Biochemistry and Molecular Biology

Research Output 1968 2019

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Article
1998
20 Citations (Scopus)

Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line

Prasad, P. D., Huang, W., Wang, H., Leibach, F. H. & Ganapathy, V., Feb 2 1998, In : Biochimica et Biophysica Acta - Biomembranes. 1369, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

Dehydroascorbic Acid
Choriocarcinoma
Ascorbic Acid
Cells
Vitamins
1997
72 Citations (Scopus)

A glycoprotein pneumococcal conjugate vaccine primes for antibody responses to a pneumococcal polysaccharide vaccine in Gambian children

Obaro, S. K., Huo, Z., Banya, W. A. S., Henderson, D. C., Monteil, M. A., Leach, A. & Greenwood, B. M., Dec 1 1997, In : Pediatric Infectious Disease Journal. 16, 12, p. 1135-1140 6 p.

Research output: Contribution to journalArticle

Conjugate Vaccines
Pneumococcal Vaccines
Antibody Formation
Glycoproteins
Polysaccharides
81 Citations (Scopus)

Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modeling

Young, J. K., Hicks, R. P., Wright, G. E. & Morrison, T. G., Nov 24 1997, In : Virology. 238, 2, p. 291-304 14 p.

Research output: Contribution to journalArticle

Biological Assay
Peptides
Amino Acid Sequence
Proteins
Viral Fusion Proteins
206 Citations (Scopus)

Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b

Huang, S., Jiang, Y., Li, Z., Nishida, E., Mathias, P., Lin, S., Ulevitch, R. J., Nemerow, G. R. & Han, J., Jan 1 1997, In : Immunity. 6, 6, p. 739-749 11 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase 6
Peptide Hydrolases
Apoptosis
T-Lymphocytes
Cell Death

Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients

Koizumi, K., Higashida, K., Arbab, A. S., Toyama, K., Arai, T. & Yoshitomi, T., Jun 26 1997, In : Kakuigaku. 34, 4, p. 259-265 7 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Mertiatide
Pediatrics
Plasma Volume
Hematocrit
Body Weight
27 Citations (Scopus)

A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-ErbB signaling to actin stress fiber disassembly

Mcmanus, M. J., Lingle, W. L., Salisbury, J. L. & Maihle, N. J., Oct 14 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 21, p. 11351-11356 6 p.

Research output: Contribution to journalArticle

Calmodulin-Binding Proteins
Stress Fibers
Protein-Tyrosine Kinases
Actins
Collagen
59 Citations (Scopus)

Cell type- and developmental stage-specific activation of NF-κB by fMet-Leu-Phe in myeloid cells

Browning, D. D., Pan, Z. K., Prossnitz, E. R. & Ye, R. D., Apr 8 1997, In : Journal of Biological Chemistry. 272, 12, p. 7995-8001 7 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
N-Formylmethionine Leucyl-Phenylalanine
Myeloid Cells
Tumor Necrosis Factor-alpha
HL-60 Cells
36 Citations (Scopus)

Characterization of N 5-methyltetrahydrofolate uptake in cultured human retinal pigment epithelial cells

Huang, W., Prasad, P. D., Kekuda, R., Leibach, F. H. & Ganapathy, V., Aug 12 1997, In : Investigative Ophthalmology and Visual Science. 38, 8, p. 1578-1587 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Folic Acid
Folic Acid Transporters
Epithelial Cells
Northern Blotting
23 Citations (Scopus)

Computer-assisted, quantitative cytokine enzyme-linked immunospot analysis of human immune effector cell function

Cui, Y. & Chang, L. J., Jun 1 1997, In : BioTechniques. 22, 6, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

Enzyme-Linked Immunospot Assay
Assays
Cytokines
Lymphocytes
Enzymes
14 Citations (Scopus)

Control of fibronectin receptor expression by fibronectin: Antisense fibronectin RNA downmodulates the induction of fibronectin receptor by transforming growth factor β1

Rajagopal, S., Huang, S., Albitar, M. & Chakrabarty, S., Feb 1 1997, In : Journal of Cellular Physiology. 170, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

Integrin alpha5beta1
Antisense RNA
Transforming Growth Factors
Fibronectins
RNA
133 Citations (Scopus)

Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

Stewart, P. L., Chiu, C. Y., Huang, S., Muir, T., Zhao, Y., Chait, B., Mathias, P. & Nemerow, G. R., Mar 17 1997, In : EMBO Journal. 16, 6, p. 1189-1198 10 p.

