Biochemistry and Molecular Biology

Research Output 1968 2019

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2000
32 Citations (Scopus)

Cell growth and matrix invasion of EBV-immortalized human B lymphocytes is regulated by expression of α(v) integrins

Huang, S., Stupack, D., Liu, A., Cheresh, D. & Nemerow, G. R., Apr 6 2000, In : Oncogene. 19, 15, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Integrins
B-Lymphocytes
Growth
Lymphoproliferative Disorders
1 Citation (Scopus)

Characterization of [Re2Cl3(μ-dppm)2(NCCH3) 2][Cl] and [Re2Cl3(μ-dppm)2(NCC6H 5)2][Cl] · 2CH2Cl2 by X-ray Crystallographic and Two-Dimensional NMR Spectroscopic Techniques

Concolino, T. E., Eglin, J. L., Hadden, C. E., Hicks, R. P., Staples, R. J., Valente, E. J. & Zubkowski, J. D., Jan 1 2000, In : Journal of Cluster Science. 11, 1, p. 109-123 15 p.

Research output: Contribution to journalArticle

Methane
phosphine
methane
Nuclear magnetic resonance
X-Rays
74 Citations (Scopus)

Cloning and functional characterization of a Na+-independent, broad-specific neutral amino acid transporter from mammalian intestine

Rajan, D. P., Kekuda, R., Huang, W., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jan 15 2000, In : Biochimica et Biophysica Acta - Biomembranes. 1463, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

Neutral Amino Acid Transport Systems
Cloning
Intestines
Organism Cloning
Amino Acid Transport System L
87 Citations (Scopus)

Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta

Wang, H., Huang, W., Sugawara, M., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jul 14 2000, In : Biochemical and Biophysical Research Communications. 273, 3, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Cloning
Placenta
Organism Cloning
Complementary DNA
19 Citations (Scopus)

Descriptive epidemiology of asthma in Trinidad, West Indies

Monteil, M. A., Juman, S., Hassanally, R., Williams, K. P., Pierre, L., Rahaman, M., Singh, H. & Trinidade, A., Jan 1 2000, In : Journal of Asthma. 37, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

Trinidad and Tobago
West Indies
Epidemiology
Asthma
Islands
22 Citations (Scopus)

Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)

Arbab, A. S., Ichikawa, T., Araki, T., Toyama, K., Nambu, A., Ohsawa, S., Kumagai, H. & Aikawa, Y., Mar 1 2000, In : Abdominal Imaging. 25, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

Echo-Planar Imaging
Hepatocellular Carcinoma
Neoplasm Metastasis
Noise
Magnetic Resonance Spectroscopy
43 Citations (Scopus)

Diagnosis and characterization of acute erythroleukemia subsets by determining the percentages of myeloblasts and proerythroblasts in 69 cases

Ramchandran, R., Bengra, C., Whitney, B., Lanclos, K. & Tuan Lo, D., Sep 11 2000, In : American Journal of Hematology. 65, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

Granulocyte Precursor Cells
Erythroblasts
Leukemia, Erythroblastic, Acute
Leukemia
Erythroid Cells
44 Citations (Scopus)

Differential influence of the 4F2 heavy chain and the protein related to b0,+ amino acid transport on substrate affinity of the heteromeric b0,+ amino acid transporter

Rajan, D. P., Huang, W., Kekuda, R., George, R. L., Wang, J., Conway, S. J., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., May 12 2000, In : Journal of Biological Chemistry. 275, 19, p. 14331-14335 5 p.

Research output: Contribution to journalArticle

CD98 Heavy Chain Antigens
Amino Acid Transport Systems
Amino Acids
Substrates
Messenger RNA
10 Citations (Scopus)

Electrogenic nature of rat sodium-dependent multivitamin transport

Prasad, P. D., Srinivas, S. R., Wang, H., Leibach, F. H., Devoe, L. D. & Ganapathy, V., Apr 21 2000, In : Biochemical and Biophysical Research Communications. 270, 3, p. 836-840 5 p.

