Projects 1975 2019

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hypertension
sodium
single nucleotide polymorphism
genes
salt stress

T cell regulation by IDO-competent plasmacytoid dendritic cells

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

5/22/094/30/12

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Dendritic Cells
T-Lymphocytes
Islets of Langerhans
Inflammation
Natriuresis
Pressure
Natriuretic Peptides
Sodium
Heart Failure
Campylobacter jejuni
Virulence
Regulon
Gastroenteritis
Biofilms
Nephritis
Antibodies
Pharmaceutical Preparations
Kidney
Glomerulonephritis
HLA-G Antigens
Dendritic Cells
Transplantation
Allografts
T-Lymphocytes
Immunity
Immunization
T-Lymphocytes
Antigen Presentation
Immunotherapy

SPORE in Prostate Cancer

Young, C., Fatemi, M., Morris, J. C., Thibodeau, S. N., Vile, R., Vasmatzis, G., Jenkins, R. B., Bergstralh, E. J., Cheville, J., Klee, G., Tindall, D. J., Davis, B., Sargent, D., Layton, D., Vuk-Pavlovic, S. & Celis, E.

National Institutes of Health

8/31/018/31/13

Project: Research project

Prostatic Neoplasms
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
Neoplasms
Therapeutics

MOLECULAR REGULATION OF ENDOTHELIAL CELL PERMEABILITY

Langan, G. P., Ratneshwar, L., Garcia, J. G. N., Birukov, K., Natarajan, V., Salgia, R., English, D. K., Patterson, C., Romer, L., Crow, M. T., Hassoun, P. & Verin, A. D.

National Institutes of Health

2/1/981/31/14

Project: Research project

Microtubules
Lung
Endothelial Cells
Permeability
Myosin Light Chains
rural community
nicotine
morbidity
mortality
school system
African Americans
Tobacco
Living Wills
Tobacco Use

Mechanisms of Vascular Dysfunction in Cirrhosis

Khurana, S.

National Institutes of Health

7/28/086/30/14

Project: Research project

Bile Acids and Salts
Gastroenterology
Blood Vessels
Vasodilation
Fibrosis
Defecation
Constipation
Brain
Therapeutics
Laxatives
Spinal Cord Diseases
Veterans
Spinal Cord Injuries
Bone Density
Photon Absorptiometry

Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke

Sazonova, I. Y., Pellock, J., Pellock, J. & Verin, A.

National Institutes of Health

12/7/871/31/15

Project: Research project

Fibrinolysin
Stroke
Tissue Plasminogen Activator
Fibrinolytic Agents
Thrombolytic Therapy
Abdominal Aortic Aneurysm
Angiotensin II
Aneurysm
Oxidative Stress
Peroxidase
Stem Cells
CXCR4 Receptors
Myocardial Ischemia
Myocardium
Cell Survival

Manipulating natural host immunoregulation via IDO during viral Infection

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

5/1/094/30/15

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Virus Diseases
T-Lymphocytes
Regulatory T-Lymphocytes
Infection
Catenins
Dendritic Cells
Autoimmune Experimental Encephalomyelitis
Brain
Multiple Sclerosis

Exercise &Overweight Children's Cognition

McDowell, J., Tomporowski, P., Davis, C. M. & Davis, C. L.

National Institutes of Health

9/5/087/31/15

Project: Research project

Cognition
Exercise
Executive Function
Pediatric Obesity
Research
Epigenomics
Cardiovascular Diseases
Depression
Methylation
Major Depressive Disorder
Blood Vessels
Type 2 Diabetes Mellitus
Indoleamine-Pyrrole 2,3,-Dioxygenase
Arginase
Cytokines

NCMHD Southeastern Exploratory Sickle Cell Center of Excellence

Adamkiewicz, T., Gibson, R. W., Ikuta, T., Kutlar, A., Gibson, R. W., Gibson, R. W. & Tuan Lo, D.

National Institutes of Health

5/28/0912/31/15

Project: Research project

Sickle Cell Anemia
Hydroxyurea
gamma-Globins
Globins
Opioid Analgesics
Epigenomics
Type 2 Diabetes Mellitus
Methylation
Cardiovascular Diseases
Obesity
Subunit Vaccines
Melanoma
Vaccines
T-Lymphocytes
Neoplasms
Molecular Chaperones
Neurodegenerative Diseases
Molecular Probes
Humulus
Metabolic Diseases
Bone and Bones
Food
Mesenchymal Stromal Cells
Stem Cells
Leptin

VASCULAR MECHANISMS IN ATHEROGENESIS

Lentz, S., Faraci, F., Farci, F., Sigmund, C. D., Heistad, D. & Weintraub, N. L.

National Institutes of Health

6/1/004/30/16

Project: Research project

Surface-Active Agents
Smooth Muscle Myocytes
Pulmonary Surfactant-Associated Protein D
Blood Vessels
Inflammation
Methylation
Genome
DNA Methylation
Epigenomics
Essential Hypertension
Acute Lung Injury
Endothelial Cells
Protein Kinase C-alpha
Adenosine
Proteins
Fecal Incontinence
Therapeutics
Lower Gastrointestinal Tract
Pelvic Floor
Muscle Strength

Engineering DNA nanoparticles to create immune tolerance

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

6/15/135/31/17

Project: Research project

Immune Tolerance
Indoleamine-Pyrrole 2,3,-Dioxygenase
Nanoparticles
DNA
Interferons
Angiotensin II
High Fat Diet
Adipose Tissue
Atherosclerosis
Blood Vessels
Catenins
beta Catenin
Dendritic Cells
Inflammation
Inflammatory Bowel Diseases
T-Lymphocytes
Recurrence
Drug Therapy
Neoplasms
Immunity
Subunit Vaccines
Interferon-gamma
T-Lymphocytes
Neoplasms
Immunotherapy

The Role of Endothelin-1 in Sickle Cell Disease

Meiler, S., Pollock, D. & Kutlar, A.

National Institutes of Health

8/15/135/31/18

Project: Research project

Sickle Cell Anemia
Endothelin-1
Translational Medical Research
Research
Pain
Nephritis
Podocytes
Peptides
Glomerulonephritis
Endothelial Cells
Campylobacter jejuni
Campylobacter
Biofilms
Virulence
Regulon
Glypicans
alpha-Fetoproteins
Hepatocellular Carcinoma
Vaccines
Autoantigens
DNA Methylation
Psychological Stress
Epigenomics
Health
Substance-Related Disorders

Stress Related Mechanisms of Hypertension Risk

Gutin, B., Layman, L., Pollock, D., Treiber, F., Pollock, J., Strong, W., Smith, D., George, V., Dong, Y., Kapuku, K. G. & Harshfield, G. A.

National Institutes of Health

7/1/026/30/19

Project: Research project

Hypertension
Renin-Angiotensin System
Natriuresis
Sodium
Biological Assay
Myeloid Cells
Carcinogenesis
Neoplasms
Inflammation
Kupffer Cells