Biochemistry and Molecular Biology

Research Output 1968 2019

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18 Citations (Scopus)

Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage

Wiemann, S. U., Satyanarayana, A., Buer, J., Kamino, K., Manns, M. P. & Rudolph, K. L., Feb 24 2005, In : Oncogene. 24, 9, p. 1501-1509 9 p.

Research output: Contribution to journalArticle

Telomere Shortening
Homeostasis
Liver
Neoplasms
Telomerase
12 Citations (Scopus)
52 Citations (Scopus)

Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function

Cui, Y., Iwakuma, T. & Chang, L. J., Jun 23 1999, In : Journal of Virology. 73, 7, p. 6171-6176 6 p.

Research output: Contribution to journalArticle

env Genes
Lentivirus
regulatory sequences
Viral RNA
RNA
19 Citations (Scopus)

Control of AKR fibroblast phenotype by fibronectin: Regulation of cell‐surface fibronectin binding receptor by fibronectin

Huang, S., Varani, J. & Chakrabarty, S., Jan 1 1994, In : Journal of Cellular Physiology. 161, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

Integrin alpha5beta1
Fibroblasts
Fibronectins
Phenotype
Antisense RNA
14 Citations (Scopus)

Control of fibronectin receptor expression by fibronectin: Antisense fibronectin RNA downmodulates the induction of fibronectin receptor by transforming growth factor β1

Rajagopal, S., Huang, S., Albitar, M. & Chakrabarty, S., Feb 1 1997, In : Journal of Cellular Physiology. 170, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

Integrin alpha5beta1
Antisense RNA
Transforming Growth Factors
Fibronectins
RNA
17 Citations (Scopus)

Cooperative disengagement of fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency

Liu, K., Caldwell, S. A. & Abrams, S. I., Feb 1 2005, In : Cancer Research. 65, 3, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Neoplasms
Phenotype
Lung
Cell Death
31 Citations (Scopus)

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H., Cowell, J. K., Kim, J., Han, J. & Huang, S., Jan 1 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Carcinogenesis
Breast Neoplasms
Proto-Oncogene Proteins c-jun
Proteins
27 Citations (Scopus)

Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer

Liu, H., Yu, X., Liu, H., Wu, D. & She, J-X., Jul 26 2016, In : Scientific Reports. 6, 30346.

Research output: Contribution to journalArticle

Small Interfering RNA
Prostatic Neoplasms
Nucleotide Aptamers
Antibodies
Heterografts
20 Citations (Scopus)

Cotransfer of circular and linear prokaryotic and eukaryotic DNA sequences into mouse cells.

Hsiung, N., Warrick, H., deRiel, J. K., Tuan Lo, D., Forget, B. G., Skoultchi, A. & Kucherlapati, R., Jan 1 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 8, p. 4852-4856 5 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Plasmids
Genes
beta-Globins
Transfection
11 Citations (Scopus)

Creation of EcR isoform-specific mutations in Drosophila melanogaster via local P element transposition, imprecise P element excision, and male recombination

Carney, G. E., Robertson, A., Davis, M. B. & Bender, M., Apr 1 2004, In : Molecular Genetics and Genomics. 271, 3, p. 282-290 9 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Genetic Recombination
Protein Isoforms
Mutation
Transposases
133 Citations (Scopus)

Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

Stewart, P. L., Chiu, C. Y., Huang, S., Muir, T., Zhao, Y., Chait, B., Mathias, P. & Nemerow, G. R., Mar 17 1997, In : EMBO Journal. 16, 6, p. 1189-1198 10 p.

Research output: Contribution to journalArticle

Adenoviridae
Integrins
Cryoelectron Microscopy
Epitopes
Immunoglobulin Fab Fragments

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

Ji, Y., Liu, Y., Xue, N., Du, T., Wang, L., Huang, R., Li, L., Yan, C. & Chen, X., Jan 1 2019, In : OncoTargets and Therapy. 12, p. 883-896 14 p.

Research output: Contribution to journalArticle

Open Access
Esophageal Neoplasms
Interleukin-6
Janus Kinase 2
Apoptosis
Salvia miltiorrhiza
31 Citations (Scopus)

Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects

Zhou, Q. M., Wang, X. F., Liu, X. J., Zhang, H., Lu, Y. Y., Huang, S. & Su, S. B., Sep 1 2011, In : European Journal of Cancer. 47, 14, p. 2240-2247 8 p.

Research output: Contribution to journalArticle

Curcumin
Mitomycin
Drug Therapy
Neoplasms
Apoptosis
25 Citations (Scopus)

Curcumin improves the tumoricidal effect of mitomycin C by suppressing ABCG2 expression in stem cell-like breast cancer cells

Zhou, Q., Ye, M., Lu, Y., Zhang, H., Chen, Q., Huang, S. & Su, S., Aug 25 2015, In : PloS one. 10, 8, e0136694.

