Neuroscience and Regenerative Medicine

Research Output

2020

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access

Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons

Tang, F. L., Zhao, L., Zhao, Y., Sun, D., Zhu, X. J., Mei, L. & Xiong, W. C., Jul 1 2020, In : Cell Death and Differentiation. 27, 7, p. 2099-2116 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization

Jackson, L., Dong, G., Althomali, W., Sayed, M. A., Eldahshan, W., Baban, B., Johnson, M. H., Filosa, J., Fagan, S. C. & Ergul, A., Aug 1 2020, In : Translational Stroke Research. 11, 4, p. 762-775 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

Enhanced Susceptibility to Chemoconvulsant-Induced Seizures in Ganglioside GM3 Synthase Knockout Mice

Tang, F. L., Wang, J., Itokazu, Y. & Yu, R. K., 2020, In : ASN Neuro. 12

Research output: Contribution to journalArticle

Open Access

Ependymal Vps35 promotes ependymal cell differentiation and survival, suppresses microglial activation, and prevents neonatal hydrocephalus

Wu, K. Y., Tang, F. L., Lee, D., Zhao, Y., Song, H., Zhu, X. J., Mei, L. & Xiong, W. C., May 6 2020, In : Journal of Neuroscience. 40, 19, p. 3862-3879 18 p.

Research output: Contribution to journalArticle

Freeze-Dried Extracellular Vesicles From Adipose-Derived Stem Cells Prevent Hypoxia-Induced Muscle Cell Injury

El Baradie, K. B. Y., Nouh, M., O’Brien, F., Liu, Y., Fulzele, S., Eroglu, A. & Hamrick, M. W., Mar 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 181.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
1 Scopus citations
1 Scopus citations

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D. Y., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W. D., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

6 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

1 Scopus citations

Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke

Jackson, L., Dumanli, S., Johnson, M. H., Fagan, S. C. & Ergul, A., Apr 28 2020, In : Journal of Neuroinflammation. 17, 1, 137.

Research output: Contribution to journalArticle

Open Access

Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons

Li, C., Meng, F., Garza, J. C., Liu, J., Lei, Y., Kirov, S. A., Guo, M. & Lu, X. Y., Jan 1 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Photobiomodulation therapy for repeated closed head injury in rats

Yang, B., Xu, J., Li, Y., Dong, Y., Li, Y., Tucker, L., Yang, L., Zong, X., Wu, C., Xu, T., Hu, S., Zhang, Q. & Yan, X., Feb 1 2020, In : Journal of Biophotonics. 13, 2, e201960117.

Research output: Contribution to journalArticle

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W. D., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M. E., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

1 Scopus citations

Probing lasting cryoinjuries to oocyte-embryo transcriptome

Eroglu, B., Szurek, E. A., Schall, P., Latham, K. E. & Eroglu, A., 2020, In : PloS one. 15, 4, e0231108.

Research output: Contribution to journalArticle

Open Access

SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M. & Lu, X., May 1 2020, In : Molecular Psychiatry. 25, 5, p. 1094-1111 18 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transcription factor Isl1 is dispensable for the development of the mouse prosensory region

He, D., Guo, R., Zheng, D., Xu, M., Li, P., Guo, L. & Gan, L., Jun 1 2020, In : Cytotechnology. 72, 3, p. 407-414 8 p.

Research output: Contribution to journalArticle

Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells

Guo, D. H., Yamamoto, M., Hernandez, C. M., Khodadadi, H., Baban, B. & Stranahan, A. M., Apr 1 2020, In : Journal of Clinical Investigation. 130, 4, p. 1961-19766 17806 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. & Lu, X. Y., Jan 1 2019, In : Molecular Psychiatry. 24, 1, p. 126-144 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity

Zong, X., Dong, Y., Li, Y., Yang, L., Li, Y., Yang, B., Tucker, L., Zhao, N., Brann, D. W., Yan, X., Hu, S. & Zhang, Q., Jan 1 2019, (Accepted/In press) In : Translational Stroke Research.

Research output: Contribution to journalArticle

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain

Lee, Y. I., Kim, Y. G., Pyeon, H. J., Ahn, J. C., Logan, S., Orock, A., Joo, K. M., Lőrincz, A. & Deák, F., Apr 15 2019, In : GeroScience. 41, 2, p. 109-123 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein e

Yiew, N. K. H., Greenway, C., Zarzour, A., Ahmadieh, S., Goo, B., Kim, D., Benson, T. W., Ogbi, M., Tang, Y. L., Chen, W., Stepp, D., Patel, V., Hilton, R., Lu, X. Y., Hui, D. Y., Kim, H. W. & Weintraub, N. L., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8577-8591 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression of aromatase and synthesis of sex steroid hormones in skeletal muscle following exercise training in ovariectomized rats

Shi, R., Tian, X., Feng, Y., Cheng, Z., Lu, J., Brann, D. W. & Zhang, Q., Mar 2019, In : Steroids. 143, p. 91-96 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression of Lhx6 in the adult and developing mouse retina

He, D., Guo, R., Zheng, D., Li, P., Dong, X. & Gan, L., Dec 2019, In : Gene Expression Patterns. 34, 119065.

Research output: Contribution to journalArticle

Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction

Raz, L., Bhaskar, K., Weaver, J., Marini, S., Zhang, Q., Thompson, J. F., Espinoza, C., Iqbal, S., Maphis, N. M., Weston, L., Sillerud, L. O., Caprihan, A., Pesko, J. C., Erhardt, E. B. & Rosenberg, G. A., Jun 2019, In : Neurobiology of Disease. 126, p. 124-136 13 p.

Research output: Contribution to journalReview article

6 Scopus citations

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival

Hagan, M. L., Bahraini, A., Pierce, J. L., Bass, S. M., Yu, K., Elsayed, R., Elsalanty, M., Johnson, M. H., McNeil, A., McNeil, P. L. & McGee-Lawrence, M. E., Feb 15 2019, In : Calcified Tissue International. 104, 2, p. 224-234 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
Open Access
4 Scopus citations

Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex

Ye, S. Y., Apple, J. E., Ren, X., Tang, F. L., Yao, L. L., Wang, Y. G., Mei, L., Zhou, Y. G. & Xiong, W. C., Nov 26 2019, In : Journal of Neuroinflammation. 16, 1, 235.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Neuron-derived estrogen regulates synaptic plasticity and memory

Lu, Y., Sareddy, G. R., Wang, J., Wang, R., Li, Y., Dong, Y., Zhang, Q., Liu, J., O’Connor, J. C., Xu, J., Vadlamudi, R. K. & Brann, D. W., Apr 10 2019, In : Journal of Neuroscience. 39, 15, p. 2792-2809 18 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations

Deák, F., Anderson, R. E., Fessler, J. L. & Sherry, D. M., Sep 20 2019, In : Frontiers in Cellular Neuroscience. 13, 428.

Research output: Contribution to journalReview article

Open Access
8 Scopus citations

Obesity in aging exacerbates neuroinflammation, dysregulating synaptic function-related genes and altering eicosanoid synthesis in the mouse hippocampus: Potential role in impaired synaptic plasticity and cognitive decline

Valcarcel-Ares, M. N., Tucsek, Z., Kiss, T., Giles, C. B., Tarantini, S., Yabluchanskiy, A., Balasubramanian, P., Gautam, T., Galvan, V., Ballabh, P., Richardson, A., Freeman, W. M., Wren, J. D., Deak, F., Ungvari, Z. & Csiszar, A., Feb 15 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Par3 is essential for the establishment of planar cell polarity of inner ear hair cells

Malt, A. L., Dailey, Z., Holbrook-Rasmussen, J., Zheng, Y., Hogan, A., Du, Q. & Lu, X., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 4999-5008 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Phosphatidylglycerol Inhibits Toll-Like Receptor–Mediated Inflammation by Danger-Associated Molecular Patterns

Choudhary, V., Uaratanawong, R., Patel, R. R., Patel, H., Bao, W., Hartney, B., Cohen, E., Chen, X., Zhong, Q., Isales, C. M. & Bollag, W. B., Apr 2019, In : Journal of Investigative Dermatology. 139, 4, p. 868-877 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions

Wang, R., Dong, Y., Lu, Y., Zhang, W., Brann, D. W. & Zhang, Q., Mar 1 2019, In : Molecular Neurobiology. 56, 3, p. 1852-1869 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Photobiomodulation in photothrombotic stroke

Tucker, L., Yang, L., Li, Y. & Zhang, Q., Jan 1 2019, Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience. Elsevier, p. 125-138 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia

Yang, L., Dong, Y., Wu, C., Li, Y., Guo, Y., Yang, B., Zong, X., Hamblin, M. R., Liu, T. C. Y. & Zhang, Q., Jun 2019, In : Journal of Biophotonics. 12, 6, e201800359.

Research output: Contribution to journalArticle

5 Scopus citations

Protein kinase C and calmodulin serve as calcium sensors for calcium-stimulated endocytosis at synapses

Jin, Y. H., Wu, X. S., Shi, B., Zhang, Z., Guo, X., Gan, L., Chen, Z. & Wu, L. G., Nov 27 2019, In : Journal of Neuroscience. 39, 48, p. 9478-9490 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome Biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Transcription factor TEAD1 is essential for vascular development by promoting vascular smooth muscle differentiation

Wen, T., Liu, J., He, X., Dong, K., Hu, G., Yu, L., Yin, Q., Osman, I., Peng, J., Zheng, Z., Xin, H., Fulton, D. J., Du, Q., Zhang, W. & Zhou, J., Dec 1 2019, In : Cell Death and Differentiation. 26, 12, p. 2790-2806 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

Jiang, X., Zhu, Z., Qin, H., Tripathi, P., Zhong, L., Elsherbini, A., Karki, S., Crivelli, S. M., Zhi, W., Wang, G., Spassieva, S. D. & Bieberich, E., Aug 16 2019, In : Frontiers in Cell and Developmental Biology. 7, 166.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

17β-estradiol regulates microglia activation and polarization in the hippocampus following global cerebral ischemia

Thakkar, R., Wang, R., Wang, J., Vadlamudi, R. K. & Brann, D. W., 2018, In : Oxidative medicine and cellular longevity. 2018, 4248526.

Research output: Contribution to journalArticle

11 Scopus citations

After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

Zhao, N., Liang, P., Zhuo, X., Su, C., Zong, X., Guo, B., Han, D., Yan, X., Hu, S., Zhang, Q. & Tie, X., May 2018, In : Basic and Clinical Pharmacology and Toxicology. 122, 5, p. 470-480 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis

Yan, M., Xing, G. L., Xiong, W. & Mei, L., Jan 1 2018, In : Annals of the New York Academy of Sciences. 1413, 1, p. 126-135 10 p.

Research output: Contribution to journalReview article

12 Scopus citations