Biochemistry and Molecular Biology

Research Output 1968 2019

Filter
Article
1999
322 Citations (Scopus)

Cutting edge: Activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype

Singh, N., Hong, S., Scherer, D. C., Serizawa, I., Burdin, N., Kronenberg, M., Koezuka, Y. & Van Kaer, L., Sep 1 1999, In : Journal of Immunology. 163, 5, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

Galactosylceramides
Natural Killer Cells
T-Lymphocytes
Phenotype
Interleukin-4
51 Citations (Scopus)

Drugs of abuse and placental transport

Ganapathy, V., Prasad, P. D., Ganapathy, M. E. & Leibach, F. H., Jun 14 1999, In : Advanced Drug Delivery Reviews. 38, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Street Drugs
Placenta
Fetus
Amphetamines
Cannabinoids
1 Citation (Scopus)

Effects of genistein on experimental metastasis of B16-BL6 mouse melanoma cells

Yan, C. & Han, R., Nov 1 1999, In : Yaoxue Xuebao. 34, 11, p. 814-817 4 p.

Research output: Contribution to journalArticle

Genistein
Melanoma
Neoplasm Metastasis
Cyclophosphamide
Lung
14 Citations (Scopus)
Genistein
Fibrosarcoma
Matrix Metalloproteinases
Human Activities
Tissue Inhibitor of Metalloproteinase-1
169 Citations (Scopus)

Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system

Chang, L. J., Urlacher, V., Iwakuma, T., Cui, Y. & Zucali, J., May 1 1999, In : Gene Therapy. 6, 5, p. 715-728 14 p.

Research output: Contribution to journalArticle

HIV-1
env Genes
Safety
Rous sarcoma virus
Product Packaging
286 Citations (Scopus)

Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter

Wu, X., Huang, W., Prasad, P. D., Seth, P., Rajan, D. P., Leibach, F. H., Chen, J., Conway, S. J. & Ganapathy, V., Sep 1 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 3, p. 1482-1492 11 p.

Research output: Contribution to journalArticle

Carnitine
Tissue Distribution
Cations
Placenta
Kidney Glomerulus
168 Citations (Scopus)

Human LAT1, a subunit of system L amino acid transporter: Molecular cloning and transport function

Prasad, P. D., Wang, H., Huang, W., Kekuda, R., Rajan, D. P., Leibach, F. H. & Ganapathy, V., Feb 16 1999, In : Biochemical and Biophysical Research Communications. 255, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Cloning
Molecular Cloning
Neutral Amino Acids
Amino Acids
108 Citations (Scopus)

Human Na+-dependent vitamin C transporter 1 (hSVCT1): Primary structure, functional characteristics and evidence for a non-functional splice variant

Wang, H., Dutta, B., Huang, W., Devoe, L. D., Leibach, F. H., Ganapathy, V. & Prasad, P. D., Nov 9 1999, In : Biochimica et Biophysica Acta - Biomembranes. 1461, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Complementary DNA
Amino Acids
Thymus
Cloning
110 Citations (Scopus)

Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, chromosomal localization

Wang, H., Huang, W., Fei, Y. J., Xia, H., Yang-Feng, T. L., Leibach, F. H., Devoe, L. D., Ganapathy, V. & Prasad, P. D., May 21 1999, In : Journal of Biological Chemistry. 274, 21, p. 14875-14883 9 p.

Research output: Contribution to journalArticle

Cloning
Biotin
Gene expression
Organism Cloning
Gene Expression
130 Citations (Scopus)

Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function

Rajan, D. P., Huang, W., Dutta, B., Devoe, L. D., Leibach, F. H., Ganapathy, V. & Prasad, P. D., Sep 7 1999, In : Biochemical and Biophysical Research Communications. 262, 3, p. 762-768 7 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Cloning
Molecular Cloning
Complementary DNA
Ascorbic Acid
8 Citations (Scopus)
Hyaluronoglucosaminidase
Hyaluronic Acid
Prostatic Neoplasms
32 Citations (Scopus)

Interaction of the N-terminus of chicken skeletal essential light chain 1 with F-actin

Andreev, O. A., Saraswat, L. D., Lowey, S., Slaughter, C. & Borejdo, J., Feb 23 1999, In : Biochemistry. 38, 8, p. 2480-2485 6 p.

