Biochemistry and Molecular Biology

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2003

Functional significance of protein kinase A activation by endothelin-1 and ATP: Negative regulation of SRF-dependent gene expression by PKA

Davis, A., Hogarth, K., Fernandes, D., Solway, J., Niu, J., Kolenko, V., Browning, D., Miano, J. M., Orlov, S. N. & Dulin, N. O., Jun 1 2003, In : Cellular Signalling. 15, 6, p. 597-604 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Genetically obese MMTV-TGF-α/Lepob Lepob female mice do not develop mammary tumors

Cleary, M. P., Phillips, F. C., Getzin, S. C., Jacobson, T. L., Jacobson, M. K., Christensen, T. A., Juneja, S. C., Grande, J. P. & Maihle, N. J., Feb 1 2003, In : Breast Cancer Research and Treatment. 77, 3, p. 205-215 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.

Boerner, J. L., Danielsen, A. J., Lovejoy, C. A., Wang, Z., Juneja, S. C., Faupel-Badger, J. M., Darce, J. R. & Maihle, N. J., Oct 2 2003, In : Oncogene. 22, 43, p. 6679-6689 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
42 Scopus citations

Involvement of protein tyrosine kinase in toll-like receptor 4-mediated NF-κB activation in human peripheral blood monocytes

Chen, L. Y., Zuraw, B. L., Zhao, M., Liu, F. T., Huang, S. & Pan, Z. K., Apr 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 4 28-4

Research output: Contribution to journalArticle

53 Scopus citations

Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier

Friedrich, A., Prasad, P. D., Freyer, D., Ganapathy, V. & Brust, P., Apr 4 2003, In : Brain Research. 968, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer

Baron, A. T., Cora, E. M., Lafky, J. M., Boardman, C. H., Buenafe, M. C., Rademaker, A., Liu, D., Fishman, D. A., Podratz, K. C. & Maihle, N. J., Feb 1 2003, In : Cancer Epidemiology Biomarkers and Prevention. 12, 2, p. 103-113 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

TAB1β (transforming growth factor-β-activated protein kinase 1-binding protein 1β), a novel splicing variant of TAB1 that interacts with p38α but not TAK1

Ge, B., Xiong, X., Jing, Q., Mosley, J. L., Filose, A., Bian, D., Huang, S. & Han, J., Jan 24 2003, In : Journal of Biological Chemistry. 278, 4, p. 2286-2293 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function

Ling, J., Pi, W., Yu, X., Bengra, C., Long, Q., Jin, H., Seyfang, A. & Tuan, D., Aug 1 2003, In : Nucleic Acids Research. 31, 15, p. 4582-4596 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene

Wang, H., Hicks, J., Khanbolooki, P., Kim, S. J., Yan, C., Wang, Y. & Boyd, D., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 453-464 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Triple analysis of the cancer epigenome: An integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation

Shi, H., Wei, S. H., Leu, Y. W., Rahmatpanah, F., Liu, J. C., Yan, P. S., Nephew, K. P. & Huang, T. H. M., May 1 2003, In : Cancer Research. 63, 9, p. 2164-2171 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

α6β1 integrin is a potential clinical marker for evaluating sperm quality in men

Reddy, V. R. K., Rajeev, S. K. & Gupta, V., Jun 1 2003, In : Fertility and sterility. 79, SUPPL. 3, p. 1590-1596 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2004

Activation of the small GTPase Rac1 by cGMP-dependent protein kinase

Hou, Y., Ye, R. D. & Browning, D. D., Jan 1 2004, In : Cellular Signalling. 16, 9, p. 1061-1069 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Amphiregulin Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma: A Study of 93 Cases

Bostwick, D. G., Qian, J. & Maihle, N. J., Feb 1 2004, In : Prostate. 58, 2, p. 164-168 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

A retrospective study of the 1996 DEN-1 epidemic in Trinidad: Demographic and clinical features

Brown, T. U., Babb, K., Nimrod, M., Carrington, C. V. F., Salas, R. A. & Monteil, M. A., Dec 1 2004, In : Dengue Bulletin. 28, p. 7-19 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Creation of EcR isoform-specific mutations in Drosophila melanogaster via local P element transposition, imprecise P element excision, and male recombination

Carney, G. E., Robertson, A., Davis, M. B. & Bender, M., Apr 1 2004, In : Molecular Genetics and Genomics. 271, 3, p. 282-290 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