Research output: Contribution to journalArticle

mitomycin
Curcumin
curcumin
Mitomycin
Stem cells
18 Citations (Scopus)

Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets

Jain, A., Samykutty, A., Jackson, C., Browning, D. D., Bollag, W. B., Thangaraju, M., Takahashi, S. & Singh, S. R., Aug 28 2015, In : Cancer Letters. 365, 1, p. 122-131 10 p.

Research output: Contribution to journalArticle

Curcumin
Breast
Epithelial Cells
DNA Repair
Breast Neoplasms
322 Citations (Scopus)

Cutting edge: Activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype

Singh, N., Hong, S., Scherer, D. C., Serizawa, I., Burdin, N., Kronenberg, M., Koezuka, Y. & Van Kaer, L., Sep 1 1999, In : Journal of Immunology. 163, 5, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

Galactosylceramides
Natural Killer Cells
T-Lymphocytes
Phenotype
Interleukin-4
186 Citations (Scopus)
Telomerase
Phosphorylation
T-Lymphocytes
Proteins
Lymphocytes
15 Citations (Scopus)

Cutting edge: IRF8 regulates bax transcription in vivo in primary myeloid cells

Yang, J., Hu, X., Zimmerman, M., Torres, C. M., Yang, D., Smith, S. B. & Liu, K., Nov 1 2011, In : Journal of Immunology. 187, 9, p. 4426-4430 5 p.

Research output: Contribution to journalArticle

Myeloid Cells
Knockout Mice
Cell Lineage
Genetic Promoter Regions
Bone Marrow Cells
26 Citations (Scopus)

C-X-C chemokine receptor 7: A functionally associated molecular marker for bladder cancer

Yates, T. J., Knapp, J., Gosalbez, M., Lokeshwar, S. D., Gomez, C. S., Benitez, A., Ekwenna, O. O., Young, E. E., Manoharan, M. & Lokeshwar, V. B., Jan 1 2013, In : Cancer. 119, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

CXC Chemokines
Chemokine Receptors
Urinary Bladder Neoplasms
Epidermal Growth Factor Receptor
Cell Line
504 Citations (Scopus)

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J. L., Dontu, G. & Wicha, M. S., Feb 1 2010, In : Journal of Clinical Investigation. 120, 2, p. 485-497 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Heterografts
Breast Neoplasms
Population
Interleukin-8 Receptors
4 Citations (Scopus)

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

Angara, K., Borin, T. F., Rashid, M. H., Lebedyeva, I. O., Ara, R., Lin, P-C., Iskander, A. S. M., Bollag, R. J., Achyut, B. R. & Arbab, A. S., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood Vessels
Neoplasms
Interleukin-8
Therapeutics
2 Citations (Scopus)

Cyclic 3′,5′-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia

Kwon, I. K., Wang, R., Prakash, N., Bozard, R., Baudino, T. A., Liu, K., Thangaraju, M., Dong, Z. & Browning, D. D., Dec 1 2011, In : Cancer. 117, 23, p. 5282-5293 12 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Protein Kinases
Cell Hypoxia
Cell Survival
Cell Death
6 Citations (Scopus)

Cyclic-GMP-elevating agents suppress polyposis in Apc Min mice by targeting the preneoplastic epithelium

Sharman, S. K., Islam, B. N., Hou, Y., Singh, N., Berger, F. G., Sridhar, S., Yoo, W. & Browning, D. D., Feb 2018, In : Cancer Prevention Research. 11, 2, p. 81-91 11 p.

Research output: Contribution to journalArticle

Cyclic GMP
Polyps
Epithelium
Intestinal Neoplasms
Phosphodiesterase 5 Inhibitors
28 Citations (Scopus)

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression

Yang, L., Fang, D., Chen, H., Lu, Y., Dong, Z., Ding, H. F., Jing, Q., Su, S. B. & Huang, S., Jan 1 2015, In : Oncotarget. 6, 25, p. 20801-20812 12 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Cyclins
Ovary
Neoplasms
Ovarian Neoplasms
13 Citations (Scopus)

Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression

Mao, L., Ding, J., Perdue, A., Yang, L., Zha, Y., Ren, M., Huang, S., Cui, H. & Ding, H. F., Aug 16 2012, In : Oncogene. 31, 33, p. 3785-3795 11 p.

Research output: Contribution to journalArticle

Cyclins
Neuroblastoma
SKP Cullin F-Box Protein Ligases
Ubiquitin-Protein Ligases
Oncogene Proteins

CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells

Chen, L., Tang, S., Zhang, F. F., Garcia, V., Falck, J. R., Schwartzman, M. L., Arbab, A. S. & Guo, A. M., Jun 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 6, p. H1468-H1479

Research output: Contribution to journalArticle

Cytochrome P-450 CYP4A
Ischemia
Endothelial Cells
Chemokine CXCL12
Pharmacology
11 Citations (Scopus)

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A. M., Ha, Y., Gnana-Prakasam, J. P., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 1 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Retina
Cystathionine
Liver
Enzyme Assays
318 Citations (Scopus)

Cysteine redox sensor in PKGIα enables oxidant-induced activation

Burgoyne, J. R., Madhani, M., Cuello, F., Charles, R. L., Brennan, J. P., Schröder, E., Browning, D. D. & Eaton, P., Sep 7 2007, In : Science. 317, 5843, p. 1393-1397 5 p.

Research output: Contribution to journalArticle

Oxidants
Oxidation-Reduction
Cysteine
Disulfides
Hydrogen Peroxide
10 Citations (Scopus)

Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis

Liu, H. Y., Zheng, G., Treber, M., Dai, J. & Woldegiorgis, G., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 4524-4531 8 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Mutagenesis
Catalysis
Cysteine
Muscle
36 Citations (Scopus)

Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer

Pejovic, T., Yates, J. E., Liu, H. Y., Hays, L. E., Akkari, Y., Torimaru, Y., Keeble, W., Rathbun, R. K., Rodgers, W. H., Bale, A. E., Ameziane, N., Zwaan, C. M., Errami, A., Thuillier, P., Cappuccini, F., Olson, S. B., Cain, J. M. & Bagby, G. C., Sep 15 2006, In : Cancer Research. 66, 18, p. 9017-9025 9 p.

Research output: Contribution to journalArticle

Cytogenetics
Ovarian Neoplasms
Epithelial Cells
Mitomycin
Fanconi Anemia
2 Citations (Scopus)

Cytokeratin-8 in anaplastic thyroid carcinoma: More than a simple structural cytoskeletal protein

Guo, D., Xu, Q., Pabla, S., Koomen, J., Biddinger, P. W., Sharma, A. K., Pabla, S., Pacholczyk, R. W., Chang, C. C., Friedrich, K., Mohammed, K., Smallridge, R. C., Copland, J. A., She, J-X. & Weinberger, P. M., Feb 14 2018, In : International journal of molecular sciences. 19, 2, 577.

Research output: Contribution to journalArticle

Keratin-8
keratins
Keratin
Cytoskeletal Proteins
cancer
16 Citations (Scopus)

Cytokine gene polymorphisms and the pathology of chronic gastritis

Moorchung, N., Srivastava, A. N., Gupta, N. K., Ghoshal, U. C., Achyut, B. R. & Mittal, B., May 2007, In : Singapore Medical Journal. 48, 5, p. 447-54 8 p.

Research output: Contribution to journalArticle

Gastritis
Pathology
Cytokines
Genes
Gastric Mucosa
21 Citations (Scopus)

Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients

Murayama, T., Jisaki, F., Ayata, M., Sakamuro, D., Hironaka, T., Hirai, K., Tsuchiya, N., Ito, K. & Furukawa, T., Jan 1 1992, In : Clinical and Experimental Rheumatology. 10, 2, p. 161-164 4 p.

Research output: Contribution to journalArticle

Synovial Fluid
Cytomegalovirus
Rheumatoid Arthritis
Genome
Polymerase Chain Reaction
312 Citations (Scopus)

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

Retinal Neurons
Streptozocin
Ganglia
Retina
Cell Death
58 Citations (Scopus)

Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to fas ligand-induced apoptosis in vitro and tumor suppression in vivo

Yang, D., Torres, C. M., Bardhan, K., Zimmerman, M., McGaha, T. L. & Liu, K., May 1 2012, In : Journal of Immunology. 188, 9, p. 4441-4449 9 p.

Research output: Contribution to journalArticle

decitabine
Fas Ligand Protein
Colon
Apoptosis
Carcinoma
4 Citations (Scopus)

Defective T-cell receptor-induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53-/- mice

Singh, N., Huang, L. & Qin, H., Feb 1 2010, In : European Journal of Immunology. 40, 2, p. 559-568 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Apoptosis
T-Lymphocytes
Neoplasms
Immunomodulation
2 Citations (Scopus)

Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study

Khodaverdian, V., Tapadar, S., MacDonald, I. A., Xu, Y., Ho, P. Y., Bridges, A., Rajpurohit, P., Sanghani, B. A., Fan, Y., Thangaraju, M., Hathaway, N. A. & Oyelere, A. K., Dec 1 2019, In : Scientific Reports. 9, 1, 4802.

