Cellular Biology and Anatomy

Research Output

2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

4 Scopus citations

Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction

Davila, A., Tian, Y., Czikora, I., S. Weissman, A., Weinand, N., Dong, G., Xu, J., Li, J., Su, H., Kapuku, G., Huo, Y. & Bagi, Z., Jan 1 2020, (Accepted/In press) In : Microcirculation.

Research output: Contribution to journalArticle

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues

Fouda, A. Y., Eldahshan, W., Narayanan, S. P., Caldwell, R. W. & Caldwell, R. B., Mar 17 2020, In : Frontiers in Pharmacology. 11, 277.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Autophagy inhibition by chloroquine and hydroxychloroquine could adversely affect acute kidney injury and other organ injury in critically ill patients with COVID-19

Edelstein, C. L., Venkatachalam, M. A. & Dong, Z., Jul 2020, In : Kidney International. 98, 1, p. 234-235 2 p.

Research output: Contribution to journalLetter

Open Access
2 Scopus citations

Autophagy in kidney homeostasis and disease

Tang, C., Livingston, M. J., Liu, Z. & Dong, Z., 2020, (Accepted/In press) In : Nature Reviews Nephrology.

Research output: Contribution to journalReview article

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats

Wang, Y., Zhang, H., Wang, Z., Wei, Y., Wang, M., Liu, M., Wang, X., Jiang, Y., Shi, G., Zhao, D., Yang, Z., Ren, Z., Li, J., Zhang, Z., Wang, Z., Zhang, B., Zong, B., Lou, X., Liu, C., Wang, Z. & 23 others, Zhang, H., Tao, N., Li, X., Zhang, X., Guo, Y., Ye, Y., Qi, Y., Li, H., Wang, M., Guo, R., Cheng, G., Li, S., Zhang, J., Liu, G., Chai, L., Lou, Q., Li, X., Cui, X., Gao, E., Dong, Z., Hu, Y., Chen, Y. H. & Ma, Y., Apr 22 2020, In : Science Translational Medicine. 12, 540, eaaw3172.

Research output: Contribution to journalArticle

Canagliflozin reduces cisplatin uptake and activates Akt to protect against cisplatin-induced nephrotoxicity

Song, Z., Zhu, J., Wei, Q., Dong, G. & Dong, Z., Apr 1 2020, In : American journal of physiology. Renal physiology. 318, 4, p. F1041-F1052

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells

Liu, T., Yuan, J., Dai, C., Xu, J., Li, S., Humphreys, B. D., Kleven, D. T. & Chen, J. K., 2020, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

Ates, K. M., Wang, T., Moreland, T., Veeranan-Karmegam, R., Ma, M., Jeter, C., Anand, P., Wenzel, W., Kim, H. G., Wolfe, L. A., Stephen, J., Adams, D. R., Markello, T., Tifft, C. J., Settlage, R., Gahl, W. A., Gonsalvez, G. B., Malicdan, M. C., Flanagan-Steet, H. & Albert Pan, Y., May 2020, In : DMM Disease Models and Mechanisms. 13, 5, dmm041913.

Research output: Contribution to journalArticle

Open Access

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Elashiry, M., Elashiry, M. M., Elsayed, R., Rajendran, M., Auersvald, C., Zeitoun, R., Rashid, M. H., Ara, R., Meghil, M. M., Liu, Y., Arbab, A. S., Arce, R. M., Hamrick, M., Elsalanty, M., Brendan, M., Pacholczyk, R. & Cutler, C. W., Jan 1 2020, In : Journal of Extracellular Vesicles. 9, 1, 1795362.

Research output: Contribution to journalArticle

Open Access

Dioleoylphosphatidylglycerol accelerates corneal epithelial wound healing

Bollag, W. B., Olala, L. O., Xie, D., Lu, X., Qin, H., Choudhary, V., Patel, R., Bogorad, D., Estes, A. & Watsky, M., Mar 2020, In : Investigative Ophthalmology and Visual Science. 61, 3, 29.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effects of Vitamin D receptor knockout and Vitamin D deficiency on corneal epithelial wound healing and nerve density in diabetic mice

Lu, X., Vick, S., Chen, Z., Chen, J. & Watsky, M. A., May 1 2020, In : Diabetes. 69, 5, p. 1042-1051 10 p.

Research output: Contribution to journalArticle

Expression of mRNAs, miRNAs, and lncRNAs in human trabecular meshwork cells upon mechanical stretch

Youngblood, H., Cai, J., Drewry, M. D., Helwa, I., Hu, E., Liu, S., Yu, H., Mu, H., Hu, Y., Perkumas, K., Aboobakar, I. F., Johnson, W. M., Stamer, W. D. & Liu, Y., May 1 2020, In : Investigative Ophthalmology and Visual Science. 61, 5, A21.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Freeze-Dried Extracellular Vesicles From Adipose-Derived Stem Cells Prevent Hypoxia-Induced Muscle Cell Injury

El Baradie, K. B. Y., Nouh, M., O’Brien, F., Liu, Y., Fulzele, S., Eroglu, A. & Hamrick, M. W., Mar 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 181.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

Liu, Z., Xu, J., Ma, Q., Zhang, X., Yang, Q., Wang, L., Cao, Y., Xu, Z., Tawfik, A. M., Sun, Y., Weintraub, N. L., Fulton, D. J., Hong, M., Dong, Z., Smith, L. E. H., Caldwell, R. B., Sodhi, A. & Huo, Y., Aug 5 2020, In : Science Translational Medicine. 12, 555

Research output: Contribution to journalArticle

Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis

Yao, Y., Liu, Q., Adrianto, I., Wu, X., Glassbrook, J., Khalasawi, N., Yin, C., Yi, Q., Dong, Z., Geissmann, F., Zhou, L. & Mi, Q. S., Dec 1 2020, In : Nature communications. 11, 1, 3822.

Research output: Contribution to journalArticle

Open Access

Implementation and evaluation of a near-peer-facilitated medical ethics curriculum for first-year medical students: a pilot study

DeFoor, M. T., East, L., Mann, P. C. & Nichols, C. A., Mar 1 2020, In : Medical Science Educator. 30, 1, p. 219-225 7 p.

Research output: Contribution to journalArticle

Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53

Liu, Y., Fu, Y., Liu, Z., Shu, S., Wang, Y., Cai, J., Tang, C. & Dong, Z., Jul 1 2020, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 7, 165792.

Research output: Contribution to journalArticle

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D. Y., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W. D., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

7 Scopus citations

Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan

Kaiser, H., Parker, E. & Hamrick, M. W., Feb 2020, In : Experimental Gerontology. 130, 110797.

Research output: Contribution to journalReview article

1 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

2 Scopus citations
3 Scopus citations

MiR-20a-containing exosomes from umbilical cord mesenchymal stem cells alleviates liver ischemia/reperfusion injury

Zhang, L., Song, Y., Chen, L., Li, D., Feng, H., Lu, Z., Fan, T., Chen, Z., Livingston, M. J. & Geng, Q., Apr 1 2020, In : Journal of Cellular Physiology. 235, 4, p. 3698-3710 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

MiR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury

Yan, Y., Ma, Z., Zhu, J., Zeng, M., Liu, H. & Dong, Z., Apr 2020, In : American Journal of Physiology - Renal Physiology. 318, 4, p. F878-F887

Research output: Contribution to journalArticle

2 Scopus citations

Novel strategy for septic acute kidney injury rescue: maintenance of the tubular integrity

Wei, Q., May 2020, In : Kidney International. 97, 5, p. 847-849 3 p.

Research output: Contribution to journalComment/debate

Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularization

Xu, J., Liu, X., Zhang, X., Marshall, B., Dong, Z., Liu, Y., Espinosa-Heidmann, D. G. & Zhang, M., Jun 1 2020, In : Journal of Pathology. 251, 2, p. 200-212 13 p.

Research output: Contribution to journalArticle

Omics Analyses in Keratoconus: from Transcriptomics to Proteomics

Cai, J., Estes, A. & Liu, Y., 2020, (Accepted/In press) In : Current Ophthalmology Reports.

Research output: Contribution to journalReview article

P53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease

Ma, Z., Li, L., Livingston, M. J., Zhang, D., Mi, Q., Zhang, M., Ding, H. F., Huo, Y., Mei, C. & Dong, Z., Sep 1 2020, In : Journal of Clinical Investigation. 130, 9, p. 5011-5026 16 p.

