Biochemistry and Molecular Biology

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2002

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effect of moderate caloric restriction and/or weight cycling on mammary tumor incidence and latency in MMTV-Neu female mice

Pape-Ansorge, K. A., Grande, J. P., Christensen, T. A., Maihle, N. J. & Cleary, M. P., 2002, In : Nutrition and Cancer. 44, 2, p. 162-168 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

Maihle, N. J., Lafky, J. M., Baron, A. T., Boardman, C. H., Greenwood, T. M., Christensen, T. A., Reiter, J. L., Cora, E. M., Lee, H., Suman, V. J., Fishman, D. A., Perez, E. A. & Podratz, K. C., Mar 1 2002, In : Journal of Clinical Ligand Assay. 25, 1, p. 57-60 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Endogenous reactivation of the RARβ2 tumor suppressor gene epigenetically silenced in breast cancer

Sirchia, S. M., Ren, M., Pili, R., Sironi, E., Somenzi, G., Ghidoni, R., Toma, S., Nicolò, G. & Sacchi, N., May 1 2002, In : Cancer Research. 62, 9, p. 2455-2461 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

Generation and characterization of polyclonal antibodies specific for human p110 sEGFR

Christensen, T. A., Reiter, J. L., Baron, A. T. & Maihle, N. J., Jan 1 2002, In : Hybridoma and Hybridomics. 21, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

Wiemann, S. U., Ande, S., Tsahuridu, M., Tillmann, H. L., Zender, L., Klempnauer, J., Flemming, P., Franco, S., Blasco, M. A., Manns, M. P. & Lenhard Rudolph, K., Jul 22 2002, In : FASEB Journal. 16, 9, p. 935-942 8 p.

Research output: Contribution to journalArticle

341 Scopus citations
153 Scopus citations

IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription

Chen, L. Y., Zuraw, B. L., Liu, F. T., Huang, S. & Pan, Z. K., Oct 1 2002, In : Journal of Immunology. 169, 7, p. 3934-3939 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Inhibition of system A amino acid transport activity by ethanol in BeWo choriocarcinoma cells

Jones, C. R., Srinivas, S. R., Devoe, L. D., Ganapathy, V. & Prasad, P. D., Jan 1 2002, In : American journal of obstetrics and gynecology. 187, 1, p. 209-216 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Leptin - A growth factor in normal and malignant breast cells and for normal mammary gland development

Hu, X., Juneja, S. C., Maihle, N. J. & Cleary, M. P., Nov 20 2002, In : Journal of the National Cancer Institute. 94, 22, p. 1704-1711 8 p.

Research output: Contribution to journalArticle

Open Access
369 Scopus citations

Methylation-specific oligonucleotide microarray: A new potential for high-throughput methylation analysis

Gitan, R. S., Shi, H., Chen, C. M., Yan, P. S. & Huang, T. H. M., 2002, In : Genome Research. 12, 1, p. 158-164 7 p.

Research output: Contribution to journalArticle

255 Scopus citations

Peptide specificity of thymic selection of CD4+CD25+ T cells

Pacholczyk, R., Kraj, P. & Ignatowicz, L., Jan 15 2002, In : Journal of Immunology. 168, 2, p. 613-620 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men

Reddy, Y. S., Gotzkowsky, S. K., Eron, J. J., Kim, J. Y., Fiske, W. D., Fiscus, S. A., Petch, L., Cohen, M. S. & Kashuba, A. D. M., Nov 1 2002, In : Journal of Infectious Diseases. 186, 9, p. 1339-1343 5 p.

Research output: Contribution to journalArticle

39 Scopus citations
8 Scopus citations

Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells

Han, Q., Leng, J., Bian, D., Mahanivong, C., Carpenter, K. A., Pan, Z. K., Han, J. & Huang, S., Dec 13 2002, In : Journal of Biological Chemistry. 277, 50, p. 48379-48385 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

Wang, W., Chen, J. X., Liao, R., Deng, Q., Zhou, J. J., Huang, S. & Sun, P., 2002, In : Molecular and Cellular Biology. 22, 10, p. 3389-3403 15 p.

Research output: Contribution to journalArticle

301 Scopus citations

Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques

Nathwani, A. C., Davidoff, A. M., Hanawa, H., Hu, Y., Hoffer, F. A., Nikanorov, A., Slaughter, C., Ng, C. Y. C., Zhou, J., Lozier, J. N., Mandrell, T. D., Vanin, E. F. & Nienhuis, A. W., Sep 1 2002, In : Blood. 100, 5, p. 1662-1669 8 p.

