Biochemistry and Molecular Biology

Research Output 1968 2019

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37 Citations (Scopus)

DNA methylation represses IFN-γ-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells

McGough, J. M., Yang, D., Huang, S., Georgi, D., Hewitt, S. M., Röcken, C., Tänzer, M., Ebert, M. P. A. & Liu, K., Dec 1 2008, In : Molecular Cancer Research. 6, 12, p. 1841-1851 11 p.

Research output: Contribution to journalArticle

STAT1 Transcription Factor
DNA Methylation
Colon
Carcinoma
Methylation
102 Citations (Scopus)

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Pathania, R., Ramachandran, S., Elangovan, S., Padia, R., Yang, P., Cinghu, S., Veeranan-Karmegam, R., Arjunan, P., Gnana-Prakasam, J. P., Sadanand, F., Pei, L., Chang, C. S., Choi, J. H., Shi, H., Manicassamy, S., Prasad, P. D., Sharma, S., Ganapathy, V., Jothi, R. & Thangaraju, M., Apr 22 2015, In : Nature Communications. 6, 6910.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
stem cells
Stem cells
maintenance
Carcinogenesis
8 Citations (Scopus)

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma

Poole, C. J., Zheng, W., Lodh, A., Yevtodiyenko, A., Liefwalker, D., Li, H., Felsher, D. W. & van Riggelen, J., Jan 1 2017, In : Oncotarget. 8, 44, p. 76898-76920 23 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
DNA Methylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Maintenance
T-Lymphocytes
127 Citations (Scopus)

Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation

Leu, Y. W., Rahmatpanah, F., Shi, H., Wei, S. H., Liu, J. C., Yan, P. S. & Huang, T. H. M., Oct 1 2003, In : Cancer Research. 63, 19, p. 6110-6115 6 p.

Research output: Contribution to journalArticle

RNA Interference
Small Interfering RNA
DNA
Genes
DNA Methylation
54 Citations (Scopus)

Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer

Gupta, N., Martin, P. M., Miyauchi, S., Ananth, S., Herdman, A. V., Martindale, R. G., Podolsky, R. & Ganapathy, V., May 5 2006, In : Biochemical and Biophysical Research Communications. 343, 2, p. 571-577 7 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Colorectal Neoplasms
Down-Regulation
Tissue
Messenger RNA
23 Citations (Scopus)

Downregulation of IFN-γR in association with loss of Fas function is linked to tumor progression

Yang, D., Stewart, T. J., Smith, K. K., Georgi, D., Abrams, S. I. & Liu, K., Jan 15 2008, In : International Journal of Cancer. 122, 2, p. 350-362 13 p.

Research output: Contribution to journalArticle

Down-Regulation
Neoplasms
Immune System
Neoplasm Metastasis
Lung
29 Citations (Scopus)

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Reduced Folate Carrier Protein
Retinal Pigments
Down-Regulation
Epithelial Cells
14 Citations (Scopus)
Mifepristone
Retinoblastoma Protein
Estrogen Receptor Modulators
Down-Regulation
Breast Neoplasms

Draft genome sequence of a novel rhabdovirus isolated from Deinocerites mosquitoes

Xu, C. L., Cantalupo, P. G., Sáenz-Robles, M. T., Baldwin, A., Fitzpatrick, D., Norris, D. E., Jackson, E. & Pipas, J. M., May 1 2018, In : Genome Announcements. 6, 19, e01438-17.

