Biochemistry and Molecular Biology

Research Output 1968 2019

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1997

PLCβ1-mediated hydrolysis of PIP2 is inhibited by the focal adhlsion protein vinculin

Petch, L. & Burridge, K., Dec 1 1997, In : FASEB Journal. 11, 3, p. A311

Research output: Contribution to journalArticle

Vinculin
Hydrolysis
hydrolysis
microfilament proteins
cell growth
41 Citations (Scopus)

Resonance Raman spectra of ferrochelatase reveal porphyrin distortion upon metal binding

Blackwood, M. E., Rush, T. S., Medlock, A. E., Dailey, H. A. & Spiro, T. G., Dec 17 1997, In : Journal of the American Chemical Society. 119, 50, p. 12170-12174 5 p.

Research output: Contribution to journalArticle

Ferrochelatase
Porphyrins
Raman scattering
Pyrroles
Metals
104 Citations (Scopus)

Structural analysis of the human BIN1 gene: Evidence for tissue-specific transcriptional regulation and alternate RNA splicing

Wechsler-Reya, R., Sakamuro, D., Zhang, J., Duhadaway, J. & Prendergast, G. C., Dec 12 1997, In : Journal of Biological Chemistry. 272, 50, p. 31453-31458 6 p.

Research output: Contribution to journalArticle

RNA Splicing
Alternative Splicing
Structural analysis
Exons
Genes
104 Citations (Scopus)

T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Ignatowicz, L., Rees, W., Pacholczyk, R. W., Ignatowicz, H., Kushnir, E., Kappler, J. & Marrack, P., Jan 1 1997, In : Immunity. 7, 2, p. 179-186 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Peptide T
T-Cell Antigen Receptor
Thymus Gland
233 Citations (Scopus)

The polyproline region of p53 is required to activate apoptosis but not growth arrest

Sakamuro, D., Sabbatini, P., White, E. & Prendergast, G. C., Jan 1 1997, In : Oncogene. 15, 8, p. 887-898 12 p.

Research output: Contribution to journalArticle

Apoptosis
Growth
Transcriptional Activation
polyproline
DNA
138 Citations (Scopus)

The Role of Body Mass Index in the Relative Risk of Developing Premenopausal versus Postmenopausal Breast Cancer

Cleary, M. P. & Maihle, N. J., Dec 1 1997, In : Experimental Biology and Medicine. 216, 1, p. 28-43 16 p.

Research output: Contribution to journalArticle

Body Mass Index
Breast Neoplasms
Fats
Animals
Adipose Tissue
4 Citations (Scopus)

The salubrious effects of ascorbic acid on cyclophosphamide instigated lipid abnormalities in fibrosarcoma bearing rats

Vasavi, H., Thangaraju, M., Babu, J. R. & Sachdanandam, P., Dec 1 1997, In : Cancer Biochemistry Biophysics. 16, 1, p. 71-83 13 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Cyclophosphamide
Ascorbic Acid
Lipids
Lipoproteins
51 Citations (Scopus)

Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene

Kong, S., Bohl, D., Li, C. & Tuan, D., Jul 1997, In : Molecular and Cellular Biology. 17, 7, p. 3955-3965 11 p.

Research output: Contribution to journalArticle

Locus Control Region
Genes
Erythroid Cells
Chloramphenicol O-Acetyltransferase
Globins
187 Citations (Scopus)

Tumor-associated hyaluronic acid: A new sensitive and specific urine marker for bladder cancer

Lokeshwar, V. B., Öbek, C., Soloway, M. S. & Block, N. L., Mar 3 1997, In : Cancer Research. 57, 4, p. 773-777 5 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Urinary Bladder Neoplasms
Urine
Neoplasms
Endothelial Cells
1996

89Sr therapy for pain relief in patients with bone metastases

Koizumi, K., Arbab, A. S., Toyama, K., Shirasu, M., Osawa, S., Araki, T., Yamaguchi, M., Onishi, H., Araki, T., Arai, T., Komatsu, H., Ueno, A. & Nokata, H., Dec 1 1996, In : Kakuigaku. 33, 11, p. 1243-1248 6 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Pain
Therapeutics
Bone Marrow
66 Citations (Scopus)

