Biochemistry and Molecular Biology

Research Output

2017

Inhibition of Epithelial-Mesenchymal Transition and Metastasis by Combined TGFbeta Knockdown and Metformin Treatment in a Canine Mammary Cancer Xenograft Model

Leonel, C., Borin, T. F., de Carvalho Ferreira, L., Moschetta, M. G., Bajgelman, M. C., Viloria-Petit, A. M. & de Campos Zuccari, D. A. P., Mar 1 2017, In : Journal of Mammary Gland Biology and Neoplasia. 22, 1, p. 27-41 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

Jain, M., Gamage, N. D. H., Alsulami, M., Shankar, A., Achyut, B. R., Angara, K., Rashid, M. H., Iskander, A., Borin, T. F., Zhi, W., Ara, R., Ali, M. M., Lebedyeva, I. O., Chwang, W. B., Guo, A., Bagher-Ebadian, H. & Arbab, A. S., Jan 31 2017, In : Scientific reports. 7, 41809.

Research output: Contribution to journalArticle

8 Scopus citations

Isolation of Extracellular Vesicles from Stem Cells

Chen, Z., Li, Y., Yu, H., Shen, Y., Ju, C., Ma, G., Liu, Y., Kim, I., Weintraub, N. L. & Tang, Y. L., 2017, In : Methods in molecular biology (Clifton, N.J.). 1660, p. 389-394 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
41 Scopus citations

Label-free ferrohydrodynamic cell separation of circulating tumor cells

Zhao, W., Cheng, R., Jenkins, B. D., Zhu, T., Okonkwo, N. E., Jones, C. E., Davis, M. B., Kavuri, S. K., Hao, Z., Schroeder, C. & Mao, L., Sep 21 2017, In : Lab on a Chip. 17, 18, p. 3097-3111 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
Open Access
4 Scopus citations

Local activation of p53 in the tumor microenvironment overcomes immune suppression and enhances antitumor immunity

Guo, G., Yu, M., Xiao, W., Celis, E. & Cui, Y., May 1 2017, In : Cancer Research. 77, 9, p. 2292-2305 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function

Hu, T., Pi, W., Zhu, X., Yu, M., Ha, H., Shi, H., Choi, J-H. & Tuan Lo, D., 2017, In : Nucleic Acids Research. 45, 8, p. 4479-4492 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Long-term sustainable dendritic cell-specific depletion murine model for periodontitis research

Finger Stadler, A., Patel, M., Pacholczyk, R., Cutler, C. W. & Arce, R. M., Oct 2017, In : Journal of Immunological Methods. 449, p. 7-14 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lv, G., Sun, D., Zhang, J., Xie, X., Wu, X., Fang, W., Tian, J., Yan, C., Wang, H. & Fu, F., Jan 1 2017, In : Acta Pharmaceutica Sinica B. 7, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Major challenges and potential microenvironment-targeted therapies in glioblastoma

Arbab, A. S., Rashid, M. H., Angara, K., Borin, T. F., Lin, P. C., Jain, M. & Achyut, B. R., Dec 16 2017, In : International journal of molecular sciences. 18, 12, 2732.

Research output: Contribution to journalReview article

7 Scopus citations

Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis

Zhang, L., Wang, Y., Rashid, M. H., Liu, M., Angara, K., Mivechi, N. F., Maihle, N. J., Arbab, A. S. & Ko, L., Feb 7 2017, In : Oncotarget. 8, 31, p. 51591-51607 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mediator complex components are frequent targets for genetic alterations in various types of human cancer

Deng, L., Zhang, C., Miao, D., Tang, X., Luo, S., Xin, H. B. & Shi, H., Dec 20 2017, In : Journal of Genetics and Genomics. 44, 12, p. 587-591 5 p.

Research output: Contribution to journalLetter

Melatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells

Gelaleti, G. B., Borin, T. F., Maschio-Signorini, L. B., Moschetta, M. G., Hellmén, E., Viloria-Petit, A. M. & Zuccari, D. A. P. C., Dec 1 2017, In : Veterinary and Comparative Oncology. 15, 4, p. 1572-1584 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Metformin alters DNA methylation genome-wide via the H19/SAHH axis

Zhong, T., Men, Y., Lu, L., Geng, T., Zhou, J., Mitsuhashi, A., Shozu, M., Maihle, N. J., Carmichael, G. G., Taylor, H. S. & Huang, Y., Apr 27 2017, In : Oncogene. 36, 17, p. 2345-2354 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer

Bucay, N., Sekhon, K., Yang, T., Majid, S., Shahryari, V., Hsieh, C., Mitsui, Y., Deng, G., Tabatabai, Z. L., Yamamura, S., Calin, G. A., Dahiya, R., Tanaka, Y. & Saini, S., May 11 2017, In : Oncogene. 36, 19, p. 2667-2679 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2

Colden, M., Dar, A. A., Saini, S., Dahiya, P. V., Shahryari, V., Yamamura, S., Tanaka, Y., Stein, G., Dahiya, R. & Majid, S., 2017, In : Cell Death and Disease. 8, 1, e2572.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

MicroRNA-720 regulates E-cadherin–αE-catenin complex and promotes renal cell carcinoma

Bhat, N. S., Colden, M., Dar, A. A., Saini, S., Arora, P., Shahryari, V., Yamamura, S., Tanaka, Y., Kato, T., Majid, S. & Dahiya, R., Dec 2017, In : Molecular cancer therapeutics. 16, 12, p. 2840-2848 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Mifepristone has limited activity to enhance the in vivo efficacy of docetaxel and enzalutamide against bone metastatic and castration-resistant prostate cancer

Yang, Y., Li, X., Mamouni, K., Kucuk, O. & Wu, D., Nov 2017, In : Anticancer research. 37, 11, p. 6235-6243 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature communications. 8, 14979.

Research output: Contribution to journalArticle

94 Scopus citations
12 Scopus citations

MYC—master regulator of the cancer epigenome and transcriptome

Poole, C. J. & van Riggelen, J., May 13 2017, In : Genes. 8, 5, 142.

Research output: Contribution to journalReview article

37 Scopus citations

Oxidative Stress in Liver Diseases: Pathogenesis, Prevention, and Therapeutics

Jadeja, R. N., Devkar, R. V. & Nammi, S., 2017, In : Oxidative medicine and cellular longevity. 2017, 8341286.

Research output: Contribution to journalEditorial

Open Access
11 Scopus citations

Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage

Cui, H., Gu, X., Chen, J., Xie, Y., Ke, S., Wu, J., Golovko, A., Morpurgo, B., Yan, C., Phillips, T. D., Xie, W., Luo, J., Zhou, Z. & Tian, Y., Jun 5 2017, In : Toxicology Letters. 275, p. 67-76 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Preparation of membrane models of gram-negative bacteria and their interaction with antimicrobial peptides studied by CD and NMR

Hicks, R., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 231-245 15 p. (Methods in Molecular Biology; vol. 1548).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy

Ellsworth, S. G., Rabatic, B. M., Chen, J., Zhao, J., Campbell, J., Wang, W., Pi, W., Stanton, P., Matuszak, M., Jolly, S., Miller, A. & Kong, F. M., Sep 2017, In : PloS one. 12, 9, e0183239.

Research output: Contribution to journalArticle

4 Scopus citations

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
16 Scopus citations

Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis

Xiao-Xu, X. X., Liu, Y., Zhang, Y. F., Guan, Y. N., Jia, Q. Q., Wang, C., Liang, H., Li, Y. Q., Yang, H. T., Qin, Y. W., Huang, S., Zhao, X. X. & Jing, Q., Oct 1 2017, In : Journal of the American Heart Association. 6, 10, e005295.

Research output: Contribution to journalArticle

6 Scopus citations

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

Daddacha, W., Koyen, A. E., Bastien, A. J., Head, P. S. E., Dhere, V. R., Nabeta, G. N., Connolly, E. C., Werner, E., Madden, M. Z., Daly, M. B., Minten, E. V., Whelan, D. R., Schlafstein, A. J., Zhang, H., Anand, R., Doronio, C., Withers, A. E., Shepard, C., Sundaram, R. K., Deng, X. & 8 others, Dynan, W. S., Wang, Y., Bindra, R. S., Cejka, P., Rothenberg, E., Doetsch, P. W., Kim, B. & Yu, D. S., Aug 22 2017, In : Cell Reports. 20, 8, p. 1921-1935 15 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

SETD1B activates iNOS expression in myeloid-derived suppressor cells

Redd, P. S., Ibrahim, M. L., Klement, J. D., Sharman, S. K., Paschall, A. V., Yang, D., Nayak-Kapoor, A. & Liu, K., Jun 1 2017, In : Cancer Research. 77, 11, p. 2834-2843 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Sildenafil normalizes bowel transit in preclinical models of constipation

Sharman, S. K., Islam, B. N., Hou, Y., Usry, M., Bridges, A., Singh, N., Sridhar, S., Rao, S. & Browning, D. D., Apr 2017, In : PloS one. 12, 4, e0176673.

