Biochemistry and Molecular Biology

Research Output

2017

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma

Poole, C. J., Zheng, W., Lodh, A., Yevtodiyenko, A., Liefwalker, D., Li, H., Felsher, D. W. & van Riggelen, J., Jan 1 2017, In : Oncotarget. 8, 44, p. 76898-76920 23 p.

Research output: Contribution to journalArticle

10 Scopus citations

Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines

Gelaleti, G. B., Borin, T. F., Maschio-Signorini, L. B., Moschetta, M. G., Jardim-Perassi, B. V., Calvinho, G. B., Facchini, M. C., Viloria-Petit, A. M. & de Campos Zuccari, D. A. P., Aug 15 2017, In : Life sciences. 183, p. 98-109 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
19 Scopus citations

Enhanced therapeutic efficacy and memory of tumor-specific CD8 T cells by ex vivo PI3K-δ inhibition

Abu Eid, R., Ahmad, S., Lin, Y., Webb, M., Berrong, Z., Shrimali, R. K., Kumai, T., Ananth, S., Rodriguez, P. C., Celis, E., Janik, J. E., Mkrtichyan, M. & Khleif, S. N., Aug 1 2017, In : Cancer Research. 77, 15, p. 4135-4145 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators

Pace, B. S., Makala, L. H., Sarkar, R., Liu, L., Takezaki, M., Mohandas, N., Dixon, G., Werner, E. M., Jeffe, D. B., Rice, T. K., Maihle, N. J. & González, J., Dec 2017, In : American Journal of Hematology. 92, 12, p. 1275-1279 5 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
2 Scopus citations

Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways

Fang, D., Chen, H., Zhu, J. Y., Wang, W., Teng, Y., Ding, H., Jing, Q., Su, S. B. & Huang, S., Mar 1 2017, In : Oncogene. 36, 11, p. 1546-1558 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor

Wu, D., Jun 2017, In : Genes and Diseases. 4, 2, p. 100-107 8 p.

Research output: Contribution to journalReview article

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib

Gao, L., Wang, X., Tang, Y., Huang, S., Hu, C. A. A. & Teng, Y., Jan 9 2017, In : Journal of Experimental and Clinical Cancer Research. 36, 1, 8.

Research output: Contribution to journalArticle

41 Scopus citations
5 Scopus citations

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

Borin, T. F., Shankar, A., Angara, K., Rashid, M. H., Jain, M., Iskander, A., Ara, R., Lebedyeva, I., Korkaya, H., Achyut, B. R. & Arbab, A. S., Jun 2017, In : PloS one. 12, 6, 0178830.

Research output: Contribution to journalArticle

4 Scopus citations

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Zhou, D., Hlady, R. A., Schafer, M. J., White, T. A., Liu, C., Choi, J. H., Miller, J. D., Roberts, L. R., LeBrasseur, N. K. & Robertson, K. D., Jan 2 2017, In : Epigenetics. 12, 1, p. 55-69 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hyaluronic acid family in bladder cancer: Potential prognostic biomarkers and therapeutic targets

Morera, D. S., Hennig, M. S., Talukder, A., Lokeshwar, S. D., Wang, J., Garcia-Roig, M., Ortiz, N., Yates, T. J., Lopez, L. E., Kallifatidis, G., Kramer, M. W., Jordan, A. R., Merseburger, A. S., Manoharan, M., Soloway, M. S., Terris, M. K. & Lokeshwar, V. B., Nov 7 2017, In : British Journal of Cancer. 117, 10, p. 1507-1517 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with index of hydroxyurea responsiveness

Zhu, X., Hu, T., Ho, M. H., Wang, Y., Yu, M., Patel, N., Pi, W., Choi, J-H., Xu, H., Ganapathy, V., Kutlar, F., Kutlar, A. & Tuan Lo, D., Nov 30 2017, In : Haematologica. 102, 12, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hypermethylated LTR retrotransposon exhibits enhancer activity

Hu, T., Zhu, X., Pi, W., Yu, M., Shi, H. & Tuan Lo, D., Mar 4 2017, In : Epigenetics. 12, 3, p. 226-237 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Id1 promotes obesity by suppressing brown adipose thermogenesis and white adipose browning

Patil, M., Sharma, B. K., Elattar, S., Chang, J., Kapil, S., Yuan, J. & Satyanarayana, A., Jun 1 2017, In : Diabetes. 66, 6, p. 1611-1625 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

Jain, M., Gamage, N. D. H., Alsulami, M., Shankar, A., Achyut, B. R., Angara, K., Rashid, M. H., Iskander, A., Borin, T. F., Zhi, W., Ara, R., Ali, M. M., Lebedyeva, I. O., Chwang, W. B., Guo, A., Bagher-Ebadian, H. & Arbab, A. S., Jan 31 2017, In : Scientific reports. 7, 41809.