Research output: Contribution to journalArticle

Adenoviridae
Integrins
Cryoelectron Microscopy
Epitopes
Immunoglobulin Fab Fragments

Development of a partial fibronectin knockout transgenic mouse model

Manshouri, T., Huang, S., Sundaresan, A., Chakravarthy, M., Chakrabarty, S. & Albitar, M., Jan 1 1997, In : Transgenics. 2, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

Fibronectins
Knockout Mice
Wound Healing
Transgenic Mice
7 Citations (Scopus)

Effect of tamoxifen on lipids and lipid metabolising marker enzymes in experimental atherosclerosis in Wistar rats

Vinitha, R., Thangaraju, M. & Sachdanandam, P., Mar 6 1997, In : Molecular and Cellular Biochemistry. 168, 1-2, p. 13-19 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Wistar Rats
Rats
Atherosclerosis
Lipids
16 Citations (Scopus)

Functional link between tyrosine phosphorylation and human serotonin transporter gene expression

Prasad, P. D., Torres-Zamorano, V., Kekuda, R., Leibach, F. H. & Ganapathy, V., Apr 23 1997, In : European Journal of Pharmacology. 325, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Tyrosine
Phosphorylation
Gene Expression
Protein-Tyrosine Kinases
34 Citations (Scopus)

Growth arrest of Epstein-Barr virus immortalized B lymphocytes by adenovirus-delivered ribozymes

Huang, S., Stupack, D., Mathias, P., Wang, Y. & Nemerow, G., Jul 22 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 15, p. 8156-8161 6 p.

Research output: Contribution to journalArticle

Catalytic RNA
Epstein-Barr Virus Nuclear Antigens
Human Herpesvirus 4
Adenoviridae
B-Lymphocytes
113 Citations (Scopus)

Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2

Fei, Y. J., Liu, W., Prasad, P. D., Kekuda, R., Oblak, T. G., Ganapathy, V. & Leibach, F. H., Jan 14 1997, In : Biochemistry. 36, 2, p. 452-460 9 p.

Research output: Contribution to journalArticle

Xenopus laevis
HeLa Cells
Human Activities
Oocytes
Catalyst activity
73 Citations (Scopus)

Interaction of anionic cephalosporins with the intestinal and renal peptide transportrs PEPT 1 and PEPT 2

Ganapathy, M. E., Prasad, P. D., Mackenzie, B., Ganapathy, V. & Leibach, F. H., Mar 13 1997, In : Biochimica et Biophysica Acta - Biomembranes. 1324, 2, p. 296-308 13 p.

Research output: Contribution to journalArticle

Cephalosporins
Kidney
Peptides
cefdinir
Cefixime
12 Citations (Scopus)

Modulatory subdomains of the HS2 enhancer differentially regulate enhancer activity in erythroid cells at different developmental stages

Cavallesco, R. & Tuan Lo, D., Jan 1 1997, In : Blood Cells, Molecules and Diseases. 23, 1, p. 8-26 19 p.

Research output: Contribution to journalArticle

Erythroid Cells
Globins
Locus Control Region
Developmental Genes
K562 Cells
103 Citations (Scopus)

Molecular and functional characterization of intestinal Na+-dependent neutral amino acid transporter B0

Kekuda, R., Torres-Zamorano, V., Fei, Y. J., Prasad, P. D., Li, H. W., Mader, L. D., Leibach, F. H. & Ganapathy, V., Jun 1 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 6 35-6

Research output: Contribution to journalArticle

Neutral Amino Acid Transport Systems
Neutral Amino Acids
Rabbits
Amino Acids
Membrane Potentials

Molecular and functional characterization of the intestinal amino acid transporter B°

Kekuda, R., Torres-Zamorano, V., Fei, Y. J., Prasad, P. D., Li, H. W., Mader, L. D., Leibach, F. H. & Ganapathy, V., Dec 1 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

amino acid transporters
Amino Acid Transport Systems
Complementary DNA
Intestines
amino acids
107 Citations (Scopus)

Molecular properties of the proteasome activator PA28 family proteins and γ-interferon regulation

Tanahashi, N., Yokota, K. Y., Ahn, J. Y., Chung, C. H., Fujiwara, T., Takahashi, E. I., DeMartino, G. N., Slaughter, C. A., Toyonaga, T., Yamamura, K. I., Shimbara, N. & Tanaka, K., Jan 1 1997, In : Genes to Cells. 2, 3, p. 195-211 17 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Interferons
Proteins
Anti-Idiotypic Antibodies
Biological Phenomena
3 Citations (Scopus)
Catenins
IGF Type 1 Receptor
Rhabdomyosarcoma
Phosphorylation
Protein-Tyrosine Kinases

PLCβ1-mediated hydrolysis of PIP2 is inhibited by the focal adhlsion protein vinculin

Petch, L. & Burridge, K., Dec 1 1997, In : FASEB Journal. 11, 3, p. A311

Research output: Contribution to journalArticle

Vinculin
Hydrolysis
hydrolysis
microfilament proteins
cell growth
41 Citations (Scopus)

Resonance Raman spectra of ferrochelatase reveal porphyrin distortion upon metal binding

Blackwood, M. E., Rush, T. S., Medlock, A. E., Dailey, H. A. & Spiro, T. G., Dec 17 1997, In : Journal of the American Chemical Society. 119, 50, p. 12170-12174 5 p.

Research output: Contribution to journalArticle

Ferrochelatase
Porphyrins
Raman scattering
Pyrroles
Metals
105 Citations (Scopus)

Structural analysis of the human BIN1 gene: Evidence for tissue-specific transcriptional regulation and alternate RNA splicing

Wechsler-Reya, R., Sakamuro, D., Zhang, J., Duhadaway, J. & Prendergast, G. C., Dec 12 1997, In : Journal of Biological Chemistry. 272, 50, p. 31453-31458 6 p.

Research output: Contribution to journalArticle

RNA Splicing
Alternative Splicing
Structural analysis
Exons
Genes
104 Citations (Scopus)

T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Ignatowicz, L., Rees, W., Pacholczyk, R. W., Ignatowicz, H., Kushnir, E., Kappler, J. & Marrack, P., Jan 1 1997, In : Immunity. 7, 2, p. 179-186 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Peptide T
T-Cell Antigen Receptor
Thymus Gland
233 Citations (Scopus)

The polyproline region of p53 is required to activate apoptosis but not growth arrest

Sakamuro, D., Sabbatini, P., White, E. & Prendergast, G. C., Jan 1 1997, In : Oncogene. 15, 8, p. 887-898 12 p.

Research output: Contribution to journalArticle

Apoptosis
Growth
Transcriptional Activation
polyproline
DNA
138 Citations (Scopus)

The Role of Body Mass Index in the Relative Risk of Developing Premenopausal versus Postmenopausal Breast Cancer

Cleary, M. P. & Maihle, N. J., Dec 1 1997, In : Experimental Biology and Medicine. 216, 1, p. 28-43 16 p.

Research output: Contribution to journalArticle

Body Mass Index
Breast Neoplasms
Fats
Animals
Adipose Tissue
4 Citations (Scopus)

The salubrious effects of ascorbic acid on cyclophosphamide instigated lipid abnormalities in fibrosarcoma bearing rats

Vasavi, H., Thangaraju, M., Babu, J. R. & Sachdanandam, P., Dec 1 1997, In : Cancer Biochemistry Biophysics. 16, 1, p. 71-83 13 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Cyclophosphamide
Ascorbic Acid
Lipids
Lipoproteins
51 Citations (Scopus)

Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene

Kong, S., Bohl, D., Li, C. & Tuan, D., Jul 1997, In : Molecular and Cellular Biology. 17, 7, p. 3955-3965 11 p.

Research output: Contribution to journalArticle

Locus Control Region
Genes
Erythroid Cells
Chloramphenicol O-Acetyltransferase
Globins
187 Citations (Scopus)

Tumor-associated hyaluronic acid: A new sensitive and specific urine marker for bladder cancer

Lokeshwar, V. B., Öbek, C., Soloway, M. S. & Block, N. L., Mar 3 1997, In : Cancer Research. 57, 4, p. 773-777 5 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Urinary Bladder Neoplasms
Urine
Neoplasms
Endothelial Cells
130 Citations (Scopus)

Tumor-derived hyaluronidase: A diagnostic urine marker for high-grade bladder cancer

Pham, H. T., Block, N. L. & Lokeshwar, V. B., Mar 3 1997, In : Cancer Research. 57, 4, p. 778-783 6 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Urinary Bladder Neoplasms
Urine
Hyaluronic Acid
Neoplasms
1996

89Sr therapy for pain relief in patients with bone metastases

Koizumi, K., Arbab, A. S., Toyama, K., Shirasu, M., Osawa, S., Araki, T., Yamaguchi, M., Onishi, H., Araki, T., Arai, T., Komatsu, H., Ueno, A. & Nokata, H., Dec 1 1996, In : Kakuigaku. 33, 11, p. 1243-1248 6 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Pain
Therapeutics
Bone Marrow
66 Citations (Scopus)

A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor

Reiter, J. L. & Maihle, N. J., Nov 28 1996, In : Nucleic Acids Research. 24, 20, p. 4050-4056 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Epidermal Growth Factor Receptor
Complementary DNA
Ligands
RNA Splice Sites
73 Citations (Scopus)

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B

Shi, L., Chen, G., Macdonald, G., Bergeron, L., Li, H., Miura, M., Rotello, R. J., Miller, D. K., Li, P., Seshadri, T., Yuan, J. & Greenberg, A. H., Oct 1 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 20, p. 11002-11007 6 p.

Research output: Contribution to journalArticle

Granzymes
Caspase 1
Apoptosis
Peptide Hydrolases
Cytotoxic T-Lymphocytes
207 Citations (Scopus)

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

Huang, S., Kamata, T., Takada, Y., Ruggeri, Z. M. & Nemerow, G. R., Jun 27 1996, In : Journal of Virology. 70, 7, p. 4502-4508 7 p.

Research output: Contribution to journalArticle

integrins
Adenoviridae
gene transfer
Integrins
Genes
66 Citations (Scopus)

A model for the quaternary structure of the proteasome activator PA28

Song, X., Mott, J. D., Von Kampen, J., Pramanik, B., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Oct 30 1996, In : Journal of Biological Chemistry. 271, 42, p. 26410-26417 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Antibodies
Proteins
Cathepsin A
Proteolysis

Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity

Mendiratta, S. K., Singh, N., Bal, V. & Rath, S., Jan 1 1996, In : Immunology. 89, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

Hybridomas
Major Histocompatibility Complex
Ligands
T-Lymphocytes
Lipopolysaccharides
274 Citations (Scopus)

BIN1 is a novel MYC-interacting protein with features of a tumour suppressor

Sakamuro, D., Elliott, K. J., Wechsler-Reya, R. & Prendergast, G. C., Sep 1 1996, In : Nature Genetics. 14, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Proteins
Oncogene Proteins
Cell Cycle Checkpoints
124 Citations (Scopus)

Bradykinin stimulates NF-κB activation and interleukin 1β gene expression in cultured human fibroblasts

Pan, Z. K., Zuraw, B. L., Lung, C. C., Prossnitz, E. R., Browning, D. D. & Ye, R. D., Nov 1 1996, In : Journal of Clinical Investigation. 98, 9, p. 2042-2049 8 p.

Research output: Contribution to journalArticle

Bradykinin
Interleukin-1
Fibroblasts
Gene Expression
Chloramphenicol O-Acetyltransferase
55 Citations (Scopus)

cDNA cloning and functional analysis of the p97 subunit of the 265 proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11

Tsurumi, C., Shimizu, Y., Saeki, M., Kato, S., Demartino, G. N., Slaughter, C. A., Fujimuro, M., Yokosawa, H., Yamasaki, M. O., Hendil, K. B., Toh-E, A., Tanahashi, N. & Tanaka, K., Jan 1 1996, In : European Journal of Biochemistry. 239, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
Functional analysis
Cloning
Proteasome Endopeptidase Complex
Organism Cloning
23 Citations (Scopus)

CDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family

Fujiwara, T., Watanabe, T. K., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 3 1996, In : FEBS Letters. 387, 2-3, p. 184-188 5 p.

Research output: Contribution to journalArticle

Cloning
Proteasome Endopeptidase Complex
Organism Cloning
Proteins
Modulators
349 Citations (Scopus)

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

Kekuda, R., Prasad, P. D., Fei, Y. J., Leibach, F. H. & Ganapathy, V., Dec 13 1996, In : Biochemical and Biophysical Research Communications. 229, 2, p. 553-558 6 p.

Research output: Contribution to journalArticle

Cloning
sigma Receptors
Organism Cloning
Complementary DNA
Guinea Pigs
202 Citations (Scopus)

Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter B(o) from a human placental choriocarcinoma cell line

Kekuda, R., Prasad, P. D., Fei, Y. J., Torres-Zamorano, V., Sinha, S., Yang-Feng, T. L., Leibach, F. H. & Ganapathy, V., Oct 7 1996, In : Journal of Biological Chemistry. 271, 31, p. 18657-18661 5 p.

Research output: Contribution to journalArticle

Neutral Amino Acid Transport Systems
Choriocarcinoma
Cloning
Organism Cloning
Amino Acid Transport Systems
46 Citations (Scopus)

Detection of a unique γ-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma

Tsutsumi, M., Sakamuro, D., Takada, A., Zang, S. C., Furukawa, T. & Taniguchi, N., Jan 1 1996, In : Hepatology. 23, 5, p. 1093-1097 5 p.

Research output: Contribution to journalArticle

gamma-Glutamyltransferase
Early Diagnosis
Hepatocellular Carcinoma
Messenger RNA
RNA
30 Citations (Scopus)

Direct detection by 15N NMR of the tryptophan tryptophylquinone aminoquinol reaction intermediate of methylamine dehydrogenase

Bishop, G. R., Valente, E. J., Whitehead, T. L., Brown, K. L., Hicks, R. P. & Davidson, V. L., Dec 1 1996, In : Journal of the American Chemical Society. 118, 50, p. 12868-12869 2 p.

Research output: Contribution to journalArticle

Reaction intermediates
Nuclear magnetic resonance
methylamine dehydrogenase
tryptophan tryptophylquinone
10 Citations (Scopus)

Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction

Yoo, J., Herman, L. E., Li, C., Krantz, S. B. & Tuan Lo, D., Mar 15 1996, In : Blood. 87, 6, p. 2558-2567 10 p.

Research output: Contribution to journalArticle

Locus Control Region
Erythroid Precursor Cells
Polymerase chain reaction
Chromatin
Polymerase Chain Reaction

Effectiveness of potassium citrate therapy in the management of nephrolithiasis

Rajpurohit, S. K., Pendse, AK., Barjatiya, MK. & Singh, PP., 1996, In : Urolithiasis. p. 450

Research output: Contribution to journalArticle

86 Citations (Scopus)

Fortnightly Review: The pneumococcal problem

Obaro, S. K., Monteil, M. A. & Henderson, D. C., Jun 15 1996, In : BMJ. 312, 7045, p. 1521-1525 5 p.

Research output: Contribution to journalArticle

Pneumonia
Anti-Bacterial Agents
Pneumococcal Infections
Streptococcus pneumoniae
Spain
43 Citations (Scopus)

Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells

Prasad, P. D., Hoffmans, B. J., Moe, A. J., Smith, C. H., Leibach, F. H. & Ganapathy, V., Jan 1 1996, In : Placenta. 17, 4, p. 201-207 7 p.

Research output: Contribution to journalArticle

Vesicular Monoamine Transport Proteins
Serotonin Plasma Membrane Transport Proteins
Choriocarcinoma
Membrane Transport Proteins
Trophoblasts