Hematology and Oncology

Research Output 1963 2019

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Article
1992
117 Citations (Scopus)

The receptor for the basement membrane glycoprotein entactin is the integrin α3/β1

Dedhar, S., Jewell, K., Rojiani, M. & Gray, V., Jan 1 1992, In : Journal of Biological Chemistry. 267, 26, p. 18908-18914 7 p.

Research output: Contribution to journalArticle

Membrane Glycoproteins
Basement Membrane
Integrins
Sepharose
Laminin
137 Citations (Scopus)

The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies

Smith, J. W., Urba, W. J., Curti, B. D., Elwood, L. J., Steis, R. G., Janik, J. E., Sharfman, W. H., Miller, L. L., Fenton, R. G., Conlon, K. C., Sznol, M., Creekmore, S. P., Wells, N. F., Ruscetti, F. W., Keller, J. R., Hestdal, K., Shimizu, M., Rossio, J. & Alvord, W. G., Jan 1 1992, In : Journal of Clinical Oncology. 10, 7, p. 1141-1152 12 p.

Research output: Contribution to journalArticle

Interleukin-1alpha
Poisons
Interleukin-1
Neoplasms
Indomethacin
6 Citations (Scopus)

The β-thalassaemias: An overview

Kutlar, A., Dec 1 1992, In : Hematology Reviews and Communications. 6, 1-3, p. 17-30 14 p.

Research output: Contribution to journalArticle

Thalassemia
Globins
Mutation
Inborn Genetic Diseases
beta-Thalassemia
76 Citations (Scopus)

β s Haplotypes in various world populations

Öner, C., Dimovski, A. J., Olivieri, N. F., Schiliro, G., Codrington, J. F., Fattoum, S., Adekile, A. D., Öner, R., Yüregir, G. T., Altay, C., Gurgey, A., Gupta, R. B., Jogessar, V. B., Kitundu, M. N., Loukopoulos, D., Tamagnini, G. P., Ribeiro, M. L. S., Kutlar, F., Gu, L. H., Lanclos, K. D. & 1 others, Huisman, T. H. J., Apr 1 1992, In : Human Genetics. 89, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

Haplotypes
Population
Hemoglobin SC Disease
Cameroon
Thalassemia
1991
10 Citations (Scopus)

Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade

Zhang, H., Gaginella, T. S., Chen, X. & Cornwell, D. G., Nov 1 1991, In : Agents and Actions. 34, 3-4, p. 397-404 8 p.

Research output: Contribution to journalArticle

Bradykinin
Prostaglandin-Endoperoxide Synthases
Arachidonic Acid
Prostaglandins
Metabolites
28 Citations (Scopus)

Certain mutations observed in the 5’ sequences of theGγ-andAγ-globin genes of βSchromosomes are specific for chromosomes with major haplotypes

Dimovski, A. J., öner, C., Agarwal, S., Gu, Y. C., Gu, L. H., Kutlar, F., Lanclos, K. D. & Huisman, T. H. J., Jan 1 1991, In : Acta Haematologica. 85, 2, p. 79-87 9 p.

Research output: Contribution to journalArticle

Globins
Haplotypes
Chromosomes
Mutation
Genes
12 Citations (Scopus)

Compound heterozygosity for a β{ring operator}-thalassemia (frameshift codons 38/39; -C) and a nondeletional swiss type of HPFH (A→C at NT -110, Gγ) in a Czechoslovakian family

Indrak, K., Indrakova, J., Kutlar, F., Pospisilova, D., Sulovska, I., Baysal, E. & Huisman, T. H. J., Jan 1 1991, In : Annals of Hematology. 63, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

Thalassemia
Heterozygote
Codon
Fetal Hemoglobin
High Pressure Liquid Chromatography
9 Citations (Scopus)

HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

Wilson, J. B., Ramachandran, M., Webber, B. B., Kutlar, F., Hazelnood, L. F., Barnett, D., Hirschler, N. V. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 4, p. 269-278 10 p.

Research output: Contribution to journalArticle

Heme
Substitution reactions
Amino Acid Substitution
Oxygen
Amino Acids
41 Citations (Scopus)

Hemoglobinopathies among the gond tribal groups of central India; interaction of α and βthalassemia with β chain variants

Gupta, R. B., Tiwary, R. S., Pande, P. L., Kutlar, F., Öner, C., Öner, R. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 5, p. 441-458 18 p.

Research output: Contribution to journalArticle

Abnormal Hemoglobins
Globins
1 Citation (Scopus)

Heterogeneity of γ-globin chain synthesis in Saudi newborns

Niazi, G. A., Yaish, H. M., Kutlar, F. & Huisman, T. H. J., Jan 1 1991, In : International Journal of Hematology. 54, 5, p. 377-383 7 p.

Research output: Contribution to journalArticle

Globins
Fetal Hemoglobin
Gene Order
Saudi Arabia
Multigene Family
38 Citations (Scopus)

Molecular characterization of Hb S(C) β‐thalassemia in American blacks

Gonzalez‐Redondo, J. M., Kutlar, A., Kutlar, F., McKie, V. C., McKie, K. M., Baysal, E. & Huisman, T. H. J., Jan 1 1991, In : American Journal of Hematology. 38, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Thalassemia
Mutation
Globins
Chromosomes
Southeastern United States
106 Citations (Scopus)

Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

Lougheed, M., Zhang, H. & Steinbrecher, U. P., Dec 1 1991, In : Journal of Biological Chemistry. 266, 22, p. 14519-14525 7 p.

Research output: Contribution to journalArticle

Cathepsins
Macrophages
LDL Lipoproteins
Apolipoproteins B
oxidized low density lipoprotein
7 Citations (Scopus)

Quantities of adult, fetal and embryonic globin chains in the blood of eighteen- to twenty-week-old human fetuses

Kutlar, F., Moscoso, H., Kiefer, C. R., Garver, F. A., Beksaç, S., Önderoglu, L., Gurgey, A., Altay, Ç. & Huisman, T. H. J., Jul 5 1991, In : Journal of Chromatography B: Biomedical Sciences and Applications. 567, 2, p. 359-368 10 p.

Research output: Contribution to journalArticle

Globins
Fetus
Blood
Program diagnostics
Immunology
10 Citations (Scopus)

The linkage of Hb Valletta [α2β287(F3)Thr→Pro] and Hb F-Malta-I [α2 Gγ2117(G19)His→Arg] in the Maltese population

Kutlar, F., Felice, A. E., Grech, J. L., Bannister, W. H., Kutlar, A., Wilson, J. B., Webber, B. B., Hu, H. & Huisman, T. H. J., Jan 1 1991, In : Human Genetics. 86, 6, p. 591-594 4 p.

Research output: Contribution to journalArticle

Mutation
Population
Heterozygote
Malta
Abnormal Hemoglobins
51 Citations (Scopus)

βthalassemia, HB s-βthalassemia and sickle cell anemia among tunisians

Fattoum, S., Guemira, F., Öner, C., Öner, R., Li, H. W., Kutlar, F. & Huisman, T. H. J., Jan 1 1991, In : Hemoglobin. 15, 1-2, p. 11-21 11 p.

Research output: Contribution to journalArticle

Thalassemia
Oligonucleotide Probes
Sickle Cell Anemia
Haplotypes
Mutation
29 Citations (Scopus)

γ chain abnormalities and γglobin gene rearrangements in newborn babies of various populations

Huisman, T. H. J., Kutlar, F. & Gu, L. H., Jan 1 1991, In : Hemoglobin. 15, 5, p. 349-379 31 p.

Research output: Contribution to journalArticle

Globins
Gene Rearrangement
Genes
Abnormal Hemoglobins
Fetal Hemoglobin
1990
9 Citations (Scopus)

Chinese in west Malaysia: the geography of beta thalassaemia mutations.

George-Kodiseri, E., Yang, K. G., Kutlar, F., Wilson, J. B., Kutlar, A., Stoming, T. A., Gonzales-Redondo, J. M. & Huisman, T. H., Jan 1 1990, In : Singapore Medical Journal. 31, 4, p. 374-377 4 p.

Research output: Contribution to journalArticle

Geography
beta-Thalassemia
Malaysia
Mutation
Codon
5 Citations (Scopus)

Compound heterozygosity for a mild β+ and a rare β0-thalassemia allele

Codrington, J., Anijs, J., Wisse, J. H., Codrington, F. A., Li, H., Kutlar, F., Ramachandran, M. & Huisman, T. H. J., Jan 1 1990, In : Acta Haematologica. 84, 3, p. 135-138 4 p.

Research output: Contribution to journalArticle

Thalassemia
Heterozygote
Alleles
Mutation
Suriname
109 Citations (Scopus)

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages

Zhang, H., Basra, H. J. K. & Steinbrecher, U. P., Jan 1 1990, In : Journal of Lipid Research. 31, 8, p. 1361-1369 9 p.

Research output: Contribution to journalArticle

Macrophages
Esterification
LDL Lipoproteins
LDL Cholesterol
Cholesterol
20 Citations (Scopus)

Effects of oxidized low density liporoteins on arachidonic acid metabolism in smooth muscle cells

Zhang, H., Davis, W. B., Chen, X., Jones, K. H., Whisler, R. L. & Cornwell, D. G., Jan 1 1990, In : Journal of Lipid Research. 31, 4, p. 551-565 15 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Metabolism
Smooth Muscle Myocytes
Muscle
Prostaglandins
118 Citations (Scopus)

Fetal hemoglobin in normal adults and β-thalassemia heterozygotes

Kutlar, A., Kutlar, F., Gu, L. G., Mayson, S. M. & Huisman, T. H. J., Jun 1 1990, In : Human Genetics. 85, 1, p. 106-110 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Thalassemia
Heterozygote
Mutation
Codon
4 Citations (Scopus)

Hb f-Brooklyn or α2gγ266(e10)LYSGLN

Plaseska, D., Li, H. J., Wilson, J. B., Kutlar, F., Kutlar, A., Huisman, T. H. J. & Kulpa, J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Hemoglobins
Blood
Abnormal Hemoglobins
Electrophoresis
Screening
4 Citations (Scopus)

Hb f-catala or α2 gy2l5(a12)trp →arg

Plaseska, D., Wilson, J. B., Kutlar, F., Font, L., Baiget, H. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

compound A 12
Spain
Substitution reactions
Amino Acids
Liquids
11 Citations (Scopus)

Hb f-charlotte, an aγ variant with a threonine residue in position γ75 and a glycine residue in position γ136

Plaseska, D., Kutlar, F., Wilson, J. B., Fei, Y. J. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 6, p. 617-625 9 p.

Research output: Contribution to journalArticle

Threonine
Glycine
Blood
Substitution reactions
Genes
4 Citations (Scopus)

Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met

Plaseska, D., Kutlar, F., Wilson, J. B., Webber, B. B., Zeng, Y. T. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

methionylmethionine
Valine
Fetal Blood
Methionine
Substitution reactions
4 Citations (Scopus)

Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

Harano, T., Harano, K., Doi, K., Ueda, S., Imai, K., Ohba, Y., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Gene Order
Globins
High performance liquid chromatography
Reverse-Phase Chromatography
13 Citations (Scopus)

Hb Hekinan observed in three chinese from macau; identification of the gag→gat mutation in the αl-globin gene

Zhao, W., Wilson, J. B., Webber, B. B., Kutlar, A., Tamagnini, G. P., Kuan, B. & Huisnan, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 6, p. 627-635 9 p.

Research output: Contribution to journalArticle

Macau
Globins
High performance liquid chromatography
Aspartic Acid
Purification
7 Citations (Scopus)

Hb lepore-Baltimore in a north sardinian family

Nasala, B., Manca, L., Wilson, J. B., Webber, B. B., Kutlar, A. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

Abnormal Hemoglobins
Italy
Amino Acids
hemoglobin Lepore Baltimore
26 Citations (Scopus)

Hb sun prae or α213o(h13)ala → proβ2 a new unstable variant occurring in low quantities

Harkness, M., Harkness, D. R., Kutlar, F., Kutlar, A., Wilson, J. B., Webber, B. B., Codrington, J. F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Solar System
Sun
Globins
Genes
Mutation
6 Citations (Scopus)

Hb zengcg or α2β2114(g16)leu → met

Plaseska, D., Wilson, J. B., Gu, L. H., Kutlar, F., Huisman, T. H. J., Zeng, Y. T. & Shen, M., Jan 1 1990, In : Hemoglobin. 14, 5, p. 555-557 3 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Abnormal Hemoglobins
Heterozygote
Amino Acid Sequence
Newborn Infant
9 Citations (Scopus)

Hemoglobin Birmingham and hemoglobin Galicia: Two unstable β chain variants characterized by small deletions and insertions

Wilson, J. B., Webber, B. B., Hu, H., Kutlar, A., Kutlar, F., Codrington, J. F., Prchal, J. T., Hall, K. M., De Pablos, J. M., Rodriguez, I. & Huisman, T. H. J., Jan 1 1990, In : Blood. 75, 9, p. 1883-1887 5 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Glutamine
Codon
Leucine
Hemoglobins
68 Citations (Scopus)

Molecular characterization of β‐thalassaemia in 174 Greek patients with thalassaemia major

Kattamis, C., Hu, H., Cheng, G., Reese, A. L., Gonzalez‐Redondo, J. M., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : British Journal of Haematology. 74, 3, p. 342-346 5 p.

Research output: Contribution to journalArticle

Thalassemia
beta-Thalassemia
Mutation
Oligonucleotide Probes
Chromosome Mapping
9 Citations (Scopus)

Myristic acid is incorporates into the two acylatable domains of the functional glycoprotein CD9 in ester, but not in amide bonds

Seehafer, J. G., Slupsky, J. R., Tang, S-C., Masellis-Smith, A. & Shaw, A. R. E., Jun 19 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1039, 2, p. 218-226 9 p.

Research output: Contribution to journalArticle

Myristic Acid
Amides
Glycoproteins
Esters
Fatty Acids
51 Citations (Scopus)

Observations on the levels of Hb A2 in patients with different β-thalassemia mutations and a δ chain variant

Codrington, J. F., Li, H. W., Kutlar, F., Gu, L. H., Ramachandran, M. & Huisman, T. H. J., Jan 1 1990, In : Blood. 76, 6, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

Thalassemia
Globins
Genes
Mutation
Heterozygote
25 Citations (Scopus)
Escherichia coli
Proteins
Amino Acyl-tRNA Synthetases
Transfer RNA
Plasmids
543 Citations (Scopus)

Role of oxidatively modified LDL in atherosclerosis

Steinbrecher, U. P., Zhang, H. & Lougheed, M., Jan 1 1990, In : Free Radical Biology and Medicine. 9, 2, p. 155-168 14 p.

Research output: Contribution to journalArticle

Atherosclerosis
Oxidation
Apolipoproteins B
Macrophages
Phosphatidylcholines
6 Citations (Scopus)

The detection of hemoglobin variants by isoelectrofocusing using EDTA-collected and filter paper-dried cord blood specimens

Kutlar, A., Ozcan, O., Brisco, J. T., Ansley, M. C. & Huisman, T. H. J., Jan 1 1990, In : American Journal of Clinical Pathology. 94, 2, p. 199-202 4 p.

Research output: Contribution to journalArticle

Fetal Blood
Edetic Acid
Hemoglobins
Abnormal Hemoglobins
Hemoglobinopathies
6 Citations (Scopus)

Variation in the level of fetal hemoglobin in (δβ)°‐thalassemia heterozygotes with different numbers of α‐globin genes

Öner, C., Gurgey, A., Altay, C., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : American Journal of Hematology. 34, 3, p. 230-231 2 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Thalassemia
Globins
Heterozygote
Fathers
1 Citation (Scopus)

αthalassemia DUE toframeshifts at codons 5, 6, 8, and 8/9; hematological observations in heterozygotes

Aga-Fal, S., Oner, R., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 4, p. 471-475 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
29 Citations (Scopus)

βthalassemia in Bulgaria

Petkov, G. H., Efremov, G. D., Efremov, D. G., Dimovski, A., Tchaicarova, P., Tchaicarov, R., Rogina, B., Agarwal, S., Kutlar, A., Kutlar, F., Reese, A. L., Stoning, T. A. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Bulgaria
Thalassemia
Mutation
Oligonucleotide Probes
DNA
75 Citations (Scopus)

βthalassemia in Turkey

Öner, R., Altay, C., Gurgey, A., Aksoy, M., Kilinc, Y., Stoming, T. A., Reese, A. L., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1990, In : Hemoglobin. 14, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Abnormal Hemoglobins
RNA Splice Sites
Thalassemia
Chromosomes
Turkey
1989
111 Citations (Scopus)

A C→T substitution at nt -101 in a conserved DNA sequence of the promotor region of the β-globin gene is associated with 'silent' β-thalassemia

Gonzalez-Redondo, J. M., Stoming, T. A., Kutlar, A., Kutlar, F., Lanclos, K. D., Howard, E. F., Fei, Y. J., Aksoy, M., Altay, C., Gurgey, A., Basak, A. N., Efremov, G. D., Petkov, G. & Huisman, T. H. J., Jan 1 1989, In : Blood. 73, 6, p. 1705-1711 7 p.

Research output: Contribution to journalArticle

Thalassemia
Globins
Conserved Sequence
DNA sequences
Hemoglobin A2
34 Citations (Scopus)

An (A)γ type of nondeletional hereditary persistence of fetal hemoglobin with a T → C mutation at position -175 to the cap site of the (A)γ globin gene

Stoming, T. A., Stoming, G. S., Lanclos, K. D., Fei, Y. J., Altay, C., Kutlar, F. & Huisman, T. H. J., Jan 1 1989, In : Blood. 73, 1, p. 329-333 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Genes
Mutation
Hemoglobin A
48 Citations (Scopus)

A search for anomalies in the ζalpha;beta; and γ globin gene arrangements in normal black, italian, turkish, and Spanish newborns

Fei, Y. J., Kutlar, F., Harris, H. F., Wilson, M. M., Milana, A., Sciacca, P., Schiliro, G., Masaia, B., Manca, L., Altay, C., Gurgey, A., de Pablos, J. M., Villegas, A. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 1, p. 45-65 21 p.

Research output: Contribution to journalArticle

Gene Order
Thalassemia
Globins
Genes
Chromosome Mapping
6 Citations (Scopus)

beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya.

Ojwang, P. J., Ogada, T., Gonzalez-Redondo, J. M., Kutlar, A., Kutlar, F. & Huisman, T. H., Jun 1 1989, In : East African Medical Journal. 66, 6, p. 377-380 4 p.

Research output: Contribution to journalArticle

alpha-Thalassemia
Kenya
Haplotypes
Genes
gamma-Globins
3 Citations (Scopus)

Clinical and Molecular Characterization of Thalassemia Intermedia and Thalassemia Major in American Blacks

GONZALEZ‐REDONDO, J. M., STOMING, T. A., Kutlar, F., Kutlar, A. & HUISMAN, T. H. J., Jan 1 1989, In : Annals of the New York Academy of Sciences. 565, 1, p. 398-401 4 p.

Research output: Contribution to journalArticle

beta-Thalassemia
Intermedia
125 Citations (Scopus)

Evidence that monoclonal antibodies against CD9 antigen induce specific association between CD9 and the platelet glycoprotein IIb-IIIa complex

Slupsky, J. R., Seehafer, J. G., Tang, S. C., Masellis-Smith, A. & Shaw, A. R. E., Jan 1 1989, In : Journal of Biological Chemistry. 264, 21, p. 12289-12293 5 p.

Research output: Contribution to journalArticle

CD9 Antigen
Integrin beta3
Platelet Membrane Glycoproteins
Platelet Glycoprotein GPIIb-IIIa Complex
Platelets
6 Citations (Scopus)

First observation of haemoglobin Malay alpha 2B2 26 (B1) Asn----Ser--a case report.

George, E., Huisman, T. H., Yang, K. G., Kutlari, F., Wilson, J. B., Kutlar, A., Storming, T. A., Gonzales-Redondo, J. M., Faridah, K. & Khalid, A. K., Sep 1 1989, In : Medical Journal of Malaysia. 44, 3, p. 259-262 4 p.

Research output: Contribution to journalArticle

Hemoglobins
Observation
Codon
Mutation
hemoglobin Malay
18 Citations (Scopus)

Hb A2-Wrens or α2δ298(FG5)Val → MEt, an unstable δ chain variant identified by sequence analysis of amplified DNA

Codrington, J. F., Kutlar, F., Harris, H. F., Wilson, J. B., Stoming, T. A. & H.J. Huisman, T., Sep 21 1989, In : BBA - Gene Structure and Expression. 1009, 1, p. 87-89 3 p.

Research output: Contribution to journalArticle

Thalassemia
DNA Sequence Analysis
Peptide T
Globins
DNA
9 Citations (Scopus)

HB brockton [α2β2138(h16)ALA→PRO] observed in a turkish girl

Ulukutlu, L., Ozsahin, H., Wilson, J. B., Webber, B. B., Hu, H., Kutlar, A., Kutlar, F. & Huisman, T. H. J., Jan 1 1989, In : Hemoglobin. 13, 5, p. 509-513 5 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Abnormal Hemoglobins
Protein Denaturation
Peptide Fragments
Turkey