Biochemistry and Molecular Biology

Research Output 1968 2019

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43 Citations (Scopus)

A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males

Wang, X., Falkner, B., Zhu, H., Shi, H., Su, S., Xu, X., Sharma, A. K., Dong, Y., Treiber, F., Gutin, B., Harshfield, G. & Snieder, H., Jan 17 2013, In : PloS one. 8, 1, e53938.

Research output: Contribution to journalArticle

Methylation
African Americans
methylation
hypertension
DNA Methylation
95 Citations (Scopus)

A genome-wide methylation study on obesity: Differential variability and differential methylation

Xu, X., Su, S., Barnes, V. A., De Miguel, C., Pollock, J., Ownby, D., Shi, H., Zhu, H., Snieder, H. & Wang, X., May 2013, In : Epigenetics. 8, 5, p. 522-533 12 p.

Research output: Contribution to journalArticle

Methylation
Obesity
Genome
Neoplasms
Genes
72 Citations (Scopus)

A glycoprotein pneumococcal conjugate vaccine primes for antibody responses to a pneumococcal polysaccharide vaccine in Gambian children

Obaro, S. K., Huo, Z., Banya, W. A. S., Henderson, D. C., Monteil, M. A., Leach, A. & Greenwood, B. M., Dec 1 1997, In : Pediatric Infectious Disease Journal. 16, 12, p. 1135-1140 6 p.

Research output: Contribution to journalArticle

Conjugate Vaccines
Pneumococcal Vaccines
Antibody Formation
Glycoproteins
Polysaccharides
4 Citations (Scopus)

Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy

Shrimali, R. K., Ahmad, S., Berrong, Z., Okoev, G., Matevosyan, A., Razavi, G. S. E., Petit, R., Gupta, S., Mkrtichyan, M. & Khleif, S. N., Aug 15 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 64.

Research output: Contribution to journalArticle

Listeria monocytogenes
Immunotherapy
Anti-Idiotypic Antibodies
Neoplasms
Listeria

Agonist-induced change in the membrane form of muscarinic cholinergic receptors (MR) in astrocytoma cells

Harden, T. K., Petch Lee, L. A. & Traynelis, S. F., Jan 1 1985, In : Federation Proceedings. 44, 5

Research output: Contribution to journalArticle

Astrocytoma
Cholinergic Receptors
Muscarinic Receptors
Membranes
26 Citations (Scopus)

Agrobacterium tumefaciens ExoR controls acid response genes and impacts exopolysaccharide synthesis, horizontal gene transfer, and virulence gene expression

Heckel, B. C., Tomlinson, A. D., Morton, E. R., Choi, J. H. & Fuqua, C., 2014, In : Journal of Bacteriology. 196, 18, p. 3221-3233 13 p.

Research output: Contribution to journalArticle

Horizontal Gene Transfer
Agrobacterium tumefaciens
Virulence
Regulon
Biofilms

AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells

Campbell, P. S., Mavingire, N., Khan, S., Rowland, L. K., Wooten, J. V., Opoku-Agyeman, A., Guevara, A., Soto, U., Cavalli, F., Loaiza-Pérez, A. I., Nagaraj, G., Denham, L. J., Adeoye, O., Jenkins, B. D., Davis, M. B., Schiff, R. & Brantley, E. J., Jan 1 2018, In : Journal of Cellular Physiology. 234, 1, p. 108-121 14 p.

Research output: Contribution to journalArticle

aminoflavone
Tamoxifen
Cells
Breast Neoplasms
Ligands

Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice

Srinivasan, M. P., Shawky, N. M., Kaphalia, B. S., Thangaraju, M. & Segar, L., Feb 1 2019, In : Biochemical Pharmacology. 160, p. 46-61 16 p.

Research output: Contribution to journalArticle

Liver Glycogen
Ketosis
Blood Glucose
Ethanol
Down-Regulation
18 Citations (Scopus)

Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells

Lu, X., Ding, Z. C., Cao, Y., Liu, C., Habtetsion, T., Yu, M., Lemos, H., Salman, H., Xu, H., Mellor, A. L. & Zhou, G., Feb 15 2015, In : Journal of Immunology. 194, 4, p. 2011-2021 11 p.

Research output: Contribution to journalArticle

Adoptive Immunotherapy
Melphalan
Alkylating Agents
T-Lymphocytes
Neoplasms
61 Citations (Scopus)

A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human β-globin locus control region

Long, Q., Bengra, C., Li, C., Kutlar, F. & Tuan Lo, D., Dec 15 1998, In : Genomics. 54, 3, p. 542-555 14 p.

