R., Tawfik, O., Susin, C., Arce, R. M. & Cutler, C. W., May 1 2019, In : Journal of Immunology. 202, 9, p. 2690-2699 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access

The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution

Piel, R. B., Dailey, H. A. & Medlock, A. E., Nov 2019, In : Molecular Genetics and Metabolism. 128, 3, p. 198-203 6 p.

Research output: Contribution to journalReview article

2 Scopus citations

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. M. & Celis, E., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

The UFMylation System in Proteostasis and Beyond

Gerakis, Y., Quintero, M., Li, H. & Hetz, C., Dec 2019, In : Trends in Cell Biology. 29, 12, p. 974-986 13 p.

Research output: Contribution to journalReview article

2 Scopus citations

Three novel players: PTK2B, SYK, and TNFRSF21 were identified to be involved in the regulation of bovine mastitis susceptibility via GWAS and post-transcriptional analysis

Yang, F., Chen, F., Li, L., Yan, L., Badri, T., Lv, C., Yu, D., Zhang, M., Jang, X., Li, J., Yuan, L., Wang, G., Li, H., Li, J. & Cai, Y., 2019, In : Frontiers in immunology. 10, AUG, 1579.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism

Cheng, Z. J., Miao, D. L., Su, Q. Y., Tang, X. L., Wang, X. L., Deng, L. B., Shi, H. & Xin, H. B., Jun 1 2019, In : Acta Pharmacologica Sinica. 40, 6, p. 814-822 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
1 Scopus citations

Type i interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Lu, C., Klement, J. D., Ibrahim, M. L., Xiao, W., Redd, P. S., Nayak, A., Zhou, G. & Liu, K., Jun 22 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 157.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

Zhu, H., Bhatt, B., Sivaprakasam, S., Cai, Y., Liu, S., Kodeboyina, S. K., Patel, N., Savage, N. M., Sharma, A. K., Kaufman, R. J., Li, H. & Singh, N., Dec 1 2019, In : Nature communications. 10, 1, 1084.

Research output: Contribution to journalArticle

12 Scopus citations

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Upregulation of MIR-130b contributes to risk of poor prognosis and racial disparity in African-American Prostate Cancer

Hashimoto, Y., Shiina, M., Dasgupta, P., Kulkarni, P., Kato, T., Wong, R. K., Tanaka, Y., Shahryari, V., Maekawa, S., Yamamura, S., Saini, S., Deng, G., Laura Tabatabai, Z., Majid, S. & Dahiya, R., 2019, In : Cancer Prevention Research. 12, 9, p. 585-598 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Vitamin B3: Niacin and transcriptome analysis in relation to the GPR109A receptor

Bridges, A., Rajpurohit, P., Prasad, P. D. & Thangaraju, M., Jan 1 2019, Molecular Nutrition: Vitamins. Elsevier, p. 673-690 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer

Qin, H., Lu, S., Thangaraju, M. & Cowell, J. K., Dec 2019, In : American Journal of Pathology. 189, 12, p. 2450-2458 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

[125 I]IodoDPA-713 binding to 18 kDa translocator protein (TSPO) in a mouse model of intracerebral hemorrhage: Implications for neuroimaging

Bonsack, F., Foss, C. A., Arbab, A. S., Alleyne, C. H., Pomper, M. G. & Sukumari-Ramesh, S., Feb 22 2018, In : Frontiers in Neuroscience. 12, FEB, 66.

Research output: Contribution to journalArticle

2 Scopus citations

A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes

Bayoumi, A. S., Park, K. M., Wang, Y., Teoh, J. P., Aonuma, T., Tang, Y. L., Su, H., Weintraub, N. L. & Kim, I., Jan 2018, In : Journal of molecular and cellular cardiology. 114, p. 72-82 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

33 Scopus citations

AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells

Campbell, P. S., Mavingire, N., Khan, S., Rowland, L. K., Wooten, J. V., Opoku-Agyeman, A., Guevara, A., Soto, U., Cavalli, F., Loaiza-Pérez, A. I., Nagaraj, G., Denham, L. J., Adeoye, O., Jenkins, B. D., Davis, M. B., Schiff, R. & Brantley, E. J., Jan 2018, In : Journal of Cellular Physiology. 234, 1, p. 108-121 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

10 Scopus citations

Androgen receptor and ALDH1 expression among internationally diverse patient populations

Jiagge, E., Jibril, A. S., Davis, M., Murga-Zamalloa, C., Kleer, C. G., Gyan, K., Divine, G., Hoenerhoff, M., Bensenhave, J., Awuah, B., Oppong, J., Adjei, E., Salem, B., Toy, K., Merajver, S., Wicha, M. & Newman, L., Mar 1 2018, In : Journal of Global Oncology. 2018, 4

Research output: Contribution to journalArticle

3 Scopus citations

An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

Wang, X., Pan, Y., Zhu, H., Hao, G., Huang, Y., Barnes, V., Shi, H., Snieder, H., Pankow, J., North, K., Grove, M., Guan, W., Demerath, E., Dong, Y. & Su, S., 2018, In : Clinical epigenetics. 10, p. 3 1 p.

