Biochemistry and Molecular Biology

Research Output 1968 2019

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2000
20 Citations (Scopus)

Solution structures in SDS micelles and functional activity at the bullfrog substance P receptor of ranatachykinin peptides

Perrine, S. A., Whitehead, T. L., Hicks, R. P., Szarek, J. L., Krause, J. E. & Simmons, M. A., May 30 2000, In : Journal of Medicinal Chemistry. 43, 9, p. 1741-1753 13 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Rana catesbeiana
Micelles
Peptides
Tachykinins
34 Citations (Scopus)

Stable and unstable transgene integration sites in the human genome: extinction of the Green Fluorescent Protein transgene in K562 cells

Migliaccio, A. R., Bengra, C., Ling, J., Pi, W., Li, C., Zeng, S., Keskintepe, M., Whitney, B., Sanchez, M., Migliaccio, G. & Tuan, D., Oct 3 2000, In : Gene. 256, 1-2, p. 197-214 18 p.

Research output: Contribution to journalArticle

K562 Cells
Human Genome
Green Fluorescent Proteins
Transgenes
Genes
179 Citations (Scopus)

Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms

Whitfield, M. L., Zheng, L. X., Baldwin, A., Ohta, T., Hurt, M. M. & Marzluff, W. F., Jun 1 2000, In : Molecular and Cellular Biology. 20, 12, p. 4188-4198 11 p.

Research output: Contribution to journalArticle

Histones
Cell Cycle
Carrier Proteins
Messenger RNA
Proteins
14 Citations (Scopus)

The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination

Kovalik, J. P., Singh, N., Mendiratta, S. K., Martin, W. D., Ignatowicz, L. & Van Kaer, L., Aug 1 2000, In : Journal of Immunology. 165, 3, p. 1285-1293 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Amino Acid Substitution
Allografts
Ligands
42 Citations (Scopus)

The application of multidimensional NMR to the study of soil humic substances

Kingery, W. L., Simpson, A. J., Hayes, M. H. B., Locke, M. A. & Hicks, R. P., Jan 1 2000, In : Soil Science. 165, 6, p. 483-494 12 p.

Research output: Contribution to journalArticle

humic substances
humic substance
nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
chemical structure
120 Citations (Scopus)

Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38α mitogen-activated protein kinase activity

Huang, S., New, L., Pan, Z., Han, J. & Nemerow, G. R., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 12266-12272 7 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Urokinase-Type Plasminogen Activator
p38 Mitogen-Activated Protein Kinases
Cells
Breast Neoplasms
2001
60 Citations (Scopus)

A 50-kDa membrane protein mediates sialic acid-independent binding and infection of conjunctival cells by adenovirus type 37

Wu, E., Fernandez, J., Fleck, S. K., Von Seggern, D. J., Huang, S. & Nemerow, G. R., Jan 20 2001, In : Virology. 279, 1, p. 78-89 12 p.

Research output: Contribution to journalArticle

N-Acetylneuraminic Acid
Adenoviridae
Membrane Proteins
Infection
Enterovirus
66 Citations (Scopus)

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

Lee, H., Akita, R. W., Sliwkowski, M. X. & Maihle, N. J., Jun 1 2001, In : Cancer Research. 61, 11, p. 4467-4473 7 p.

Research output: Contribution to journalArticle

Neuregulin-1
Protein Isoforms
Breast Neoplasms
Inhibitory Concentration 50
Growth
38 Citations (Scopus)

An efficient animation of wrinkled cloth with approximate implicit integration

Kang, Y. M., Choi, J-H., Cho, H. G. & Lee, D. H., May 1 2001, In : Visual Computer. 17, 3, p. 147-157 11 p.

Research output: Contribution to journalArticle

Animation
Splines
Linear systems
Defects
10 Citations (Scopus)

An incremental increase in the complexity of peptides bound to class II MHC changes the diversity of positively selected αβ TCRs

Pacholczyk, R. W., Kraj, P. & Ignatowicz, L., Feb 15 2001, In : Journal of Immunology. 166, 4, p. 2357-2363 7 p.