Research output: Contribution to journalArticle

Rats
Biotin
Sodium
Membranes
Oocytes
26 Citations (Scopus)

Evaluation of an isogenic major outer membrane protein-deficient mutant in the human model of Haemophilus ducreyi infection

Throm, R. E., Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Slaughter, C. A., Hansen, E. J. & Spinola, S. M., May 1 2000, In : Infection and Immunity. 68, 5, p. 2602-2607 6 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Haemophilus Infections
Membrane Proteins
Open Reading Frames
Porins
25 Citations (Scopus)

Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases

Medlock, A. E. & Dailey, H. A., Jun 27 2000, In : Biochemistry. 39, 25, p. 7461-7467 7 p.

Research output: Contribution to journalArticle

Ferrochelatase
Yeast
Yeasts
Schizosaccharomyces
Saccharomyces cerevisiae
112 Citations (Scopus)

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor α in mammalian retinal pigment epithelium

Chancy, C. D., Kekuda, R., Huang, W., Prasad, P. D., Kuhnel, J. M., Sirotnak, F. M., Roon, P., Ganapathy, V. & Smith, S. B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20676-20684 9 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Retinal Pigment Epithelium
Folic Acid
Polarization
185 Citations (Scopus)

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death

Hicks, G. G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L., Arapovic, D., White, E. K., Koury, M. J., Oltz, E. M., Van Kaer, L. & Ruley, H. E., Feb 1 2000, In : Nature Genetics. 24, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

Chromosomal Instability
RNA-Binding Protein FUS
Lymphocyte Activation
B-Lymphocytes
Transcription Factors
155 Citations (Scopus)

In organello formaldehyde crosslinking of proteins to mtDNA: Identification of bifunctional proteins

Kaufman, B. A., Newman, S. M., Hallberg, R. L., Slaughter, C. A., Perlman, P. S. & Butow, R. A., Jul 5 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 14, p. 7772-7777 6 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Formaldehyde
Proteins
DNA
High Mobility Group Proteins
357 Citations (Scopus)

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

Arthur, W. T., Petch Lee, L. A. & Burridge, K., Jun 1 2000, In : Current Biology. 10, 12, p. 719-722 4 p.

Research output: Contribution to journalArticle

integrins
Integrins
pseudopodia
Pseudopodia
GTP Phosphohydrolases
75 Citations (Scopus)

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

Ge, K., Duhadaway, J., Sakamuro, D., Wechsler-Reya, R., Reynolds, C. & Prendergast, G. C., Jan 17 2000, In : International Journal of Cancer. 85, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

Cell Death
Breast Neoplasms
Estrogen Receptors
Breast
Neoplasms
30 Citations (Scopus)

Lymphocytes lacking IκB-α develop normally, but have selective defects in proliferation and function

Chen, C. L., Singh, N., Yull, F. E., Strayhorn, D., Van Kaer, L. & Kerr, L. D., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5418-5427 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Lymphocytes
Liver
T-Lymphocytes
Recombinases
78 Citations (Scopus)

Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase

Browning, D. D., McShane, M. P., Marty, C. & Ye, R. D., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2811-2816 6 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
p38 Mitogen-Activated Protein Kinases
Fibroblasts
Nitric Oxide
Chemical activation
108 Citations (Scopus)

PKCε modulates NF-κB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes

Li, R. C. X., Ping, P., Zhang, J., Wead, W. B., Cao, X., Gao, J., Zheng, Y., Huang, S., Han, J. & Bolli, R., Dec 7 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 4 48-4

Research output: Contribution to journalArticle

Transcription Factor AP-1
Mitogen-Activated Protein Kinases
Cardiac Myocytes
Protein Kinase C
Rabbits
109 Citations (Scopus)

Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A

Hatanaka, T., Huang, W., Wang, H., Sugawara, M., Prasad, P. D., Leibach, F. H. & Ganapathy, V., Jul 31 2000, In : Biochimica et Biophysica Acta - Biomembranes. 1467, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Tissue
Amino Acids
Cells
Neutral Amino Acids
88 Citations (Scopus)

Primary structure genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+ - and H+ -coupled glutamine transporter

Fei, Y. J., Sugawara, M., Nakanishi, T., Huang, W., Wang, H., Prasad, P. D., Leibach, F. H. & Ganapathy, V., Aug 4 2000, In : Journal of Biological Chemistry. 275, 31, p. 23707-23717 11 p.

