Hematology and Oncology

Research Output 1963 2019

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Article
1989
14 Citations (Scopus)

The types of hemoglobins and globin chains in hydrops fetalis

Kutlar, F., Reese, A. L., Hsia, Y. E., Kleman, K. M. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 7-8, p. 671-683 13 p.

Research output: Contribution to journalArticle

Hydrops Fetalis
Globins
Hemoglobins
Cells
Blood
6 Citations (Scopus)

Two rare unstable β chain variants, HB mozhaisk or α2β292(f8)his ARG and HB DJELFA or α2β298(FG5)VAL→ALA, each being observed for the second time

Bird, A. R., Elliott, T., Wison, J. B., Webber, B. B., Hu, H., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 2, p. 193-197 5 p.

Research output: Contribution to journalArticle

Cellulose Acetate Electrophoresis
Abnormal Hemoglobins
Amino Acid Sequence
High Pressure Liquid Chromatography

α‐thalassemia among Pediatric Hemoglobin S Homozygotes: Molecular and Clinical Studies

FELICE, A. E., ZHAO, J., Kutlar, A., RHODES, M., McKie, K. & McKie, V., Jan 1 1989, In : Annals of the New York Academy of Sciences. 565, 1, p. 381-382 2 p.

Research output: Contribution to journalArticle

Sickle Hemoglobin
alpha-Thalassemia
Homozygote
Pediatrics
Clinical Studies
18 Citations (Scopus)

βthalassemia intermedia in two turkish families is caused by the interaction of HB knossos [β27(b9)ALA→SER] and of HB city of Hope [β69(e13)gly→ser] with b°thalassemia

Kutlar, A., Kutlar, F., Aksoy, M., Gurgey, A., Altay, C., Wilson, J. B., Diaz-Chico, J. C., Hu, H. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 1, p. 7-16 10 p.

Research output: Contribution to journalArticle

Thalassemia
beta-Thalassemia
Abnormal Hemoglobins
Oligonucleotide Probes
High performance liquid chromatography
1990
9 Citations (Scopus)

Chinese in west Malaysia: the geography of beta thalassaemia mutations.

George-Kodiseri, E., Yang, K. G., Kutlar, F., Wilson, J. B., Kutlar, A., Stoming, T. A., Gonzales-Redondo, J. M. & Huisman, T. H., Jan 1 1990, In : Singapore Medical Journal. 31, 4, p. 374-377 4 p.

Research output: Contribution to journalArticle

Geography
beta-Thalassemia
Malaysia
Mutation
Codon
5 Citations (Scopus)

Compound heterozygosity for a mild β+ and a rare β0-thalassemia allele

Codrington, J., Anijs, J., Wisse, J. H., Codrington, F. A., Li, H., Kutlar, F., Ramachandran, M. & Huisman, T. H. J., Jan 1 1990, In : Acta Haematologica. 84, 3, p. 135-138 4 p.

Research output: Contribution to journalArticle

Thalassemia
Heterozygote
Alleles
Mutation
Suriname
109 Citations (Scopus)

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages

Zhang, H., Basra, H. J. K. & Steinbrecher, U. P., Jan 1 1990, In : Journal of Lipid Research. 31, 8, p. 1361-1369 9 p.

Research output: Contribution to journalArticle

Macrophages
Esterification
LDL Lipoproteins
LDL Cholesterol
Cholesterol
20 Citations (Scopus)

Effects of oxidized low density liporoteins on arachidonic acid metabolism in smooth muscle cells

Zhang, H., Davis, W. B., Chen, X., Jones, K. H., Whisler, R. L. & Cornwell, D. G., Jan 1 1990, In : Journal of Lipid Research. 31, 4, p. 551-565 15 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Metabolism
Smooth Muscle Myocytes
Muscle
Prostaglandins
118 Citations (Scopus)

Fetal hemoglobin in normal adults and β-thalassemia heterozygotes

Kutlar, A., Kutlar, F., Gu, L. G., Mayson, S. M. & Huisman, T. H. J., Jun 1 1990, In : Human Genetics. 85, 1, p. 106-110 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Thalassemia
Heterozygote
Mutation
Codon
6 Citations (Scopus)

Growth factor-dependent regulation of transferrin receptor in proliferating and quiescent macrophages

Lokeshwar, B. L. & Lin, H. S., Oct 15 1990, In : Cellular Immunology. 130, 2, p. 401-415 15 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Intercellular Signaling Peptides and Proteins
Macrophages
Macrophage Colony-Stimulating Factor
Colony-Stimulating Factor Receptors
4 Citations (Scopus)

Hb f-Brooklyn or α2gγ266(e10)LYSGLN

Plaseska, D., Li, H. J., Wilson, J. B., Kutlar, F., Kutlar, A., Huisman, T. H. J. & Kulpa, J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Hemoglobins
Blood
Abnormal Hemoglobins
Electrophoresis
Screening
4 Citations (Scopus)

Hb f-catala or α2 gy2l5(a12)trp →arg

Plaseska, D., Wilson, J. B., Kutlar, F., Font, L., Baiget, H. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

compound A 12
Spain
Substitution reactions
Amino Acids
Liquids
11 Citations (Scopus)

Hb f-charlotte, an aγ variant with a threonine residue in position γ75 and a glycine residue in position γ136

Plaseska, D., Kutlar, F., Wilson, J. B., Fei, Y. J. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 6, p. 617-625 9 p.

Research output: Contribution to journalArticle

Threonine
Glycine
Blood
Substitution reactions
Genes
4 Citations (Scopus)

Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met

Plaseska, D., Kutlar, F., Wilson, J. B., Webber, B. B., Zeng, Y. T. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

methionylmethionine
Valine
Fetal Blood
Methionine
Substitution reactions
4 Citations (Scopus)

Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

Harano, T., Harano, K., Doi, K., Ueda, S., Imai, K., Ohba, Y., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Gene Order
Globins
High performance liquid chromatography
Reverse-Phase Chromatography
13 Citations (Scopus)

Hb Hekinan observed in three chinese from macau; identification of the gag→gat mutation in the αl-globin gene

Zhao, W., Wilson, J. B., Webber, B. B., Kutlar, A., Tamagnini, G. P., Kuan, B. & Huisnan, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 6, p. 627-635 9 p.

Research output: Contribution to journalArticle

Macau
Globins
High performance liquid chromatography
Aspartic Acid
Purification
7 Citations (Scopus)

Hb lepore-Baltimore in a north sardinian family

Nasala, B., Manca, L., Wilson, J. B., Webber, B. B., Kutlar, A. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

Abnormal Hemoglobins
Italy
Amino Acids
hemoglobin Lepore Baltimore
26 Citations (Scopus)

Hb sun prae or α213o(h13)ala → proβ2 a new unstable variant occurring in low quantities

Harkness, M., Harkness, D. R., Kutlar, F., Kutlar, A., Wilson, J. B., Webber, B. B., Codrington, J. F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Solar System
Sun
Globins
Genes
Mutation
6 Citations (Scopus)

Hb zengcg or α2β2114(g16)leu → met

Plaseska, D., Wilson, J. B., Gu, L. H., Kutlar, F., Huisman, T. H. J., Zeng, Y. T. & Shen, M., Jan 1 1990, In : Hemoglobin. 14, 5, p. 555-557 3 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Abnormal Hemoglobins
Heterozygote
Amino Acid Sequence
Newborn Infant
9 Citations (Scopus)

Hemoglobin Birmingham and hemoglobin Galicia: Two unstable β chain variants characterized by small deletions and insertions

Wilson, J. B., Webber, B. B., Hu, H., Kutlar, A., Kutlar, F., Codrington, J. F., Prchal, J. T., Hall, K. M., De Pablos, J. M., Rodriguez, I. & Huisman, T. H. J., Jan 1 1990, In : Blood. 75, 9, p. 1883-1887 5 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Glutamine
Codon
Leucine
Hemoglobins
68 Citations (Scopus)

Molecular characterization of β‐thalassaemia in 174 Greek patients with thalassaemia major

Kattamis, C., Hu, H., Cheng, G., Reese, A. L., Gonzalez‐Redondo, J. M., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : British Journal of Haematology. 74, 3, p. 342-346 5 p.

Research output: Contribution to journalArticle

Thalassemia
beta-Thalassemia
Mutation
Oligonucleotide Probes
Chromosome Mapping
9 Citations (Scopus)

Myristic acid is incorporates into the two acylatable domains of the functional glycoprotein CD9 in ester, but not in amide bonds

Seehafer, J. G., Slupsky, J. R., Tang, S-C., Masellis-Smith, A. & Shaw, A. R. E., Jun 19 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1039, 2, p. 218-226 9 p.

Research output: Contribution to journalArticle

Myristic Acid
Amides
Glycoproteins
Esters
Fatty Acids
51 Citations (Scopus)

Observations on the levels of Hb A2 in patients with different β-thalassemia mutations and a δ chain variant

Codrington, J. F., Li, H. W., Kutlar, F., Gu, L. H., Ramachandran, M. & Huisman, T. H. J., Jan 1 1990, In : Blood. 76, 6, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

Thalassemia
Globins
Genes
Mutation
Heterozygote
25 Citations (Scopus)
Escherichia coli
Proteins
Amino Acyl-tRNA Synthetases
Transfer RNA
Plasmids
543 Citations (Scopus)

Role of oxidatively modified LDL in atherosclerosis

Steinbrecher, U. P., Zhang, H. & Lougheed, M., Jan 1 1990, In : Free Radical Biology and Medicine. 9, 2, p. 155-168 14 p.

Research output: Contribution to journalArticle

Atherosclerosis
Oxidation
Apolipoproteins B
Macrophages
Phosphatidylcholines
6 Citations (Scopus)

The detection of hemoglobin variants by isoelectrofocusing using EDTA-collected and filter paper-dried cord blood specimens

Kutlar, A., Ozcan, O., Brisco, J. T., Ansley, M. C. & Huisman, T. H. J., Jan 1 1990, In : American Journal of Clinical Pathology. 94, 2, p. 199-202 4 p.

Research output: Contribution to journalArticle

Fetal Blood
Edetic Acid
Hemoglobins
Abnormal Hemoglobins
Hemoglobinopathies
6 Citations (Scopus)

Variation in the level of fetal hemoglobin in (δβ)°‐thalassemia heterozygotes with different numbers of α‐globin genes

Öner, C., Gurgey, A., Altay, C., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : American Journal of Hematology. 34, 3, p. 230-231 2 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Thalassemia
Globins
Heterozygote
Fathers
1 Citation (Scopus)

αthalassemia DUE toframeshifts at codons 5, 6, 8, and 8/9; hematological observations in heterozygotes

Aga-Fal, S., Oner, R., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 4, p. 471-475 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
29 Citations (Scopus)

βthalassemia in Bulgaria

Petkov, G. H., Efremov, G. D., Efremov, D. G., Dimovski, A., Tchaicarova, P., Tchaicarov, R., Rogina, B., Agarwal, S., Kutlar, A., Kutlar, F., Reese, A. L., Stoning, T. A. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Bulgaria
Thalassemia
Mutation
Oligonucleotide Probes
DNA
75 Citations (Scopus)

βthalassemia in Turkey

Öner, R., Altay, C., Gurgey, A., Aksoy, M., Kilinc, Y., Stoming, T. A., Reese, A. L., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Abnormal Hemoglobins
RNA Splice Sites
Thalassemia
Chromosomes
Turkey
1991
10 Citations (Scopus)

Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade

Zhang, H., Gaginella, T. S., Chen, X. & Cornwell, D. G., Nov 1 1991, In : Agents and Actions. 34, 3-4, p. 397-404 8 p.

Research output: Contribution to journalArticle

Bradykinin
Prostaglandin-Endoperoxide Synthases
Arachidonic Acid
Prostaglandins
Metabolites
28 Citations (Scopus)

Certain mutations observed in the 5’ sequences of theGγ-andAγ-globin genes of βSchromosomes are specific for chromosomes with major haplotypes

Dimovski, A. J., öner, C., Agarwal, S., Gu, Y. C., Gu, L. H., Kutlar, F., Lanclos, K. D. & Huisman, T. H. J., Jan 1 1991, In : Acta Haematologica. 85, 2, p. 79-87 9 p.