Research output: Contribution to journalArticle

143 Scopus citations

The solitary long terminal repeats of ERV-9 endogenous retrovirus are conserved during primate evolution and possess enhancer activities in embryonic and hematopoietic cells

Ling, J., Pi, W., Bollag, R. J., Zeng, S., Keskintepe, M., Saliman, H., Krantz, S., Whitney, B. & Tuan Lo, D., 2002, In : Journal of Virology. 76, 5, p. 2410-2423 14 p.

Research output: Contribution to journalArticle

54 Scopus citations

Transport of D-serine via the amino acid transporter ATB0,+ expressed in the colon

Hatanaka, T., Huang, W., Nakanishi, T., Bridges, C. C., Ganapathy, V., Smith, S. B., Prasad, P. D., Ganapathy, V. & Ganapathy, M. E., 2002, In : Biochemical and Biophysical Research Communications. 291, 2, p. 291-295 5 p.

Research output: Contribution to journalArticle

69 Scopus citations

Velocity-coded colour magnetic resonance angiography and perfusion-weighted magnetic resonance imaging for the evaluation of extracranial-to-intracranial arterial bypass surgery

Miyazawa, N., Aoki, S., Toyama, K., Arbab, A. S., Hori, M., Umeda, T., Araki, T. & Nukui, H., Dec 2002, In : Clinical Neurology and Neurosurgery. 105, 1, p. 48-59 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-α female mice

Cleary, M. P., Jacobson, M. K., Phillips, F. C., Getzin, S. C., Grande, J. P. & Maihle, N. J., Sep 1 2002, In : Cancer Epidemiology Biomarkers and Prevention. 11, 9, p. 836-843 8 p.

Research output: Contribution to journalArticle

58 Scopus citations
2003

Activation of cGMP-dependent protein kinase by protein kinase C

Hou, Y., Lascola, J., Dulin, N. O., Ye, R. D. & Browning, D. D., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16706-16712 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Climatic variables are associated with seasonal acute asthma admissions to accident and emergency room facilities in Trinidad, West Indies

Ivey, M. A., Simeon, D. T. & Monteil, M. A., Nov 1 2003, In : Clinical and Experimental Allergy. 33, 11, p. 1526-1530 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles

Hicks, R. P., Mones, E., Kim, H., Koser, B. W., Nichols, D. A. & Bhattacharjee, A. K., Apr 1 2003, In : Biopolymers. 68, 4, p. 459-470 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer

Yan, P. S., Shi, H., Rahmatpanah, F., Hsiau, T. H. C., Hsiau, A. H. A., Leu, Y. W., Liu, J. C. & Huang, T. H. M., Oct 1 2003, In : Cancer Research. 63, 19, p. 6178-6186 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

Differential regulation of cell motility and invasion by FAK

Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., Huang, S., Li, E., Nemerow, G. R., Leng, J., Spencer, K. S. R., Cheresh, D. A. & Schlaepfer, D. D., Mar 3 2003, In : Journal of Cell Biology. 160, 5, p. 753-767 15 p.

Research output: Contribution to journalArticle

425 Scopus citations

Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation

Leu, Y. W., Rahmatpanah, F., Shi, H., Wei, S. H., Liu, J. C., Yan, P. S. & Huang, T. H. M., Oct 1 2003, In : Cancer Research. 63, 19, p. 6110-6115 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

Functional significance of protein kinase A activation by endothelin-1 and ATP: Negative regulation of SRF-dependent gene expression by PKA

Davis, A., Hogarth, K., Fernandes, D., Solway, J., Niu, J., Kolenko, V., Browning, D., Miano, J. M., Orlov, S. N. & Dulin, N. O., Jun 1 2003, In : Cellular Signalling. 15, 6, p. 597-604 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Genetically obese MMTV-TGF-α/Lepob Lepob female mice do not develop mammary tumors

Cleary, M. P., Phillips, F. C., Getzin, S. C., Jacobson, T. L., Jacobson, M. K., Christensen, T. A., Juneja, S. C., Grande, J. P. & Maihle, N. J., Feb 1 2003, In : Breast Cancer Research and Treatment. 77, 3, p. 205-215 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.