Research output: Contribution to journalArticle

Peptides
Epithelial Cells
118 Citations (Scopus)

Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine

Martin, P. M., El-sherbeny, A., Roon, P., Schoenlein, P. V., Ganapathy, V. & Smith, S. B., Jan 1 2001, In : Experimental Eye Research. 73, 1, p. 45-57 13 p.

Research output: Contribution to journalArticle

Excitatory Amino Acids
Retinal Ganglion Cells
Homocysteine
Cell Death
Ganglia
27 Citations (Scopus)

A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women

Baron, A. T., Lafky, J. M., Maihle, N. J., Suman, V. J., Hillman, D. W., Buenafe, M. C., Boardman, C. H., Podratz, K. C. & Perez, E. A., Jan 1 2001, In : Cancer Epidemiology Biomarkers and Prevention. 10, 11, p. 1175-1185 11 p.

Research output: Contribution to journalArticle

Gonadotropins
Epidermal Growth Factor Receptor
Steroids
Hormones
Serum
9 Citations (Scopus)

Associations between climate variables and asthma visits to accident and emergency facilities in Trinidad, West Indies

Ivey, M. A., Simeon, D. T., Juman, S., Hassanally, R., Williams, K. & Monteil, M. A., Jan 1 2001, In : Allergology International. 50, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

Trinidad and Tobago
West Indies
Climate
Accidents
Emergencies
50 Citations (Scopus)

Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells

Liu, K., Li, Y., Prabhu, V., Young, L., Becker, K. G., Munson, P. J. & Weng, N. P., Jun 15 2001, In : Journal of Immunology. 166, 12, p. 7335-7344 10 p.

Research output: Contribution to journalArticle

Transcriptional Activation
T-Lymphocytes
Complementary DNA
Clone Cells
Genes
64 Citations (Scopus)

Bin1 mediates apoptosis by c-Myc in transformed primary cells

DuHadaway, J. B., Sakamuro, D., Ewert, D. L. & Prendergast, G. C., Apr 1 2001, In : Cancer Research. 61, 7, p. 3151-3156 6 p.

Research output: Contribution to journalArticle

Cell Death
Capital Punishment
Apoptosis
Tumor Suppressor Proteins
Genes
22 Citations (Scopus)

Brain perfusion measured by flow-sensitive alternating inversion recovery (FAIR) and dynamic susceptibility contrast-enhanced magnetic resonance imaging: Comparison with nuclear medicine technique

Arbab, A. S., Aoki, S., Toyama, K., Kumagai, H., Arai, T., Kabasawa, H., Takahashi, Y. & Araki, T., Jan 1 2001, In : European Radiology. 11, 4, p. 635-641 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Nuclear Medicine
Perfusion Imaging
Inosine Monophosphate
Perfusion
39 Citations (Scopus)

Chemoattractant-stimulated NF-κB Activation Is Dependent on the Low Molecular Weight GTPase RhoA

Huang, S., Chen, L. Y., Zuraw, B. L., Ye, R. D. & Pan, Z. K., Nov 2 2001, In : Journal of Biological Chemistry. 276, 44, p. 40977-40981 5 p.

Research output: Contribution to journalArticle

N-Formylmethionine Leucyl-Phenylalanine
GTP Phosphohydrolases
Chemotactic Factors
Molecular Weight
Chemical activation
83 Citations (Scopus)

Cloning and functional characterization of a new subtype of the amino acid transport system N

Nakanishi, T., Kekuda, R., Fei, Y. J., Hatanaka, T., Sugawara, M., Martindale, R. G., Leibach, F. H., Prasad, P. D. & Ganapathy, V., Dec 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Organism Cloning
Glutamine
Amino Acids
Amino Acid Transport System A
186 Citations (Scopus)
Telomerase
Phosphorylation
T-Lymphocytes
Proteins
Lymphocytes
14 Citations (Scopus)

