Biochemistry and Molecular Biology

Research Output 1968 2019

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Review article
2019

Dietary myo-inositol chemoprevents lung carcinogenesis via boosting immune system in Kras mouse model

Piranlioglu, R., Korkaya, H. & Hassan, K. A., Jan 1 2019, In : Journal of Thoracic Disease. 11, 3, p. 632-635 4 p.

Research output: Contribution to journalReview article

Inositol
Immune System
Carcinogenesis
Lung
3 Citations (Scopus)

Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy

Canning, M., Guo, G., Yu, M., Myint, C., Groves, M. W., Byrd, J. K. & Cui, Y., Jan 1 2019, In : Frontiers in Cell and Developmental Biology. 7, APR, 52.

Research output: Contribution to journalReview article

Open Access
Immunotherapy
Carcinoma, squamous cell of head and neck
Therapeutics
Papillomavirus Infections
Transcriptome
2018
1 Citation (Scopus)

Clinical utility of plecanatide in the treatment of chronic idiopathic constipation

Islam, B. N., Sharman, S. K. & Browning, D. D., Jan 1 2018, In : International Journal of General Medicine. 11, p. 323-330 8 p.

Research output: Contribution to journalReview article

Constipation
Pharmaceutical Preparations
Therapeutics
Phosphodiesterase Inhibitors
Enterotoxins

Delineating pro-angiogenic myeloid cells in cancer therapy

Johnson, B. W., Achyut, B. R., Fulzele, S., Mondal, A. K., Kolhe, R. & Arbab, A. S., Sep 2018, In : International journal of molecular sciences. 19, 9, 2565.

Research output: Contribution to journalReview article

Myeloid Cells
Tumors
therapy
cancer
cells
2017
8 Citations (Scopus)

Arachidonic acid metabolite as a novel therapeutic target in breast cancer metastasis

Borin, T. F., Angara, K., Rashid, M. H., Achyut, B. R. & Arbab, A. S., Dec 8 2017, In : International journal of molecular sciences. 18, 12, 2661.

Research output: Contribution to journalReview article

metabolites
metastasis
Metabolites
Arachidonic Acid
breast
14 Citations (Scopus)

Designing therapeutic cancer vaccines by mimicking viral infections

Sultan, H., Fesenkova, V. I., Addis, D., Fan, A. E., Kumai, T., Wu, J., Salazar, A. M. & Celis, E., Feb 1 2017, In : Cancer Immunology, Immunotherapy. 66, 2, p. 203-213 11 p.

Research output: Contribution to journalReview article

Cancer Vaccines
Virus Diseases
Epitopes
Peptides
Neoplasm Antigens

Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor

Wu, D., Jun 1 2017, In : Genes and Diseases. 4, 2, p. 100-107 8 p.

Research output: Contribution to journalReview article

Tumors
Neoplasms
Proteins
Cells
Microfilament Proteins
4 Citations (Scopus)

Major challenges and potential microenvironment-targeted therapies in glioblastoma

Arbab, A. S., Rashid, M. H., Angara, K., Borin, T. F., Lin, P. C., Jain, M. & Achyut, B. R., Dec 16 2017, In : International journal of molecular sciences. 18, 12, 2732.

Research output: Contribution to journalReview article

Glioblastoma
Tumors
therapy
tumors
Chemotherapy
31 Citations (Scopus)

MYC—master regulator of the cancer epigenome and transcriptome

Poole, C. J. & van Riggelen, J., May 13 2017, In : Genes. 8, 5, 142.

Research output: Contribution to journalReview article

Transcriptome
Transcription Factors
Genes
Neoplasms
Oncogenes
6 Citations (Scopus)

The dual roles of MYC in genomic instability and cancer chemoresistance

Kumari, A., Folk, W. P. & Sakamuro, D., Jun 7 2017, In : Genes. 8, 6, 158.

Research output: Contribution to journalReview article

Genomic Instability
Neoplasms
Double-Stranded DNA Breaks
Histones
Cytoprotection
23 Citations (Scopus)

Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma

Angara, K., Borin, T. F. & Arbab, A. S., Aug 1 2017, In : Translational Oncology. 10, 4, p. 650-660 11 p.

Research output: Contribution to journalReview article

Glioblastoma
Blood Vessels
Neoplasms
Therapeutics
Central Nervous System
2016
8 Citations (Scopus)

A perspective on promoting diversity in the biomedical research workforce: The national heart, lung, and blood institute's pri de program

Boyington, J. E. A., Maihle, N. J., Rice, T. K., Gonzalez, J. E., Hess, C. A., Makala, L. H., Jeffe, D. B., Ogedegbe, G., Rao, D. C., Dávila-Román, V. G., Pace, B. S., Jean-Louis, G. & Boutjdir, M., Jun 1 2016, In : Ethnicity and Disease. 26, 3, p. 379-386 8 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Biomedical Research
Research
Health
Research Personnel
52 Citations (Scopus)

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

Sivaprakasam, S., Prasad, P. D. & Singh, N., Aug 1 2016, In : Pharmacology and Therapeutics. 164, p. 144-151 8 p.

Research output: Contribution to journalReview article

Volatile Fatty Acids
Dietary Fiber
Carcinogenesis
Inflammation
Intestinal Neoplasms
96 Citations (Scopus)

Crosstalk between long noncoding RNAs and microRNAs in health and disease

Bayoumi, A. S., Sayed, A., Broskova, Z., Teoh, J. P., Wilson, J., Su, H., Tang, Y. L. & Kim, I., Mar 11 2016, In : International journal of molecular sciences. 17, 3, 356.

Research output: Contribution to journalReview article

Long Noncoding RNA
Untranslated RNA
Crosstalk
crosstalk
RNA
18 Citations (Scopus)

DNA damage response in nephrotoxic and ischemic kidney injury

Yan, M., Tang, C., Ma, Z., Huang, S. & Dong, Z., Dec 15 2016, In : Toxicology and Applied Pharmacology. 313, p. 104-108 5 p.

Research output: Contribution to journalReview article

DNA Damage
Acute Kidney Injury
Kidney
DNA
Wounds and Injuries
7 Citations (Scopus)

Essential role of Ufm1 conjugation in the hematopoietic system

Cai, Y., Singh, N. & Li, H., Jun 1 2016, In : Experimental Hematology. 44, 6, p. 442-446 5 p.

Research output: Contribution to journalReview article

Hematopoietic System
Ubiquitin
Ubiquitins
Ubiquitin-Protein Ligases
Hematologic Diseases
1 Citation (Scopus)

Genomic-based diagnosis of arrhythmia disease in a personalized medicine era

Omar, A., Zhou, M., Berman, A. E., Sorrentino, R. A., Yar, N., Weintraub, N. L., Kim, I., Lei, W. & Tang, Y. L., Nov 1 2016, In : Expert Review of Precision Medicine and Drug Development. 1, 6, p. 497-504 8 p.

Research output: Contribution to journalReview article

Precision Medicine
Cardiac Arrhythmias
Drug Discovery
Cardiac Myocytes
Channelopathies
29 Citations (Scopus)
suppressors
Tumor Microenvironment
Tumors
tumors
Carcinogenesis
31 Citations (Scopus)

SLC transporters as a novel class of tumour suppressors: Identity, function and molecular mechanisms

Bhutia, Y. D., Babu, E., Ramachandran, S., Yang, S., Thangaraju, M. & Ganapathy, V., May 1 2016, In : Biochemical Journal. 473, 9, p. 1113-1124 12 p.

Research output: Contribution to journalReview article

Tumors
Neoplasms
Butyrates
Propionates
Pyruvic Acid
18 Citations (Scopus)

Targeting translation: EIF4E as an emerging anticancer drug target

Lu, C., Makala, L., Wu, D. & Cai, Y., Jan 18 2016, In : Expert Reviews in Molecular Medicine. 18, e2.

Research output: Contribution to journalReview article

Eukaryotic Initiation Factor-4E
Peptide Initiation Factors
Cyclin D1
Pharmaceutical Preparations
Vascular Endothelial Growth Factor A
2015
5 Citations (Scopus)

A survey of computational methods in transcriptome-wide alternative splicing analysis

Wang, J., Ye, Z., Huang, T. H. M., Shi, H. & Jin, V., Mar 1 2015, In : Biomolecular Concepts. 6, 1, p. 59-66 8 p.

Research output: Contribution to journalReview article

Alternative Splicing
Computational methods
Transcriptome
Software
Genes
31 Citations (Scopus)

E3 ubiquitin ligase Skp2 as an attractive target in cancer therapy

Hao, Z. & Huang, S., Jan 15 2015, In : Frontiers in Bioscience - Landmark. 20, 3, p. 474-490 17 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
Tumors
Genes
Neoplasms
Cell proliferation
1 Citation (Scopus)

Epigenetic and Immune Regulation of Colorectal Cancer Stem Cells

Paschall, A. V. & Liu, K., Dec 1 2015, In : Current Colorectal Cancer Reports. 11, 6, p. 414-421 8 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Epigenomics
Colorectal Neoplasms
Neoplasms
Immune Evasion
66 Citations (Scopus)

Long non-coding RNAs as master regulators in cardiovascular diseases

Archer, K., Broskova, Z., Bayoumi, A. S., Teoh, J. P., Davila, A., Tang, Y., Su, H. & Kim, I. M., Oct 5 2015, In : International journal of molecular sciences. 16, 10, p. 23651-23667 17 p.

Research output: Contribution to journalReview article

Long Noncoding RNA
regulators
RNA
Cardiovascular Diseases
heart diseases
68 Citations (Scopus)

Molecular markers for bladder cancer screening, early diagnosis, and surveillance: The WHO/ICUD consensus

Schmitz-Dräger, B. J., Droller, M., Lokeshwar, V. B., Lotan, Y., Hudson, ML. A., Van Rhijn, B. W., Marberger, M. J., Fradet, Y., Hemstreet, G. P., Malmstrom, P. U., Ogawa, O., Karakiewicz, P. I. & Shariat, S. F., Feb 24 2015, In : Urologia Internationalis. 94, 1, p. 1-24 24 p.

Research output: Contribution to journalReview article

Early Detection of Cancer
Urinary Bladder Neoplasms
Early Diagnosis
Urine
Cell Biology
15 Citations (Scopus)
Tumor Microenvironment
Immunotherapy
Neoplasms
DNA Damage
Genetic Suppression
9 Citations (Scopus)

Programmed death-1 & its ligands: Promising targets for cancer immunotherapy

Shrimali, R. K., Janik, J. E., Abu-Eid, R., Mkrtichyan, M. & Khleif, S. N., Jan 1 2015, In : Immunotherapy. 7, 7, p. 777-792 16 p.

Research output: Contribution to journalReview article

Immunotherapy
Ligands
Tumor Escape
Neoplasms
Immune Tolerance
55 Citations (Scopus)

The role of CD44 in disease pathophysiology and targeted treatment

Jordan, A. R., Racine, R. R., Hennig, M. J. P. & Lokeshwar, V. B., Jan 1 2015, In : Frontiers in immunology. 6, APR, 182.

Research output: Contribution to journalReview article

Hyaluronic Acid
Ligands
Biodiversity
Interstitial Lung Diseases
Membrane Glycoproteins
2014
20 Citations (Scopus)

Negative Regulators of Brown Adipose Tissue (BAT)-Mediated Thermogenesis

Sharma, B. K., Patil, M. & Ande, S., Jan 1 2014, In : Journal of Cellular Physiology. 229, 12, p. 1901-1907 7 p.

Research output: Contribution to journalReview article

Brown Adipose Tissue
Thermogenesis
Tissue
Computerized tomography
Energy Metabolism

Research progress of phosphodiesterases and phosphodiesterase inhibitors

Chen, C. L. & Huang, S., Jan 1 2014, In : Chinese Pharmacological Bulletin. 30, 2, p. 283-286 4 p.

Research output: Contribution to journalReview article

Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Protein Isoforms
Research
Guanosine Monophosphate
35 Citations (Scopus)

The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy

Bhutia, Y. D., Babu, E., Prasad, P. D. & Ganapathy, V., Dec 1 2014, In : Asian Journal of Pharmaceutical Sciences. 9, 6, p. 293-303 11 p.

Research output: Contribution to journalReview article

Amino Acid Transport Systems
Drug Therapy
Amino Acids
Neoplasms
Prodrugs
2013
14 Citations (Scopus)

Current understanding on antihepatocarcinoma effects of xiao Chai Hu Tang and its constituents

Zheng, N., Dai, J., Cao, H., Sun, S., Fang, J., Li, Q., Su, S., Zhang, Y., Qiu, M. & Huang, S., Jul 19 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 529458.

Research output: Contribution to journalReview article

Chronic Hepatitis
Liver Diseases
China
Fibrosis
Chronic Disease
65 Citations (Scopus)

Drugging the undruggable: Transcription therapy for cancer

Yan, C. & Higgins, P. J., Jan 1 2013, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1835, 1, p. 76-85 10 p.

Research output: Contribution to journalReview article

Transcription Factors
Epigenomics
Neoplasms
Proteins
Clinical Trials
74 Citations (Scopus)

HER2 and breast cancer stem cells: More than meets the eye

Korkaya, H. & Wicha, M. S., Jun 15 2013, In : Cancer Research. 73, 12, p. 3489-3493 5 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Breast Neoplasms
Neoplasms
Population
erbB-2 Genes
75 Citations (Scopus)

Role of urokinase receptor in tumor progression and development

Noh, H., Hong, S. & Huang, S., Sep 3 2013, In : Theranostics. 3, 7, p. 487-495 9 p.

Research output: Contribution to journalReview article

Urokinase-Type Plasminogen Activator
Neoplasms
Neoplasm Metastasis
Vitronectin
Epithelial-Mesenchymal Transition
92 Citations (Scopus)
Volatile Fatty Acids
Dietary Fiber
Bacteria
Colon
Membrane Transport Proteins
2012
27 Citations (Scopus)
Glioma
Stem Cells
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor
Therapeutics
10 Citations (Scopus)

Cord blood endothelial progenitor cells as therapeutic and imaging probes

Janic, B. & Arbab, A. S., Aug 1 2012, In : Imaging in Medicine. 4, 4, p. 477-490 14 p.