A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor

Reiter, J. L. & Maihle, N. J., Nov 28 1996, In : Nucleic Acids Research. 24, 20, p. 4050-4056 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Epidermal Growth Factor Receptor
Complementary DNA
Ligands
RNA Splice Sites
73 Citations (Scopus)

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B

Shi, L., Chen, G., Macdonald, G., Bergeron, L., Li, H., Miura, M., Rotello, R. J., Miller, D. K., Li, P., Seshadri, T., Yuan, J. & Greenberg, A. H., Oct 1 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 20, p. 11002-11007 6 p.

Research output: Contribution to journalArticle

Granzymes
Caspase 1
Apoptosis
Peptide Hydrolases
Cytotoxic T-Lymphocytes
207 Citations (Scopus)

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

Huang, S., Kamata, T., Takada, Y., Ruggeri, Z. M. & Nemerow, G. R., Jun 27 1996, In : Journal of Virology. 70, 7, p. 4502-4508 7 p.

Research output: Contribution to journalArticle

integrins
Adenoviridae
gene transfer
Integrins
Genes
66 Citations (Scopus)

A model for the quaternary structure of the proteasome activator PA28

Song, X., Mott, J. D., Von Kampen, J., Pramanik, B., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Oct 30 1996, In : Journal of Biological Chemistry. 271, 42, p. 26410-26417 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Antibodies
Proteins
Cathepsin A
Proteolysis

Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity

Mendiratta, S. K., Singh, N., Bal, V. & Rath, S., Jan 1 1996, In : Immunology. 89, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

Hybridomas
Major Histocompatibility Complex
Ligands
T-Lymphocytes
Lipopolysaccharides
274 Citations (Scopus)

BIN1 is a novel MYC-interacting protein with features of a tumour suppressor

Sakamuro, D., Elliott, K. J., Wechsler-Reya, R. & Prendergast, G. C., Sep 1 1996, In : Nature Genetics. 14, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Proteins
Oncogene Proteins
Cell Cycle Checkpoints
124 Citations (Scopus)

Bradykinin stimulates NF-κB activation and interleukin 1β gene expression in cultured human fibroblasts

Pan, Z. K., Zuraw, B. L., Lung, C. C., Prossnitz, E. R., Browning, D. D. & Ye, R. D., Nov 1 1996, In : Journal of Clinical Investigation. 98, 9, p. 2042-2049 8 p.

Research output: Contribution to journalArticle

Bradykinin
Interleukin-1
Fibroblasts
Gene Expression
Chloramphenicol O-Acetyltransferase
55 Citations (Scopus)

cDNA cloning and functional analysis of the p97 subunit of the 265 proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11

Tsurumi, C., Shimizu, Y., Saeki, M., Kato, S., Demartino, G. N., Slaughter, C. A., Fujimuro, M., Yokosawa, H., Yamasaki, M. O., Hendil, K. B., Toh-E, A., Tanahashi, N. & Tanaka, K., Jan 1 1996, In : European Journal of Biochemistry. 239, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
Functional analysis
Cloning
Proteasome Endopeptidase Complex
Organism Cloning
23 Citations (Scopus)

CDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family

Fujiwara, T., Watanabe, T. K., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 3 1996, In : FEBS Letters. 387, 2-3, p. 184-188 5 p.

Research output: Contribution to journalArticle

Cloning
Proteasome Endopeptidase Complex
Organism Cloning
Proteins
Modulators
348 Citations (Scopus)

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

Kekuda, R., Prasad, P. D., Fei, Y. J., Leibach, F. H. & Ganapathy, V., Dec 13 1996, In : Biochemical and Biophysical Research Communications. 229, 2, p. 553-558 6 p.