Research output: Contribution to journalArticle

6 Scopus citations

Isolation of Extracellular Vesicles from Stem Cells

Chen, Z., Li, Y., Yu, H., Shen, Y., Ju, C., Ma, G., Liu, Y., Kim, I., Weintraub, N. L. & Tang, Y. L., Jan 1 2017, In : Methods in molecular biology (Clifton, N.J.). 1660, p. 389-394 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
30 Scopus citations

Label-free ferrohydrodynamic cell separation of circulating tumor cells

Zhao, W., Cheng, R., Jenkins, B. D., Zhu, T., Okonkwo, N. E., Jones, C. E., Davis, M. B., Kavuri, S. K., Hao, Z., Schroeder, C. & Mao, L., Jan 1 2017, In : Lab on a Chip. 17, 18, p. 3097-3111 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Local activation of p53 in the tumor microenvironment overcomes immune suppression and enhances antitumor immunity

Guo, G., Yu, M., Xiao, W., Celis, E. & Cui, Y., May 1 2017, In : Cancer Research. 77, 9, p. 2292-2305 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function

Hu, T., Pi, W., Zhu, X., Yu, M., Ha, H., Shi, H., Choi, J-H. & Tuan Lo, D., Jan 1 2017, In : Nucleic Acids Research. 45, 8, p. 4479-4492 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Long-term sustainable dendritic cell-specific depletion murine model for periodontitis research

Finger Stadler, A., Patel, M., Pacholczyk, R., Cutler, C. W. & Arce, R. M., Oct 2017, In : Journal of Immunological Methods. 449, p. 7-14 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lv, G., Sun, D., Zhang, J., Xie, X., Wu, X., Fang, W., Tian, J., Yan, C., Wang, H. & Fu, F., Jan 1 2017, In : Acta Pharmaceutica Sinica B. 7, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Major challenges and potential microenvironment-targeted therapies in glioblastoma

Arbab, A. S., Rashid, M. H., Angara, K., Borin, T. F., Lin, P. C., Jain, M. & Achyut, B. R., Dec 16 2017, In : International journal of molecular sciences. 18, 12, 2732.

Research output: Contribution to journalReview article

5 Scopus citations

Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis

Zhang, L., Wang, Y., Rashid, M. H., Liu, M., Angara, K., Mivechi, N. F., Maihle, N. J., Arbab, A. S. & Ko, L., Feb 7 2017, In : Oncotarget. 8, 31, p. 51591-51607 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mediator complex components are frequent targets for genetic alterations in various types of human cancer

Deng, L., Zhang, C., Miao, D., Tang, X., Luo, S., Xin, H. B. & Shi, H., Dec 20 2017, In : Journal of Genetics and Genomics. 44, 12, p. 587-591 5 p.

Research output: Contribution to journalLetter

Melatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells

Gelaleti, G. B., Borin, T. F., Maschio-Signorini, L. B., Moschetta, M. G., Hellmén, E., Viloria-Petit, A. M. & Zuccari, D. A. P. C., Dec 1 2017, In : Veterinary and Comparative Oncology. 15, 4, p. 1572-1584 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Metformin alters DNA methylation genome-wide via the H19/SAHH axis

Zhong, T., Men, Y., Lu, L., Geng, T., Zhou, J., Mitsuhashi, A., Shozu, M., Maihle, N. J., Carmichael, G. G., Taylor, H. S. & Huang, Y., Apr 27 2017, In : Oncogene. 36, 17, p. 2345-2354 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition

Bayoumi, A. S., Teoh, J. P., Aonuma, T., Yuan, Z., Ruan, X., Tang, Y., Su, H., Weintraub, N. L. & Kim, I. M., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1603-1614 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mifepristone has limited activity to enhance the in vivo efficacy of docetaxel and enzalutamide against bone metastatic and castration-resistant prostate cancer

Yang, Y., Li, X., Mamouni, K., Kucuk, O. & Wu, D., Nov 2017, In : Anticancer research. 37, 11, p. 6235-6243 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature Communications. 8, 14979.

Research output: Contribution to journalArticle

66 Scopus citations
11 Scopus citations

MYC—master regulator of the cancer epigenome and transcriptome

Poole, C. J. & van Riggelen, J., May 13 2017, In : Genes. 8, 5, 142.