324 Scopus citations

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules

Manfredini, S., Vertuani, S., Pavan, B., Vitali, F., Scaglianti, M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. & Dalpiaz, A., Oct 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 20, p. 5453-5463 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Diet-induced obesity and mammary tumor development in MMTV-neu female mice

Cleary, M. P., Grande, J. P., Juneja, S. C. & Maihle, N. J., Dec 1 2004, In : Nutrition and Cancer. 50, 2, p. 174-180 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Dynamic retrotransposition of ERV-9 LTR and L1 in the β-globin gene locus during primate evolution

Ling, J., Zhang, L., Jin, H., Pi, W., Kosteas, T., Anagnou, N. P., Goodman, M. & Tuan, D., Mar 2004, In : Molecular Phylogenetics and Evolution. 30, 3, p. 867-871 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ectopic expression of nonliganded retinoic acid receptor β abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells

Arce, J. D. C., Soto, U., Van Riggelen, J., Schwarz, E., Zur Hausen, H. & Rösl, F., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45408-45416 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-α mice

Cleary, M. P., Grande, J. P. & Maihle, N. J., Aug 1 2004, In : International Journal of Obesity. 28, 8, p. 956-962 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Expression of peroxisome proliterator-activated receptor (PPARγ) mRNA in adipose and muscle tissue of Holstein and Charolais cattle

Huff, P. W., Ren, M. Q., Lozeman, F. J., Weselake, R. J. & Wegner, J., Mar 2004, In : Canadian Journal of Animal Science. 84, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate

Gopal, E., Fei, Y. J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P., Smith, S. B., Prasad, P. D. & Ganapathy, V., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44522-44532 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development

Kalinichenko, V. V., Gusarova, G. A., Kim, I., Shin, B., Yoder, H. M., Clark, J., Sapozhnikov, A. M., Whitsett, J. A. & Costa, R. H., Mar 1 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 3 30-3, p. L521-L530

Research output: Contribution to journalArticle

52 Scopus citations

Growth performance, carcass characteristics and bioavailability of isoflavones in pigs fed soy bean based diets

Kuhn, G., Hennig, U., Kalbe, C., Rehfeldt, C., Ren, M. Q., Moors, S. & Degen, G. H., Aug 1 2004, In : Archives of Animal Nutrition. 58, 4, p. 265-276 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter

Ling, J., Ainol, L., Zhang, L., Yu, X., Pi, W. & Tuan Lo, D., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 51704-51713 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Identification and characterization of the major Huperzine A metabolite in rat blood

Garcia, G. E., Hicks, R. P., Skanchy, D., Moorad-Doctor, D. R., Doctor, B. P. & Ved, H. S., Jan 1 2004, In : Journal of Analytical Toxicology. 28, 5, p. 379-383 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Leptin Receptor-Deficient MMTV-TGF-α/LeprdbLepr db Female Mice Do Not Develop Oncogene-Induced Mammary Tumors

Cleary, M. P., Juneja, S. C., Phillips, F. C., Hu, X., Grande, J. P. & Maihle, N. J., Feb 2004, In : Experimental Biology and Medicine. 229, 2, p. 182-193 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway

Bian, D., Su, S., Mahanivong, C., Cheng, R. K., Han, Q., Pan, Z. K., Sun, P. & Huang, S., Jun 15 2004, In : Cancer Research. 64, 12, p. 4209-4217 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling

Satyanarayana, A., Greenberg, R. A., Schaetzlein, S., Buer, J., Masutomi, K., Hahn, W. C., Zimmermann, S., Martens, U., Manns, M. P. & Rudolph, K. L., Jun 1 2004, In : Molecular and Cellular Biology. 24, 12, p. 5459-5474 16 p.

Research output: Contribution to journalArticle

58 Scopus citations

Nuclear magnetic resonance and molecular modeling analysis of the interaction of the antimalarial drugs artelinic acid and artesunic acid with β-cyclodextrin

Hartell, M. G., Hicks, R., Bhattacharjee, A. K., Koser, B. W., Carvalho, K. & Van Hamont, J. E., Jan 1 2004, In : Journal of Pharmaceutical Sciences. 93, 8, p. 2076-2089 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Müller Cells

El-Sherbeny, A., Naggar, H., Miyauchi, S., Ola, M. S., Maddox, D. M., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

P38 mitogen-activated protein kinase regulation of endothelial cell migration depends on urokinase plasminogen activator expression

Yu, J., Bian, D., Mahanivong, C., Cheng, R. K., Zhou, W. & Huang, S., Nov 26 2004, In : Journal of Biological Chemistry. 279, 48, p. 50446-50454 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Pfg-nmr investigations of the binding of cationic neuropeptides to anionic and zwitterionic micelles