Research output: Contribution to journalArticle

alanylproline
Actins
Chickens
Lysine
Light
102 Citations (Scopus)

Interdependent regulation of intracellular acidification and SHP-1 in apoptosis

Thangaraju, M., Sharma, K., Liu, D., Shen, S. H. & Srikant, C. B., Apr 1 1999, In : Cancer Research. 59, 7, p. 1649-1654 6 p.

Research output: Contribution to journalArticle

Apoptosis
Somatostatin
Sodium-Hydrogen Antiporter
Proton-Translocating ATPases
Nigericin
96 Citations (Scopus)

Molecular and functional characterization of the intestinal Na+- dependent multivitamin transporter

Prasad, P. D., Wang, H., Huang, W., Fei, Y. J., Leibach, F. H., Devoe, L. D. & Ganapathy, V., Jun 1 1999, In : Archives of Biochemistry and Biophysics. 366, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

Complementary DNA
Biotin
Vitamins
Cells
Amino Acids
92 Citations (Scopus)

Molecular and ligand-binding characterization of the σ-receptor in the Jurkat human T lymphocyte cell line

Ganapathy, M. E., Prasad, P. D., Huang, W., Seth, P., Leibach, F. H. & Ganapathy, V., Apr 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 1, p. 251-260 10 p.

Research output: Contribution to journalArticle

Jurkat Cells
Haloperidol
Ligands
Progesterone
T-Lymphocytes
43 Citations (Scopus)

NF-κB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells

Hsu, M. H., Wang, M., Browning, D. D., Mukaida, N. & Ye, R. D., May 15 1999, In : Blood. 93, 10, p. 3241-3249 9 p.

Research output: Contribution to journalArticle

Interleukin-8
Gene expression
Chemical activation
Gene Expression
Pertussis Toxin
85 Citations (Scopus)

Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

Tu, Y., Popov, S., Slaughter, C. & Ross, E. M., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 38260-38267 8 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Lipoylation
GTPase-Activating Proteins
GTP Phosphohydrolases
GTP-Binding Proteins
116 Citations (Scopus)

PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits

Ping, P., Zhang, J., Huang, S., Cao, X., Tang, X. L., Li, R. C. X., Zheng, Y. T., Qiu, Y., Clerk, A., Sugden, P., Han, J. & Bolli, R., Jan 1 1999, In : American Journal of Physiology - Heart and Circulatory Physiology. 277, 5 46-5

Research output: Contribution to journalArticle

Ischemic Preconditioning
JNK Mitogen-Activated Protein Kinases
Protein Kinase C
Rabbits
Reperfusion
83 Citations (Scopus)

Primary structure and functional characteristics of a mammalian sodium- coupled high affinity dicarboxylate transporter

Kekuda, R., Wang, H., Huang, W., Pajor, A. M., Leibach, F. H., Devoe, L. D., Prasad, P. D. & Ganapathy, V., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3422-3429 8 p.

Research output: Contribution to journalArticle

Dicarboxylic Acid Transporters
Succinic Acid
Citric Acid
Sodium
Rats
5 Citations (Scopus)

Protein tyrosine kinase inhibitor genistein suppresses in vitro invasion of HT1080 human fibrosarcoma cells

Yan, C. & Han, R., Jul 3 1999, In : Chinese Journal of Oncology. 21, 3, p. 171-174 4 p.

Research output: Contribution to journalArticle

Genistein
Fibrosarcoma
Protein Kinase Inhibitors
Protein-Tyrosine Kinases
Matrix Metalloproteinases
89 Citations (Scopus)

Regulation of acidification and apoptosis by SHP-1 and Bcl-2

Thangaraju, M., Sharma, K., Leber, B., Andrews, D. W., Shen, S. H. & Srikant, C. B., Oct 8 1999, In : Journal of Biological Chemistry. 274, 41, p. 29549-29557 9 p.

Research output: Contribution to journalArticle

Acidification
Somatostatin
Apoptosis
Membranes
Ligation
57 Citations (Scopus)

Secreted Site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins

Cheng, D., Espenshade, P. J., Slaughter, C. A., Jaen, J. C., Brown, M. S. & Goldstein, J. L., Aug 6 1999, In : Journal of Biological Chemistry. 274, 32, p. 22805-22812 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Peptides
Sterol Regulatory Element Binding Protein 2
Peptide Hydrolases
Biosynthesis
20 Citations (Scopus)

Sickle cell telemedicine and standard clinical encounters: A comparison of patient satisfaction

Woods, K. F., Kutlar, A., Johnson, J. A., Waller, J. L., Grigsby, R. K., Stachura, M. E. & Rahn, D. W., Dec 1 1999, In : Telemedicine Journal. 5, 4, p. 349-356 8 p.

Research output: Contribution to journalArticle

Telemedicine
Patient Satisfaction
Sensitivity Training Groups
Sickle Cell Anemia
Confidentiality
385 Citations (Scopus)

Solution structure of BID, an intracellular amplifier of apoptotic signaling

Chou, J. J., Li, H., Salvesen, G. S., Yuan, J. & Wagner, G., Mar 5 1999, In : Cell. 96, 5, p. 615-624 10 p.

Research output: Contribution to journalArticle

Caspase 8
Bacterial Toxins
Mitochondria
Sequence Homology
208 Citations (Scopus)

Subtype-selective expression of the five somatostatin receptors (hSSTR1- 5) in human pancreatic islet cells: A quantitative double-label immunohistochemical analysis

Kumar, U., Sasi, R., Suresh, S., Patel, A., Thangaraju, M., Metrakos, P., Patel, S. C. & Patel, Y. C., Jan 1 1999, In : Diabetes. 48, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans
somatostatin receptor 5
Glucagon
Insulin
somatostatin receptor type 1
13 Citations (Scopus)

Tyrosine phosphorylation of caldesmon is required for binding to the Shc·Grb2 complex

Wang, Z., Danielsen, A. J., Maihle, N. J. & McManus, M. J., Nov 19 1999, In : Journal of Biological Chemistry. 274, 47, p. 33807-33813 7 p.

Research output: Contribution to journalArticle

Calmodulin-Binding Proteins
Phosphorylation
Tyrosine
Fibroblasts
Myosins
2000
17 Citations (Scopus)

A (GATA)7 motif located in the 5' boundary area of the human β-globin locus control region exhibits silencer activity in erythroid cells

Ramchandran, R., Bengra, C., Whitney, B., Lanclos, K. & Tuan Lo, D., Jan 1 2000, In : American Journal of Hematology. 65, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

Locus Control Region
Phosphoglycerate Kinase
Erythroid Cells
Chloramphenicol O-Acetyltransferase
Globins
116 Citations (Scopus)

Activation of NF-κB by bradykinin through a Gα(q)- and Gβγ-dependent pathway that involves phosphoinositide 3-kinase and Akt

Xie, P., Browning, D. D., Hay, N., Mackman, N. & Ye, R. D., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24907-24914 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Bradykinin
Phosphatidylinositols
Phosphotransferases
Chemical activation
96 Citations (Scopus)

Adenovirus vector pseudotyping in fiber-expressing cell lines: Improved transduction of Epstein-Barr virus-transformed B cells

Von Seggern, D. J., Huang, S., Fleck, S. K., Stevenson, S. C. & Nemerow, G. R., Jan 1 2000, In : Journal of Virology. 74, 1, p. 354-362 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 4
fiber cells
Adenoviridae
Human Herpesvirus 4
B-lymphocytes
2 Citations (Scopus)

A retrospective analysis of invasive Streptococcus pneumoniae infections in Trinidad.

Williams, K. P. & Monteil, M. A., Mar 2000, In : The West Indian medical journal. 49, 1, p. 61-64 4 p.

Research output: Contribution to journalArticle

Trinidad and Tobago
Pneumococcal Infections
Pneumonia
Amoxicillin
Body Fluids
32 Citations (Scopus)

Cell growth and matrix invasion of EBV-immortalized human B lymphocytes is regulated by expression of α(v) integrins

Huang, S., Stupack, D., Liu, A., Cheresh, D. & Nemerow, G. R., Apr 6 2000, In : Oncogene. 19, 15, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Integrins
B-Lymphocytes
Growth
Lymphoproliferative Disorders
1 Citation (Scopus)

Characterization of [Re2Cl3(μ-dppm)2(NCCH3) 2][Cl] and [Re2Cl3(μ-dppm)2(NCC6H 5)2][Cl] · 2CH2Cl2 by X-ray Crystallographic and Two-Dimensional NMR Spectroscopic Techniques

Concolino, T. E., Eglin, J. L., Hadden, C. E., Hicks, R. P., Staples, R. J., Valente, E. J. & Zubkowski, J. D., Jan 1 2000, In : Journal of Cluster Science. 11, 1, p. 109-123 15 p.

Research output: Contribution to journalArticle

Methane
phosphine
methane
Nuclear magnetic resonance
X-Rays
75 Citations (Scopus)

Cloning and functional characterization of a Na+-independent, broad-specific neutral amino acid transporter from mammalian intestine

Rajan, D. P., Kekuda, R., Huang, W., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jan 15 2000, In : Biochimica et Biophysica Acta - Biomembranes. 1463, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

Neutral Amino Acid Transport Systems
Cloning
Intestines
Organism Cloning
Amino Acid Transport System L
87 Citations (Scopus)

Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta

Wang, H., Huang, W., Sugawara, M., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jul 14 2000, In : Biochemical and Biophysical Research Communications. 273, 3, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Cloning
Placenta
Organism Cloning
Complementary DNA
19 Citations (Scopus)

Descriptive epidemiology of asthma in Trinidad, West Indies

Monteil, M. A., Juman, S., Hassanally, R., Williams, K. P., Pierre, L., Rahaman, M., Singh, H. & Trinidade, A., Jan 1 2000, In : Journal of Asthma. 37, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

Trinidad and Tobago
West Indies
Epidemiology
Asthma
Islands
22 Citations (Scopus)

Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)

Arbab, A. S., Ichikawa, T., Araki, T., Toyama, K., Nambu, A., Ohsawa, S., Kumagai, H. & Aikawa, Y., Mar 1 2000, In : Abdominal Imaging. 25, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

Echo-Planar Imaging
Hepatocellular Carcinoma
Neoplasm Metastasis
Noise
Magnetic Resonance Spectroscopy
43 Citations (Scopus)

Diagnosis and characterization of acute erythroleukemia subsets by determining the percentages of myeloblasts and proerythroblasts in 69 cases

Ramchandran, R., Bengra, C., Whitney, B., Lanclos, K. & Tuan Lo, D., Sep 11 2000, In : American Journal of Hematology. 65, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

Granulocyte Precursor Cells
Erythroblasts
Leukemia, Erythroblastic, Acute
Leukemia
Erythroid Cells
44 Citations (Scopus)

Differential influence of the 4F2 heavy chain and the protein related to b0,+ amino acid transport on substrate affinity of the heteromeric b0,+ amino acid transporter

Rajan, D. P., Huang, W., Kekuda, R., George, R. L., Wang, J., Conway, S. J., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., May 12 2000, In : Journal of Biological Chemistry. 275, 19, p. 14331-14335 5 p.

Research output: Contribution to journalArticle

CD98 Heavy Chain Antigens
Amino Acid Transport Systems
Amino Acids
Substrates
Messenger RNA
10 Citations (Scopus)

Electrogenic nature of rat sodium-dependent multivitamin transport

Prasad, P. D., Srinivas, S. R., Wang, H., Leibach, F. H., Devoe, L. D. & Ganapathy, V., Apr 21 2000, In : Biochemical and Biophysical Research Communications. 270, 3, p. 836-840 5 p.

