Hematology and Oncology

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1992

The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies

Smith, J. W., Urba, W. J., Curti, B. D., Elwood, L. J., Steis, R. G., Janik, J. E., Sharfman, W. H., Miller, L. L., Fenton, R. G., Conlon, K. C., Sznol, M., Creekmore, S. P., Wells, N. F., Ruscetti, F. W., Keller, J. R., Hestdal, K., Shimizu, M., Rossio, J. & Alvord, W. G., Jan 1 1992, In : Journal of Clinical Oncology. 10, 7, p. 1141-1152 12 p.

Research output: Contribution to journalArticle

138 Scopus citations

The β-thalassaemias: An overview

Kutlar, A., Dec 1 1992, In : Hematology Reviews and Communications. 6, 1-3, p. 17-30 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

βs Haplotypes in various world populations

Öner, C., Dimovski, A. J., Olivieri, N. F., Schiliro, G., Codrington, J. F., Fattoum, S., Adekile, A. D., Öner, R., Yüregir, G. T., Altay, C., Gurgey, A., Gupta, R. B., Jogessar, V. B., Kitundu, M. N., Loukopoulos, D., Tamagnini, G. P., Ribeiro, M. L. S., Kutlar, F., Gu, L. H., Lanclos, K. D. & 1 others, Huisman, T. H. J., Apr 1 1992, In : Human Genetics. 89, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

76 Scopus citations
1991

Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade

Zhang, H., Gaginella, T. S., Chen, X. & Cornwell, D. G., Nov 1 1991, In : Agents and Actions. 34, 3-4, p. 397-404 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Certain mutations observed in the 5’ sequences of theGγ-andAγ-globin genes of βSchromosomes are specific for chromosomes with major haplotypes

Dimovski, A. J., öner, C., Agarwal, S., Gu, Y. C., Gu, L. H., Kutlar, F., Lanclos, K. D. & Huisman, T. H. J., Jan 1 1991, In : Acta Haematologica. 85, 2, p. 79-87 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Compound heterozygosity for a β{ring operator}-thalassemia (frameshift codons 38/39; -C) and a nondeletional swiss type of HPFH (A→C at NT -110, Gγ) in a Czechoslovakian family

Indrak, K., Indrakova, J., Kutlar, F., Pospisilova, D., Sulovska, I., Baysal, E. & Huisman, T. H. J., Jan 1 1991, In : Annals of Hematology. 63, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

Wilson, J. B., Ramachandran, M., Webber, B. B., Kutlar, F., Hazelnood, L. F., Barnett, D., Hirschler, N. V. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 4, p. 269-278 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hemoglobinopathies among the gond tribal groups of central India; interaction of α and βthalassemia with β chain variants

Gupta, R. B., Tiwary, R. S., Pande, P. L., Kutlar, F., Öner, C., Öner, R. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 5, p. 441-458 18 p.

Research output: Contribution to journalArticle

41 Scopus citations

Heterogeneity of γ-globin chain synthesis in Saudi newborns

Niazi, G. A., Yaish, H. M., Kutlar, F. & Huisman, T. H. J., Jan 1 1991, In : International Journal of Hematology. 54, 5, p. 377-383 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular characterization of Hb S(C) β‐thalassemia in American blacks

Gonzalez‐Redondo, J. M., Kutlar, A., Kutlar, F., McKie, V. C., McKie, K. M., Baysal, E. & Huisman, T. H. J., Sep 1991, In : American Journal of Hematology. 38, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

Lougheed, M., Zhang, H. & Steinbrecher, U. P., Dec 1 1991, In : Journal of Biological Chemistry. 266, 22, p. 14519-14525 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Quantities of adult, fetal and embryonic globin chains in the blood of eighteen- to twenty-week-old human fetuses

Kutlar, F., Moscoso, H., Kiefer, C. R., Garver, F. A., Beksaç, S., Önderoglu, L., Gurgey, A., Altay, Ç. & Huisman, T. H. J., Jul 5 1991, In : Journal of Chromatography B: Biomedical Sciences and Applications. 567, 2, p. 359-368 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

The linkage of Hb Valletta [α2β287(F3)Thr→Pro] and Hb F-Malta-I [α2 Gγ2117(G19)His→Arg] in the Maltese population

Kutlar, F., Felice, A. E., Grech, J. L., Bannister, W. H., Kutlar, A., Wilson, J. B., Webber, B. B., Hu, H. & Huisman, T. H. J., Jan 1 1991, In : Human Genetics. 86, 6, p. 591-594 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

βthalassemia, HB s-βthalassemia and sickle cell anemia among tunisians

Fattoum, S., Guemira, F., Öner, C., Öner, R., Li, H. W., Kutlar, F. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 1-2, p. 11-21 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

γ chain abnormalities and γglobin gene rearrangements in newborn babies of various populations

Huisman, T. H. J., Kutlar, F. & Gu, L. H., Jan 1 1991, In : Hemoglobin. 15, 5, p. 349-379 31 p.

Research output: Contribution to journalArticle

29 Scopus citations
1990

Chinese in west Malaysia: the geography of beta thalassaemia mutations.

George-Kodiseri, E., Yang, K. G., Kutlar, F., Wilson, J. B., Kutlar, A., Stoming, T. A., Gonzales-Redondo, J. M. & Huisman, T. H., Jan 1 1990, In : Singapore Medical Journal. 31, 4, p. 374-377 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Compound heterozygosity for a mild β+ and a rare β0-thalassemia allele

Codrington, J., Anijs, J., Wisse, J. H., Codrington, F. A., Li, H., Kutlar, F., Ramachandran, M. & Huisman, T. H. J., Jan 1 1990, In : Acta Haematologica. 84, 3, p. 135-138 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages

Zhang, H., Basra, H. J. K. & Steinbrecher, U. P., Jan 1 1990, In : Journal of Lipid Research. 31, 8, p. 1361-1369 9 p.

Research output: Contribution to journalArticle

109 Scopus citations

Effects of oxidized low density liporoteins on arachidonic acid metabolism in smooth muscle cells

Zhang, H., Davis, W. B., Chen, X., Jones, K. H., Whisler, R. L. & Cornwell, D. G., Jan 1 1990, In : Journal of Lipid Research. 31, 4, p. 551-565 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Fetal hemoglobin in normal adults and β-thalassemia heterozygotes

Kutlar, A., Kutlar, F., Gu, L. G., Mayson, S. M. & Huisman, T. H. J., Jun 1 1990, In : Human Genetics. 85, 1, p. 106-110 5 p.

Research output: Contribution to journalArticle

118 Scopus citations

Hb f-Brooklyn or α2gγ266(e10)LYSGLN

Plaseska, D., Li, H. J., Wilson, J. B., Kutlar, F., Kutlar, A., Huisman, T. H. J. & Kulpa, J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hb f-catala or α2gy2l5(a12)trp →arg

Plaseska, D., Wilson, J. B., Kutlar, F., Font, L., Baiget, H. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hb f-charlotte, an aγ variant with a threonine residue in position γ75 and a glycine residue in position γ136

Plaseska, D., Kutlar, F., Wilson, J. B., Fei, Y. J. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 6, p. 617-625 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met

Plaseska, D., Kutlar, F., Wilson, J. B., Webber, B. B., Zeng, Y. T. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

Harano, T., Harano, K., Doi, K., Ueda, S., Imai, K., Ohba, Y., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hb Hekinan observed in three chinese from macau; identification of the gag→gat mutation in the αl-globin gene

Zhao, W., Wilson, J. B., Webber, B. B., Kutlar, A., Tamagnini, G. P., Kuan, B. & Huisnan, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 6, p. 627-635 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Hb lepore-Baltimore in a north sardinian family

