Research Output 1965 2019

2019

A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium?

Mannon, E. C., Sun, J., Wilson, K., Brands, M. W., Martinez-Quinones, P., Baban, B. & O'Connor, P. M., Mar 1 2019, In : Pharmacological Research. 141, p. 236-248 13 p.

Research output: Contribution to journalReview article

Cholinergic Agents
Anti-Inflammatory Agents
Epithelium
Spleen
Vagus Nerve Stimulation
2 Citations (Scopus)

Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study

Ahmed, H. A., Ishrat, T., Pillai, B., Bunting, K. M., Vazdarjanova, A., Waller, J. L., Ergul, A. & Fagan, S. C., Feb 1 2019, In : Behavioural Brain Research. 359, p. 560-569 10 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Stroke
Cognitive Dysfunction
Clinical Studies
Cognition
2 Citations (Scopus)

Augmented astrocyte microdomain Ca 2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice

Diaz, J. R., Kim, K. J., Brands, M. W. & Filosa, J. A., Mar 1 2019, In : Glia. 67, 3, p. 551-565 15 p.

Research output: Contribution to journalArticle

Arterioles
Angiotensin II
Astrocytes
Hypertension
TRPV Cation Channels

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Apoptosis
Proteolysis
Mitochondrial Dynamics
Kidney
2 Citations (Scopus)
Leptin
Drinking
Sucrose
Carbohydrates
Saccharin
3 Citations (Scopus)

Dose–response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke

Ishrat, T., Fouda, A. Y., Pillai, B., Eldahshan, W., Ahmed, H., Waller, J. L., Ergul, A. & Fagan, S. C., Aug 1 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 8, p. 1635-1647 13 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Tissue Plasminogen Activator
Stroke
Therapeutics
Hemorrhage

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein e

Yiew, N. K. H., Greenway, C., Zarzour, A., Ahmadieh, S., Goo, B., Kim, D., Benson, T. W., Ogbi, M., Tang, Y. L., Chen, W., Stepp, D., Patel, V., Hilton, R., Lu, X. Y., Hui, D. Y., Kim, H. W. & Weintraub, N. L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 21, p. 8577-8591 15 p.

Research output: Contribution to journalArticle

Apolipoproteins
Lipid Metabolism
Adipocytes
Lipids
Lipoproteins

Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry

Filgueira, F. P., Lobato, N. S., Nascimento, D. L., Ceravolo, G. S., Giachini, F. R. C., Lima, V. V., Dantas, A. P., Fortes, Z. B., Webb, R. C., Tostes, R. C. & Carvalho, M. H. C., Jan 1 2019, In : Steroids. 141, p. 46-54 9 p.

Research output: Contribution to journalArticle

Equilin
Vasodilator Agents
Endothelium
Estradiol
Calcium
3 Citations (Scopus)

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journalArticle

Homocysteine
Neuroglia
Up-Regulation
Antioxidants
Oxidative Stress
3 Citations (Scopus)

Formyl peptide receptor-1 activation exerts a critical role for the dynamic plasticity of arteries via actin polymerization

Wenceslau, C. F., McCarthy, C. G., Szasz, T., Calmasini, F. B., Mamenko, M. & Webb, R. C., Mar 1 2019, In : Pharmacological Research. 141, p. 276-290 15 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Polymerization
Actins
Arteries
Blood Vessels
2 Citations (Scopus)

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis

Barman, S. A., Li, X., Haigh, S., Kondrikov, D., Mahboubi, K., Bordan, Z., Stepp, D. W., Zhou, J., Wang, Y., Weintraub, D. S., Traber, P., Snider, W., Jonigk, D., Sullivan, J., Ryan Crislip, G., Butcher, J. T., Thompson, J., Su, Y., Chen, F. & Fulton, D. J. R., May 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 5, p. L784-L797

Research output: Contribution to journalArticle

Galectin 3
Vascular Smooth Muscle
Pulmonary Hypertension
Smooth Muscle Myocytes
Fibrosis
Open Access
Hemodynamics
Kidney

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., Jun 17 2019, In : Marine Drugs. 17, 6, 360.

Research output: Contribution to journalArticle

Open Access
Illness Behavior
Endotoxemia
Acute Lung Injury
Matrix Metalloproteinase 9
Lipopolysaccharides
3 Citations (Scopus)

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 1 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journalArticle

Open Access
Hyperhomocysteinemia
Retinal Ganglion Cells
Neuroglia
Antioxidants
Excitatory Amino Acids

Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction

Calmasini, F. B., Klee, N., Webb, R. C. & Priviero, F., Oct 2019, In : Sexual Medicine Reviews. 7, 4, p. 604-613 10 p.