Research output: Contribution to journalArticle

Cloning
sigma Receptors
Organism Cloning
Complementary DNA
Guinea Pigs
200 Citations (Scopus)

Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter B(o) from a human placental choriocarcinoma cell line

Kekuda, R., Prasad, P. D., Fei, Y. J., Torres-Zamorano, V., Sinha, S., Yang-Feng, T. L., Leibach, F. H. & Ganapathy, V., Oct 7 1996, In : Journal of Biological Chemistry. 271, 31, p. 18657-18661 5 p.

Research output: Contribution to journalArticle

Neutral Amino Acid Transport Systems
Choriocarcinoma
Cloning
Organism Cloning
Amino Acid Transport Systems
46 Citations (Scopus)

Detection of a unique γ-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma

Tsutsumi, M., Sakamuro, D., Takada, A., Zang, S. C., Furukawa, T. & Taniguchi, N., Jan 1 1996, In : Hepatology. 23, 5, p. 1093-1097 5 p.

Research output: Contribution to journalArticle

gamma-Glutamyltransferase
Early Diagnosis
Hepatocellular Carcinoma
Messenger RNA
RNA
30 Citations (Scopus)

Direct detection by 15N NMR of the tryptophan tryptophylquinone aminoquinol reaction intermediate of methylamine dehydrogenase

Bishop, G. R., Valente, E. J., Whitehead, T. L., Brown, K. L., Hicks, R. P. & Davidson, V. L., Dec 1 1996, In : Journal of the American Chemical Society. 118, 50, p. 12868-12869 2 p.

Research output: Contribution to journalArticle

Reaction intermediates
Nuclear magnetic resonance
methylamine dehydrogenase
tryptophan tryptophylquinone
10 Citations (Scopus)

Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction

Yoo, J., Herman, L. E., Li, C., Krantz, S. B. & Tuan Lo, D., Mar 15 1996, In : Blood. 87, 6, p. 2558-2567 10 p.

Research output: Contribution to journalArticle

Locus Control Region
Erythroid Precursor Cells
Polymerase chain reaction
Chromatin
Polymerase Chain Reaction

Effectiveness of potassium citrate therapy in the management of nephrolithiasis

Rajpurohit, S. K., Pendse, AK., Barjatiya, MK. & Singh, PP., 1996, In : Urolithiasis. p. 450

Research output: Contribution to journalArticle

86 Citations (Scopus)

Fortnightly Review: The pneumococcal problem

Obaro, S. K., Monteil, M. A. & Henderson, D. C., Jun 15 1996, In : BMJ. 312, 7045, p. 1521-1525 5 p.

Research output: Contribution to journalArticle

Pneumonia
Anti-Bacterial Agents
Pneumococcal Infections
Streptococcus pneumoniae
Spain
43 Citations (Scopus)

Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells

Prasad, P. D., Hoffmans, B. J., Moe, A. J., Smith, C. H., Leibach, F. H. & Ganapathy, V., Jan 1 1996, In : Placenta. 17, 4, p. 201-207 7 p.

Research output: Contribution to journalArticle

Vesicular Monoamine Transport Proteins
Serotonin Plasma Membrane Transport Proteins
Choriocarcinoma
Membrane Transport Proteins
Trophoblasts
16 Citations (Scopus)

Hemicellulose is an important leaf-feeding resistance factor in corn to the fall armyworm

Hedin, P. A., Davis, F. M., Williams, W. P., Hicks, R. P. & Fisher, T. H., Jan 1 1996, In : Journal of Chemical Ecology. 22, 9, p. 1655-1668 14 p.

Research output: Contribution to journalArticle

Spodoptera frugiperda
R Factors
hemicellulose
Zea mays
maize
50 Citations (Scopus)

Human coproporphyrinogen oxidase is not a metalloprotein

Medlock, A. E. & Dailey, H. A., Dec 1 1996, In : Journal of Biological Chemistry. 271, 51, p. 32507-32510 4 p.

Research output: Contribution to journalArticle

Coproporphyrinogen Oxidase
Metalloproteins
Metals
Metal analysis
His-His-His-His-His-His
44 Citations (Scopus)

Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP

Muller, U., Brandsch, M., Prasad, P. D., Fei, Y. J., Ganapathy, V. & Leibach, F. H., Jan 17 1996, In : Biochemical and Biophysical Research Communications. 218, 2, p. 461-465 5 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Cholera Toxin
Cyclic AMP
Protein Kinase C
Phosphorylation
3 Citations (Scopus)

Modeling of the recognition site of the NK1 receptor

Saebo, S., Keene, E., Fang, T., Lynn, B. C. & Hicks, R. P., Jul 31 1996, In : Journal of Molecular Structure: THEOCHEM. 366, 1-2, p. 65-77 13 p.

Research output: Contribution to journalArticle

Substance P
amino acids
Amino Acids
Molecular mechanics
polypeptides
22 Citations (Scopus)

Modulation of chemosensitivity in human colon carcinoma cells by downregulating Protein Kinase Cα expression

Chakrabarty, S. & Huang, S., Jul 1 1996, In : Journal of Experimental Therapeutics and Oncology. 1, 4, p. 218-221 4 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Down-Regulation
Carcinoma
Mitomycin
38 Citations (Scopus)

Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence

Chambliss, K. L., Slaughter, C. A., Schreiner, R., Hoffmann, G. F. & Michael Gibson, K., Aug 5 1996, In : Journal of Biological Chemistry. 271, 29, p. 17330-17334 5 p.

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Complementary DNA
Liver
Clone Cells
31 Citations (Scopus)
SCID Mice
HIV-1
Immunity
Lymphocytes
HIV Infections
53 Citations (Scopus)

Role of Escherichia coli RNA polymerase alpha subunit in modulation of pausing, termination and anti-termination by the transcription elongation factor NusA

Liu, K., Zhang, Y., Severinov, K., Das, A. & Hanna, M. M., Jan 2 1996, In : EMBO Journal. 15, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
Transcription
Escherichia coli
Transcription Factors
Modulation
29 Citations (Scopus)

Sodium-dependent carnitine transport in human placental choriocarcinoma cells

Prasad, P. D., Huang, W., Ramamoorthy, S., Carter, A. L., Leibach, F. H. & Ganapathy, V., Oct 2 1996, In : Biochimica et Biophysica Acta - Biomembranes. 1284, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

Choriocarcinoma
Carnitine
Sodium
Cell membranes
Intracellular Space
23 Citations (Scopus)

Sodium-dependent high-affinity binding of carnitine to human placental brush border membranes

Roque, A. S., Prasad, P. D., Bhatia, J. J., Leibach, F. H. & Ganapathy, V., Jul 25 1996, In : Biochimica et Biophysica Acta - Biomembranes. 1282, 2, p. 274-282 9 p.

Research output: Contribution to journalArticle

Carnitine
Brushes
Microvilli
Sodium
Membranes

Sodium-dependent high-affinity binding sites for carnitine in human placental brush border membranes

Rogue, A. S., Prasad, P. D., Bhatia, J. J., Leibach, F. H. & Ganapathy, V., Jan 1 1996, In : Journal of Investigative Medicine. 44, 1

Research output: Contribution to journalArticle

Carnitine
Brushes
Microvilli
Sodium
Binding Sites
25 Citations (Scopus)

Solution structure of cyanocobalamin (vitamin B12) by NMR-restrained molecular dynamics and simulated annealing calculations

Marques, H. M., Hicks, R. P. & Brown, K. L., Jan 1 1996, In : Chemical Communications. 12, p. 1427-1428 2 p.