Research output: Contribution to journalArticle

Open Access
Histone Demethylases
Structure-Activity Relationship
Iron
Catalytic Domain
deferiprone
1 Citation (Scopus)

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock

Subramani, K., Chu, X., Warren, M., Lee, M., Lu, S., Singh, N. & Raju, R. P., Mar 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 3, p. 688-695 8 p.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Niacin
NAD
Sirtuin 1
Nicotinamide Mononucleotide
81 Citations (Scopus)

Degradation of Oxidized Insulin B Chain by the Multiproteinase Complex Macropain (Proteasome)

Dick, L. R., Moomaw, C. R., DeMartino, G. N. & Slaughter, C. A., Mar 1 1991, In : Biochemistry. 30, 10, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Insulin
Degradation
Peptides
Antipain
8 Citations (Scopus)
Iron-Regulatory Proteins
Gliosis
Retina
Blood Vessels
Microglia
17 Citations (Scopus)

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

Hong, Y., Manoharan, I., Suryawanshi, A., Shanmugam, A., Swafford, D., Ahmad, S., Chinnadurai, R., Manicassamy, B., He, Y., Mellor, A. L., Thangaraju, M., Munn, D. H. & Manicassamy, S., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
Dendritic Cells
Immunity
Tumor Microenvironment
26 Citations (Scopus)

Deletion of the amino acid transporter SLC6A14 suppresses tumour growth in spontaneous mouse models of breast cancer

Babu, E., Bhutia, Y. D., Ramachandran, S., Gnana-Prakasam, J. P., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Jul 1 2015, In : Biochemical Journal. 469, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Tumors
Breast Neoplasms
Amino Acids
Growth
46 Citations (Scopus)

De novo design of selective antibiotic peptides by incorporation of unnatural amino acids

Hicks, R. P., Bhonsle, J. B., Venugopal, D., Koser, B. W. & Magill, A. J., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3026-3036 11 p.

Research output: Contribution to journalArticle

Anti-Bacterial Agents
Amino Acids
Peptides
Magainins
Pharmaceutical Preparations
28 Citations (Scopus)

De novo transcriptome sequencing in a songbird, the dark-eyed junco (Junco hyemalis): genomic tools for an ecological model system

Peterson, M. P., Whittaker, D. J., Ambreth, S., Sureshchandra, S., Buechlein, A., Podicheti, R., Choi, J. H., Lai, Z., Mockatis, K., Colbourne, J., Tang, H. & Ketterson, E. D., Jul 9 2012, In : BMC Genomics. 13, 1, 305.

Research output: Contribution to journalArticle

Songbirds
Transcriptome
Ecosystem
Natural History
Genes
17 Citations (Scopus)

Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.

Corlazzoli, F., Rossetti, S., Bistulfi, G., Ren, M. & Sacchi, N., Jan 1 2009, In : PLoS One. 4, 1

Research output: Contribution to journalArticle

Retinoic Acid Receptors
retinoic acid
Tretinoin
Epigenomics
epigenetics
31 Citations (Scopus)

Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer

Hu, X., Bardhan, K., Paschall, A. V., Yang, D., Waller, J. L., Park, M. A., Nayak, A., Samuel, T. A., Abrams, S. I. & Liu, K., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 19103-19115 13 p.

Research output: Contribution to journalArticle

Deregulation
Tumors
Bearings (structural)
Apoptosis
Neoplasms
19 Citations (Scopus)

Descriptive epidemiology of asthma in Trinidad, West Indies

Monteil, M. A., Juman, S., Hassanally, R., Williams, K. P., Pierre, L., Rahaman, M., Singh, H. & Trinidade, A., Jan 1 2000, In : Journal of Asthma. 37, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

Trinidad and Tobago
West Indies
Epidemiology
Asthma
Islands
82 Citations (Scopus)

Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity

Manfredini, S., Pavan, B., Vertuani, S., Scaglianti, M., Compagnone, D., Biondi, C., Scatturin, A., Tanganelli, S., Ferraro, L., Prasad, P. D. & Dalpiaz, A., Jan 31 2002, In : Journal of Medicinal Chemistry. 45, 3, p. 559-562 4 p.

Research output: Contribution to journalArticle

Kynurenic Acid
Prodrugs
Ascorbic Acid
Pharmaceutical Preparations
Retinal Pigments
1 Citation (Scopus)

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Zhang, J., Wang, N., Xie, X., Yan, C., Fu, F., Yao, J. & Wang, H., Jun 1 2017, In : Wuhan University Journal of Natural Sciences. 22, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

Quinazolines
Cytotoxicity
Bioactivity
Antineoplastic Agents
Cells
22 Citations (Scopus)

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules

Manfredini, S., Vertuani, S., Pavan, B., Vitali, F., Scaglianti, M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. D. & Dalpiaz, A., Oct 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 20, p. 5453-5463 11 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Ascorbic Acid
Molecules
Acids