Research output: Contribution to journalArticle

Rhabdoviridae
Culicidae
Genome
Grenada
Open Reading Frames
44 Citations (Scopus)
Adenosine Triphosphate
Apoptosis
Wounds and Injuries
Kidney
Mitochondrial Membranes
51 Citations (Scopus)

Drugs of abuse and placental transport

Ganapathy, V., Prasad, P. D., Ganapathy, M. E. & Leibach, F. H., Jun 14 1999, In : Advanced Drug Delivery Reviews. 38, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Street Drugs
Placenta
Fetus
Amphetamines
Cannabinoids
29 Citations (Scopus)

Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy

Wang, Q., Navitskaya, S., Chakravarthy, H., Huang, C., Kady, N., Lydic, T. A., Chen, Y. E., Yin, K. J., Powell, F. L., Martin, P. M., Grant, M. B. & Busik, J. V., Sep 1 2016, In : EBioMedicine. 11, p. 138-150 13 p.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Vascular Endothelial Growth Factor A
Anti-Inflammatory Agents
Retina
Bone
32 Citations (Scopus)

Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway

Zhang, L. N., Karp, P., Gerard, C. J., Pastor, E., Laux, D., Munson, K., Yan, Z., Liu, X., Godwin, S., Thomas, C. P., Zabner, J., Shi, H., Caldwell, C. W., Peluso, R., Carter, B. & Engelhardt, J. F., Dec 1 2004, In : Molecular Therapy. 10, 6, p. 990-1002 13 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Proteasome Endopeptidase Complex
Cystic Fibrosis
Genetic Therapy
Doxorubicin
10 Citations (Scopus)

Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction

Yoo, J., Herman, L. E., Li, C., Krantz, S. B. & Tuan Lo, D., Mar 15 1996, In : Blood. 87, 6, p. 2558-2567 10 p.

Research output: Contribution to journalArticle

Locus Control Region
Erythroid Precursor Cells
Polymerase chain reaction
Chromatin
Polymerase Chain Reaction
23 Citations (Scopus)

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J. H., Choi, J. H., Ho, T. H. & Robertson, K. D., Jan 1 2016, In : Oncotarget. 7, 2, p. 1927-1946 20 p.

Research output: Contribution to journalArticle

DNA Methylation
Renal Cell Carcinoma
Developmental Genes
Phenotype
Cell Line
3 Citations (Scopus)

Dynamic retrotransposition of ERV-9 LTR and L1 in the β-globin gene locus during primate evolution

Ling, J., Zhang, L., Jin, H., Pi, W., Kosteas, T., Anagnou, N. P., Goodman, M. & Tuan Lo, D., Jan 1 2004, In : Molecular Phylogenetics and Evolution. 30, 3, p. 867-871 5 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
beta-Globins
primate
Primates
loci
223 Citations (Scopus)

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

Robinson, P. J., Sontag, J. M., Liu, J. P., Fykse, E. M., Slaughter, C., McMahontt, H. & Südhof, T. C., Jan 1 1993, In : Nature. 365, 6442, p. 163-166 4 p.

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
Protein Kinase C
Phosphorylation
Endocytosis
4 Citations (Scopus)

Dysplastic hepatocytes develop nuclear inclusions in a mouse model of viral hepatitis

Thakur, P., Lamoke, F., Chaffin, J. M., Bartoli, M., Lee, J. R. & Duncan, M. B., Jun 16 2014, In : PloS one. 9, 6, e99872.

Research output: Contribution to journalArticle

nuclear inclusions
viral hepatitis
Intranuclear Inclusion Bodies
Hepatitis
hepatocytes
13 Citations (Scopus)

Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models

Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In : Blood. 122, 6, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Neoplasms
Hematopoietic Stem Cells
Bone Marrow Neoplasms
Clonal Evolution
Severe Combined Immunodeficiency
832 Citations (Scopus)

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. & Yanagisawa, M., Aug 12 1994, In : Cell. 78, 3, p. 473-485 13 p.

Research output: Contribution to journalArticle

Endothelins
Metalloproteases
Endothelin-1
Chemical activation
Membranes
10 Citations (Scopus)

Ectopic expression of nonliganded retinoic acid receptor β abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells

Arce, J. D. C., Soto, U., Van Riggelen, J., Schwarz, E., Zur Hausen, H. & Rösl, F., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45408-45416 9 p.

Research output: Contribution to journalArticle

Retinoic Acid Receptors
Transcription Factor AP-1
Cells
Carcinoma
Degradation

Effectiveness of potassium citrate therapy in the management of nephrolithiasis

Rajpurohit, S. K., Pendse, AK., Barjatiya, MK. & Singh, PP., 1996, In : Urolithiasis. p. 450

Research output: Contribution to journalArticle

5 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Induced Pluripotent Stem Cells
Regeneration
Duchenne Muscular Dystrophy
Muscles
21 Citations (Scopus)
Fibrosarcoma
Tumor Biomarkers
Vitamin E
Cyclophosphamide
Rats
19 Citations (Scopus)

Effect of curcumin on pro-angiogenic factors in the xenograft model of breast cancer

Ferreira, L. C., Arbab, A. S., Jardim-Perassi, B. V., Borin, T. F., Varma, N. R. S., Iskander, A. S. M., Shankar, A., Ali, M. M. & de Campos Zuccari, D. A. P., Dec 1 2015, In : Anti-Cancer Agents in Medicinal Chemistry. 15, 10, p. 1285-1296 12 p.

Research output: Contribution to journalArticle

Curcumin
Angiogenesis Inducing Agents
Heterografts
Breast Neoplasms
Neoplasms
45 Citations (Scopus)

Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-α mice

Cleary, M. P., Grande, J. P. & Maihle, N. J., Aug 1 2004, In : International Journal of Obesity. 28, 8, p. 956-962 7 p.

Research output: Contribution to journalArticle

High Fat Diet
Body Weight
Breast Neoplasms
Obesity
Fat-Restricted Diet
33 Citations (Scopus)

Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats

Yocum, G. T., Wilson, L. B., Ashari, P., Jordan, E. K., Frank, J. A. & Arbab, A. S., May 1 2005, In : Radiology. 235, 2, p. 547-552 6 p.

Research output: Contribution to journalArticle

Lysine
Mesenchymal Stromal Cells
Stem Cells
Intravenous Injections
Kidney
85 Citations (Scopus)

Effect of melatonin on tumor growth and angiogenesis in xenograft model of breast cancer

Jardim-Perassi, B. V., Arbab, A. S., Ferreira, L. C., Borin, T. F., Varma, N. R. S., Iskander, A. S. M., Shankar, A., Ali, M. M. & De Campos Zuccari, D. A. P., Jan 9 2014, In : PloS one. 9, 1, e85311.

Research output: Contribution to journalArticle

melatonin
Melatonin
angiogenesis
Heterografts
breast neoplasms
7 Citations (Scopus)

Effect of tamoxifen on lipids and lipid metabolising marker enzymes in experimental atherosclerosis in Wistar rats

Vinitha, R., Thangaraju, M. & Sachdanandam, P., Mar 6 1997, In : Molecular and Cellular Biochemistry. 168, 1-2, p. 13-19 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Wistar Rats
Rats
Atherosclerosis
Lipids
12 Citations (Scopus)

Effect of α-domain substitution on the structure, property and function of human neuronal growth inhibitory factor

Ding, Z-C., Zheng, Q., Cai, B., Yu, W. H., Teng, X. C., Wang, Y., Zhou, G. M., Wu, H. M., Sun, H. Z., Zhang, M. J. & Huang, Z. X., Nov 1 2007, In : Journal of Biological Inorganic Chemistry. 12, 8, p. 1173-1179 7 p.

Research output: Contribution to journalArticle

Substitution reactions
Growth
Bioassay
Human Activities
Biological Assay
Ion Channels
Buffers
Neoplasms
Flunarizine
Cell Line
19 Citations (Scopus)

Effects of ferumoxides - Protamine sulfate labeling on immunomodulatory characteristics of macrophage-like THP-1 cells

Janic, B., Iskander, A. S. M., Rad, A. M., Soltanian-Zadeh, H. & Arbab, A. S., Jun 25 2008, In : PloS one. 3, 6, e2499.

Research output: Contribution to journalArticle

protamines
Protamines
Macrophages
Labeling
sulfates
1 Citation (Scopus)

Effects of genistein on experimental metastasis of B16-BL6 mouse melanoma cells

Yan, C. & Han, R., Nov 1 1999, In : Yaoxue Xuebao. 34, 11, p. 814-817 4 p.

Research output: Contribution to journalArticle

Genistein
Melanoma
Neoplasm Metastasis
Cyclophosphamide
Lung
14 Citations (Scopus)
Genistein
Fibrosarcoma
Matrix Metalloproteinases
Human Activities
Tissue Inhibitor of Metalloproteinase-1
62 Citations (Scopus)

Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-α mice

Dogan, S., Hu, X., Zhang, Y., Maihle, N. J., Grande, J. P. & Cleary, M. P., Dec 27 2007, In : Breast Cancer Research. 9, 6, R91.

Research output: Contribution to journalArticle

High Fat Diet
Leptin
Obesity
Fats
Body Weight
3 Citations (Scopus)

Effects of novel polyether ionophore hainanmycin on nutrient digestion, metabolism and ruminal characteristics of goats

Mingqiang, R., Zanming, S., Ruqian, Z., Tianshui, L. & Jie, C., Jan 1 1998, In : Journal of Animal and Feed Sciences. 7, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

Ionophores
Rumen
ionophores
Goats
Digestion
35 Citations (Scopus)

Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis

Bhatt, K., Feng, L., Pabla, N., Liu, K., Smith, S. & Dong, Z., Mar 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 3, p. F499-F507

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Apoptosis
Kidney
Cytochromes c
23 Citations (Scopus)

Effects of the incorporation of CHAPS into SDS micelles on neuropeptide-micelle binding: Separation of the role of electrostatic interactions from hydrophobic interactions

Whitehead, T. L., Jones, L. M. & Hicks, R. P., Jun 11 2001, In : Biopolymers. 58, 7, p. 593-605 13 p.

Research output: Contribution to journalArticle

Micelles
Coulomb interactions
Neuropeptides
Static Electricity
Hydrophobic and Hydrophilic Interactions
20 Citations (Scopus)

Effects of tyrosine kinase inhibitors and CXCR4 antagonist on tumor growth and angiogenesis in rat glioma model: MRI and protein analysis study

Ali, M. M., Kumar, S., Shankar, A., Varma, N. R. S., Iskander, A. S. M., Janic, B., Chwang, W. B., Jain, R., Babajeni-Feremi, A., Borin, T. F., Bagher-Ebadian, H., Brown, S. L., Ewing, J. R. & Arbab, A. S., Dec 2013, In : Translational Oncology. 6, 6, p. 660-669 10 p.

Research output: Contribution to journalArticle

Glioma
Protein-Tyrosine Kinases
Glioblastoma
Growth
Magnetic Resonance Imaging
169 Citations (Scopus)

Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system

Chang, L. J., Urlacher, V., Iwakuma, T., Cui, Y. & Zucali, J., May 1 1999, In : Gene Therapy. 6, 5, p. 715-728 14 p.

Research output: Contribution to journalArticle

HIV-1
env Genes
Safety
Rous sarcoma virus
Product Packaging
8 Citations (Scopus)

Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines

Gelaleti, G. B., Borin, T. F., Maschio-Signorini, L. B., Moschetta, M. G., Jardim-Perassi, B. V., Calvinho, G. B., Facchini, M. C., Viloria-Petit, A. M. & de Campos Zuccari, D. A. P., Aug 15 2017, In : Life sciences. 183, p. 98-109 12 p.

Research output: Contribution to journalArticle

Interleukin-17
Melatonin
Carcinogenesis
Cells
Breast Neoplasms
491 Citations (Scopus)

Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI

Arbab, A. S., Yocum, G. T., Kalish, H., Jordan, E. K., Anderson, S. A., Khakoo, A. Y., Read, E. J. & Frank, J. A., Aug 15 2004, In : Blood. 104, 4, p. 1217-1223 7 p.

Research output: Contribution to journalArticle

Protamines
Magnetic resonance
Labeling
Stem cells
Magnetic Resonance Imaging
3 Citations (Scopus)

EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer

Maihle, N. J., Lafky, J. M., Baron, A. T., Boardman, C. H., Greenwood, T. M., Christensen, T. A., Reiter, J. L., Cora, E. M., Lee, H., Suman, V. J., Fishman, D. A., Perez, E. A. & Podratz, K. C., Mar 1 2002, In : Journal of Clinical Ligand Assay. 25, 1, p. 57-60 4 p.

Research output: Contribution to journalArticle

Biomarkers
Epidermal Growth Factor Receptor
Ovarian Neoplasms
Protein Isoforms
Breast Neoplasms
27 Citations (Scopus)

EGFR isoforms and gene regulation in human endometrial cancer cells

Albitar, L., Pickett, G., Morgan, M., Wilken, J. A., Maihle, N. J. & Leslie, K. K., Jun 25 2010, In : Molecular Cancer. 9, 166.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Epidermal Growth Factor Receptor
Protein Isoforms
Genes
Epidermal Growth Factor
3 Citations (Scopus)

Electrochemical Detection of Alginate Penetration in Immobilized Layer-by-Layer Films by Unnatural Amino Acid Containing Antimicrobial Peptides

Vinogradov, S. M., Satterwhite-Warden, J. E., Hicks, R. P., Anderson, E. & Hvastkovs, E. G., Dec 20 2015, In : Electrochimica Acta. 186, p. 245-252 8 p.

Research output: Contribution to journalArticle

Alginate
Peptides
Amino acids
Biofilms
Assays
10 Citations (Scopus)

Electrogenic nature of rat sodium-dependent multivitamin transport

Prasad, P. D., Srinivas, S. R., Wang, H., Leibach, F. H., Devoe, L. D. & Ganapathy, V., Apr 21 2000, In : Biochemical and Biophysical Research Communications. 270, 3, p. 836-840 5 p.

Research output: Contribution to journalArticle

Rats
Biotin
Sodium
Membranes
Oocytes
15 Citations (Scopus)
Electrophoresis
Monoclonal Antibodies
Enzymes
Gels
Alleles
82 Citations (Scopus)

Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis

Tian, F. J., An, L. N., Wang, G. K., Zhu, J. Q., Li, Q., Zhang, Y. Y., Zeng, A., Zou, J., Zhu, R. F., Han, X. S., Shen, N., Yang, H. T., Zhao, X. X., Huang, S., Qin, Y. W. & Jing, Q., Jul 1 2014, In : Cardiovascular Research. 103, 1, p. 100-110 11 p.

Research output: Contribution to journalArticle

Foam Cells
MicroRNAs
Atherosclerosis
Macrophages
Apolipoproteins E
26 Citations (Scopus)

Elevated serum levels of transforming growth factor-α in breast cancer patients

Chakrabarty, S., Huang, S., Moskal, T. L. & Fritsche, H. A., May 16 1994, In : Cancer Letters. 79, 2, p. 157-160 4 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Breast Neoplasms
Serum
Neoplasms
Carcinoembryonic Antigen
9 Citations (Scopus)

Elevated urokinase-specific surface receptor expression is maintained through its interaction with urokinase plasminogen activator

Mahanivong, C., Yu, J. & Huang, S., Mar 1 2007, In : Molecular Carcinogenesis. 46, 3, p. 165-175 11 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Urokinase-Type Plasminogen Activator
Urokinase Plasminogen Activator Receptors
RNA
Monoclonal Antibodies