Nasala, B., Manca, L., Wilson, J. B., Webber, B. B., Kutlar, A. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Hb sun prae or α213o(h13)ala → proβ2 a new unstable variant occurring in low quantities

Harkness, M., Harkness, D. R., Kutlar, F., Kutlar, A., Wilson, J. B., Webber, B. B., Codrington, J. F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Hb zengcg or α2β2114(g16)leu → met

Plaseska, D., Wilson, J. B., Gu, L. H., Kutlar, F., Huisman, T. H. J., Zeng, Y. T. & Shen, M., Jan 1 1990, In : Hemoglobin. 14, 5, p. 555-557 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hemoglobin Birmingham and hemoglobin Galicia: Two unstable β chain variants characterized by small deletions and insertions

Wilson, J. B., Webber, B. B., Hu, H., Kutlar, A., Kutlar, F., Codrington, J. F., Prchal, J. T., Hall, K. M., De Pablos, J. M., Rodriguez, I. & Huisman, T. H. J., Jan 1 1990, In : Blood. 75, 9, p. 1883-1887 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular characterization of β‐thalassaemia in 174 Greek patients with thalassaemia major

Kattamis, C., Hu, H., Cheng, G., Reese, A. L., Gonzalez‐Redondo, J. M., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Mar 1990, In : British Journal of Haematology. 74, 3, p. 342-346 5 p.

Research output: Contribution to journalArticle

68 Scopus citations

Myristic acid is incorporates into the two acylatable domains of the functional glycoprotein CD9 in ester, but not in amide bonds

Seehafer, J. G., Slupsky, J. R., Tang, S. C., Masellis-Smith, A. & Shaw, A. R. E., Jun 19 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1039, 2, p. 218-226 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Observations on the levels of Hb A2 in patients with different β-thalassemia mutations and a δ chain variant

Codrington, J. F., Li, H. W., Kutlar, F., Gu, L. H., Ramachandran, M. & Huisman, T. H. J., Jan 1 1990, In : Blood. 76, 6, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

52 Scopus citations

Role of oxidatively modified LDL in atherosclerosis

Steinbrecher, U. P., Zhang, H. & Lougheed, M., Jan 1 1990, In : Free Radical Biology and Medicine. 9, 2, p. 155-168 14 p.

Research output: Contribution to journalArticle

545 Scopus citations

The detection of hemoglobin variants by isoelectrofocusing using EDTA-collected and filter paper-dried cord blood specimens

Kutlar, A., Ozcan, O., Brisco, J. T., Ansley, M. C. & Huisman, T. H. J., Jan 1 1990, In : American Journal of Clinical Pathology. 94, 2, p. 199-202 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Variation in the level of fetal hemoglobin in (δβ)°‐thalassemia heterozygotes with different numbers of α‐globin genes

Öner, C., Gurgey, A., Altay, C., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : American Journal of Hematology. 34, 3, p. 230-231 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

αthalassemia DUE toframeshifts at codons 5, 6, 8, and 8/9; hematological observations in heterozygotes

Aga-Fal, S., Oner, R., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 4, p. 471-475 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

βthalassemia in Bulgaria

Petkov, G. H., Efremov, G. D., Efremov, D. G., Dimovski, A., Tchaicarova, P., Tchaicarov, R., Rogina, B., Agarwal, S., Kutlar, A., Kutlar, F., Reese, A. L., Stoning, T. A. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

βthalassemia in Turkey

Öner, R., Altay, C., Gurgey, A., Aksoy, M., Kilinc, Y., Stoming, T. A., Reese, A. L., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

75 Scopus citations
1989

A C→T substitution at nt -101 in a conserved DNA sequence of the promotor region of the β-globin gene is associated with 'silent' β-thalassemia

Gonzalez-Redondo, J. M., Stoming, T. A., Kutlar, A., Kutlar, F., Lanclos, K. D., Howard, E. F., Fei, Y. J., Aksoy, M., Altay, C., Gurgey, A., Basak, A. N., Efremov, G. D., Petkov, G. & Huisman, T. H. J., Jan 1 1989, In : Blood. 73, 6, p. 1705-1711 7 p.

Research output: Contribution to journalArticle

111 Scopus citations

An (A)γ type of nondeletional hereditary persistence of fetal hemoglobin with a T → C mutation at position -175 to the cap site of the (A)γ globin gene

Stoming, T. A., Stoming, G. S., Lanclos, K. D., Fei, Y. J., Altay, C., Kutlar, F. & Huisman, T. H. J., Jan 1 1989, In : Blood. 73, 1, p. 329-333 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

A search for anomalies in the ζalpha;beta; and γ globin gene arrangements in normal black, italian, turkish, and Spanish newborns

Fei, Y. J., Kutlar, F., Harris, H. F., Wilson, M. M., Milana, A., Sciacca, P., Schiliro, G., Masaia, B., Manca, L., Altay, C., Gurgey, A., de Pablos, J. M., Villegas, A. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 1, p. 45-65 21 p.

Research output: Contribution to journalArticle

48 Scopus citations

beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya.

Ojwang, P. J., Ogada, T., Gonzalez-Redondo, J. M., Kutlar, A., Kutlar, F. & Huisman, T. H., Jun 1 1989, In : East African Medical Journal. 66, 6, p. 377-380 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Clinical and Molecular Characterization of Thalassemia Intermedia and Thalassemia Major in American Blacks

GONZALEZ‐REDONDO, J. M., STOMING, T. A., KUTLAR, F., KUTLAR, A. & HUISMAN, T. H. J., Jul 1989, In : Annals of the New York Academy of Sciences. 565, 1, p. 398-401 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Evidence that monoclonal antibodies against CD9 antigen induce specific association between CD9 and the platelet glycoprotein IIb-IIIa complex

Slupsky, J. R., Seehafer, J. G., Tang, S. C., Masellis-Smith, A. & Shaw, A. R. E., Jan 1 1989, In : Journal of Biological Chemistry. 264, 21, p. 12289-12293 5 p.

Research output: Contribution to journalArticle

125 Scopus citations

First observation of haemoglobin Malay alpha 2B2 26 (B1) Asn----Ser--a case report.

George, E., Huisman, T. H., Yang, K. G., Kutlari, F., Wilson, J. B., Kutlar, A., Storming, T. A., Gonzales-Redondo, J. M., Faridah, K. & Khalid, A. K., Sep 1 1989, In : Medical Journal of Malaysia. 44, 3, p. 259-262 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hb A2-Wrens or α2δ298(FG5)Val → MEt, an unstable δ chain variant identified by sequence analysis of amplified DNA

Codrington, J. F., Kutlar, F., Harris, H. F., Wilson, J. B., Stoming, T. A. & H.J. Huisman, T., Sep 21 1989, In : BBA - Gene Structure and Expression. 1009, 1, p. 87-89 3 p.

Research output: Contribution to journalArticle

18 Scopus citations

HB brockton [α2β2138(h16)ALA→PRO] observed in a turkish girl

Ulukutlu, L., Ozsahin, H., Wilson, J. B., Webber, B. B., Hu, H., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 5, p. 509-513 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

HB Chandigarh or α2β294(FGl)ASP→GLY observed in an indian family

Dash, S., Webber, B. B., Kutlar, A., Huisman, T. H. J. & Wilson, J. B., Jan 1 1989, In : Hemoglobin. 13, 7-8, p. 749-752 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hb evans or α262(e11)val→metβ2; an unstable hemoglobin causing a mild hemolytic anemia

Wilson, J. B., Webber, B. B., Kutlar, A., Reese, A. L., Mckie, V. C., Lutcher, C. L., Felice, A. E. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 6, p. 557-566 10 p.

Research output: Contribution to journalArticle

13 Scopus citations