Research output: Contribution to journalArticle

Rats
Biotin
Sodium
Membranes
Oocytes
26 Citations (Scopus)

Evaluation of an isogenic major outer membrane protein-deficient mutant in the human model of Haemophilus ducreyi infection

Throm, R. E., Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Slaughter, C. A., Hansen, E. J. & Spinola, S. M., May 1 2000, In : Infection and Immunity. 68, 5, p. 2602-2607 6 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Haemophilus Infections
Membrane Proteins
Open Reading Frames
Porins
25 Citations (Scopus)

Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases

Medlock, A. E. & Dailey, H. A., Jun 27 2000, In : Biochemistry. 39, 25, p. 7461-7467 7 p.

Research output: Contribution to journalArticle

Ferrochelatase
Yeast
Yeasts
Schizosaccharomyces
Saccharomyces cerevisiae
112 Citations (Scopus)

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor α in mammalian retinal pigment epithelium

Chancy, C. D., Kekuda, R., Huang, W., Prasad, P. D., Kuhnel, J. M., Sirotnak, F. M., Roon, P., Ganapathy, V. & Smith, S. B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20676-20684 9 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Retinal Pigment Epithelium
Folic Acid
Polarization
187 Citations (Scopus)

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death

Hicks, G. G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L., Arapovic, D., White, E. K., Koury, M. J., Oltz, E. M., Van Kaer, L. & Ruley, H. E., Feb 1 2000, In : Nature Genetics. 24, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

Chromosomal Instability
RNA-Binding Protein FUS
Lymphocyte Activation
B-Lymphocytes
Transcription Factors
155 Citations (Scopus)

In organello formaldehyde crosslinking of proteins to mtDNA: Identification of bifunctional proteins

Kaufman, B. A., Newman, S. M., Hallberg, R. L., Slaughter, C. A., Perlman, P. S. & Butow, R. A., Jul 5 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 14, p. 7772-7777 6 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Formaldehyde
Proteins
DNA
High Mobility Group Proteins
357 Citations (Scopus)

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

Arthur, W. T., Petch, L. A. & Burridge, K., Jun 1 2000, In : Current Biology. 10, 12, p. 719-722 4 p.

Research output: Contribution to journalArticle

integrins
Integrins
pseudopodia
Pseudopodia
GTP Phosphohydrolases
76 Citations (Scopus)

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

Ge, K., Duhadaway, J., Sakamuro, D., Wechsler-Reya, R., Reynolds, C. & Prendergast, G. C., Jan 17 2000, In : International Journal of Cancer. 85, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

Cell Death
Breast Neoplasms
Estrogen Receptors
Breast
Neoplasms
31 Citations (Scopus)

Lymphocytes lacking IκB-α develop normally, but have selective defects in proliferation and function

Chen, C. L., Singh, N., Yull, F. E., Strayhorn, D., Van Kaer, L. & Kerr, L. D., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5418-5427 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Lymphocytes
Liver
T-Lymphocytes
Recombinases
78 Citations (Scopus)

Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase

Browning, D. D., McShane, M. P., Marty, C. & Ye, R. D., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2811-2816 6 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
p38 Mitogen-Activated Protein Kinases
Fibroblasts
Nitric Oxide
Chemical activation
106 Citations (Scopus)

PhyloDraw: A phylogenetic tree drawing system

Choi, J. H., Jung, H. Y., Kim, H. S. & Cho, H. G., Jan 1 2000, In : Bioinformatics. 16, 11, p. 1056-1058 3 p.

Research output: Contribution to journalArticle

Phylogenetic Tree
Tree diagram
Distance Matrix
Control Parameter
Layout
108 Citations (Scopus)

PKCε modulates NF-κB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes

Li, R. C. X., Ping, P., Zhang, J., Wead, W. B., Cao, X., Gao, J., Zheng, Y., Huang, S., Han, J. & Bolli, R., Dec 7 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 4 48-4

Research output: Contribution to journalArticle

Transcription Factor AP-1
Mitogen-Activated Protein Kinases
Cardiac Myocytes
Protein Kinase C
Rabbits