Research output: Contribution to journalReview article

35 Scopus citations

Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage

Cui, H., Gu, X., Chen, J., Xie, Y., Ke, S., Wu, J., Golovko, A., Morpurgo, B., Yan, C., Phillips, T. D., Xie, W., Luo, J., Zhou, Z. & Tian, Y., Jun 5 2017, In : Toxicology Letters. 275, p. 67-76 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Preparation of membrane models of gram-negative bacteria and their interaction with antimicrobial peptides studied by CD and NMR

Hicks, R., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 231-245 15 p. (Methods in Molecular Biology; vol. 1548).

Research output: Chapter in Book/Report/Conference proceedingChapter

Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy

Ellsworth, S. G., Rabatic, B. M., Chen, J., Zhao, J., Campbell, J., Wang, W., Pi, W., Stanton, P., Matuszak, M., Jolly, S., Miller, A. & Kong, F. M., Sep 2017, In : PloS one. 12, 9, e0183239.

Research output: Contribution to journalArticle

4 Scopus citations

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
12 Scopus citations

Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis

Xiao-Xu, X. X., Liu, Y., Zhang, Y. F., Guan, Y. N., Jia, Q. Q., Wang, C., Liang, H., Li, Y. Q., Yang, H. T., Qin, Y. W., Huang, S., Zhao, X. X. & Jing, Q., Oct 1 2017, In : Journal of the American Heart Association. 6, 10, e005295.

Research output: Contribution to journalArticle

4 Scopus citations

Recent trends in racial and regional disparities in cervical cancer incidence and mortality in United States

Yoo, W., Kim, S., Huh, W. K., Dilley, S., Coughlin, S. S., Partridge, E. E., Chung, Y., Dicks, V., Lee, J. K. & Bae, S., Feb 2017, In : PloS one. 12, 2, e0172548.

Research output: Contribution to journalArticle

26 Scopus citations

SETD1B activates iNOS expression in myeloid-derived suppressor cells

Redd, P. S., Ibrahim, M. L., Klement, J. D., Sharman, S. K., Paschall, A. V., Yang, D., Nayak-Kapoor, A. & Liu, K., Jun 1 2017, In : Cancer Research. 77, 11, p. 2834-2843 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Sildenafil normalizes bowel transit in preclinical models of constipation

Sharman, S. K., Islam, B. N., Hou, Y., Usry, M., Bridges, A., Singh, N., Sridhar, S., Rao, S. & Browning, D. D., Apr 2017, In : PloS one. 12, 4, e0176673.

Research output: Contribution to journalArticle

6 Scopus citations

Sildenafil suppresses inflammation-driven colorectal cancer in mice

Islam, B. N., Sharman, S. K., Hou, Y., Bridges, A. E., Singh, N., Kim, S., Kolhe, R. B., Trillo-Tinoco, J., Rodriguez, P. C., Berger, F. G., Sridhar, S. & Browning, D. D., Jul 1 2017, In : Cancer Prevention Research. 10, 7, p. 377-388 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth

Zheng, J., Zhao, S., Yu, X., Huang, S. & Liu, H., Mar 23 2017, In : Theranostics. 7, 5, p. 1373-1388 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase i independent of Cdk2 activation

Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. Å. & Liu, K., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 592-597 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

STAT3-mediated activation of miR-21 is involved in downregulation of TIMP3 and neovascularization in the ischemic retina

Gutsaeva, D. R., Thounaojam, M., Rajpurohit, S., Powell, F. L., Martin, P. M., Goei, S., Duncan, M. & Bartoli, M., Jan 1 2017, In : Oncotarget. 8, 61, p. 103568-103580 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Systemic levels of estrogens and PGE2 synthesis in relation to postmenopausal breast cancer risk

Kim, S., Campbell, J., Yoo, W., Taylor, J. A. & Sandler, D. P., Mar 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 3, p. 383-388 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Taming immune suppressor: Application of myeloid-derived suppressor cells in anti-cancer gene therapy

Achyut, B. R. & Arbab, A. S., Jan 1 2017, In : Translational Cancer Research. 6, p. S160-S162

Research output: Contribution to journalEditorial

Teaching Biochemistry and Genetics to Students of Medicine, Pharmacy, and Dentistry: 6 th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017

Niederhoffer, E. C., Cline, S. D., Osheroff, N., Simmons, J. M., Diekman, A. B., Franklin, D. S., Abali, E. E., Bateman, R. C., Fontes, J. D., Lindsley, J. E., Pearson, D., Rubenstein, P. A., Slaughter, C. A., Bernstein, J. A., Hyland, K. M., Park, V. M., Sobering, A. K., Weiler, T. A. & Dasgupta, S., Dec 1 2017, In : Medical Science Educator. 27, 4, p. 855-859 5 p.

Research output: Contribution to journalArticle

3 Scopus citations