Differential roles of the NPXXY motif in formyl peptide receptor signaling

He, R., Browning, D. D. & Ye, R. D., Mar 15 2001, In : Journal of Immunology. 166, 6, p. 4099-4105 7 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Chemotaxis
Hydrogen Bonding
G-Protein-Coupled Receptors
Mitogen-Activated Protein Kinases
60 Citations (Scopus)

Display of green fluorescent protein on Escherichia coli cell surface

Shi, H. & Wen Su, W., Jan 2 2001, In : Enzyme and Microbial Technology. 28, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Escherichia coli
Display devices
Fluorescence
Proteins
221 Citations (Scopus)

Dissecting complex epigenetic alterations in breast cancer using CpG island microarrays

Yan, P. S., Chen, C. M., Shi, H., Rahmatpanah, F., Wei, S. H., Caldwell, C. W. & Huang, T. H. M., Dec 1 2001, In : Cancer Research. 61, 23, p. 8375-8380 6 p.

Research output: Contribution to journalArticle

CpG Islands
Epigenomics
Breast Neoplasms
Neoplasms
Glypicans

Dissecting complex genetic and epigenetic alterations in cancer genomes using cpg island microarrays

Hui-Ming Huang, T., Shi, H., Rahmatpanah, F. & Yan, P., Apr 2001, In : Nature Genetics. 27, 4S, 1 p.

Research output: Contribution to journalArticle

Islands
Epigenomics
Genome
Neoplasms
23 Citations (Scopus)

Effects of the incorporation of CHAPS into SDS micelles on neuropeptide-micelle binding: Separation of the role of electrostatic interactions from hydrophobic interactions

Whitehead, T. L., Jones, L. M. & Hicks, R. P., Jun 11 2001, In : Biopolymers. 58, 7, p. 593-605 13 p.

Research output: Contribution to journalArticle

Micelles
Coulomb interactions
Neuropeptides
Static Electricity
Hydrophobic and Hydrophilic Interactions
47 Citations (Scopus)

Endothelin-1 Stimulates Leptin Production in Adipocytes

Xiong, Y., Tanaka, H., Richardson, J. A., Williams, S. C., Slaughter, C. A., Nakamura, M., Chen, J. L. & Yanagisawa, M., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 28471-28477 7 p.

Research output: Contribution to journalArticle

Endothelin-1
Leptin
Adipocytes
Northern Blotting
White Adipocytes
82 Citations (Scopus)

Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A

Hatanaka, T., Huang, W., Ling, R., Prasad, P. D., Sugawara, M., Leibach, F. H. & Ganapathy, V., Feb 9 2001, In : Biochimica et Biophysica Acta - Biomembranes. 1510, 1-2, p. 10-17 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Amino Acid Transport Systems
Liver
Amino Acids
Neutral Amino Acids
65 Citations (Scopus)

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Shamsul Ola, M., Martin, P. M., El-Sherbeny, A., Roon, P., Agarwal, N., Sarthy, V. P., Casellas, P., Ganapathy, V. & Smith, S. B., Nov 1 2001, In : Molecular Brain Research. 95, 1-2, p. 86-95 10 p.

Research output: Contribution to journalArticle

Retina
Messenger RNA
Proteins
Ganglia
Retinal Pigments
53 Citations (Scopus)

Feeding daidzein to late pregnant sows influences the estrogen receptor beta and type 1 insulin-like growth factor receptor mRNA expression in newborn piglets

Ren, M. Q., Kuhn, G., Wegner, J., Nürnberg, G., Chen, J. & Ender, K., Aug 6 2001, In : Journal of Endocrinology. 170, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Estrogen Receptor beta
Estrogen Receptors
Messenger RNA
Hypothalamus
42 Citations (Scopus)

Functional Analysis of Type 1α cGMP-dependent Protein Kinase Using Green Fluorescent Fusion Proteins

Browning, D. D., Mc Shane, M., Marty, C. & Ye, R. D., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 13039-13048 10 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Functional analysis
Green Fluorescent Proteins
Fusion reactions
Proteins
274 Citations (Scopus)

Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro

Shamblott, M. J., Axelman, J., Littlefield, J. W., Blumenthal, P. D., Huggins, G. R., Cui, Y., Cheng, L. & Gearhart, J. D., Jan 2 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 1, p. 113-118 6 p.

