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2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

5 Scopus citations

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Association of Self-Reported Burnout and Protective Factors in Single Institution Resident Physicians

Wood, E. A., Egan, S. C., Ange, B., Garduno, H., Williams, D. R. & Wyatt, T. R., Jun 1 2020, In : Journal of graduate medical education. 12, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

Open Access

COVID-19 virulence in aged patients might be impacted by the host cellular MicroRNAs abundance/profile

Fulzele, S., Sahay, B., Yusufu, I., Lee, T. J., Sharma, A., Kolhe, R. & Isales, C. M., May 1 2020, In : Aging and Disease. 11, 3, p. 509-522 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D. Y., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W. D., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

8 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

2 Scopus citations

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W. D., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M. E., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

2 Scopus citations

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw

Elsayed, R., Kurago, Z., Cutler, C. W., Arce, R. M., Gerber, J., Celis, E., Sultan, H., Elashiry, M., Meghil, M., Sun, C., Auersvald, C. M., Awad, M. E., Zeitoun, R., Elsayed, R., Eldin M. Elshikh, M., Isales, C. & Elsalanty, M. E., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2595-2608 14 p.

Research output: Contribution to journalArticle

Open Access

Shape Loss of Autoclaved, Machine-Bent Cobalt-Chrome and Titanium Spine Surgery Rods

Willson, R., Zhou, H., Fulzele, S., Mitchell, S. M. & Chutkan, N., 2020, (Accepted/In press) In : Global Spine Journal.

Research output: Contribution to journalArticle

Open Access

The role of tryptophan metabolites in musculoskeletal stem cell aging

Anaya, J. M., Bollag, W. B., Hamrick, M. W. & Isales, C. M., Sep 2 2020, In : International journal of molecular sciences. 21, 18, p. 1-13 13 p., 6670.

Research output: Contribution to journalArticle

Open Access
2019

Advances in Molecular biomarker for early diagnosis of Osteoarthritis

Munjal, A., Bapat, S., Hubbard, D., Hunter, M., Kolhe, R. & Fulzele, S., 2019, In : Biomolecular Concepts. 10, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Association of Dietary Niacin Intake With Incident Hip Fracture, BMD, and Body Composition: The Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Raiford, M., Le, B., Isales, C. M., Shikany, J. M., Coughlin, S. S. & Robbins, J. A., Apr 2019, In : Journal of Bone and Mineral Research. 34, 4, p. 643-652 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

Kim, B. J., Lee, J. Y., Park, S. J., Lee, S. H., Kim, S. J., Yoo, H. J., De Pena, S. I. R., McGee-Lawrence, M., Isales, C. M., Koh, J. M. & Hamrick, M. W., 2019, In : Aging. 11, 21, p. 9388-9404 17 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
6 Scopus citations

Lower hand grip strength in older adults with non-alcoholic fatty liver disease: A nationwide population-based study

Kim, B. J., Ahn, S. H., Lee, S. H., Hong, S., Hamrick, M. W., Isales, C. M. & Koh, J. M., Jul 1 2019, In : Aging. 11, 13, p. 4547-4560 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Meta-analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair: Methodological guidelines and quality assessment

Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D. & Fulzele, S., 2019, In : Stem Cells International. 2019, 3826054.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Monomethylfumarate protects against ovariectomy-related changes in body composition

Bollag, A. E., Guo, T., Ding, K. H., Choudhary, V., Chen, X., Zhong, Q., Xu, J., Yu, K., Awad, M. E., Elsalanty, M., Johnson, M. H., McGee-Lawrence, M. E., Bollag, W. B. & Isales, C. M., Oct 2019, In : Journal of Endocrinology. 243, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

Phosphatidylglycerol Inhibits Toll-Like Receptor–Mediated Inflammation by Danger-Associated Molecular Patterns

Choudhary, V., Uaratanawong, R., Patel, R. R., Patel, H., Bao, W., Hartney, B., Cohen, E., Chen, X., Zhong, Q., Isales, C. M. & Bollag, W. B., Apr 2019, In : Journal of Investigative Dermatology. 139, 4, p. 868-877 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study

Le, B., Bůžková, P., Robbins, J. A., Fink, H. A., Raiford, M., Isales, C. M., Shikany, J. M., Coughlin, S. S. & Carbone, L. D., Aug 15 2019, In : Calcified Tissue International. 105, 2, p. 161-172 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

The detrimental effects of kynurenine, a tryptophan metabolite, on human bone metabolism

Kim, B. J., Hamrick, M. W., Yoo, H. J., Lee, S. H., Kim, S. J., Koh, J. M. & Isales, C. M., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2334-2342 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat

Pierce, J. L., Ding, K. H., Xu, J., Sharma, A. K., Yu, K., Arbona, N. M., Rodr guez-Santos, Z., Bernard, P. J., Bollag, W. B., Johnson, M. H., Hamrick, M. W., Begun, D. L., Shi, X. M., Isales, C. M. & McGee-Lawrence, M. E., Oct 2019, In : Journal of Endocrinology. 243, 1, p. 27-42 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In : Pharmacology and Therapeutics. 198, p. 90-108 19 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

An application of interdependence theory to military medical research teams: Cultural noise, tradeoffs, and meaning

Lawless, W. F., Wood, J., Stachura, M. E. & Wood, E. A., Jan 29 2018, (Accepted/In press) In : Journal of Enterprise Transformation. p. 1-15 15 p.

Research output: Contribution to journalArticle

Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly

Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration

Kennon, J. C., Awad, M. E., Chutkan, N., Devine, J. & Fulzele, S., Jan 1 2018, In : Biomolecular Concepts. 9, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
3 Scopus citations

Differences in Medical Students' Academic Performance between a Pass/Fail and Tiered Grading System

Ange, B., Wood, E. A., Thomas, A. M. & Wallach, P. M., Nov 1 2018, In : Southern medical journal. 111, 11, p. 683-687 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effect of plasma-derived extracellular vesicles on erythrocyte deformability in polymicrobial sepsis

Subramani, K., Raju, S. P., Chu, X., Warren, M., Pandya, C. D., Hoda, N., Fulzele, S. & Raju, R., Dec 2018, In : International Immunopharmacology. 65, p. 244-247 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Giant cell lesion of the jaw as a presenting feature of Noonan syndrome

Sinnott, B. P. & Patel, M., 2018, In : BMJ Case Reports. 2018, bcr-2017-224115.

Research output: Contribution to journalArticle

1 Scopus citations

Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: A nationwide population-based study

Kim, B. J., Lee, S. H., Kwak, M. K., Isales, C. M., Koh, J. M. & Hamrick, M. W., Aug 1 2018, In : Aging. 10, 8, p. 2051-2061 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

Yang, G., Pillich, H., White, R., Czikora, I., Pochic, I., Yue, Q., Hudel, M., Gorshkov, B. A., Verin, A. D., Sridhar, S., Isales, C. M., Eaton, D. C., Hamacher, J., Chakraborty, T. & Lucas, R., Feb 11 2018, In : Toxins. 10, 2, 79.

Research output: Contribution to journalArticle

1 Scopus citations

Modulation of miRNAS by vitamin C in human bone marrow stromal cells

Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In : Nutrients. 10, 2, 186.

Research output: Contribution to journalArticle

4 Scopus citations

Multimodal Sensor System for Pressure Ulcer Wound Assessment and Care

Chang, M. C., Yu, T., Luo, J., Duan, K., Tu, P., Zhao, Y., Nagraj, N., Rajiv, V., Priebe, M., Wood, E. A. & Stachura, M. E., Mar 2018, In : IEEE Transactions on Industrial Informatics. 14, 3, p. 1186-1196 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2 Scopus citations

Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy

Bollag, W. B., Ding, K. H., Choudhary, V., Xu, J., Zhong, Q., Elsayed, R., Bailey, L. J., Elsalanty, M., Yu, K., Johnson, M. H., McGee-Lawrence, M. E. & Isales, C. M., Oct 15 2018, In : Molecular and Cellular Endocrinology. 474, p. 176-183 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The impact of an Emergency Medical Technician basic course prior to medical school on medical students

Wyatt, T. R., Wood, E. A., McManus, J., Ma, K. & Wallach, P. M., Jan 1 2018, In : Medical Education Online. 23, 1, 1474699.

Research output: Contribution to journalArticle

The positive association of total protein intake with femoral neck strength (KNHANES IV)

Kim, B. J., Lee, S. H., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jun 1 2018, In : Osteoporosis International. 29, 6, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Alshenibr, W., Tashkandi, M. M., Alsaqer, S. F., Alkheriji, Y., Wise, A., Fulzele, S., Mehra, P., Goldring, M. B., Gerstenfeld, L. C. & Bais, M. V., Aug 2 2017, In : Arthritis Research and Therapy. 19, 1, 179.

Research output: Contribution to journalArticle

10 Scopus citations

Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Isales, C. M. & Hill, W. D., May 1 2017, In : Osteoporosis International. 28, 5, p. 1631-1640 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific reports. 7, 1, 2029.

Research output: Contribution to journalArticle

65 Scopus citations

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In : Scientific reports. 7, 1, 09731.

Research output: Contribution to journalArticle

12 Scopus citations

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years

Kindler, J. M., Pollock, N. K., Laing, E. M., Oshri, A., Jenkins, N. T., Isales, C. M., Hamrick, M. W., Ding, K. H., Hausman, D. B., McCabe, G. P., Martin, B. R., Hill Gallant, K. M., Warden, S. J., Weaver, C. M., Peacock, M. & Lewis, R. D., Jul 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1537-1545 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

37 Scopus citations
53 Scopus citations