Research output: Contribution to journalReview article

Fetal Blood
Blood Cells
Cell Tracking
Growth Disorders
Therapeutics
33 Citations (Scopus)
T-Lymphocytes
Drug Therapy
Recurrence
Immunotherapy
Immunity
2011
347 Citations (Scopus)

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Korkaya, H., Liu, S. & Wicha, M. S., Oct 3 2011, In : Journal of Clinical Investigation. 121, 10, p. 3804-3809 6 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Neoplastic Stem Cells
Breast Neoplasms
Cytokines
Mesenchymal Stromal Cells
172 Citations (Scopus)

Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots

Korkaya, H., Liu, S. & Wicha, M. S., Oct 1 2011, In : Clinical Cancer Research. 17, 19, p. 6125-6128 4 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Tumor Microenvironment
Cytokines
Stem Cells
Inflammation
2010
27 Citations (Scopus)

CGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment

Browning, D. D., Kwon, I. K. & Wang, R., Jan 1 2010, In : Future Medicinal Chemistry. 2, 1, p. 65-80 16 p.

Research output: Contribution to journalReview article

Cyclic GMP-Dependent Protein Kinases
Colonic Neoplasms
Protein Kinases
Catenins
Intestines
30 Citations (Scopus)

Expression and function of iron-regulatory proteins in retina

Gnana-Prakasam, J. P., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2010, In : IUBMB Life. 62, 5, p. 363-370 8 p.

Research output: Contribution to journalReview article

Iron-Regulatory Proteins
Retina
Iron
Hemochromatosis
Iron Overload
3 Citations (Scopus)

Next generation sequencing: Advances in characterizing the Methylome

Taylor, K. H., Shi, H. & Caldwell, C. W., Sep 1 2010, In : Genes. 1, 2, p. 143-165 23 p.

Research output: Contribution to journalReview article

Lymphoma
Technology
Epigenomics
DNA Methylation
DNA Sequence Analysis
2009
25 Citations (Scopus)

A dual role of Cdk2 in DNA damage response

Ande, S. & Kaldis, P., May 18 2009, In : Cell Division. 4, 9.

Research output: Contribution to journalReview article

S Phase
DNA Damage
DNA Repair
DNA
Cell Cycle
29 Citations (Scopus)

Clinical implementation of soluble EGFR (sEGFR) as a theragnostic serum biomarker of breast, lung and ovarian cancer

Baron, A. T., Wilken, J. A., Haggstrom, D. E., Goodrich, S. T. & Maihle, N. J., May 1 2009, In : IDrugs. 12, 5, p. 302-308 7 p.

Research output: Contribution to journalReview article

Proto-Oncogenes
Ovarian Neoplasms
Lung Neoplasms
Biomarkers
Breast Neoplasms
62 Citations (Scopus)

In vivo cellular imaging for translational medical research

Arbab, A. S., Janic, B., Haller, J., Pawelczyk, E., Liu, W. & Frank, J. A., Jun 2 2009, In : Current Medical Imaging Reviews. 5, 1, p. 19-38 20 p.

Research output: Contribution to journalReview article

Translational Medical Research
Stem Cells
Clinical Trials
Cell- and Tissue-Based Therapy
Fluorescent Dyes
415 Citations (Scopus)

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

Ganapathy, V., Thangaraju, M. & Prasad, P. D., Jan 1 2009, In : Pharmacology and Therapeutics. 121, 1, p. 29-40 12 p.

Research output: Contribution to journalReview article

Food
Neoplasms
Monocarboxylic Acid Transporters
Butyrates
Glycolysis
56 Citations (Scopus)

Potential new urinary markers in the early detection of bladder cancer

Shirodkar, S. P. & Lokeshwar, V. B., Sep 1 2009, In : Current Opinion in Urology. 19, 5, p. 488-493 6 p.

Research output: Contribution to journalReview article

Early Detection of Cancer
Urinary Bladder Neoplasms
Tumor Biomarkers
Cell Cycle Proteins
Molecular Biology
33 Citations (Scopus)

Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas

Rath, P., Shi, H., Maruniak, J. A., Litofsky, N. S., Maria, B. L. & Kirk, M. D., Oct 12 2009, In : Current Stem Cell Research and Therapy. 4, 1, p. 44-49 6 p.

Research output: Contribution to journalReview article

Thymidine Kinase
Simplexvirus
Glioma
Genetic Therapy
Stem Cells