Research output: Contribution to journalArticle

Globins
Haplotypes
Chromosomes
Mutation
Genes
12 Citations (Scopus)

Compound heterozygosity for a β{ring operator}-thalassemia (frameshift codons 38/39; -C) and a nondeletional swiss type of HPFH (A→C at NT -110, Gγ) in a Czechoslovakian family

Indrak, K., Indrakova, J., Kutlar, F., Pospisilova, D., Sulovska, I., Baysal, E. & Huisman, T. H. J., Jan 1 1991, In : Annals of Hematology. 63, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

Thalassemia
Heterozygote
Codon
Fetal Hemoglobin
High Pressure Liquid Chromatography
9 Citations (Scopus)

HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

Wilson, J. B., Ramachandran, M., Webber, B. B., Kutlar, F., Hazelnood, L. F., Barnett, D., Hirschler, N. V. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 4, p. 269-278 10 p.

Research output: Contribution to journalArticle

Heme
Substitution reactions
Amino Acid Substitution
Oxygen
Amino Acids
41 Citations (Scopus)

Hemoglobinopathies among the gond tribal groups of central India; interaction of α and βthalassemia with β chain variants

Gupta, R. B., Tiwary, R. S., Pande, P. L., Kutlar, F., Öner, C., Öner, R. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 5, p. 441-458 18 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
Molecular Sequence Data
Abnormal Hemoglobins
Hemoglobinopathies
Thalassemia
1 Citation (Scopus)

Heterogeneity of γ-globin chain synthesis in Saudi newborns

Niazi, G. A., Yaish, H. M., Kutlar, F. & Huisman, T. H. J., Jan 1 1991, In : International Journal of Hematology. 54, 5, p. 377-383 7 p.

Research output: Contribution to journalArticle

Globins
Fetal Hemoglobin
Gene Order
Saudi Arabia
Multigene Family
38 Citations (Scopus)

Molecular characterization of Hb S(C) β‐thalassemia in American blacks

Gonzalez‐Redondo, J. M., Kutlar, A., Kutlar, F., McKie, V. C., McKie, K. M., Baysal, E. & Huisman, T. H. J., Jan 1 1991, In : American Journal of Hematology. 38, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Thalassemia
Mutation
Globins
Chromosomes
Southeastern United States
106 Citations (Scopus)

Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

Lougheed, M., Zhang, H. & Steinbrecher, U. P., Dec 1 1991, In : Journal of Biological Chemistry. 266, 22, p. 14519-14525 7 p.

Research output: Contribution to journalArticle

Cathepsins
Macrophages
LDL Lipoproteins
Apolipoproteins B
oxidized low density lipoprotein
7 Citations (Scopus)

Quantities of adult, fetal and embryonic globin chains in the blood of eighteen- to twenty-week-old human fetuses

Kutlar, F., Moscoso, H., Kiefer, C. R., Garver, F. A., Beksaç, S., Önderoglu, L., Gurgey, A., Altay, Ç. & Huisman, T. H. J., Jul 5 1991, In : Journal of Chromatography B: Biomedical Sciences and Applications. 567, 2, p. 359-368 10 p.

Research output: Contribution to journalArticle

Globins
Fetus
Blood
Program diagnostics
Immunology
10 Citations (Scopus)

The linkage of Hb Valletta [α2β287(F3)Thr→Pro] and Hb F-Malta-I [α2 Gγ2117(G19)His→Arg] in the Maltese population

Kutlar, F., Felice, A. E., Grech, J. L., Bannister, W. H., Kutlar, A., Wilson, J. B., Webber, B. B., Hu, H. & Huisman, T. H. J., Jan 1 1991, In : Human Genetics. 86, 6, p. 591-594 4 p.

Research output: Contribution to journalArticle

Mutation
Population
Heterozygote
Malta
Abnormal Hemoglobins
51 Citations (Scopus)

βthalassemia, HB s-βthalassemia and sickle cell anemia among tunisians

Fattoum, S., Guemira, F., Öner, C., Öner, R., Li, H. W., Kutlar, F. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 1-2, p. 11-21 11 p.

Research output: Contribution to journalArticle

Thalassemia
Oligonucleotide Probes
Sickle Cell Anemia
Haplotypes
Mutation
29 Citations (Scopus)

γ chain abnormalities and γglobin gene rearrangements in newborn babies of various populations

Huisman, T. H. J., Kutlar, F. & Gu, L. H., Jan 1 1991, In : Hemoglobin. 15, 5, p. 349-379 31 p.

Research output: Contribution to journalArticle

Globins
Gene Rearrangement
Genes
Abnormal Hemoglobins
Fetal Hemoglobin
1992
11 Citations (Scopus)

A NOVEL β°‐THALASSAEMIA MUTATION (CODON 15, TGG→TGA) IS PREVALENT IN A POPULATION OF CENTRAL PORTUGAL

Ribeiro, M. L. S., Baysal, E., Kutlar, F., Tamagnini, G. P., Goncalves, P., Lopes, D. & Huisman, T. H. J., Jan 1 1992, In : British Journal of Haematology. 80, 4, p. 567-568 2 p.

Research output: Contribution to journalArticle

Thalassemia
Globins
Portugal
beta-Thalassemia
Codon
19 Citations (Scopus)

Anti-CD3 Monoclonal Antibody Treatment of Patients with CD3-Negative Tumors: A Phase IA/B Study

Urba, W. J., Ewel, C., Kopp, W., Rossio, J., Beveridge, J., Fenton, R., Janik, J., Longo, D. L. & Janik, J. E., Jan 1 1992, In : Cancer Research. 52, 9, p. 2394-2401 8 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
Neoplasms
Therapeutics
Interleukin-2 Receptors
Headache
19 Citations (Scopus)

Black β‐thalassemia homozygotes with specific sequence variations in the 5′ hypersensitive site‐2 of the locus control region have high levels of fetal hemoglobin

Beris, P., Kitundu, M. N., Baysal, E., Öner, C., Lanclos, K. D., Dimovski, A. J., Kutlar, F. & Huisman, T. H. J., Jan 1 1992, In : American Journal of Hematology. 41, 2, p. 97-101 5 p.

Research output: Contribution to journalArticle

Locus Control Region
Fetal Hemoglobin
Thalassemia
Homozygote
Haplotypes
6 Citations (Scopus)

HB shelby [α2β2131(h9)GLN→LYS]-βdeg;thalassemia [codon 15 (TGG→TGA)] identified by DNA sequencing

Cürük, M. A., Kutlar, A. & Huisman, T. H. J., Jan 1 1992, In : Hemoglobin. 16, 5, p. 417-419 3 p.

Research output: Contribution to journalArticle

Abnormal Hemoglobins
DNA
3 Citations (Scopus)

Intensive therapy with cisplatin, interleukin-2 and interferon-alpha-2a in patients with metastatic melanoma. A phase II Study.

Sznol, M., Steis, R. G., Smith, J. W., Janik, J. E., Sharfman, W. H., Urba, W. J., Fenton, R. G., Creekmore, S. P., Beveridge, J. & Longo, D. L., Jul 1 1992, In : The Online journal of current clinical trials [electronic resource]. Doc No 9

Research output: Contribution to journalArticle

Cisplatin
Interleukin-2
Melanoma
Body Surface Area
Interferon-alpha
29 Citations (Scopus)
Seminal Plasma Proteins
Transforming Growth Factors
Semen
Prostate
Intercellular Signaling Peptides and Proteins
40 Citations (Scopus)

Molecular characterization of β-thalassemia in Czechoslovakia

Indrak, K., Brabec, V., Indrakova, J., Chrobak, L., Sakalova, A., Jarosova, M., Cermak, J., Fei, Y. J., Kutlar, F., Gu, Y. C., Baysal, E. & Huisman, T. H. J., Jan 1 1992, In : Human Genetics. 88, 4, p. 399-404 6 p.

Research output: Contribution to journalArticle

Czechoslovakia
Thalassemia
Codon
Mutation
Alleles
31 Citations (Scopus)

Pilot study of interleukin-2 and lymphokine-activated killer cells combined with immunomodulatory doses of chemotherapy and sequenced with interferon alfa-2a in patients with metastatic melanoma and renal cell carcinoma

Sznol, M., Clark, J. W., Smith, J. W., Steis, R. G., Urba, W. J., Rubinstein, L. V., Vandermolen, L. A., Janik, J. E., Sharfman, W. H., Fenton, R. G., Creekmore, S. P., Kremers, P., Conlon, K., Hersey, J., Beveridge, J. & Longo, D. L., Jun 17 1992, In : Journal of the National Cancer Institute. 84, 12, p. 929-937 9 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Renal Cell Carcinoma
Interleukin-2
Melanoma
Drug Therapy