Research output: Contribution to journalArticle

Embryoid Bodies
Cell Culture Techniques
Pluripotent Stem Cells
Vascular Endothelium
Stem Cells
12 Citations (Scopus)

Hyaluronsäure und hyaluronidase. Zwei neue blasenkarzinommarker

Translated title of the contribution: Hyaluronic acid and hyaluronidase. Two new markers for bladder cancerHautmann, S. H., Schroeder, G. L., Civantos, F., Duncan, R. C., Gnann, R., Friedrich, M. G., Hellstern, A., Huland, H., Soloway, M. S. & Lokeshwar, V. B., Apr 3 2001, In : Urologe - Ausgabe A. 40, 2, p. 121-126 6 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Hyaluronic Acid
Urinary Bladder Neoplasms
Urine
Urinary Bladder
82 Citations (Scopus)

Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A

Ling, R., Bridges, C. C., Sugawara, M., Fujita, T., Leibach, F. H., Prasad, P. D. & Ganapathy, V., May 2 2001, In : Biochimica et Biophysica Acta - Biomembranes. 1512, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
varespladib methyl
Gene expression
Gene Expression
Acids
171 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Enzyme activity
Messenger RNA
Proto-Oncogene Proteins c-ets
141 Citations (Scopus)

Na+ - and CI- -coupled active transport of carnitine by the amino acid transporter ATB0,+ from mouse colon expressed in HRPE cells and Xenopus oocytes

Nakanishi, T., Hatanaka, T., Huang, W., Prasad, P. D., Leibach, F. H., Ganapathy, M. E. & Ganapathy, V., Apr 15 2001, In : Journal of Physiology. 532, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Retinal Pigments
Carnitine
Active Biological Transport
Xenopus
54 Citations (Scopus)

Na+- and Cl--coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B0,+

Hatanaka, T., Nakanishi, T., Huang, W., Leibach, F. H., Prasad, P. D., Ganapathy, V. & Ganapathy, M. E., Jan 1 2001, In : Journal of Clinical Investigation. 107, 8, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Active Biological Transport
Nitric Oxide Synthase
Acids
Nitroarginine
28 Citations (Scopus)

Positive selection of CD4+ t cells is induced in vivo by agonist and inhibited by antagonist peptides

Kraj, P., Pacholczyk, R., Ignatowicz, H., Kisielow, P., Jensen, P. & Ignatowicz, L., Aug 20 2001, In : Journal of Experimental Medicine. 194, 4, p. 407-416 10 p.

Research output: Contribution to journalArticle

Peptides
Thymocytes
T-Lymphocytes
Major Histocompatibility Complex
Thymus Gland
28 Citations (Scopus)

Recent advances in NMR: Expanding its role in rational drug design

Hicks, R. P., Jan 1 2001, In : Current Medicinal Chemistry. 8, 6, p. 627-650 24 p.

Research output: Contribution to journalArticle

Drug Design
Nuclear magnetic resonance
Technology
Liquid Chromatography
Pharmaceutical Preparations
45 Citations (Scopus)

Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells

Bridges, C. C., Ola, M. S., Prasad, P. D., El-Sherbeny, A., Ganapathy, V. & Smith, S. B., Dec 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Retinal Pigments
Taurine
Nitric Oxide
Epithelial Cells
Nitric Oxide Donors
228 Citations (Scopus)

Stromal and Epithelial Expression of Tumor Markers Hyaluronic Acid and HYAL1 Hyaluronidase in Prostate Cancer

Lokeshwar, V. B., Rubinowicz, D., Schroeder, G. L., Forgacs, E., Minna, J. D., Block, N. L., Nadji, M. & Lokeshwar, B. L., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 11922-11932 11 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Hyaluronic Acid
Tumor Biomarkers
Prostatic Neoplasms
Tissue
96 Citations (Scopus)

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells

Bridges, C. C., Kekuda, R., Wang, H., Prasad, P. D., Mehta, P., Huang, W., Smith, S. B. & Ganapathy, V., Jan 30 2001, In : Investigative Ophthalmology and Visual Science. 42, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Retinal Pigments
Cystine
Epithelial Cells
Light
84 Citations (Scopus)

Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N

Nakanishi, T., Sugawara, M., Huang, W., Martindale, R. G., Leibach, F. H., Ganapathy, M. E., Prasad, P. D. & Ganapathy, V., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 281, 5, p. 1343-1348 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Tissue
Amino Acids
Liver
Histidine
46 Citations (Scopus)

Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide

Ramanathan, S., Pooyan, S., Stein, S., Prasad, P. D., Wang, J., Leibowitz, M. J., Ganapathy, V. & Sinko, P. J., Sep 11 2001, In : Pharmaceutical Research. 18, 7, p. 950-956 7 p.

Research output: Contribution to journalArticle

Sodium
Permeability
CHO Cells
Biotin
Human Immunodeficiency Virus tat Gene Products
58 Citations (Scopus)

Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4)

Friedrich, A., George, R. L., Bridges, C. C., Prasad, P. D. & Ganapathy, V., Jun 6 2001, In : Biochimica et Biophysica Acta - Biomembranes. 1512, 2, p. 299-307 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Choline
Microvessels
Cations
Rats
47 Citations (Scopus)

Vitamin C transport in human lens epithelial cells: Evidence for the presence of SVCT2

Kannan, R., Stolz, A., Ji, Q., Prasad, P. D. & Ganapathy, V., Jan 1 2001, In : Experimental eye research. 73, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Lenses
Ascorbic Acid
Epithelial Cells
Oxidants
Polymerase Chain Reaction
15 Citations (Scopus)

α/βTCRs differ in the degree of their specificity for the positively selecting MHC/peptide ligand

Kraj, P., Pacholczyk, R. & Ignatowicz, L., Feb 15 2001, In : Journal of Immunology. 166, 4, p. 2251-2259 9 p.

Research output: Contribution to journalArticle

Ligands
Peptides
Cytochromes c
T-Lymphocytes
51 Citations (Scopus)

αv Integrin, p38 Mitogen-activated Protein Kinase, and Urokinase Plasminogen Activator Are Functionally Linked in Invasive Breast Cancer Cells

Chen, J., Baskerville, C., Han, Q., Pan, Z. K. & Huang, S., Dec 21 2001, In : Journal of Biological Chemistry. 276, 51, p. 47901-47905 5 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Urokinase-Type Plasminogen Activator
p38 Mitogen-Activated Protein Kinases
Integrins
Cells
2002
36 Citations (Scopus)

A chromosomal region 7p11.2 transcript map: Its development and application to the study of EGFR amplicons in glioblastoma

Eley, G. D., Reiter, J. L., Pandita, A., Park, S., Jenkins, R. B., Maihle, N. J. & James, C. D., Jan 1 2002, In : Neuro-Oncology. 4, 2, p. 86-94 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
P1 Bacteriophage Artificial Chromosomes
Radiation Hybrid Mapping
Chromosomes
71 Citations (Scopus)
Matrix Metalloproteinase 13
Cyclic GMP-Dependent Protein Kinases
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinases
1 Citation (Scopus)

Analysis of genome by visualization of genomic signature

Choi, J-H., Lee, S. K., Yee, S. B., Kim, Y. J., Cho, H. G. & Kim, K. W., Mar 1 2002, In : Korean Journal of Genetics. 24, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Visualization
Genes
Genome
Chromosomes
Nucleic Acid Databases
38 Citations (Scopus)

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

Shamsul Ola, M., Martin, P. M., Maddox, D., El-Sherbeny, A., Huang, W., Roon, P., Agarwal, N., Ganapathy, V. & Smith, S. B., Nov 15 2002, In : Molecular Brain Research. 107, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Retina
Streptozocin
N-Methyl-D-Aspartate Receptors