Biochemistry and Molecular Biology

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2020

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

Wang, L., Liu, Y., Du, T., Yang, H., Lei, L., Guo, M., Ding, H., Zhang, J., Wang, H., Chen, X. & Yan, C., Feb 1 2020, In : Cell Death and Differentiation. 27, 2, p. 662-675 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium

Song, W., Sheng, L., Chen, F., Tian, Y., Li, L., Wang, G., Li, H. & Cai, Y., Mar 1 2020, In : Cell Stress and Chaperones. 25, 2, p. 223-233 11 p.

Research output: Contribution to journalArticle

Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function

Upadhyay, K. K., Jadeja, R. N., Vyas, H. S., Pandya, B., Joshi, A., Vohra, A., Thounaojam, M. C., Martin, P. M., Bartoli, M. & Devkar, R. V., Jan 2020, In : Redox Biology. 28, 101314.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

Yu, M., Guo, G., Huang, L., Deng, L., Chang, C. S., Achyut, B. R., Canning, M., Xu, N., Arbab, A. S., Bollag, R. J., Rodriguez, P. C., Mellor, A. L., Shi, H., Munn, D. H. & Cui, Y., Dec 1 2020, In : Nature communications. 11, 1, 515.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Clinical Parameters Outperform Molecular Subtypes for Predicting Outcome in Bladder Cancer: Results from Multiple Cohorts, Including TCGA

Morera, D. S., Hasanali, S. L., Belew, D., Ghosh, S., Klaassen, Z., Jordan, A. R., Wang, J., Terris, M. K., Bollag, R. J., Merseburger, A. S., Stenzl, A., Soloway, M. S. & Lokeshwar, V. B., Jan 1 2020, In : The Journal of urology. 203, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In : International Journal of Cancer. 146, 8, p. 2243-2254 12 p.

Research output: Contribution to journalArticle

Open Access

Homocysteine induces inflammation in retina and brain

Elsherbiny, N. M., Sharma, I., Kira, D., Alhusban, S., Samra, Y. A., Jadeja, R., Martin, P., Al-Shabrawey, M. & Tawfik, A., Mar 2020, In : Biomolecules. 10, 3, 393.

Research output: Contribution to journalArticle

Open Access
Open Access
4 Scopus citations

Invasion of Human Retinal Pigment Epithelial Cells by Porphyromonas gingivalis leading to Vacuolar/Cytosolic localization and Autophagy dysfunction In-Vitro

Arjunan, P., Swaminathan, R., Yuan, J., Al-Shabrawey, M., Espinosa-Heidmann, D. G., Nussbaum, J., Martin, P. M. & Cutler, C. W., Dec 1 2020, In : Scientific reports. 10, 1, 7468.

Research output: Contribution to journalArticle

Open Access

Molecular Bio-Imaging Probe for Non-Invasive Differentiation Between Human Leiomyoma Versus Leiomyosarcoma

Shalaby, S., Khater, M., Laknaur, A., Arbab, A. & Al-Hendy, A., Feb 1 2020, In : Reproductive Sciences. 27, 2, p. 644-654 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice

Achyut, B. R., Zhang, H., Angara, K., Mivechi, N. F., Arbab, A. S. & Ko, L., Apr 28 2020, In : Cancer Letters. 476, p. 57-66 10 p.

Research output: Contribution to journalArticle

Open Access

PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo

Li, F., Liu, Z., Sun, H., Li, C., Wang, W., Ye, L., Yan, C., Tian, J. & Wang, H., Feb 2020, In : Acta Pharmaceutica Sinica B. 10, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice

Gunebakan, E., Yalcin, E., Dulger, E. C., Yigitbasi, A., Ates, N., Caglayan, A., Beker, M. C., Sahin, K., Korkaya, H. & Kilic, E., Feb 1 2020, In : Biomedicines. 8, 2, 23.

Research output: Contribution to journalArticle

Open Access

Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades

Huang, Y., Feng, G., Cai, J., Peng, Q., Yang, Z., Yan, C., Yang, L. & Wang, Z., May 1 2020, In : Life sciences. 248, 117449.