Research output: Contribution to journalArticle

Asparagine
Glutamine
Oocytes
Rats
Substrates
36 Citations (Scopus)

Proteolytic cleavage of the Fe - S subunit hinge region of Rhodobacter capsulatus bc1 complex: Effects of inhibitors and mutations

Valkova-Valchanova, M., Darrouzet, E., Moomaw, C. R., Slaughter, C. A. & Daldal, F., Dec 19 2000, In : Biochemistry. 39, 50, p. 15484-15492 9 p.

Research output: Contribution to journalArticle

Rhodobacter capsulatus
Hinges
Proteolysis
Mutation
Conformations
16 Citations (Scopus)

Ras-independent oncogenic transformation by an EGF-receptor mutant

Boerner, J. L., McManus, M. J., Martin, G. S. & Maihle, N. J., Apr 12 2000, In : Journal of Cell Science. 113, 6, p. 935-942 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Ligands
Phosphoproteins
Stress Fibers
Fibroblasts
20 Citations (Scopus)

Solution structures in SDS micelles and functional activity at the bullfrog substance P receptor of ranatachykinin peptides

Perrine, S. A., Whitehead, T. L., Hicks, R. P., Szarek, J. L., Krause, J. E. & Simmons, M. A., May 30 2000, In : Journal of Medicinal Chemistry. 43, 9, p. 1741-1753 13 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Rana catesbeiana
Micelles
Peptides
Tachykinins
34 Citations (Scopus)

Stable and unstable transgene integration sites in the human genome: extinction of the Green Fluorescent Protein transgene in K562 cells

Migliaccio, A. R., Bengra, C., Ling, J., Pi, W., Li, C., Zeng, S., Keskintepe, M., Whitney, B., Sanchez, M., Migliaccio, G. & Tuan, D., Oct 3 2000, In : Gene. 256, 1-2, p. 197-214 18 p.

Research output: Contribution to journalArticle

K562 Cells
Human Genome
Green Fluorescent Proteins
Transgenes
Genes
179 Citations (Scopus)

Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms

Whitfield, M. L., Zheng, L. X., Baldwin, A., Ohta, T., Hurt, M. M. & Marzluff, W. F., Jun 1 2000, In : Molecular and Cellular Biology. 20, 12, p. 4188-4198 11 p.

Research output: Contribution to journalArticle

Histones
Cell Cycle
Carrier Proteins
Messenger RNA
Proteins
14 Citations (Scopus)

The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination

Kovalik, J. P., Singh, N., Mendiratta, S. K., Martin, W. D., Ignatowicz, L. & Van Kaer, L., Aug 1 2000, In : Journal of Immunology. 165, 3, p. 1285-1293 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Amino Acid Substitution
Allografts
Ligands
42 Citations (Scopus)

The application of multidimensional NMR to the study of soil humic substances

Kingery, W. L., Simpson, A. J., Hayes, M. H. B., Locke, M. A. & Hicks, R. P., Jan 1 2000, In : Soil Science. 165, 6, p. 483-494 12 p.

