Biochemistry and Molecular Biology

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Cloning and functional characterization of a Na+-independent, broad-specific neutral amino acid transporter from mammalian intestine

Rajan, D. P., Kekuda, R., Huang, W., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jan 15 2000, In : Biochimica et Biophysica Acta - Biomembranes. 1463, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Cloning and functional characterization of a new subtype of the amino acid transport system N

Nakanishi, T., Kekuda, R., Fei, Y. J., Hatanaka, T., Sugawara, M., Martindale, R. G., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6, p. C1757-C1768

Research output: Contribution to journalArticle

85 Scopus citations

Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta

Kekuda, R., Prasad, P. D., Wu, X., Wang, H., Fei, Y. J., Leibach, F. H. & Ganapathy, V., Jun 26 1998, In : Journal of Biological Chemistry. 273, 26, p. 15971-15979 9 p.

Research output: Contribution to journalArticle

360 Scopus citations

Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney

Gopal, E., Umapathy, N. S., Martin, P. M., Ananth, S., Gnana-Prakasam, J. P., Becker, H., Wagner, C. A., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Biochimica et Biophysica Acta - Biomembranes. 1768, 11, p. 2690-2697 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
45 Scopus citations

Cloning and functional expression of a cDNA encoding a mammalian sodium- dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate

Prasad, P. D., Wang, H., Kekuda, R., Fujita, T., Fei, Y. J., Devoe, L. D., Leibach, F. H. & Ganapathy, V., Mar 27 1998, In : Journal of Biological Chemistry. 273, 13, p. 7501-7508 8 p.

Research output: Contribution to journalArticle

162 Scopus citations

Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta

Wang, H., Huang, W., Sugawara, M., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Jul 14 2000, In : Biochemical and Biophysical Research Communications. 273, 3, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

87 Scopus citations

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

Kekuda, R., Prasad, P. D., Fei, Y. J., Leibach, F. H. & Ganapathy, V., Dec 13 1996, In : Biochemical and Biophysical Research Communications. 229, 2, p. 553-558 6 p.

Research output: Contribution to journalArticle

355 Scopus citations

Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)

Srinivas, S. R., Gopal, E., Zhuang, L., Itagaki, S., Martin, P. M., Fei, Y. J., Ganapathy, V. & Prasad, P. D., Dec 15 2005, In : Biochemical Journal. 392, 3, p. 655-664 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Cloning of a functional sodium-dependent pantothenate/biotin transporter from rabbit intestine and Caco-2 cells

Prasad, P. D., Sheikh, S., Huang, W., Leibach, F. H. & Ganapathy, V., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

2 Scopus citations

Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type β1

Ranganathan, G., Blatti, S. P., Subramaniam, M., Fass, D. N., Maihle, N. J. & Getz, M. J., Jan 31 1991, In : Journal of Biological Chemistry. 266, 1, p. 496-501 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cloning of the human thiamine transporter, a member of the folate transporter family

Dutta, B., Huang, W., Molero, M., Kekuda, R., Leibach, F. H., Devoe, L. D., Ganapathy, V. & Prasad, P. D., Nov 5 1999, In : Journal of Biological Chemistry. 274, 45, p. 31925-31929 5 p.

Research output: Contribution to journalArticle

141 Scopus citations

Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter B(o) from a human placental choriocarcinoma cell line

Kekuda, R., Prasad, P. D., Fei, Y. J., Torres-Zamorano, V., Sinha, S., Yang-Feng, T. L., Leibach, F. H. & Ganapathy, V., Oct 7 1996, In : Journal of Biological Chemistry. 271, 31, p. 18657-18661 5 p.

Research output: Contribution to journalArticle

210 Scopus citations

c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms

Sakamuro, D., Eviner, V., Elliott, K. J., Showe, L., White, E. & Prendergast, G. C., Dec 7 1995, In : Oncogene. 11, 11, p. 2410-2418 9 p.

Research output: Contribution to journalArticle

153 Scopus citations

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

Thangaraju, M., Carswell, K. N., Prasad, P. D. & Ganapathy, V., Jan 1 2009, In : Biochemical Journal. 417, 1, p. 379-389 11 p.

Research output: Contribution to journalArticle

96 Scopus citations

Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8

Cresci, G. A., Thangaraju, M., Mellinger, J. D., Liu, K. & Ganapathy, V., Mar 1 2010, In : Journal of Gastrointestinal Surgery. 14, 3, p. 449-461 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma

Shankar, A., Borin, T. F., Iskander, A., Varma, N. R. S., Achyut, B. R., Jain, M., Mikkelsen, T., Guo, A. M., Chwang, W. B., Ewing, J. R., Bagher-Ebadian, H. & Arbab, A. S., Mar 9 2016, In : OncoTargets and Therapy. 9, p. 1205-1219 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., Ustun, C., Rao, R., Fernandez, P., Chen, J., Balusu, R., Koul, S., Atadja, P., Marquez, V. E. & Bhalla, K. N., 2009, In : Blood. 114, 13, p. 2733-2743 11 p.

Research output: Contribution to journalArticle

265 Scopus citations

Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth

Pathania, R., Ramachandran, S., Mariappan, G., Thakur, P., Shi, H., Choi, J. H., Manicassamy, S., Kolhe, R., Prasad, P. D., Sharma, S., Lokeshwar, B. L., Ganapathy, V. & Thangaraju, M., Jun 1 2016, In : Cancer Research. 76, 11, p. 3224-3235 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations

Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle

Ren, M. Q., Wegner, J., Bellmann, O., Brockmann, G. A., Schneider, F., Teuscher, F. & Ender, K., Oct 1 2002, In : Domestic Animal Endocrinology. 23, 3, p. 371-381 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Comparison of prevalence and severity of asthma among adolescents in the Caribbean islands of Trinidad and Tobago: Results of a nationwide cross-sectional survey

Monteil, M. A., Joseph, G., Changkit, C., Wheeler, G. & Antoine, R. M., Sep 14 2005, In : BMC Public Health. 5, 96.

Research output: Contribution to journalArticle

17 Scopus citations

Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles

Hicks, R. P., Mones, E., Kim, H., Koser, B. W., Nichols, D. A. & Bhattacharjee, A. K., Apr 1 2003, In : Biopolymers. 68, 4, p. 459-470 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Competitive ubiquitination activates the tumor suppressor p53

Li, X., Guo, M., Cai, L., Du, T., Liu, Y., Ding, H. F., Wang, H., Zhang, J., Chen, X. & Yan, C., Jun 1 2020, In : Cell Death and Differentiation. 27, 6, p. 1807-1818 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Complete distal renal tubular acidosis: Biochemical profile of a case

Rajpurohit, S. K., Pendse, AK., Ahmed, A. & Singh, PP., 1992, In : Indian Journal of Clinical Biochemistry. 7, 2, p. 205-206 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Complete genome sequence and analysis of the industrial Saccharomyces cerevisiae strain N85 used in Chinese rice wine production

Zhang, W., Li, Y., Chen, Y., Xu, S., Du, G., Shi, H., Zhou, J. & Chen, J., Jan 1 2018, In : DNA Research. 25, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Computational methods for detection of differentially methylated regions using kernel distance and scan statistics

Dunbar, F., Xu, H., Ryu, D., Ghosh, S., Shi, H. & George, V., Apr 2019, In : Genes. 10, 4, 298.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Computer-assisted, quantitative cytokine enzyme-linked immunospot analysis of human immune effector cell function

Cui, Y. & Chang, L. J., Jun 1997, In : BioTechniques. 22, 6, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Concentration-independent MRI of pH with a dendrimer-based pH-responsive nanoprobe

Bhuiyan, M. P. I., Aryal, M. P., Janic, B., Karki, K., Varma, N. R. S., Ewing, J. R., Arbab, A. S. & Ali, M. M., Nov 1 2015, In : Contrast Media and Molecular Imaging. 10, 6, p. 481-486 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Concurrent PD-1 blockade negates the effects of OX40 agonist antibody in combination immunotherapy through inducing T-cell apoptosis

Shrimali, R. K., Ahmad, S., Verma, V., Zeng, P., Ananth, S., Gaur, P., Gittelman, R. M., Yusko, E., Sanders, C., Robins, H., Hammond, S. A., Janik, J. E., Mkrtichyan, M., Gupta, S. & Khleif, S. N., Sep 2017, In : Cancer Immunology Research. 5, 9, p. 755-766 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

Conformational analysis of met‐enkephalin in both aqueous solution and in the presence of sodium dodecyl sulfate micelles using multidimensional NMR and molecular modeling

Graham, W. H., Carter, E. S. & Hicks, R. P., Jan 1 1992, In : Biopolymers. 32, 12, p. 1755-1764 10 p.

Research output: Contribution to journalArticle

103 Scopus citations

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

Liu, K., Schoonmaker, M. M., Levine, B. L., June, C. H., Hodes, R. J. & Weng, N. P., Apr 27 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 9, p. 5147-5152 6 p.

Research output: Contribution to journalArticle

198 Scopus citations

Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease

Ren, M. Q. & Cowell, J. K., Jun 23 2011, In : Blood. 117, 25, p. 6837-6847 11 p.

Research output: Contribution to journalArticle

28 Scopus citations
16 Scopus citations

Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function

Cui, Y., Iwakuma, T. & Chang, L. J., Jun 23 1999, In : Journal of Virology. 73, 7, p. 6171-6176 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Control of AKR fibroblast phenotype by fibronectin: Regulation of cell‐surface fibronectin binding receptor by fibronectin

Huang, S., Varani, J. & Chakrabarty, S., Jan 1 1994, In : Journal of Cellular Physiology. 161, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Control of fibronectin receptor expression by fibronectin: Antisense fibronectin RNA downmodulates the induction of fibronectin receptor by transforming growth factor β1

Rajagopal, S., Huang, S., Albitar, M. & Chakrabarty, S., Feb 1 1997, In : Journal of Cellular Physiology. 170, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer

Liu, H., Yu, X., Liu, H., Wu, D. & She, J-X., Jul 26 2016, In : Scientific reports. 6, 30346.

Research output: Contribution to journalArticle

29 Scopus citations

Cotransfer of circular and linear prokaryotic and eukaryotic DNA sequences into mouse cells.

Hsiung, N., Warrick, H., deRiel, J. K., Tuan, D., Forget, B. G., Skoultchi, A. & Kucherlapati, R., Aug 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 8, p. 4852-4856 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Creation of EcR isoform-specific mutations in Drosophila melanogaster via local P element transposition, imprecise P element excision, and male recombination

Carney, G. E., Robertson, A., Davis, M. B. & Bender, M., Apr 1 2004, In : Molecular Genetics and Genomics. 271, 3, p. 282-290 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In : International Journal of Cancer. 146, 8, p. 2243-2254 12 p.

Research output: Contribution to journalArticle

Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

Stewart, P. L., Chiu, C. Y., Huang, S., Muir, T., Zhao, Y., Chait, B., Mathias, P. & Nemerow, G. R., Mar 17 1997, In : EMBO Journal. 16, 6, p. 1189-1198 10 p.

Research output: Contribution to journalArticle

136 Scopus citations

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

Ji, Y., Liu, Y., Xue, N., Du, T., Wang, L., Huang, R., Li, L., Yan, C. & Chen, X., 2019, In : OncoTargets and Therapy. 12, p. 883-896 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Curcumin analogue UBS109 prevents bone loss in breast cancer bone metastasis mouse model: Involvement in osteoblastogenesis and osteoclastogenesis

Yamaguchi, M., Zhu, S., Zhang, S., Wu, D., Moore, T. M., Snyder, J. P. & Shoji, M., Jul 2014, In : Cell and Tissue Research. 357, 1, p. 245-252 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects

Zhou, Q. M., Wang, X. F., Liu, X. J., Zhang, H., Lu, Y. Y., Huang, S. & Su, S. B., Sep 1 2011, In : European Journal of Cancer. 47, 14, p. 2240-2247 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Curcumin improves the tumoricidal effect of mitomycin C by suppressing ABCG2 expression in stem cell-like breast cancer cells

Zhou, Q., Ye, M., Lu, Y., Zhang, H., Chen, Q., Huang, S. & Su, S., Aug 25 2015, In : PloS one. 10, 8, e0136694.

Research output: Contribution to journalArticle

31 Scopus citations

Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets

Jain, A., Samykutty, A., Jackson, C., Browning, D., Bollag, W. B., Thangaraju, M., Takahashi, S. & Singh, S. R., Aug 28 2015, In : Cancer Letters. 365, 1, p. 122-131 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer

Saini, S., Arora, S., Majid, S., Shahryari, V., Chen, Y., Deng, G., Yamamura, S., Ueno, K. & Dahiya, R., Oct 2011, In : Cancer Prevention Research. 4, 10, p. 1698-1709 12 p.

Research output: Contribution to journalArticle

Open Access
148 Scopus citations

Cutting edge: IRF8 regulates bax transcription in vivo in primary myeloid cells

Yang, J., Hu, X., Zimmerman, M., Torres, C. M., Yang, D., Smith, S. B. & Liu, K., Nov 1 2011, In : Journal of Immunology. 187, 9, p. 4426-4430 5 p.

Research output: Contribution to journalArticle

16 Scopus citations