Boerner, J. L., Danielsen, A. J., Lovejoy, C. A., Wang, Z., Juneja, S. C., Faupel-Badger, J. M., Darce, J. R. & Maihle, N. J., Oct 2 2003, In : Oncogene. 22, 43, p. 6679-6689 11 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
42 Scopus citations

Involvement of protein tyrosine kinase in toll-like receptor 4-mediated NF-κB activation in human peripheral blood monocytes

Chen, L. Y., Zuraw, B. L., Zhao, M., Liu, F. T., Huang, S. & Pan, Z. K., Apr 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 4 28-4, p. L607-L613

Research output: Contribution to journalArticle

53 Scopus citations

Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier

Friedrich, A., Prasad, P. D., Freyer, D., Ganapathy, V. & Brust, P., Apr 4 2003, In : Brain Research. 968, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Multiple mechanisms for HSV-1 induction of interferon α production by peripheral blood mononuclear cells

Rong, Q., Alexander, T. S., Koski, G. K. & Rosenthal, K. S., Feb 1 2003, In : Archives of Virology. 148, 2, p. 329-344 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer

Baron, A. T., Cora, E. M., Lafky, J. M., Boardman, C. H., Buenafe, M. C., Rademaker, A., Liu, D., Fishman, D. A., Podratz, K. C. & Maihle, N. J., Feb 1 2003, In : Cancer Epidemiology Biomarkers and Prevention. 12, 2, p. 103-113 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

TAB1β (transforming growth factor-β-activated protein kinase 1-binding protein 1β), a novel splicing variant of TAB1 that interacts with p38α but not TAK1

Ge, B., Xiong, X., Jing, Q., Mosley, J. L., Filose, A., Bian, D., Huang, S. & Han, J., Jan 24 2003, In : Journal of Biological Chemistry. 278, 4, p. 2286-2293 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells

Satyanarayana, A., Wiemann, S. U., Buer, J., Lauber, J., Dittmar, K. E. J., Wüstefeld, T., Blasco, M. A., Manns, M. P. & Rudolph, K. L., Aug 1 2003, In : EMBO Journal. 22, 15, p. 4003-4013 11 p.

Research output: Contribution to journalArticle

127 Scopus citations

The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function

Ling, J., Pi, W., Yu, X., Bengra, C., Long, Q., Jin, H., Seyfang, A. & Tuan, D., Aug 1 2003, In : Nucleic Acids Research. 31, 15, p. 4582-4596 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene

Wang, H., Hicks, J., Khanbolooki, P., Kim, S. J., Yan, C., Wang, Y. & Boyd, D., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 453-464 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Triple analysis of the cancer epigenome: An integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation

Shi, H., Wei, S. H., Leu, Y. W., Rahmatpanah, F., Liu, J. C., Yan, P. S., Nephew, K. P. & Huang, T. H. M., May 1 2003, In : Cancer Research. 63, 9, p. 2164-2171 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

α6β1 integrin is a potential clinical marker for evaluating sperm quality in men

Reddy, V. R. K., Rajeev, S. K. & Gupta, V., Jun 1 2003, In : Fertility and sterility. 79, SUPPL. 3, p. 1590-1596 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2004

Activation of the small GTPase Rac1 by cGMP-dependent protein kinase

Hou, Y., Ye, R. D. & Browning, D. D., Jan 1 2004, In : Cellular Signalling. 16, 9, p. 1061-1069 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Amphiregulin Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma: A Study of 93 Cases

Bostwick, D. G., Qian, J. & Maihle, N. J., Feb 1 2004, In : Prostate. 58, 2, p. 164-168 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

A retrospective study of the 1996 DEN-1 epidemic in Trinidad: Demographic and clinical features

Brown, T. U., Babb, K., Nimrod, M., Carrington, C. V. F., Salas, R. A. & Monteil, M. A., Dec 1 2004, In : Dengue Bulletin. 28, p. 7-19 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Creation of EcR isoform-specific mutations in Drosophila melanogaster via local P element transposition, imprecise P element excision, and male recombination

Carney, G. E., Robertson, A., Davis, M. B. & Bender, M., Apr 1 2004, In : Molecular Genetics and Genomics. 271, 3, p. 282-290 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

326 Scopus citations

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules

Manfredini, S., Vertuani, S., Pavan, B., Vitali, F., Scaglianti, M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. & Dalpiaz, A., Oct 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 20, p. 5453-5463 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Diet-induced obesity and mammary tumor development in MMTV-neu female mice

Cleary, M. P., Grande, J. P., Juneja, S. C. & Maihle, N. J., Dec 1 2004, In : Nutrition and Cancer. 50, 2, p. 174-180 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Dynamic retrotransposition of ERV-9 LTR and L1 in the β-globin gene locus during primate evolution

Ling, J., Zhang, L., Jin, H., Pi, W., Kosteas, T., Anagnou, N. P., Goodman, M. & Tuan, D., Mar 2004, In : Molecular Phylogenetics and Evolution. 30, 3, p. 867-871 5 p.

Research output: Contribution to journalArticle

3 Scopus citations