Research output: Contribution to journalArticle

humic substances
humic substance
nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
chemical structure
120 Citations (Scopus)

Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38α mitogen-activated protein kinase activity

Huang, S., New, L., Pan, Z., Han, J. & Nemerow, G. R., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 12266-12272 7 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Urokinase-Type Plasminogen Activator
p38 Mitogen-Activated Protein Kinases
Cells
Breast Neoplasms
1999
54 Citations (Scopus)
Phosphorylation
p38 Mitogen-Activated Protein Kinases
Lipopolysaccharides
Nitric Oxide
Neutrophils
6 Citations (Scopus)

A preliminary study of neopterin as a potential marker for severe dengue virus infection

Babb, K., Carrington, C. V. F. & Monteil, M. A., Jan 1 1999, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 93, 4, p. 447-448 2 p.

Research output: Contribution to journalArticle

Severe Dengue
Neopterin
Dengue Virus
Dengue
Virus Diseases
40 Citations (Scopus)

A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells

Huang, S., Reddy, V., Dasgupta, N. & Nemerow, G. R., Apr 1 1999, In : Journal of Virology. 73, 4, p. 2798-2802 5 p.

Research output: Contribution to journalArticle

Adenoviridae
serotypes
Amino Acids
amino acids
cells
48 Citations (Scopus)

Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta

Kenney, S. P., Kekuda, R., Prasad, P. D., Leibach, F. H., Devoe, L. D. & Ganapathy, V., Jan 1 1999, In : American Journal of Obstetrics and Gynecology. 181, 2, p. 491-497 7 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Serotonin Plasma Membrane Transport Proteins
Placenta
Paroxetine
Colforsin
86 Citations (Scopus)

Characterization of the Moraxella catarrhalis uspA1 and uspA2 genes and their encoded products

Cope, L. D., Lafontaine, E. R., Slaughter, C. A., Hasemann, C. A., Aebi, C., Henderson, F. W., McCracken, G. H. & Hansen, E. J., Jul 1 1999, In : Journal of Bacteriology. 181, 13, p. 4026-4034 9 p.

Research output: Contribution to journalArticle

Moraxella (Branhamella) catarrhalis
Genes
Amino Acid Motifs
Proteins
Sequence Analysis
58 Citations (Scopus)

Cloning and expression of a b0,+-like amino acid transporter functioning asa heterodimer with 4F2hc-instead of rBAT. A new candidate gene for cystinuria

Rajan, D. P., Kekuda, R., Huang, W., Wang, H., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Oct 8 1999, In : Journal of Biological Chemistry. 274, 41, p. 29005-29010 6 p.

Research output: Contribution to journalArticle

CD98 Heavy Chain Antigens
Cystinuria
Amino Acid Transport Systems
Cloning
CD98 Light Chains Antigens
138 Citations (Scopus)

Cloning of the human thiamine transporter, a member of the folate transporter family

Dutta, B., Huang, W., Molero, M., Kekuda, R., Leibach, F. H., Devoe, L. D., Ganapathy, V. & Prasad, P. D., Nov 5 1999, In : Journal of Biological Chemistry. 274, 45, p. 31925-31929 5 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Cloning
Thiamine
Organism Cloning
Complementary DNA
197 Citations (Scopus)

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

Liu, K., Schoonmaker, M. M., Levine, B. L., June, C. H., Hodes, R. J. & Weng, N. P., Apr 27 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 9, p. 5147-5152 6 p.

Research output: Contribution to journalArticle

Telomerase
Lymphocytes
human TERT protein
Messenger RNA
52 Citations (Scopus)

Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function

Cui, Y., Iwakuma, T. & Chang, L. J., Jun 23 1999, In : Journal of Virology. 73, 7, p. 6171-6176 6 p.

