Research Output per year
Research Output 1992 2019
Article
15
Citations
(Scopus)
Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms
Pye, C., Elsherbiny, N. M., Ibrahim, A. S., Liou, G. I., Chadli, A., Al-Shabrawey, M. & Elmarakby, A. A., Jan 1 2014, In : Pharmacological Research. 85, p. 45-54 10 p.Research output: Contribution to journal › Article
Adenosine Kinase
Experimental Diabetes Mellitus
Oxidants
Anti-Inflammatory Agents
Kidney
21
Citations
(Scopus)
Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition
Chadli, A., Bruinsma, E. S., Stensgard, B. & Toft, D., Mar 4 2008, In : Biochemistry. 47, 9, p. 2850-2857 8 p.Research output: Contribution to journal › Article
Progesterone Receptors
Proteins
Conformations
Nucleotides
Adenosine Triphosphate
6
Citations
(Scopus)
Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity
Kabbaj, F. Z., Lu, S., Faouzi, M. E. A., Meddah, B., Proksch, P., Cherrah, Y., Altenbach, H. J., Aly, A. H., Chadli, A. & Debbab, A., Jan 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 1, p. 126-131 6 p.Research output: Contribution to journal › Article
Chaetomium
Metabolites
Cells
Endophytes
Cell Line
54
Citations
(Scopus)
Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23
Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.Research output: Contribution to journal › Article
Steroid Receptors
Adenosine Triphosphate
Dissection
Molecules
Molecular Chaperones
11
Citations
(Scopus)
Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium
Okoye, F. B. C., Lu, S., Nworu, C. S., Esimone, C. O., Proksch, P., Chadli, A. & Debbab, A., Aug 7 2013, In : Tetrahedron Letters. 54, 32, p. 4210-4214 5 p.Research output: Contribution to journal › Article
Apocynaceae
Endophytes
Lactones
Metabolites
Fungi
11
Citations
(Scopus)
Development of screening methods for detection of carbohydrate-binding proteins by use of soluble glycosylated polyacrylamide-based copolymers
Chadli, A., Caron, M., Tichá, M., Joubert, R., Bladier, D. & Kocourek, J., Jan 1 1992, In : Analytical Biochemistry. 204, 1, p. 198-203 6 p.Research output: Contribution to journal › Article
Lectins
Screening
Copolymers
Assays
Polymers
132
Citations
(Scopus)
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
Chadli, A., Bouhouche, I., Sullivan, W., Stensgard, B., McMahon, N., Catelli, M. G. & Toft, D. O., Nov 7 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12524-12529 6 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
Molecular Chaperones
Dimerization
Glutathione Transferase
Adenosine Triphosphate
47
Citations
(Scopus)
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway
Chadli, A., Graham, J. D., Abel, M. G., Jackson, T. A., Gordon, D. F., Wood, W. M., Felts, S. J., Horwitz, K. B. & Toft, D., Mar 1 2006, In : Molecular and Cellular Biology. 26, 5, p. 1722-1730 9 p.Research output: Contribution to journal › Article
Progesterone Receptors
Myosins
Adenosine Triphosphatases
Adenosine Triphosphate
Binding Sites
34
Citations
(Scopus)
GCUNC45 is the first Hsp90 Co-chaperone to show α/β isoform specificity
Chadli, A., Felts, S. J. & Toft, D. O., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 9509-9512 4 p.Research output: Contribution to journal › Article
Protein Isoforms
Molecular Chaperones
Normal Distribution
Eukaryotic Cells
Progesterone Receptors
62
Citations
(Scopus)
Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis
Patwardhan, C. A., Fauq, A., Peterson, L. B., Miller, C., Blagg, B. S. J. & Chadli, A., Mar 8 2013, In : Journal of Biological Chemistry. 288, 10, p. 7313-7325 13 p.Research output: Contribution to journal › Article
Cell death
Cell Death
Apoptosis
Caspase 7
Neoplasms
38
Citations
(Scopus)
Heat-induced oligomerization of the molecular chaperone Hsp90: Inhibition by ATP and geldanamycin and activation by transition metal oxyanions
Chadli, A., Ladjimi, M. M., Baulieu, E. E. & Catelli, M. G., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 4133-4139 7 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
Oligomerization
Molecular Chaperones