Whitehead, T. L., Jones, L. M. & Hicks, R. P., Feb 2004, In : Journal of Biomolecular Structure and Dynamics. 21, 4, p. 567-576 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women

Min, S. S., Corbett, A. H., Rezk, N., Cu-Uvin, S., Fiscus, S. A., Petch, L., Cohen, M. S. & Kashuba, A. D. M., Dec 15 2004, In : Journal of Acquired Immune Deficiency Syndromes. 37, 5, p. 1577-1580 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Recent advances in Drosophila genomics

Davis, M. B. & White, K. P., Sep 21 2004, In : Genome Biology. 5, 8, 339.

Research output: Contribution to journalArticle

3 Scopus citations

Sasa Health exerts a protective effect on Her2/NeuN mammary tumorigenesis

Ren, M., Reilly, R. T. & Sacchi, N., Sep 1 2004, In : Anticancer research. 24, 5 A, p. 2879-2884 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Serine racemase and D-serine transport in human placenta and evidence for a transplacental gradient for D-serine in humans

Chen, Z., Huang, W., Srinivas, S. R., Jones, C. R., Ganapathy, V. & Prasad, P. D., Jul 1 2004, In : Journal of the Society for Gynecologic Investigation. 11, 5, p. 294-303 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Smoking at home is strongly associated with symptoms of asthma and rhinitis in children of primary school age in Trinidad and Tobago

Monteil, M. A., Joseph, G., Kit, C. C., Wheeler, G. & Antoine, R. M., Sep 2004, In : Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 16, 3, p. 193-198 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Sperm membrane protein profiles of fertile and infertile men: Identification and characterization of fertility-associated sperm antigen

Rajeev, S. K. & Reddy, K. V. R., Feb 2004, In : Human Reproduction. 19, 2, p. 234-242 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates

Bhattacharjee, A. K., Hartell, M. G., Nichols, D. A., Hicks, R. P., Stanton, B., Van Hamont, J. E. & Milhous, W. K., Jan 2004, In : European Journal of Medicinal Chemistry. 39, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

The anthrax protective antigen (PA63) bound conformation of a peptide inhibitor of the binding of lethal factor to PA63: As determined by trNOESY NMR and molecular modeling

Hicks, R. P., Bhattacharjee, A. K., Koser, B. W. & Traficante, D. D., Oct 21 2004, In : Journal of Medicinal Chemistry. 47, 22, p. 5347-5355 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

The association of dimethylsulfoxide and model membranes studied by pulse-field gradient NMR

Kennedy, A., Long, C. J., Hmel, P. J., Hicks, R. & Reid, T. J., Jan 1 2004, In : Spectroscopy. 18, 2, p. 265-269 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans

Pi, W., Yang, Z., Wang, J., Ruan, L., Yu, X., Ling, J., Krantz, S., Isales, C. M., Conway, S. J., Lin, S. & Tuan Lo, D., Jan 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 3, p. 805-810 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

Martin, P. M., Ola, M. S., Agarwal, N., Ganapathy, V. & Smith, S. B., Apr 7 2004, In : Molecular Brain Research. 123, 1-2, p. 66-75 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Transporter-Mediated Effects of Diclofenamic Acid and Its Ascorbyl Pro-drug in the In Vivo Neurotropic Activity of Ascorbyl Nipecotic Acid Conjugate

Dalpiaz, A., Pavan, B., Scaglianti, M., Vitali, F., Bortolotti, F., Biondi, C., Scatturin, A., Tanganelli, S., Ferraro, L., Prasad, P. & Manfredini, S., Jan 2004, In : Journal of Pharmaceutical Sciences. 93, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2005

African dust clouds are associated with increased paediatric asthma accident and emergency admissions on the Caribbean island of Trinidad

Gyan, K., Henry, W., Lacaille, S., Laloo, A., Lamsee-Ebanks, C., McKay, S., Antoine, R. M. & Monteil, M. A., Jul 1 2005, In : International Journal of Biometeorology. 49, 6, p. 371-376 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

A novel protein kinase C (PKCε) is required for fMet-Leu-Phe-induced activation of NF-κB in human peripheral blood monocytes

Chen, L. Y., Doerner, A., Lehmann, P. F., Huang, S., Zhong, G. & Pan, Z. K., Jun 10 2005, In : Journal of Biological Chemistry. 280, 23, p. 22497-22501 5 p.

Research output: Contribution to journalArticle

15 Scopus citations