Research output: Contribution to journalArticle

Locus Control Region
Endogenous Retroviruses
Globins
Terminal Repeat Sequences
Retroelements
5 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
20 Citations (Scopus)

Alterations in Fas expression are characteristic of, but not solely responsible for, enhanced metastatic competence

Liu, K. & Abrams, S. I., Jun 15 2003, In : Journal of Immunology. 170, 12, p. 5973-5980 8 p.

Research output: Contribution to journalArticle

Mental Competency
Sarcoma
Aptitude
Neoplasms
Phenotype
13 Citations (Scopus)

A Method to Detect Differentially Methylated Loci With Next-Generation Sequencing

Xu, H., Podolsky, R. H., Ryu, D., Wang, X., Su, S., Shi, H. & George, V., May 1 2013, In : Genetic Epidemiology. 37, 4, p. 377-382 6 p.

Research output: Contribution to journalArticle

Methylation
Alleles
DNA Methylation
B-Cell Chronic Lymphocytic Leukemia
Epigenomics
15 Citations (Scopus)

Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy

Chaudhary, K., Shinde, R., Liu, H., Gnana-Prakasam, J. P., Veeranan-Karmegam, R., Huang, L., Ravishankar, B., Bradley, J., Kvirkvelia, N., McMenamin, M., Xiao, W., Kleven, D., Mellor, A. L., Madaio, M. P. & McGaha, T. L., Jun 15 2015, In : Journal of Immunology. 194, 12, p. 5713-5724 12 p.

Research output: Contribution to journalArticle

Autophagy
Kidney
Amino Acids
Antibodies
Wounds and Injuries
34 Citations (Scopus)
Amino Acid Sequence
Antibodies
p-Azobenzenearsonate
Hybridomas
Radioimmunoassay
18 Citations (Scopus)

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., Jan 1 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Pancreatic Neoplasms
Pharmaceutical Preparations
Pharmacology
Up-Regulation
66 Citations (Scopus)

A model for the quaternary structure of the proteasome activator PA28

Song, X., Mott, J. D., Von Kampen, J., Pramanik, B., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Oct 30 1996, In : Journal of Biological Chemistry. 271, 42, p. 26410-26417 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Antibodies
Proteins
Cathepsin A
Proteolysis
259 Citations (Scopus)

A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: Implications for cellular magnetic resonance imaging

Arbab, A. S., Wilson, L. B., Ashari, P., Jordan, E. K., Lewis, B. K. & Frank, J. A., Oct 1 2005, In : NMR in Biomedicine. 18, 6, p. 383-389 7 p.

Research output: Contribution to journalArticle

Magnetic resonance
Metabolism
Nanoparticles
Transfection
Magnetic Resonance Imaging
28 Citations (Scopus)

Amphiregulin Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma: A Study of 93 Cases

Bostwick, D. G., Qian, J. & Maihle, N. J., Feb 1 2004, In : Prostate. 58, 2, p. 164-168 5 p.

Research output: Contribution to journalArticle

Prostatic Intraepithelial Neoplasia
Epithelium
Adenocarcinoma
Epidermal Growth Factor Receptor
Androgens
23 Citations (Scopus)

Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation

Powell, F. L., Mazzone, V., Persichini, T., Maraschi, A., Harris, B. M., Venema, R. C., Colasanti, M., Gliozzi, M., Muscoli, C., Bartoli, M. & Mollace, V., May 3 2015, In : Journal of Neuroinflammation. 12, 1, 84.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Nitric Oxide Synthase Type III
Amyloid
Nitric Oxide
Oxidative Stress
27 Citations (Scopus)
Pituitary Neoplasms
Caspases
Apoptosis
Cell Death
X-Linked Inhibitor of Apoptosis Protein
65 Citations (Scopus)

An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation

Flickinger, T. W., Maihle, N. J. & Kung, H. J., Jan 1 1992, In : Molecular and Cellular Biology. 12, 2, p. 883-893 11 p.

Research output: Contribution to journalArticle

erbB Genes
Ligands
Messenger RNA
Chickens
Transforming Growth Factor alpha
81 Citations (Scopus)

Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modeling

Young, J. K., Hicks, R. P., Wright, G. E. & Morrison, T. G., Nov 24 1997, In : Virology. 238, 2, p. 291-304 14 p.

Research output: Contribution to journalArticle

Biological Assay
Peptides
Amino Acid Sequence
Proteins
Viral Fusion Proteins
1 Citation (Scopus)

Analysis of genome by visualization of genomic signature

Choi, J-H., Lee, S. K., Yee, S. B., Kim, Y. J., Cho, H. G. & Kim, K. W., Mar 1 2002, In : Korean Journal of Genetics. 24, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Visualization
Genes
Genome
Chromosomes
Nucleic Acid Databases
16 Citations (Scopus)

Analysis of phenylthiohydantoin amino acid mixtures for sequencing by thermospray liquid chromatography/mass spectrometry

Pramanik, B. C., Hinton, S. M., Millington, D. S., Dourdeville, T. A. & Slaughter, C. A., Nov 15 1988, In : Analytical Biochemistry. 175, 1, p. 305-318 14 p.

Research output: Contribution to journalArticle

Phenylthiohydantoin
Liquid chromatography
Protein Sequence Analysis
Liquid Chromatography
Mass spectrometry
38 Citations (Scopus)

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

Shamsul Ola, M., Martin, P. M., Maddox, D., El-Sherbeny, A., Huang, W., Roon, P., Agarwal, N., Ganapathy, V. & Smith, S. B., Nov 15 2002, In : Molecular Brain Research. 107, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Retina
Streptozocin
N-Methyl-D-Aspartate Receptors

Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity

Mendiratta, S. K., Singh, N., Bal, V. & Rath, S., Jan 1 1996, In : Immunology. 89, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

Hybridomas
Major Histocompatibility Complex
Ligands
T-Lymphocytes
Lipopolysaccharides

ANALYSIS OF β‐GLOBIN GENES IN β^ THALASSEMIA

Tuan Lo, D., Biro, P. A., De Riel, J. K. & Forget, B. G., Jan 1 1980, In : Annals of the New York Academy of Sciences. 344, 1, p. 12-30 19 p.

Research output: Contribution to journalArticle

Genetic Suppression
Nucleic Acid Hybridization
Chromosome Deletion
Thalassemia
Globins
45 Citations (Scopus)

An anti-tumor role for cGMP-dependent protein kinase

Hou, Y., Gupta, N., Schoenlein, P., Wong, E., Martindale, R., Ganapathy, V. & Browning, D., Aug 18 2006, In : Cancer Letters. 240, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Colon
Neoplasms
Growth
Oligonucleotide Array Sequence Analysis
65 Citations (Scopus)

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

Lee, H., Akita, R. W., Sliwkowski, M. X. & Maihle, N. J., Jun 1 2001, In : Cancer Research. 61, 11, p. 4467-4473 7 p.

Research output: Contribution to journalArticle

Neuregulin-1
Protein Isoforms
Breast Neoplasms
Inhibitory Concentration 50
Growth
32 Citations (Scopus)

An atypical Protein Kinase C (PKCζ) plays a critical role in lipopolysaccharide-activated NF-κB in human peripheral blood monocytes and macrophages

Huang, X. S., Chen, L. Y., Doerner, A. M., Pan, W. W., Smith, L., Huang, S., Papadimos, T. J. & Pan, Z. K., May 1 2009, In : Journal of Immunology. 182, 9, p. 5810-5815 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Lipopolysaccharides
Monocytes
Macrophages
Transforming Growth Factors
1 Citation (Scopus)

Androgen receptor and ALDH1 expression among internationally diverse patient populations

Jiagge, E., Jibril, A. S., Davis, M. B., Murga-Zamalloa, C., Kleer, C. G., Gyan, K., Divine, G., Hoenerhoff, M., Bensenhave, J., Awuah, B., Oppong, J., Adjei, E., Salem, B., Toy, K., Merajver, S., Wicha, M. & Newman, L., Mar 1 2018, In : Journal of Global Oncology. 2018, 4

Research output: Contribution to journalArticle

Androgen Receptors
Triple Negative Breast Neoplasms
African Americans
Population
Breast Neoplasms
38 Citations (Scopus)

An efficient animation of wrinkled cloth with approximate implicit integration

Kang, Y. M., Choi, J-H., Cho, H. G. & Lee, D. H., May 1 2001, In : Visual Computer. 17, 3, p. 147-157 11 p.

Research output: Contribution to journalArticle

Animation
Splines
Linear systems
Defects
92 Citations (Scopus)

An efficient screen for peroxisome-deficient mutants of Pichia pastoris

Liu, H., Tan, X., Veenhuis, M., McCollum, D. & Cregg, J. M., Jan 1 1992, In : Journal of Bacteriology. 174, 15, p. 4943-4951 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Pichia
Methanol
Oleic Acid
alcohol oxidase
2 Citations (Scopus)

An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

Wang, X., Pan, Y., Zhu, H., Hao, G., Huang, Y., Barnes, V., Shi, H., Snieder, H., Pankow, J., North, K., Grove, M., Guan, W., Demerath, E., Dong, Y. & Su, S., Jan 1 2018, In : Clinical epigenetics. 10, 1 p.

Research output: Contribution to journalArticle

African Americans
Young Adult
Neutrophils
Obesity
Gene Expression
197 Citations (Scopus)

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human 'β-like globin' genes

Tuan Lo, D., Solomon, W. B., London, I. M. & Lee, D. P., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 8, p. 2554-2558 5 p.

Research output: Contribution to journalArticle

Globins
Genes
Erythroid Cells
Genetic Complementation Test
23 Citations (Scopus)

A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis

Starr, M. E., Steele, A. M., Saito, M., Hacker, B. J., Evers, B. M., Saito, H. & Raju, R., Dec 22 2014, In : PloS one. 9, 12, e115705.

Research output: Contribution to journalArticle

sepsis (infection)
reproducibility
laboratory animals
Sepsis
Animals
10 Citations (Scopus)

An incremental increase in the complexity of peptides bound to class II MHC changes the diversity of positively selected αβ TCRs

Pacholczyk, R. W., Kraj, P. & Ignatowicz, L., Feb 15 2001, In : Journal of Immunology. 166, 4, p. 2357-2363 7 p.

Research output: Contribution to journalArticle

Peptides
Epithelial Cells
94 Citations (Scopus)

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B., Pardoll, D., Mellor, A., Shi, H. & Munn, D., May 23 2013, In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Transcription Factors
Co-Repressor Proteins
Thymus Gland
122 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Phosphotransferases
DNA
Collagenases
185 Citations (Scopus)

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function

Lokeshwar, V. B., Fregien, N. & Bourguignon, L. Y. W., Aug 1 1994, In : Journal of Cell Biology. 126, 4, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

Ankyrins
Hyaluronic Acid
Proteins
COS Cells
Cell Adhesion Molecules
5 Citations (Scopus)

An Orthotopic mouse model of spontaneous breast cancer metastasis

Paschall, A. V. & Liu, K., Aug 14 2016, In : Journal of Visualized Experiments. 2016, 114, e54040.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Bearings (structural)
5 Citations (Scopus)

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

Tumor Escape
Osteopontin
T-Lymphocytes
Immunotherapy
Colon
43 Citations (Scopus)

A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing protein 1 (DDRGK1) and modulates NF-κB signaling

Wu, J., Lei, G., Mei, M., Tang, Y. & Li, H., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15126-15136 11 p.

Research output: Contribution to journalArticle

Protein Stability
Tumors
Assays
Proteins
Ubiquitination
62 Citations (Scopus)

A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress

Brown, V. M., Krynetski, E. Y., Krynetskaia, N. F., Grieger, D., Mukatira, S. T., Murti, K. G., Slaughter, C. A., Park, H. W. & Evans, W. E., Feb 13 2004, In : Journal of Biological Chemistry. 279, 7, p. 5984-5992 9 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Glyceraldehyde-3-Phosphate Dehydrogenases
DNA Damage
U5 Small Nuclear Ribonucleoproteins
rev Gene Products
2 Citations (Scopus)

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

Mamouni, K., Zhang, S., Li, X., Chen, Y., Yang, Y., Kim, J., Bartlett, M. G., Coleman, I. M., Nelson, P. S., Kucuk, O. & Wu, D., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 789-799 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Flavonoids
Prostatic Neoplasms
Growth
Dietary Supplements
17 Citations (Scopus)

A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression

Nair, R. R., Avila, H., Ma, X., Wang, Z., Lennartz, M., Darnay, B. G., Boyd, D. D. & Yan, C., Mar 1 2008, In : Molecular Pharmacology. 73, 3, p. 919-929 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Gene Expression
Homologous Recombination
Reporter Genes
Small Molecule Libraries
39 Citations (Scopus)
NF-kappa B
Homologous Recombination
Matrix Metalloproteinase 9
Transcription
Matrix Metalloproteinases
7 Citations (Scopus)

A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

Mangaonkar, A., Mondal, A. K., Fulzule, S., Pundkar, C., Park, E. J., Jillella, A., Kota, V., Xu, H., Savage, N. M., Shi, H., Munn, D. & Kolhe, R., Dec 1 2017, In : Scientific Reports. 7, 1, 12892.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Acute Myeloid Leukemia
Mortality
Messenger RNA
Bone Marrow
15 Citations (Scopus)

A novel protein kinase C (PKCε) is required for fMet-Leu-Phe-induced activation of NF-κB in human peripheral blood monocytes

Chen, L. Y., Doerner, A., Lehmann, P. F., Huang, S., Zhong, G. & Pan, Z. K., Jun 10 2005, In : Journal of Biological Chemistry. 280, 23, p. 22497-22501 5 p.

Research output: Contribution to journalArticle

N-Formylmethionine Leucyl-Phenylalanine
Protein Kinase C
Monocytes
Blood
Chemical activation