Research output: Contribution to journalArticle

9 Scopus citations

Sildenafil suppresses inflammation-driven colorectal cancer in mice

Islam, B. N., Sharman, S. K., Hou, Y., Bridges, A. E., Singh, N., Kim, S., Kolhe, R. B., Trillo-Tinoco, J., Rodriguez, P. C., Berger, F. G., Sridhar, S. & Browning, D. D., Jul 1 2017, In : Cancer Prevention Research. 10, 7, p. 377-388 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways

Imai-Sumida, M., Chiyomaru, T., Majid, S., Saini, S., Nip, H., Dahiya, R., Tanaka, Y. & Yamamura, S., 2017, In : Oncotarget. 8, 54, p. 92032-92042 11 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth

Zheng, J., Zhao, S., Yu, X., Huang, S. & Liu, H., Mar 23 2017, In : Theranostics. 7, 5, p. 1373-1388 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sirtuin 2 mutations in human cancers impair its function in genome maintenance

Head, P. E., Zhang, H., Bastien, A. J., Koyen, A. E., Withers, A. E., Daddacha, W. B., Cheng, X. & Yu, D. S., Jun 16 2017, In : Journal of Biological Chemistry. 292, 24, p. 9919-9931 13 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase i independent of Cdk2 activation

Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. Å. & Liu, K., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 592-597 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
11 Scopus citations

Taming immune suppressor: Application of myeloid-derived suppressor cells in anti-cancer gene therapy

Achyut, B. R. & Arbab, A. S., 2017, In : Translational Cancer Research. 6, p. S160-S162

Research output: Contribution to journalEditorial

1 Scopus citations

Teaching Biochemistry and Genetics to Students of Medicine, Pharmacy, and Dentistry: 6 th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017

Niederhoffer, E. C., Cline, S. D., Osheroff, N., Simmons, J. M., Diekman, A. B., Franklin, D. S., Abali, E. E., Bateman, R. C., Fontes, J. D., Lindsley, J. E., Pearson, D., Rubenstein, P. A., Slaughter, C. A., Bernstein, J. A., Hyland, K. M., Park, V. M., Sobering, A. K., Weiler, T. A. & Dasgupta, S., Dec 1 2017, In : Medical Science Educator. 27, 4, p. 855-859 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

The cell polarity protein Scrib functions as a tumor suppressor in liver cancer

Kapil, S., Sharma, B. K., Patil, M., Elattar, S., Yuan, J., Hou, S. X., Kolhe, R. B. & Ande, S., 2017, In : Oncotarget. 8, 16, p. 26515-26531 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

The dual roles of MYC in genomic instability and cancer chemoresistance

Kumari, A., Folk, W. P. & Sakamuro, D., Jun 7 2017, In : Genes. 8, 6, 158.

Research output: Contribution to journalReview article

15 Scopus citations

The expression of RUNDC3B is associated with promoter methylation in lymphoid malignancies

Burmeister, D. W., Smith, E. H., Cristel, R. T., McKay, S. D., Shi, H., Arthur, G. L., Davis, J. W. & Taylor, K. H., Mar 1 2017, In : Hematological Oncology. 35, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

The impact of antibiotic usage on the efficacy of chemoimmunotherapy is contingent on the source of tumorreactive T cells

Kuczma, M. P., Ding, Z-C., Li, T., Habtetsion, T., Chen, T., Hao, Z., Bryan, L. J., Singh, N., Kochenderfer, J. N. & Zhou, G., 2017, In : Oncotarget. 8, 67, p. 111931-111942 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

The MLL1-H3K4me3 axis-mediated PD-L1 expression and pancreatic cancer immune evasion

Lu, C., Paschall, A. V., Shi, H., Savage, N., Waller, J. L., Sabbatini, M. E., Oberlies, N. H., Pearce, C. & Liu, K., 2017, In : Journal of the National Cancer Institute. 109, 6, djw283.

Research output: Contribution to journalArticle

60 Scopus citations

The Relationship Between Probiotics and Dietary Fiber Consumption and Cardiovascular Health

Prasad, P. D., Gurav, A., Zhu, H., Martin, P. M., Vijay-Kumar, M. & Singh, N., Jul 13 2017, Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber's Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health. Elsevier Inc., p. 73-90 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The role of miR-24 as a race related genetic factor in prostate cancer

Hashimoto, Y., Shiina, M., Kato, T., Yamamura, S., Tanaka, Y., Majid, S., Saini, S., Shahryari, V., Kulkarni, P., Dasgupta, P., Mitsui, Y., Sumida, M., Deng, G., Tabatabai, L., Kumar, D. & Dahiya, R., 2017, In : Oncotarget. 8, 10, p. 16581-16593 13 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands

Cahill, M. A. & Medlock, A. E., Jul 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 171, p. 11-33 23 p.

Research output: Contribution to journalReview article

15 Scopus citations

Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish

Dimri, M., Bilogan, C., Pierce, L. X., Naegele, G., Vasanji, A., Gibson, I., McClendon, A., Tae, K. & Sakaguchi, T. F., Jul 15 2017, In : Development (Cambridge). 144, 14, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations