Biochemistry and Molecular Biology

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2019

Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity

Pan, Y., Choi, J-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In : Scientific reports. 9, 1, 3433.

Research output: Contribution to journalArticle

2 Scopus citations

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

Amro, A., Chen, Y., Barry, R., Susick, L., Bensenhaver, J., Proctor, E., Petersen, L., Nathanson, S. D., Ali, H., Loutfi, R., Chitale, D., Simonds, A., Kuklinski, M., Park, K. U., Davis, M. & Newman, L. A., Jul 1 2019, In : Breast Journal. 25, 4, p. 667-671 5 p.

Research output: Contribution to journalArticle

DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis

Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Nov 29 2019, In : Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evaluation of angiogenesis process after metformin and LY294002 treatment in mammary tumor

Moschetta, M. G., Leonel, C., Maschio-Signorini, L. B., Borin, T. F., Gelaleti, G. B., Jardim-Perassi, B. V., Ferreira, L. C., Sonehara, N. M., Carvalho, L. G. S., Hellmén, E. & Zuccari, D. A. P. D. C., Jan 1 2019, In : Anti-Cancer Agents in Medicinal Chemistry. 19, 5, p. 655-666 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Alptekin, A., Ye, B., Yu, Y., Poole, C. J., van Riggelen, J., Zha, Y. & Ding, H. F., Dec 12 2019, In : Oncogene. 38, 50, p. 7504-7520 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

3 Scopus citations

HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival

Ajith, A., Portik-Dobos, V., Nguyen-Lefebvre, A. T., Callaway, C., Horuzsko, D. D., Kapoor, R., Zayas, C., Maenaka, K., Mulloy, L. L. & Horuzsko, A., 2019, In : FASEB Journal. 33, 4, p. 5220-5236 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., Browning, D. D., Liu, K., Blumberg, R., Singh, N. & Li, H., Dec 1 2019, In : Cell Discovery. 5, 1, 7.

Research output: Contribution to journalArticle

6 Scopus citations

Intracellular reduction in ATP levels contributes to CYT997-induced suppression of metastasis of head and neck squamous carcinoma

Zhao, X., Lang, L., He, L., Gao, L., Chyan, D., Xiong, Y., Li, H., Peng, H. & Teng, Y., Feb 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 2, p. 1174-1182 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Loss of fas expression and function is coupled with colon cancer resistance to immune checkpoint inhibitor immunotherapy

Xiao, W., Ibrahim, M. L., Redd, P. S., Klement, J. D., Lu, C., Yang, D., Savage, N. M. & Liu, K., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 420-430 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Jadeja, R. N., Jones, M. A., Fromal, O., Powell, F. L., Khurana, S., Singh, N. & Martin, P. M., Jan 1 2019, In : Aging. 11, 2, p. 386-400 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice

Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In : Cancer Research. 79, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin

Folk, W. P., Kumari, A., Iwasaki, T., Pyndiah, S., Johnson, J. C., Cassimere, E. K., Abdulovic-Cui, A. L. & Sakamuro, D., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5700-5719 20 p.

Research output: Contribution to journalArticle

5 Scopus citations

M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway

Jadeja, R. N., Chu, X., Wood, C., Bartoli, M. & Khurana, S., Nov 2019, In : Biochemical Pharmacology. 169, 113613.

Research output: Contribution to journalArticle

5 Scopus citations

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
Open Access
7 Scopus citations

Monosodium urate contributes to retinal inflammation and progression of diabetic retinopathy

Thounaojam, M. C., Montemari, A., Powell, F. L., Malla, P., Gutsaeva, D. R., Bachettoni, A., Ripandelli, G., Repossi, A., Tawfik, A., Martin, P. M., Facchiano, F. & Bartoli, M., 2019, In : Diabetes. 68, 5, p. 1014-1025 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL

Poole, C. J., Lodh, A., Choi, J. H. & Van Riggelen, J., Jul 2 2019, In : Epigenetics and Chromatin. 12, 1, 41.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration

Han, X. S., Wang, C., Guo, F. H., Huang, S., Qin, Y. W., Zhao, X. X. & Jing, Q., Jan 1 2019, In : Protein and Cell. 10, 1, p. 43-59 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Plasticity and potency of mammary stem cell subsets during mammary gland development

Lee, E., Piranlioglu, R., Wicha, M. S. & Korkaya, H., May 1 2019, In : International journal of molecular sciences. 20, 9, 2357.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journalArticle

6 Scopus citations

Renal iron accelerates the progression of diabetic nephropathy in the HFE gene knockout mouse model of iron overload

Chaudhary, K., Chilakala, A., Ananth, S., Mandala, A., Veeranan-Karmegam, R., Powell, F. L., Ganapathy, V. & Gnana-Prakasam, J. P., Aug 2019, In : American Journal of Physiology - Renal Physiology. 317, 2, p. F512-F517

Research output: Contribution to journalArticle

2 Scopus citations

Role of a novel race-related tumor suppressor microRNA located in frequently deleted chromosomal locus 8p21 in prostate cancer progression

Bhagirath, DI., Yang, T. L., Tabatabai, Z. L., Shahryari, V., Majid, S., Dahiya, R., Tanaka, Y. & Saini, S., Jul 4 2019, In : Carcinogenesis. 40, 5, p. 633-642 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes erythropoiesis at early stage targeted by ufmylation pathway

Chen, F., Xing, C., Zhang, W., Li, J., Hu, T., Li, L., Li, H. & Cai, Y., Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 18560-18570 11 p.

Research output: Contribution to journalArticle

Sequencing small non-coding rna from formalin-fixed tissues and serum-derived exosomes from castration-resistant prostate cancer patients

Bhagirath, D., Dahiya, R., Majid, S., Tabatabai, Z. L. & Saini, S., Nov 2019, In : Journal of Visualized Experiments. 2019, 153, e60549.

Research output: Contribution to journalArticle

Small molecule BKM1972 inhibits human prostate cancer growth and overcomes docetaxel resistance in intraosseous models

Chen, Y., Gera, L., Zhang, S., Li, X., Yang, Y., Mamouni, K., Wu, A. Y., Liu, H. Y., Kucuk, O. & Wu, D., Apr 1 2019, In : Cancer Letters. 446, p. 62-72 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Stimulator of interferon genes agonists attenuate type I diabetes progression in NOD mice

Lemos, H., Mohamed, E., Huang, L., Chandler, P. R., Ou, R., Pacholczyk, R. & Mellor, A. L., Dec 1 2019, In : Immunology. 158, 4, p. 353-361 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Systemic antibiotic therapy reduces circulating inflammatory dendritic cells and Treg–Th17 plasticity in periodontitis

Rajendran, M., Looney, S., Singh, N., Elashiry, M., Meghil, M. M., El-Awady, A. R., Tawfik, O., Susin, C., Arce, R. M. & Cutler, C. W., May 1 2019, In : Journal of Immunology. 202, 9, p. 2690-2699 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. M. & Celis, E., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Three novel players: PTK2B, SYK, and TNFRSF21 were identified to be involved in the regulation of bovine mastitis susceptibility via GWAS and post-transcriptional analysis

Yang, F., Chen, F., Li, L., Yan, L., Badri, T., Lv, C., Yu, D., Zhang, M., Jang, X., Li, J., Yuan, L., Wang, G., Li, H., Li, J. & Cai, Y., 2019, In : Frontiers in immunology. 10, AUG, 1579.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism

Cheng, Z. J., Miao, D. L., Su, Q. Y., Tang, X. L., Wang, X. L., Deng, L. B., Shi, H. & Xin, H. B., Jun 1 2019, In : Acta Pharmacologica Sinica. 40, 6, p. 814-822 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
1 Scopus citations

Type i interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Lu, C., Klement, J. D., Ibrahim, M. L., Xiao, W., Redd, P. S., Nayak, A., Zhou, G. & Liu, K., Jun 22 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 157.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

Zhu, H., Bhatt, B., Sivaprakasam, S., Cai, Y., Liu, S., Kodeboyina, S. K., Patel, N., Savage, N. M., Sharma, A. K., Kaufman, R. J., Li, H. & Singh, N., Dec 1 2019, In : Nature communications. 10, 1, 1084.

Research output: Contribution to journalArticle

12 Scopus citations

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Upregulation of MIR-130b contributes to risk of poor prognosis and racial disparity in African-American Prostate Cancer

Hashimoto, Y., Shiina, M., Dasgupta, P., Kulkarni, P., Kato, T., Wong, R. K., Tanaka, Y., Shahryari, V., Maekawa, S., Yamamura, S., Saini, S., Deng, G., Laura Tabatabai, Z., Majid, S. & Dahiya, R., 2019, In : Cancer Prevention Research. 12, 9, p. 585-598 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer

Qin, H., Lu, S., Thangaraju, M. & Cowell, J. K., Dec 2019, In : American Journal of Pathology. 189, 12, p. 2450-2458 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

[125 I]IodoDPA-713 binding to 18 kDa translocator protein (TSPO) in a mouse model of intracerebral hemorrhage: Implications for neuroimaging

Bonsack, F., Foss, C. A., Arbab, A. S., Alleyne, C. H., Pomper, M. G. & Sukumari-Ramesh, S., Feb 22 2018, In : Frontiers in Neuroscience. 12, FEB, 66.

Research output: Contribution to journalArticle

2 Scopus citations

A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes

Bayoumi, A. S., Park, K. M., Wang, Y., Teoh, J. P., Aonuma, T., Tang, Y. L., Su, H., Weintraub, N. L. & Kim, I., Jan 2018, In : Journal of molecular and cellular cardiology. 114, p. 72-82 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

33 Scopus citations

AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells

Campbell, P. S., Mavingire, N., Khan, S., Rowland, L. K., Wooten, J. V., Opoku-Agyeman, A., Guevara, A., Soto, U., Cavalli, F., Loaiza-Pérez, A. I., Nagaraj, G., Denham, L. J., Adeoye, O., Jenkins, B. D., Davis, M. B., Schiff, R. & Brantley, E. J., Jan 2018, In : Journal of Cellular Physiology. 234, 1, p. 108-121 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

10 Scopus citations

Androgen receptor and ALDH1 expression among internationally diverse patient populations

Jiagge, E., Jibril, A. S., Davis, M., Murga-Zamalloa, C., Kleer, C. G., Gyan, K., Divine, G., Hoenerhoff, M., Bensenhave, J., Awuah, B., Oppong, J., Adjei, E., Salem, B., Toy, K., Merajver, S., Wicha, M. & Newman, L., Mar 1 2018, In : Journal of Global Oncology. 2018, 4

Research output: Contribution to journalArticle

3 Scopus citations

An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

Wang, X., Pan, Y., Zhu, H., Hao, G., Huang, Y., Barnes, V., Shi, H., Snieder, H., Pankow, J., North, K., Grove, M., Guan, W., Demerath, E., Dong, Y. & Su, S., 2018, In : Clinical epigenetics. 10, p. 3 1 p.

Research output: Contribution to journalArticle

7 Scopus citations

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

Mamouni, K., Zhang, S., Li, X., Chen, Y., Yang, Y., Kim, J., Bartlett, M. G., Coleman, I. M., Nelson, P. S., Kucuk, O. & Wu, D., Aug 2018, In : Neoplasia (United States). 20, 8, p. 789-799 11 p.

Research output: Contribution to journalArticle

4 Scopus citations