Research output: Contribution to journalArticle

Vitamins
Vitamin B 12
Simulated annealing
Molecular dynamics
Nuclear magnetic resonance
194 Citations (Scopus)
Caspase 1
Poly(ADP-ribose) Polymerases
Proteolysis
Peptide Hydrolases
Tumor Necrosis Factor-alpha
24 Citations (Scopus)

Suramin induces phosphorylation of the high-affinity nerve growth factor receptor in PC12 cells and dorsal root ganglion neurons

Gill, J. S., Connolly, D. C., McManus, M. J., Maihle, N. J. & Windebank, A. J., Mar 1 1996, In : Journal of Neurochemistry. 66, 3, p. 963-972 10 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Suramin
Phosphorylation
PC12 Cells
Spinal Ganglia
6 Citations (Scopus)

Tc-99m MIBI uptake in a bronchial carcinoid tumor

Arbab, A. S., Koizumi, K., Arai, T., Araki, T., Ozawa, K., Hashimoto, R. & Hemmi, A., Dec 20 1996, In : Clinical nuclear medicine. 21, 12, p. 1005-1006 2 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Carcinoid Tumor
Single-Photon Emission-Computed Tomography
Neoplasms
Electron Microscopy
94 Citations (Scopus)

The cell adhesion molecule, GP116, is a new CD44 variant (ex14/v10) involved in hyaluronic acid binding and endothelial cell proliferation

Lokeshwar, V. B., Lida, N. & Bourguignon, L. Y. W., Oct 10 1996, In : Journal of Biological Chemistry. 271, 39, p. 23853-23864 12 p.

Research output: Contribution to journalArticle

Endothelial cells
Cell proliferation
Cell Adhesion Molecules
Hyaluronic Acid
Endothelial Cells
1995
208 Citations (Scopus)

Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

Petch Lee, L. A., Bockholt, S. M., Bouton, A., Parsons, J. T. & Burridge, K., Jan 1 1995, In : Journal of Cell Science. 108, 4, p. 1371-1379 9 p.

Research output: Contribution to journalArticle

Tyrosine
Phosphorylation
Paxillin
Phosphotyrosine
Focal Adhesions
25 Citations (Scopus)

Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization

Yang-Feng, T. L., Ma, Y. Y., Liang, R., Prasad, P. D., Leibach, F. H. & Ganapathy, V., May 25 1995, In : Biochemical and Biophysical Research Communications. 210, 3, p. 874-879 6 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Hybrid Cells
Chromosomes
In Situ Hybridization
Complementary DNA
9 Citations (Scopus)

A study of recurrent stone formers with special reference to renal tubular acidosis

Singh, P. P., Pendse, A. K., Ahmed, A., Ramavataram, D. V. & Rajpurohit, S. K., 1995, In : Urological Research. 23, 3, p. 201-3 3 p.

Research output: Contribution to journalArticle

Renal Tubular Acidosis
Citric Acid
Calcium
Ammonium Compounds
Acids
59 Citations (Scopus)

cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p

Akiyama, K. Y., Yokota, K. Y., Kagawa, S., Shimbara, N., DeMartino, G. N., Slaughter, C. A., Noda, C. & Tanaka, K., Apr 17 1995, In : FEBS Letters. 363, 1-2, p. 151-156 6 p.

Research output: Contribution to journalArticle

Cloning
Yeast
Adenosine Triphosphatases
Organism Cloning
Complementary DNA
153 Citations (Scopus)

c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms

Sakamuro, D., Eviner, V., Elliott, K. J., Showe, L., White, E. & Prendergast, G. C., Dec 7 1995, In : Oncogene. 11, 11, p. 2410-2418 9 p.

Research output: Contribution to journalArticle

Epithelial Cells
Apoptosis
Temperature
Cell Death
G1 Phase Cell Cycle Checkpoints
21 Citations (Scopus)
Dictyostelium
Chemotaxis
Folic Acid
Biological Assay
Protein-Tyrosine Kinases
241 Citations (Scopus)

Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2

Ganapathy, M. E., Brandsch, M., Prasad, P. D., Ganapathy, V. & Leibach, F. H., Jan 1 1995, In : Journal of Biological Chemistry. 270, 43, p. 25672-25677 6 p.

Research output: Contribution to journalArticle

Lactams
Anti-Bacterial Agents
Kidney
Cyclacillin
Cefadroxil