Research output: Contribution to journalArticle

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W. D., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M. E., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

2 Scopus citations

Protein kinase C-δ mediates kidney tubular injury in cold storage-associated kidney transplantation

Zhu, J., Zhang, G., Song, Z., Xiang, X., Shu, S., Liu, Z., Yang, D., Wei, Q. & Dong, Z., May 2020, In : Journal of the American Society of Nephrology. 31, 5, p. 1050-1065 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Qupath automated analysis of optic nerve degeneration in brown Norway rats

Mysona, B. A., Segar, S., Hernandez, C., Kim, C., Zhao, J., Mysona, D. & Bollinger, K. E., 2020, In : Translational Vision Science and Technology. 9, 3, 22.

Research output: Contribution to journalArticle

Open Access

Special issue: The kynurenine pathway in aging

Hamrick, M. W. & Isales, C. M., Jun 2020, In : Experimental Gerontology. 134, 110895.

Research output: Contribution to journalEditorial

The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis

Zhang, P., Yi, L., Qu, S., Dai, J., Li, X., Liu, B., Li, H., Ai, K., Zheng, P., Qiu, S., Li, Y., Wang, Y., Xiang, X., Chai, X., Dong, Z. & Zhang, D., Mar 6 2020, In : Molecular Therapy - Nucleic Acids. 19, p. 1027-1042 16 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors

Khambu, B., Hong, H., Liu, S., Liu, G., Chen, X., Dong, Z., Wan, J. & Yin, X. M., May 1 2020, In : Cell Death and Disease. 11, 5, 333.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration

Youssef El Baradie, K. B. & Hamrick, M. W., 2020, (Accepted/In press) In : Connective Tissue Research.

Research output: Contribution to journalArticle

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Sharma, A. K., Roberts, R. L., Benson, R. D., Pierce, J. L., Yu, K., Hamrick, M. W. & McGee-Lawrence, M. E., May 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 354.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

Lee, H., Smith, S. B., Sheu, S. S. & Yoon, Y., May 8 2020, In : Journal of Biological Chemistry. 295, 19, p. 6543-6560 18 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access

Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes

Chen, Z., Lu, X., McGee-Lawrence, M. E. & Watsky, M. A., Dec 1 2020, In : Scientific reports. 10, 1, 2840.

Research output: Contribution to journalArticle

Open Access

Ultrasound measurement of change in kidney volume is a sensitive indicator of severity of renal parenchymal injury

Crislip, G. R., Patel, B., Mohamed, R., Ray, S. C., Wei, Q., Sun, J., Polichnowski, A. J., Sullivan, J. C. & O’Connor, P. M., Aug 2020, In : American Journal of Physiology - Renal Physiology. 319, 3, p. F447-F457

Research output: Contribution to journalArticle

Utility of LysM-Cre and CdH5-Cre driver mice in retinal and brain research: An imaging study using tdtomato reporter mouse

Fouda, A. Y., Xu, Z., Priya Narayanan, S., William Caldwell, R. & Caldwell, R. B., Mar 2020, In : Investigative Ophthalmology and Visual Science. 61, 3, 51.

Research output: Contribution to journalArticle

Open Access

Variations in Healthy Swallowing Mechanics During Various Bolus Conditions Using Computational Analysis of Swallowing Mechanics (CASM)

Lenell, C., Brates, D., Pearson, W. G. & Molfenter, S., Apr 1 2020, In : Dysphagia. 35, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Vitamin C is a source of oxoaldehyde and glycative stress in age-related cataract and neurodegenerative diseases

Fan, X., Sell, D. R., Hao, C., Liu, S., Wang, B., Wesson, D. W., Siedlak, S., Zhu, X., Kavanagh, T. J., Harrison, F. E. & Monnier, V. M., Jul 1 2020, In : Aging Cell. 19, 7, ACEL13176.

Research output: Contribution to journalArticle

Open Access
2019

3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands

Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In : ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.

Research output: Contribution to journalArticle

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

Tang, C., Han, H., Liu, Z., Liu, Y., Yin, L., Cai, J., He, L., Liu, Y., Chen, G., Zhang, Z., Yin, X. M. & Dong, Z., Sep 1 2019, In : Cell Death and Disease. 10, 9, 677.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations