Biochemistry and Molecular Biology

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Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer

Hu, X., Bardhan, K., Paschall, A. V., Yang, D., Waller, J. L., Park, M. A., Nayak, A., Samuel, T. A., Abrams, S. I. & Liu, K., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 19103-19115 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Descriptive epidemiology of asthma in Trinidad, West Indies

Monteil, M. A., Juman, S., Hassanally, R., Williams, K. P., Pierre, L., Rahaman, M., Singh, H. & Trinidade, A., Jan 1 2000, In : Journal of Asthma. 37, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity

Manfredini, S., Pavan, B., Vertuani, S., Scaglianti, M., Compagnone, D., Biondi, C., Scatturin, A., Tanganelli, S., Ferraro, L., Prasad, P. D. & Dalpiaz, A., Jan 31 2002, In : Journal of Medicinal Chemistry. 45, 3, p. 559-562 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Zhang, J., Wang, N., Xie, X., Yan, C., Fu, F., Yao, J. & Wang, H., Jun 1 2017, In : Wuhan University Journal of Natural Sciences. 22, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules

Manfredini, S., Vertuani, S., Pavan, B., Vitali, F., Scaglianti, M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. & Dalpiaz, A., Oct 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 20, p. 5453-5463 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Detection of differentially methylated regions using bayes factor for ordinal group responses

Dunbar, F., Xu, H., Ryu, D., Ghosh, S., Shi, H. & George, V., Sep 2019, In : Genes. 10, 9, 721.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors

Li, N., Chen, M., Truong, S., Yan, C. & Buttyan, R., Oct 2014, In : Prostate. 74, 14, p. 1400-1410 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Determining the effect of the incorporation of unnatural amino acids into antimicrobial peptides on the interactions with zwitterionic and anionic membrane model systems

Russell, A. L., Kennedy, A. M., Spuches, A. M., Gibson, W. S., Venugopal, D., Klapper, D., Srouji, A. H., Bhonsle, J. B. & Hicks, R. P., Nov 1 2011, In : Chemistry and Physics of Lipids. 164, 8, p. 740-758 19 p.

Research output: Contribution to journalArticle

13 Scopus citations

Development of a novel animal model to differentiate radiation necrosis from tumor recurrence

Kumar, S., Arbab, A. S., Jain, R., Kim, J., DeCarvalho, A. C., Shankar, A., Mikkelsen, T. & Brown, S. L., Jul 2012, In : Journal of Neuro-Oncology. 108, 3, p. 411-420 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Development of a partial fibronectin knockout transgenic mouse model

Manshouri, T., Huang, S., Sundaresan, A., Chakravarthy, M., Chakrabarty, S. & Albitar, M., Jan 1 1997, In : Transgenics. 2, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In : International Journal of Cancer. 139, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Diagnosis and characterization of acute erythroleukemia subsets by determining the percentages of myeloblasts and proerythroblasts in 69 cases

Ramchandran, R., Bengra, C., Whitney, B., Lanclos, K. & Tuan Lo, D., Sep 11 2000, In : American Journal of Hematology. 65, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: A RPE specific phenomenon

Ananth, S., Zhuang, L., Gopal, E., Itagaki, S., Ellappan, B., Smith, S. B., Ganapathy, V. & Martin, P., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 75-80 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
29 Scopus citations

Diet-induced obesity and mammary tumor development in MMTV-neu female mice

Cleary, M. P., Grande, J. P., Juneja, S. C. & Maihle, N. J., Dec 1 2004, In : Nutrition and Cancer. 50, 2, p. 174-180 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer

Yan, P. S., Shi, H., Rahmatpanah, F., Hsiau, T. H. C., Hsiau, A. H. A., Leu, Y. W., Liu, J. C. & Huang, T. H. M., Oct 1 2003, In : Cancer Research. 63, 19, p. 6178-6186 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians

Shiina, M., Hashimoto, Y., Kato, T., Yamamura, S., Tanaka, Y., Majid, S., Saini, S., Varahram, S., Kulkarni, P., Dasgupta, P., Mitsui, Y., Sumida, M., Tabatabai, L., Deng, G., Kumar, D. & Dahiya, R., Jan 1 2017, In : Oncotarget. 8, 5, p. 8356-8368 13 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Differential influence of the 4F2 heavy chain and the protein related to b0,+ amino acid transport on substrate affinity of the heteromeric b0,+ amino acid transporter

Rajan, D. P., Huang, W., Kekuda, R., George, R. L., Wang, J., Conway, S. J., Devoe, L. D., Leibach, F. H., Prasad, P. D. & Ganapathy, V., May 12 2000, In : Journal of Biological Chemistry. 275, 19, p. 14331-14335 5 p.

Research output: Contribution to journalArticle

44 Scopus citations
Open Access
3 Scopus citations

Differential methylation tests of regulatory regions

Ryu, D., Xu, H., George, V., Su, S., Wang, X., Shi, H. & Podolsky, R. H., Jun 1 2016, In : Statistical Applications in Genetics and Molecular Biology. 15, 3, p. 237-251 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases

Bell, S. M., Connolly, D. C., Maihle, N. J. & Degen, J. L., Sep 1993, In : Molecular and Cellular Biology. 13, 9, p. 5888-5897 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Differential PI3Kδ signaling in CD4+ T-cell subsets enables selective targeting of t regulatory cells to enhance cancer immunotherapy

Ahmad, S., Abu-Eid, R., Shrimali, R. K., Webb, M., Verma, V., Doroodchi, A., Berrong, Z., Samara, R., Rodriguez, P. C., Mkrtichyan, M. & Khleif, S. N., Apr 15 2017, In : Cancer Research. 77, 8, p. 1892-1904 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2

Ganapathy, M. E., Brandsch, M., Prasad, P. D., Ganapathy, V. & Leibach, F. H., Jan 1 1995, In : Journal of Biological Chemistry. 270, 43, p. 25672-25677 6 p.

Research output: Contribution to journalArticle

246 Scopus citations

Differential regulation of cell motility and invasion by FAK

Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., Huang, S., Li, E., Nemerow, G. R., Leng, J., Spencer, K. S. R., Cheresh, D. A. & Schlaepfer, D. D., Mar 3 2003, In : Journal of Cell Biology. 160, 5, p. 753-767 15 p.

Research output: Contribution to journalArticle

422 Scopus citations

Direct detection by 15N NMR of the tryptophan tryptophylquinone aminoquinol reaction intermediate of methylamine dehydrogenase

Bishop, G. R., Valente, E. J., Whitehead, T. L., Brown, K. L., Hicks, R. P. & Davidson, V. L., Dec 1 1996, In : Journal of the American Chemical Society. 118, 50, p. 12868-12869 2 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity

Pan, Y., Choi, J-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In : Scientific reports. 9, 1, 3433.

Research output: Contribution to journalArticle

1 Scopus citations

Disease outcomes are influenced by the Yang (M1) or Yin (M2) of macrophage function

Rosenthal, K. S., Drakovac, S. & Stone, S., Jul 1 2012, In : Infectious Diseases in Clinical Practice. 20, 4, p. 272-276 5 p.

Research output: Contribution to journalArticle

Disease tropism of c-erbB: Effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation

Pelley, R. J., Maihle, N. J., Boerkoel, C., Shu, H. K., Carter, T. H., Moscovici, C. & Kung, H. J., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 18, p. 7164-7168 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid

Somenzi, G., Sala, G., Rossetti, S., Ren, M. Q., Ghidoni, R. & Sacchi, N., Sep 5 2007, In : PloS one. 2, 9, e836.

Research output: Contribution to journalArticle

25 Scopus citations

Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells

Salh, B., Assi, K., Huang, S., O'Brien, L., Steinbrecher, U. & Gómez-Muñoz, A., Oct 1 2002, In : Journal of Leukocyte Biology. 72, 4, p. 790-799 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Putiri, E. L., Tiedemann, R. L., Thompson, J. J., Liu, C., Ho, T., Choi, J. H. & Robertson, K. D., Jun 23 2014, In : Genome Biology. 15, 6, R81.

Research output: Contribution to journalArticle

54 Scopus citations

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distinct transcript isoforms of the atypical chemokine receptor 1 (ACKR1) / Duffy Antigen Receptor for Chemokines (DARC) gene are expressed in lymphoblasts and altered isoform levels are associated with genetic ancestry and the duffy-null allele

Davis, M. B., Walens, A., Hire, R., Mumin, K., Brown, A. M., Ford, D. J., Howerth, E. W. & Monteil, M., Oct 16 2015, In : PloS one. 10, 10, 140098.

Research output: Contribution to journalArticle

8 Scopus citations

Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

Amro, A., Chen, Y., Barry, R., Susick, L., Bensenhaver, J., Proctor, E., Petersen, L., Nathanson, S. D., Ali, H., Loutfi, R., Chitale, D., Simonds, A., Kuklinski, M., Park, K. U., Davis, M. & Newman, L. A., Jul 1 2019, In : Breast Journal. 25, 4, p. 667-671 5 p.

Research output: Contribution to journalArticle

Disturbance of tumor necrosis factor alpha-mediated beta interferon signaling in cervical carcinoma cells

Bachmann, A., Hanke, B., Zawatzky, R., Soto, U., Van Riggelen, J., Zur Hausen, H. & Rösl, F., Jan 1 2002, In : Journal of Virology. 76, 1, p. 280-291 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma

Bennett, L. B., Schnabel, J. L., Kelchen, J. M., Taylor, K. H., Guo, J., Arthur, G. L., Papageorgio, C. N., Shi, H. & Caldwell, C. W., Sep 1 2009, In : Genes Chromosomes and Cancer. 48, 9, p. 828-841 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8

Guo, C., Pei, L., Xiao, X., Wei, Q., Chen, J., Ding, H., Huang, S., Fan, G., Shi, H. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1194-1205 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA methylation represses IFN-γ-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells

McGough, J. M., Yang, D., Huang, S., Georgi, D., Hewitt, S. M., Röcken, C., Tänzer, M., Ebert, M. P. A. & Liu, K., Dec 1 2008, In : Molecular Cancer Research. 6, 12, p. 1841-1851 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis

Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Nov 29 2019, In : Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells

Fukuhara, S., Chang, I., Mitsui, Y., Chiyomaru, T., Yamamura, S., Majid, S., Saini, S., Hirata, H., Deng, G., Gill, A., Wong, D. K., Shiina, H., Nonomura, N., Dahiya, R. & Tanaka, Y., Jan 1 2014, In : Oncotarget. 5, 22, p. 11297-11307 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Pathania, R., Ramachandran, S., Elangovan, S., Padia, R., Yang, P., Cinghu, S., Veeranan-Karmegam, R., Arjunan, P., Gnana-Prakasam, J. P., Sadanand, F., Pei, L., Chang, C. S., Choi, J. H., Shi, H., Manicassamy, S., Prasad, P. D., Sharma, S., Ganapathy, V., Jothi, R. & Thangaraju, M., Apr 22 2015, In : Nature communications. 6, 6910.

Research output: Contribution to journalArticle

114 Scopus citations

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma

Poole, C. J., Zheng, W., Lodh, A., Yevtodiyenko, A., Liefwalker, D., Li, H., Felsher, D. W. & van Riggelen, J., Jan 1 2017, In : Oncotarget. 8, 44, p. 76898-76920 23 p.

Research output: Contribution to journalArticle

11 Scopus citations

Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation

Leu, Y. W., Rahmatpanah, F., Shi, H., Wei, S. H., Liu, J. C., Yan, P. S. & Huang, T. H. M., Oct 1 2003, In : Cancer Research. 63, 19, p. 6110-6115 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer

Gupta, N., Martin, P. M., Miyauchi, S., Ananth, S., Herdman, A. V., Martindale, R. G., Podolsky, R. & Ganapathy, V., May 5 2006, In : Biochemical and Biophysical Research Communications. 343, 2, p. 571-577 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Downregulation of IFN-γR in association with loss of Fas function is linked to tumor progression

Yang, D., Stewart, T. J., Smith, K. K., Georgi, D., Abrams, S. I. & Liu, K., Jan 15 2008, In : International Journal of Cancer. 122, 2, p. 350-362 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
14 Scopus citations

Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis

Cho, S. G., Du, Q., Huang, S. & Dong, Z., Jul 1 2010, In : American Journal of Physiology - Renal Physiology. 299, 1, p. F199-F206

Research output: Contribution to journalArticle

47 Scopus citations

Drugs of abuse and placental transport

Ganapathy, V., Prasad, P. D., Ganapathy, M. E. & Leibach, F. H., Jun 14 1999, In : Advanced Drug Delivery Reviews. 38, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

52 Scopus citations