Research output: Contribution to journalArticle

env Genes
Lentivirus
regulatory sequences
Viral RNA
RNA
322 Citations (Scopus)

Cutting edge: Activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype

Singh, N., Hong, S., Scherer, D. C., Serizawa, I., Burdin, N., Kronenberg, M., Koezuka, Y. & Van Kaer, L., Sep 1 1999, In : Journal of Immunology. 163, 5, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

Galactosylceramides
Natural Killer Cells
T-Lymphocytes
Phenotype
Interleukin-4
51 Citations (Scopus)

Drugs of abuse and placental transport

Ganapathy, V., Prasad, P. D., Ganapathy, M. E. & Leibach, F. H., Jun 14 1999, In : Advanced Drug Delivery Reviews. 38, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Street Drugs
Placenta
Fetus
Amphetamines
Cannabinoids
1 Citation (Scopus)

Effects of genistein on experimental metastasis of B16-BL6 mouse melanoma cells

Yan, C. & Han, R., Nov 1 1999, In : Yaoxue Xuebao. 34, 11, p. 814-817 4 p.

Research output: Contribution to journalArticle

Genistein
Melanoma
Neoplasm Metastasis
Cyclophosphamide
Lung
14 Citations (Scopus)
Genistein
Fibrosarcoma
Matrix Metalloproteinases
Human Activities
Tissue Inhibitor of Metalloproteinase-1
166 Citations (Scopus)

Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system

Chang, L. J., Urlacher, V., Iwakuma, T., Cui, Y. & Zucali, J., May 1 1999, In : Gene Therapy. 6, 5, p. 715-728 14 p.

Research output: Contribution to journalArticle

HIV-1
env Genes
Safety
Rous sarcoma virus
Product Packaging
286 Citations (Scopus)

Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter

Wu, X., Huang, W., Prasad, P. D., Seth, P., Rajan, D. P., Leibach, F. H., Chen, J., Conway, S. J. & Ganapathy, V., Sep 1 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 3, p. 1482-1492 11 p.

Research output: Contribution to journalArticle

Carnitine
Tissue Distribution
Cations
Placenta
Kidney Glomerulus
168 Citations (Scopus)

Human LAT1, a subunit of system L amino acid transporter: Molecular cloning and transport function

Prasad, P. D., Wang, H., Huang, W., Kekuda, R., Rajan, D. P., Leibach, F. H. & Ganapathy, V., Feb 16 1999, In : Biochemical and Biophysical Research Communications. 255, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Cloning
Molecular Cloning
Neutral Amino Acids
Amino Acids
108 Citations (Scopus)

Human Na+-dependent vitamin C transporter 1 (hSVCT1): Primary structure, functional characteristics and evidence for a non-functional splice variant

Wang, H., Dutta, B., Huang, W., Devoe, L. D., Leibach, F. H., Ganapathy, V. & Prasad, P. D., Nov 9 1999, In : Biochimica et Biophysica Acta - Biomembranes. 1461, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Complementary DNA
Amino Acids
Thymus
Cloning
110 Citations (Scopus)

Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, chromosomal localization

Wang, H., Huang, W., Fei, Y. J., Xia, H., Yang-Feng, T. L., Leibach, F. H., Devoe, L. D., Ganapathy, V. & Prasad, P. D., May 21 1999, In : Journal of Biological Chemistry. 274, 21, p. 14875-14883 9 p.

Research output: Contribution to journalArticle

Cloning
Biotin
Gene expression
Organism Cloning
Gene Expression
130 Citations (Scopus)

Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function

Rajan, D. P., Huang, W., Dutta, B., Devoe, L. D., Leibach, F. H., Ganapathy, V. & Prasad, P. D., Sep 7 1999, In : Biochemical and Biophysical Research Communications. 262, 3, p. 762-768 7 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Cloning
Molecular Cloning
Complementary DNA
Ascorbic Acid
8 Citations (Scopus)
Hyaluronoglucosaminidase
Hyaluronic Acid
Prostatic Neoplasms
32 Citations (Scopus)

Interaction of the N-terminus of chicken skeletal essential light chain 1 with F-actin

Andreev, O. A., Saraswat, L. D., Lowey, S., Slaughter, C. & Borejdo, J., Feb 23 1999, In : Biochemistry. 38, 8, p. 2480-2485 6 p.

Research output: Contribution to journalArticle

alanylproline
Actins
Chickens
Lysine
Light