Research output: Contribution to journalArticle

7 Scopus citations

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

Mamouni, K., Zhang, S., Li, X., Chen, Y., Yang, Y., Kim, J., Bartlett, M. G., Coleman, I. M., Nelson, P. S., Kucuk, O. & Wu, D., Aug 2018, In : Neoplasia (United States). 20, 8, p. 789-799 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Antigen-Specific antitumor responses induced by OX40 agonist are enhanced by the ido inhibitor indoximod

Berrong, Z., Mkrtichyan, M., Ahmad, S., Webb, M., Mohamed, E., Okoev, G., Matevosyan, A., Shrimali, R. K., Eid, R. A., Hammond, S., Janik, J. E. & Khleif, S. N., Feb 2018, In : Cancer Immunology Research. 6, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

AR negative triple negative or “Quadruple Negative” breast cancers in African American women have an enriched basal and immune signature

Davis, M. B., Tripathi, S., Hughley, R., He, Q., Bae, S., Karanam, B., Martini, R., Newman, L., Colomb, W., Grizzle, W. & Yates, C., Jun 2018, In : PloS one. 13, 6, e0196909.

Research output: Contribution to journalArticle

13 Scopus citations

Article Watch: December 2018

Slaughter, C. A., Dec 1 2018, In : Journal of biomolecular techniques : JBT. 29, 4, p. 105-112 8 p.

Research output: Contribution to journalReview article

Open Access

A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: Observation from a prospective study 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

Liu, H., Liu, Z., Liu, X. W., Xu, S., Wang, L., Liu, Y., Zhou, J., Gu, L., Gao, Y., Liu, X. Y., Shi, H., Sun, Z. & Deng, D., Sep 24 2018, In : BMC Cancer. 18, 1, 918.

Research output: Contribution to journalArticle

2 Scopus citations

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

Wang, Z., He, Y., Deng, W., Lang, L., Yang, H., Jin, B., Kolhe, R. B., Ding, H., Zhang, J., Hai, T. & Yan, C., Jan 4 2018, In : Oncogene. 37, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Breast Cancer Disparities: How Can We Leverage Genomics to Improve Outcomes?

Davis, M. B. & Newman, L. A., Jan 2018, In : Surgical Oncology Clinics of North America. 27, 1, p. 217-234 18 p.

Research output: Contribution to journalReview article

10 Scopus citations

Canonical wnt signaling in CD11c + APCs regulates microbiota-Induced inflammation and immune cell homeostasis in the colon

Swafford, D., Shanmugam, A., Ranganathan, P., Hussein, M. S., Koni, P. A., Prasad, P. D., Thangaraju, M. & Manicassamy, S., May 1 2018, In : Journal of Immunology. 200, 9, p. 3259-3268 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Carbon monoxide releasing molecule A-1 attenuates acetaminophen-mediated hepatotoxicity and improves survival of mice by induction of Nrf2 and related genes

Upadhyay, K. K., Jadeja, R. N., Thadani, J. M., Joshi, A., Vohra, A., Mevada, V., Patel, R., Khurana, S. & Devkar, R. V., Dec 1 2018, In : Toxicology and Applied Pharmacology. 360, p. 99-108 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

CD38 deficiency promotes inflammatory response through activating sirt1/NF-κB-mediated inhibition of TLR2 expression in macrophages

Qian, Y., Chen, C., Ma, L., Wang, Z., Wang, L. F., Zuo, L., Yang, Y., Huang, X., Jiang, M., Wang, X., Shi, H., Fu, M., Deng, K. Y. & Xin, H. B., 2018, In : Mediators of Inflammation. 2018, 8736949.