Research output: Contribution to journalReview article

Blood Vessels
Immune System
Inflammation
Cardiovascular Diseases
Penile Erection

Increased ENaC activity during kidney preservation in Wisconsin solution

Khedr, S., Palygin, O., Pavlov, T. S., Blass, G., Levchenko, V., Alsheikh, A., Brands, M. W., El-Meanawy, A. & Staruschenko, A., Apr 29 2019, In : BMC Nephrology. 20, 1, 145.

Research output: Contribution to journalArticle

Open Access
Epithelial Sodium Channels
Kidney
Dogs
Tissue Survival
Messenger RNA
2 Citations (Scopus)

Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4

Abdul, Y., Abdelsaid, M., Li, W., Webb, R. C., Sullivan, J. C., Dong, G. & Ergul, A., Mar 1 2019, In : Molecular Neurobiology. 56, 3, p. 1607-1617 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Blood Vessels
Stroke
Endothelial Cells
Iron

Interleukin-10 negatively modulates extracellular signal-regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion

Bressan, A. F., Fonseca, G. A., Tostes, R. C., Webb, R. C., Lima, V. V. & Giachini, F. R., Feb 1 2019, In : Fundamental and Clinical Pharmacology. 33, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Angiotensin II
Interleukin-10
Aorta
Third Ventricle
Solitary Nucleus
Leptin
Leptin Receptors
Rhombencephalon

Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+/H+ exchanger-1 antagonism

Li, W., Ward, R., Dong, G., Ergul, A. & O'Connor, P., Jul 2019, In : Physiological reports. 7, 13, e14142.

Research output: Contribution to journalArticle

Open Access
Sodium-Hydrogen Antiporter
Protons
Stroke
Middle Cerebral Artery Infarction
Reactive Oxygen Species
5 Citations (Scopus)

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Ward, R., Li, W., Abdul, Y., Jackson, L. D., Dong, G., Jamil, S., Filosa, J., Fagan, S. C. & Ergul, A., Apr 2019, In : Pharmacological Research. 142, p. 237-250 14 p.

Research output: Contribution to journalArticle

Inflammasomes
Ischemia
Stroke
Brain-Derived Neurotrophic Factor
Aquaporin 4
1 Citation (Scopus)

Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice

Xu, W., Zhou, H., Xuan, H., Saha, P., Wang, G. & Chen, W., Feb 15 2019, In : Molecular and Cellular Endocrinology. 482, p. 1-10 10 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Muscle
Skeletal Muscle
Glycogen
Lipodystrophy

Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity

Tang, J., Zhou, H., Sahay, K., Xu, W., Yang, J., Zhang, W. & Chen, W., Jun 1 2019, In : International Journal of Obesity. 43, 6, p. 1269-1280 12 p.

Research output: Contribution to journalArticle

Adipogenesis
Insulin Resistance
Obesity
Adipocytes
PPAR gamma
1 Citation (Scopus)

Paying the toll for inflammation: Immunoreceptor-mediated vascular dysfunction in hypertension

McCarthy, C. G., Goulopoulou, S. & Webb, R. C., Mar 1 2019, In : Hypertension. 73, 3, p. 514-521 8 p.

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Inflammation

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Cao, Y., Zhang, X., Wang, L., Yang, Q., Ma, Q., Xu, J., Wang, J., Kovacs, L., Ayon, R. J., Liu, Z., Zhang, M., Zhou, Y., Zeng, X., Xu, Y., Wang, Y., Fulton, D. J., Weintraub, N. L., Lucas, R., Dong, Z., Yuan, J. X. J. & 8 others, Sullivan, J. C., Meadows, L., Barman, S. A., Wu, C., Quan, J., Hong, M., Su, Y. & Huo, Y., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13394-13403 10 p.

Research output: Contribution to journalArticle

Open Access
Glycolysis
Pulmonary Hypertension
Lung
Endothelial Cells
Rodentia
1 Citation (Scopus)

Phosphatidylglycerol Inhibits Toll-Like Receptor–Mediated Inflammation by Danger-Associated Molecular Patterns

Choudhary, V., Uaratanawong, R., Patel, R. R., Patel, H., Bao, W., Hartney, B., Cohen, E., Chen, X., Zhong, Q., Isales, C. M. & Bollag, W. B., Apr 2019, In : Journal of Investigative Dermatology. 139, 4, p. 868-877 10 p.

Research output: Contribution to journalArticle

Phosphatidylglycerols
Psoriasis
Inflammation
Toll-Like Receptors
Skin
1 Citation (Scopus)

Postprandial Effects on ENaC-Mediated Sodium Absorption

Blass, G., Klemens, C. A., Brands, M. W., Palygin, O. & Staruschenko, A., Dec 1 2019, In : Scientific Reports. 9, 1, 4296.

Research output: Contribution to journalArticle

Open Access
Renin-Angiotensin System
Sodium
Insulin
Meals
Member 1 Solute Carrier Family 12
2 Citations (Scopus)

Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation

Li, W., Valenzuela, J. P., Ward, R., Abdelbary, M., Dong, G., Fagan, S. C. & Ergul, A., Jan 1 2019, In : Experimental Neurology. 311, p. 106-114 9 p.

Research output: Contribution to journalArticle

Stroke
Wounds and Injuries
Middle Cerebral Artery Infarction
Vascular System Injuries
Menopause

Progression of micturition dysfunction associated with the development of heart failure in rats: Model of overactive bladder

Mora, A. G., Furquim, S. R., Tartarotti, S. P., Andrade, D. R., Janussi, S. C., Krikorian, K., Rocha, T., Franco-Penteado, C. F., Priolli, D. G., Priviero, F. & Claudino, M. A., Jun 1 2019, In : Life sciences. 226, p. 107-116 10 p.

Research output: Contribution to journalArticle

Overactive Urinary Bladder
Urination
Rats
Heart Failure
Fistula

Recent advances in sex differences in kidney function

Layton, A. T. & Sullivan, J. C., Feb 1 2019, In : American journal of physiology. Renal physiology. 316, 2, p. F328-F331

Research output: Contribution to journalEditorial

Sex Characteristics
Kidney
Cardiovascular Physiological Phenomena
Kidney
5 Citations (Scopus)

Stroke and the neurovascular unit: Glial cells, sex differences, and hypertension

Morrison, H. W. & Filosa, J. A., Mar 2019, In : American Journal of Physiology - Cell Physiology. 316, 3, p. C325-C339

Research output: Contribution to journalArticle

Neuroglia
Sex Characteristics
Stroke
Hypertension
Translational Medical Research

Targeting endothelial barrier dysfunction caused by circulating bacterial and mitochondrial n-formyl peptides with deformylase

Martinez-Quinones, P., Komic, A., McCarthy, C. G., Webb, R. C. & Wenceslau, C. F., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1270.

Research output: Contribution to journalArticle

Open Access
peptide deformylase
Systemic Inflammatory Response Syndrome
Peptides
Formyl Peptide Receptor
Sepsis
3 Citations (Scopus)

Tetrahydrobiopterin improves endothelial function in patients with cystic fibrosis

Jeong, J. H., Lee, N., Tucker, M. A., Rodriguez-Miguelez, P., Looney, J., Thomas, J., Derella, C. C., Elmarakby, A. A., Musall, J. B., Sullivan, J. C., McKie, K. T., Forseen, C. J., Davison, G. W. & Harris, R. A., Jan 2019, In : Journal of Applied Physiology. 126, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Dilatation
Blood Vessels
Nitric Oxide
Biological Availability

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
1 Citation (Scopus)

Toll-like receptor 4 and blood pressure: Lessons from animal studies

Nunes, K. P., De Oliveira, A. A., Lima, V. V. & Clinton Webb, R., Jan 1 2019, In : Frontiers in Physiology. 10, MAY, 655.

Research output: Contribution to journalReview article

Open Access
Toll-Like Receptor 4
Immune System
Animal Models
Blood Pressure
Hypertension

Transcriptional profiling of uterine leiomyoma rats treated by a traditional herb pair, curcumae rhizoma and sparganii rhizoma

Yu, C. H., Zhao, J. S., Zhao, H., Peng, T., Shen, D. C., Xu, Q. X., Li, Y., Webb, R. C., Wang, M. H., Shi, X. M., Peng, C. & Ding, W. J., Jan 1 2019, In : Brazilian Journal of Medical and Biological Research. 52, 6, e8132.

Research output: Contribution to journalArticle

Open Access
Leiomyoma
Rats
Microarrays
Metabolism
Gene expression

TRPV4 deletion protects against hypokalemia during systemic K+ deficiency

Tomilin, V., Mamenko, M., Zaika, O., Wingo, C. S. & Pochynyuk, O., May 1 2019, In : American Journal of Physiology - Renal Physiology. 316, 5, p. F948-F956

Research output: Contribution to journalArticle

TRPV Cation Channels
Hypokalemia
Proton-Translocating ATPases
Diet
Kidney
1 Citation (Scopus)

Urinary concentrating defect in mice lacking Epac1 or Epac2

Cherezova, A., Tomilin, V., Buncha, V., Zaika, O., Ortiz, P. A., Mei, F., Cheng, X., Mamenko, M. & Pochynyuk, O., Jan 1 2019, In : FASEB Journal. 33, 2, p. 2156-2170 15 p.

Research output: Contribution to journalArticle

Polyuria
Kidney
Defects
Arginine Vasopressin
Protein Isoforms
2 Citations (Scopus)

Voltage gated proton channels modulate mitochondrial reactive oxygen species production by complex I in renal medullary thick ascending limb

Patel, B., Zheleznova, N. N., Ray, S. C., Sun, J., Cowley, A. W. & O'Connor, P. M., Oct 2019, In : Redox Biology. 27, 101191.

Research output: Contribution to journalArticle

Open Access
Protons
Reactive Oxygen Species
Extremities
Kidney
Electric potential
2018
1 Citation (Scopus)

Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD

Rodriguez-Miguelez, P., Gregg, J., Seigler, N., Bass, L., Thomas, J., Pollock, J. S., Sullivan, J. C., Dillard, T. A. & Harris, R. A., Sep 1 2018, In : CHEST. 154, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Dilatation
Placebos
Nitric Oxide
Cardiovascular Diseases
3 Citations (Scopus)

Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease

Feng, W., Zhang, K., Liu, Y., Chen, J., Cai, Q., He, W., Zhang, Y., Wang, M-H., Wang, J. & Huang, H., Mar 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 3, p. H475-H483

Research output: Contribution to journalArticle

Advanced Oxidation Protein Products
Chronic Renal Insufficiency
Cardiac Myocytes
Apoptosis
Endoplasmic Reticulum Stress
4 Citations (Scopus)
Proto-Oncogene Proteins c-akt
Vascular Smooth Muscle
Type 2 Diabetes Mellitus
Superoxide Dismutase
Copper
26 Downloads (Pure)

Alanine aminotransferase levels are associated with cardiometabolic risk factors in Hispanic/Latino farmworkers

Raed, A., Pollock, N. K., Bhagatwala, J., Cromer, P. R., Mazzoli, A. J., Zhu, H., Francisco, T., Bilz, J., Azevedo, R., Clarke, J., Lee, S., Murugappan, A., Pasham, V., Stewart, D., Dong, Y., Huang, Y., Parikh, S., Layman, D. & Dong, Y., Feb 28 2018, In : Journal of Environment and Health Science. 4, 1, p. 20-25

Research output: Contribution to journalArticle

File
5 Citations (Scopus)

Amino acids as signaling molecules modulating bone turnover

Ding, K., Cain, M., Davis, M., Bergson, C. M., McGee Lawrence, M. E., Perkins, C., Hardigan, T., Shi, X. M., Zhong, Q., Xu, J., Bollag, W. B., Hill, W. D., Elsalanty, M. E., Hunter, D. M., Isales, M. C., Lopez, P., Hamrick, M. W. & Isales, C. M., Oct 2018, In : Bone. 115, p. 15-24 10 p.

Research output: Contribution to journalReview article

Bone Remodeling
Amino Acids
Protein-Restricted Diet
Mesenchymal Stromal Cells
Calcium-Sensing Receptors
2 Citations (Scopus)

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

Benson, T. W., Weintraub, N. L., Kim, H. W., Seigler, N., Kumar, S., Pye, J., Horimatsu, T., Pellenberg, R., Stepp, D. W., Lucas, R., Bogdanov, V. Y., Litwin, S. E., Brittain, J. E. & Harris, R. A., Oct 1 2018, In : Laboratory Investigation. 98, 10, p. 1300-1310 11 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Peroxidase
Meals
Erythrocytes
Fats
5 Citations (Scopus)

Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats

Nunes, K. P., de Oliveira, A. A., Szasz, T., Biancardi, V. C. & Webb, R. C., Sep 2018, In : Journal of Sexual Medicine. 15, 9, p. 1235-1245 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Erectile Dysfunction
Cyclic GMP
Oxidative Stress
Phenylephrine
3 Citations (Scopus)
Renal Artery
Sprague Dawley Rats
Arterial Pressure
Insulin
Kidney

Compromised regulation of the collecting duct ENaC activity in mice lacking AT1a receptor

Mamenko, M., Zaika, O., Tomilin, V., Jensen, V. B. & Pochynyuk, O., Sep 1 2018, In : Journal of Cellular Physiology. 233, 9, p. 7217-7225 9 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Aldosterone
Ducts
Angiotensin II
Animals
1 Citation (Scopus)

Cutting the Fat dissecting sources of variability in cardiovascular and metabolic phenotypes of high-fat fed dahl salt-sensitive rats

Taylor, L. E. & Sullivan, J. C., Jan 1 2018, In : Hypertension. 72, 5, p. 1081-1083 3 p.

Research output: Contribution to journalComment/debate

Inbred Dahl Rats
Fats
Phenotype