Projects 1975 2019

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Myeloid Cells
Carcinogenesis
Neoplasms
Inflammation
Kupffer Cells

Stress Related Mechanisms of Hypertension Risk

Gutin, B., Layman, L., Pollock, D., Treiber, F., Pollock, J., Strong, W., Smith, D., George, V., Dong, Y., Kapuku, K. G. & Harshfield, G. A.

National Institutes of Health

7/1/026/30/19

Project: Research project

Hypertension
Renin-Angiotensin System
Natriuresis
Sodium
Biological Assay
DNA Methylation
Psychological Stress
Epigenomics
Health
Substance-Related Disorders
Glypicans
alpha-Fetoproteins
Hepatocellular Carcinoma
Vaccines
Autoantigens
Campylobacter jejuni
Campylobacter
Biofilms
Virulence
Regulon
Nephritis
Podocytes
Peptides
Glomerulonephritis
Endothelial Cells

The Role of Endothelin-1 in Sickle Cell Disease

Meiler, S., Pollock, D. & Kutlar, A.

National Institutes of Health

8/15/135/31/18

Project: Research project

Sickle Cell Anemia
Endothelin-1
Translational Medical Research
Research
Pain
Subunit Vaccines
Interferon-gamma
T-Lymphocytes
Neoplasms
Immunotherapy
T-Lymphocytes
Recurrence
Drug Therapy
Neoplasms
Immunity
Catenins
beta Catenin
Dendritic Cells
Inflammation
Inflammatory Bowel Diseases

Engineering DNA nanoparticles to create immune tolerance

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

6/15/135/31/17

Project: Research project

Immune Tolerance
Indoleamine-Pyrrole 2,3,-Dioxygenase
Nanoparticles
DNA
Interferons
Angiotensin II
High Fat Diet
Adipose Tissue
Atherosclerosis
Blood Vessels
Fecal Incontinence
Therapeutics
Lower Gastrointestinal Tract
Pelvic Floor
Muscle Strength
Acute Lung Injury
Endothelial Cells
Protein Kinase C-alpha
Adenosine
Proteins
Methylation
Genome
DNA Methylation
Epigenomics
Essential Hypertension
Subunit Vaccines
Melanoma
Vaccines
T-Lymphocytes
Neoplasms
Molecular Chaperones
Neurodegenerative Diseases
Molecular Probes
Humulus
Metabolic Diseases

VASCULAR MECHANISMS IN ATHEROGENESIS

Lentz, S., Faraci, F., Farci, F., Sigmund, C. D., Heistad, D. & Weintraub, N. L.

National Institutes of Health

6/1/004/30/16

Project: Research project

Surface-Active Agents
Smooth Muscle Myocytes
Pulmonary Surfactant-Associated Protein D
Blood Vessels
Inflammation
Bone and Bones
Food
Mesenchymal Stromal Cells
Stem Cells
Leptin

NCMHD Southeastern Exploratory Sickle Cell Center of Excellence

Adamkiewicz, T., Gibson, R. W., Ikuta, T., Kutlar, A., Gibson, R. W., Gibson, R. W. & Tuan Lo, D.

National Institutes of Health

5/28/0912/31/15

Project: Research project

Sickle Cell Anemia
Hydroxyurea
gamma-Globins
Globins
Opioid Analgesics
Epigenomics
Type 2 Diabetes Mellitus
Methylation
Cardiovascular Diseases
Obesity
Blood Vessels
Type 2 Diabetes Mellitus
Indoleamine-Pyrrole 2,3,-Dioxygenase
Arginase
Cytokines

Exercise &Overweight Children's Cognition

McDowell, J., Tomporowski, P., Davis, C. M. & Davis, C. L.

National Institutes of Health

9/5/087/31/15

Project: Research project

Cognition
Exercise
Executive Function
Pediatric Obesity
Research
Epigenomics
Cardiovascular Diseases
Depression
Methylation
Major Depressive Disorder

Manipulating natural host immunoregulation via IDO during viral Infection

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

5/1/094/30/15

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Virus Diseases
T-Lymphocytes
Regulatory T-Lymphocytes
Infection
Catenins
Dendritic Cells
Autoimmune Experimental Encephalomyelitis
Brain
Multiple Sclerosis
Stem Cells
CXCR4 Receptors
Myocardial Ischemia
Myocardium
Cell Survival

Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke

Sazonova, I. Y., Pellock, J., Pellock, J. & Verin, A.

National Institutes of Health

12/7/871/31/15

Project: Research project

Fibrinolysin
Stroke
Tissue Plasminogen Activator
Fibrinolytic Agents
Thrombolytic Therapy
Abdominal Aortic Aneurysm
Angiotensin II
Aneurysm
Oxidative Stress
Peroxidase
Spinal Cord Diseases
Veterans
Spinal Cord Injuries
Bone Density
Photon Absorptiometry

Mechanisms of Vascular Dysfunction in Cirrhosis

Khurana, S.

National Institutes of Health

7/28/086/30/14

Project: Research project

Bile Acids and Salts
Gastroenterology
Blood Vessels
Vasodilation
Fibrosis
Defecation
Constipation
Brain
Therapeutics
Laxatives
rural community
nicotine
morbidity
mortality
school system
African Americans
Tobacco
Living Wills
Tobacco Use

MOLECULAR REGULATION OF ENDOTHELIAL CELL PERMEABILITY

Langan, G. P., Ratneshwar, L., Garcia, J. G. N., Birukov, K., Natarajan, V., Salgia, R., English, D. K., Patterson, C., Romer, L., Crow, M. T., Hassoun, P. & Verin, A. D.

National Institutes of Health

2/1/981/31/14

Project: Research project

Microtubules
Lung
Endothelial Cells
Permeability
Myosin Light Chains

SPORE in Prostate Cancer

Young, C., Fatemi, M., Morris, J. C., Thibodeau, S. N., Vile, R., Vasmatzis, G., Jenkins, R. B., Bergstralh, E. J., Cheville, J., Klee, G., Tindall, D. J., Davis, B., Sargent, D., Layton, D., Vuk-Pavlovic, S. & Celis, E.

National Institutes of Health

8/31/018/31/13

Project: Research project

Prostatic Neoplasms
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
Neoplasms
Therapeutics
Immunity
Immunization
T-Lymphocytes
Antigen Presentation
Immunotherapy
HLA-G Antigens
Dendritic Cells
Transplantation
Allografts
T-Lymphocytes
Nephritis
Antibodies
Pharmaceutical Preparations
Kidney
Glomerulonephritis
Campylobacter jejuni
Virulence
Regulon
Gastroenteritis
Biofilms
Natriuresis
Pressure
Natriuretic Peptides
Sodium
Heart Failure

T cell regulation by IDO-competent plasmacytoid dendritic cells

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

5/22/094/30/12

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Dendritic Cells
T-Lymphocytes
Islets of Langerhans
Inflammation
hypertension
sodium
single nucleotide polymorphism
genes
salt stress
Microtubules
Endothelial Cells
Lung
Thrombin
Phosphorylation
Campylobacter jejuni
Membrane Proteins
Vaccines
Campylobacter Infections
Immunity
Adenosine Triphosphate
Lung
Endothelial Cells
Electric Impedance
GTP-Binding Proteins

IDO dependent T cell suppression

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

12/1/0411/30/10

Project: Research project

T-Lymphocytes
Allografts
Immunity
Cell Proliferation
Indoleamine-Pyrrole 2,3,-Dioxygenase
Subunit Vaccines
Neoplasms
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
T-Lymphocyte Epitopes
Transforming Growth Factor beta
Permeability
Endothelial Cells
p38 Mitogen-Activated Protein Kinases
Electric Impedance
Heart Rate
Genes
Cardiovascular Diseases
Genetic Databases
Twin Studies