Research output: Contribution to journalArticle

4 Scopus citations

CDK9 expression shows role as a potential prognostic biomarker in breast cancer patients who fail to achieve pathologic complete response after neoadjuvant chemotherapy

Schlafstein, A. J., Withers, A. E., Rudra, S., Danelia, D., Switchenko, J. M., Mister, D., Harari, S., Zhang, H., Daddacha, W., Ehdaivand, S., Li, X., Torres, M. A. & Yu, D. S., 2018, In : International Journal of Breast Cancer. 2018, 6945129.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Clinical utility of plecanatide in the treatment of chronic idiopathic constipation

Islam, B. N., Sharman, S. K. & Browning, D. D., 2018, In : International Journal of General Medicine. 11, p. 323-330 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Complete genome sequence and analysis of the industrial Saccharomyces cerevisiae strain N85 used in Chinese rice wine production

Zhang, W., Li, Y., Chen, Y., Xu, S., Du, G., Shi, H., Zhou, J. & Chen, J., 2018, In : DNA Research. 25, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
17 Scopus citations

Correction: Regulation of minichromosome maintenance gene family by MicroRNA-1296 and genistein in prostate cancer (Cancer Research (2010)70 (2809-2818) DOI: 10.1158/0008-5472.CAN-09-4176)

Majid, S., Dar, A. A., Saini, S., Chen, Y., Shahryari, V. & Liu, J., Jul 1 2018, In : Cancer Research. 78, 13, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

Angara, K., Borin, T. F., Rashid, M. H., Lebedyeva, I., Ara, R., Lin, P. C., Iskander, A. S. M., Bollag, R. J., Achyut, B. R. & Arbab, A. S., Oct 2018, In : Neoplasia (United States). 20, 10, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cyclic-GMP-elevating agents suppress polyposis in Apc Min mice by targeting the preneoplastic epithelium

Sharman, S. K., Islam, B. N., Hou, Y., Singh, N., Berger, F. G., Sridhar, S., Yoo, W. & Browning, D. D., Feb 2018, In : Cancer Prevention Research. 11, 2, p. 81-91 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cytokeratin-8 in anaplastic thyroid carcinoma: More than a simple structural cytoskeletal protein

Guo, D., Xu, Q., Pabla, S., Koomen, J., Biddinger, P. W., Sharma, A. K., Pabla, S., Pacholczyk, R. W., Chang, C. C., Friedrich, K., Mohammed, K., Smallridge, R. C., Copland, J. A., She, J-X. & Weinberger, P. M., Feb 14 2018, In : International journal of molecular sciences. 19, 2, 577.

Research output: Contribution to journalArticle

2 Scopus citations

Delineating pro-angiogenic myeloid cells in cancer therapy

Johnson, B. W., Achyut, B. R., Fulzele, S., Mondal, A. K., Kolhe, R. & Arbab, A. S., Sep 2018, In : International journal of molecular sciences. 19, 9, 2565.

Research output: Contribution to journalReview article

Draft genome sequence of a novel rhabdovirus isolated from Deinocerites mosquitoes

Xu, C. L., Cantalupo, P. G., Sáenz-Robles, M. T., Baldwin, A., Fitzpatrick, D., Norris, D. E., Jackson, E. & Pipas, J. M., May 1 2018, In : Genome Announcements. 6, 19, e01438-17.

Research output: Contribution to journalArticle

2 Scopus citations

Elevated miR-182-5p associates with renal cancer cell mitotic arrest through diminished MALAT-1 expression

Kulkarni, P., Dasgupta, P., Bhat, N. S., Shahryari, V., Shiina, M., Hashimoto, Y., Majid, S., Deng, G., Saini, S., Tabatabai, Z. L., Yamamura, S., Tanaka, Y. & Dahiya, R., Nov 2018, In : Molecular Cancer Research. 16, 11, p. 1750-1760 11 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells

Prusinski Fernung, L., Yang, Q., Sakamuro, D., Kumari, A., Mas, A. & Al-Hendy, A., Oct 1 2018, In : Biology of reproduction. 99, 4, p. 735-748 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Exosome-Derived Dystrophin from Allograft Myogenic Progenitors Improves Cardiac Function in Duchenne Muscular Dystrophic Mice

Su, X., Jin, Y., Shen, Y., Ju, C., Cai, J., Liu, Y., Kim, I., Wang, Y., Yu, H., Weintraub, N. L., Jiang, M. & Tang, Y. L., 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalArticle

8 Scopus citations

Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro

Ruan, X. F., Li, Y. J., Ju, C. W., Shen, Y., Lei, W., Chen, C., Li, Y., Yu, H., Liu, Y., Kim, I., Wang, X. L., Weintraub, N. L. & Tang, Y. L., Apr 1 2018, In : Acta Pharmacologica Sinica. 39, 4, p. 579-586 8 p.

Research output: Contribution to journalArticle

15 Scopus citations