Research output: Contribution to journalArticle

SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth

Lu, C., Klement, J. D., Yang, D., Albers, T., Lebedyeva, I. O., Waller, J. L. & Liu, K., Apr 28 2020, In : Cancer Letters. 476, p. 87-96 10 p.

Research output: Contribution to journalArticle

The role of melatonin on miRNAs modulation in triple-negative breast cancer cells

Ferreira, L. C., Orso, F., Dettori, D., Lacerda, J. Z., Borin, T. F., Taverna, D. & Zuccari, D. A. P. C., Jan 1 2020, In : PloS one. 15, 2, e0228062.

Research output: Contribution to journalArticle

Open Access

UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis

Wang, L., Xu, Y., Rogers, H., Saidi, L., Noguchi, C. T., Li, H., Yewdell, J. W., Guydosh, N. R. & Ye, Y., Jan 1 2020, In : Cell Research. 30, 1, p. 5-20 16 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients

Mitchell, A., Hasanali, S. L., Morera, D. S., Baskar, R., Wang, X., Khan, R., Talukder, A., Li, C. S., Manoharan, M., Jordan, A. R., Wang, J., Bollag, R. J., Singh, N., Albo, D., Ghosh, S. & Lokeshwar, V. B., Jan 1 2019, In : Cancer biomarkers : section A of Disease markers. 26, 3, p. 291-301 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice

Srinivasan, M. P., Shawky, N. M., Kaphalia, B. S., Thangaraju, M. & Segar, L., Feb 2019, In : Biochemical Pharmacology. 160, p. 46-61 16 p.

Research output: Contribution to journalArticle

A potential role for SMAD9 in goose follicular selection through regulation of mRNA levels of luteinizing hormone receptor

Yu, D., Zhang, L., Wang, H., Chen, F., Chen, J., Zhang, Z., Li, J., Xing, C., Li, H., Li, J. & Cai, Y., Sep 1 2019, In : Theriogenology. 135, p. 204-212 9 p.

Research output: Contribution to journalArticle

Atypical chemokine receptor 1 (DARC/ACKR1) in breast tumors is associated with survival, circulating chemokines, tumor-infiltrating immune cells, and African ancestry

Jenkins, B. D., Martini, R. N., Hire, R., Brown, A., Bennett, B., Brown, I., Howerth, E. W., Egan, M., Hodgson, J., Yates, C., Kittles, R., Chitale, D., Ali, H., Nathanson, D., Nikolinakos, P., Newman, L., Monteil, M. & Davis, M. B., Apr 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 4, p. 690-700 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

B-arrestins regulate stem cell-like phenotype and response to chemotherapy in bladder cancer

Kallifatidis, G., Smith, D. K., Morera, D. S., Gao, J., Hennig, M. J., Hoy, J. J., Pearce, R. F., Dabke, I. R., Li, J., Merseburger, A. S., Kuczyk, M. A., Lokeshwar, V. B. & Lokeshwar, B. L., Apr 2019, In : Molecular cancer therapeutics. 18, 4, p. 801-811 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

BRN4 is a novel driver of neuroendocrine differentiation in castration-resistant prostate cancer and is selectively released in extracellular vesicles with BRN2

Bhagirath, D., Yang, T. L., Tabatabai, Z. L., Majid, S., Dahiya, R., Tanaka, Y. & Saini, S., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6532-6545 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

Xue, N., Lai, F., Du, T., Ji, M., Liu, D., Yan, C., Zhang, S., Yu, X., Jin, J. & Chen, X., Sep 1 2019, In : Cellular and Molecular Life Sciences. 76, 17, p. 3433-3447 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Competitive ubiquitination activates the tumor suppressor p53

Li, X., Guo, M., Cai, L., Du, T., Liu, Y., Ding, H. F., Wang, H., Zhang, J., Chen, X. & Yan, C., Jan 1 2019, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access

Computational methods for detection of differentially methylated regions using kernel distance and scan statistics

Dunbar, F., Xu, H., Ryu, D., Ghosh, S., Shi, H. & George, V., Apr 2019, In : Genes. 10, 4, 298.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

Ji, Y., Liu, Y., Xue, N., Du, T., Wang, L., Huang, R., Li, L., Yan, C. & Chen, X., Jan 1 2019, In : OncoTargets and Therapy. 12, p. 883-896 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells

Chen, L., Tang, S., Zhang, F. F., Garcia, V., Falck, J. R., Schwartzman, M. L., Arbab, A. S. & Guo, A. M., Jun 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 6, p. H1468-H1479

Research output: Contribution to journalArticle

Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study

Khodaverdian, V., Tapadar, S., MacDonald, I. A., Xu, Y., Ho, P. Y., Bridges, A., Rajpurohit, P., Sanghani, B. A., Fan, Y., Thangaraju, M., Hathaway, N. A. & Oyelere, A. K., Dec 1 2019, In : Scientific reports. 9, 1, 4802.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock

Subramani, K., Chu, X., Warren, M., Lee, M., Lu, S., Singh, N. & Raju, R. P., Mar 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 3, p. 688-695 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Detection of differentially methylated regions using bayes factor for ordinal group responses

Dunbar, F., Xu, H., Ryu, D., Ghosh, S., Shi, H. & George, V., Sep 2019, In : Genes. 10, 9, 721.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
2 Scopus citations

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity

Pan, Y., Choi, J-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In : Scientific reports. 9, 1, 3433.

Research output: Contribution to journalArticle

1 Scopus citations

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

Amro, A., Chen, Y., Barry, R., Susick, L., Bensenhaver, J., Proctor, E., Petersen, L., Nathanson, S. D., Ali, H., Loutfi, R., Chitale, D., Simonds, A., Kuklinski, M., Park, K. U., Davis, M. & Newman, L. A., Jul 1 2019, In : Breast Journal. 25, 4, p. 667-671 5 p.

Research output: Contribution to journalArticle

DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis

Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Nov 29 2019, In : Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Evaluation of angiogenesis process after metformin and LY294002 treatment in mammary tumor

Moschetta, M. G., Leonel, C., Maschio-Signorini, L. B., Borin, T. F., Gelaleti, G. B., Jardim-Perassi, B. V., Ferreira, L. C., Sonehara, N. M., Carvalho, L. G. S., Hellmén, E. & Zuccari, D. A. P. D. C., Jan 1 2019, In : Anti-Cancer Agents in Medicinal Chemistry. 19, 5, p. 655-666 12 p.

Research output: Contribution to journalArticle

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

2 Scopus citations

HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival

Ajith, A., Portik-Dobos, V., Nguyen-Lefebvre, A. T., Callaway, C., Horuzsko, D. D., Kapoor, R., Zayas, C., Maenaka, K., Mulloy, L. L. & Horuzsko, A., Jan 1 2019, In : FASEB Journal. 33, 4, p. 5220-5236 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., Browning, D. D., Liu, K., Blumberg, R., Singh, N. & Li, H., Dec 1 2019, In : Cell Discovery. 5, 1, 7.

Research output: Contribution to journalArticle

5 Scopus citations

Intracellular reduction in ATP levels contributes to CYT997-induced suppression of metastasis of head and neck squamous carcinoma

Zhao, X., Lang, L., He, L., Gao, L., Chyan, D., Xiong, Y., Li, H., Peng, H. & Teng, Y., Feb 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 2, p. 1174-1182 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Loss of fas expression and function is coupled with colon cancer resistance to immune checkpoint inhibitor immunotherapy

Xiao, W., Ibrahim, M. L., Redd, P. S., Klement, J. D., Lu, C., Yang, D., Savage, N. M. & Liu, K., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 420-430 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Jadeja, R. N., Jones, M. A., Fromal, O., Powell, F. L., Khurana, S., Singh, N. & Martin, P. M., Jan 1 2019, In : Aging. 11, 2, p. 386-400 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice

Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In : Cancer Research. 79, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin

Folk, W. P., Kumari, A., Iwasaki, T., Pyndiah, S., Johnson, J. C., Cassimere, E. K., Abdulovic-Cui, A. L. & Sakamuro, D., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5700-5719 20 p.

Research output: Contribution to journalArticle

3 Scopus citations

M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway

Jadeja, R. N., Chu, X., Wood, C., Bartoli, M. & Khurana, S., Nov 2019, In : Biochemical Pharmacology. 169, 113613.

Research output: Contribution to journalArticle

5 Scopus citations

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
Open Access
6 Scopus citations