Transition metals
Hot Temperature
113
Citations
(Scopus)
HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor
Patricia Hernández, M., Chadli, A. & Toft, D. O., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11873-11881 9 p.Research output: Contribution to journal › Article
Progesterone Receptors
HSP40 Heat-Shock Proteins
Adenosine Triphosphate
Hormones
Stoichiometry
41
Citations
(Scopus)
Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains
Johnson, B. D., Chadli, A., Felts, S. J., Bouhouche, I., Catelli, M. G. & Toft, D. O., Oct 20 2000, In : Journal of Biological Chemistry. 275, 42, p. 32499-32507 9 p.Research output: Contribution to journal › Article
Citrate (si)-Synthase
Firefly Luciferases
Humulus
Peptides
Molecular Chaperones
55
Citations
(Scopus)
Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production
Chen, F., Pandey, D., Chadli, A., Catravas, J. D., Chen, T. & Fulton, D. J. R., Jun 1 2011, In : Antioxidants and Redox Signaling. 14, 11, p. 2107-2119 13 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
NADPH Oxidase
Superoxides
Hydrogen Peroxide
Enzymes
58
Citations
(Scopus)
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature Communications. 8, 14979.Research output: Contribution to journal › Article
suppressors
plastic properties
Plasticity
Tumors
cascades
16
Citations
(Scopus)
Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones
Chen, F., Haigh, S., Yu, Y., Benson, T., Wang, Y., Li, X., Dou, H., Bagi, Z., Verin, A. D., Stepp, D. W., Csanyi, G., Chadli, A., Weintraub, N. L., Smith, S. M. E. & Fulton, D. J., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 793-805 13 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
Carbon Monoxide
Superoxides
Enzyme activity
Protein Binding
8
Citations
(Scopus)
Oligoclonal β-galactoside-binding immunoglobulins antigenically related to 14kda lectin in human serum and cerebrospinal fluid: Purification and characterization
Joubert-Caron, R., Caron, M., Bochet, P., Chadli, A., Delaporte, P., Schuller, E. & Bladier, D., Jan 1 1994, In : International Journal of Biochemistry. 26, 6, p. 813-823 11 p.Research output: Contribution to journal › Article
Cerebrospinal fluid
Galactosides
Lectins
Purification
Cerebrospinal Fluid
50
Citations
(Scopus)
Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production
Chen, F., Yu, Y., Qian, J., Wang, Y., Cheng, B., Dimitropoulou, C., Patel, V. S., Chadli, A., Rudic, R. D., Stepp, D. W., Catravas, J. D. & Fulton, D. J., Dec 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 12, p. 2989-2999 11 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
NADP
Reactive Oxygen Species
Oxidoreductases
18
Citations
(Scopus)
Presence of an aromatase inhibitor, possibly heat shock protein 90, in dominant follicles of cattle
Driancourt, M. A., Guet, P., Reynaud, K., Chadli, A. & Catelli, M. G., Jan 1999, In : Journal of Reproduction and Fertility. 115, 1, p. 45-58 14 p.Research output: Contribution to journal › Article
HSP90 Heat-Shock Proteins
Aromatase Inhibitors
Aromatase
Follicular Fluid
Proteins
2
Citations
(Scopus)
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature Communications. 10, 1, 1430.Research output: Contribution to journal › Article
immunity
mice
Tumors
Immunity
tumors
5
Citations
(Scopus)
Production and characterization of a monoclonal antibody able to discriminate galectin-1 from galectin-2 and galectin-3
Cornillot, J. D., Pontet, M., Dupuy, C., Chadli, A., Caron, M., Joubert-Caron, R., Bourin, P. & Bladier, D., May 1 1998, In : Glycobiology. 8, 5, p. 425-432 8 p.Research output: Contribution to journal › Article
Galectin 2
Galectin 1
Galectin 3
Monoclonal Antibodies
Brain
4
Citations
(Scopus)
Progesterone receptor chaperone complex-based high-throughput screening assay: Identification of capsaicin as an inhibitor of the Hsp90 machine
Patwardhan, C. A., Alfa, E., Lu, S. & Chadli, A., Feb 24 2015, In : Journal of Biomolecular Screening. 20, 2, p. 223-229 7 p.Research output: Contribution to journal › Article
High-Throughput Screening Assays
Capsaicin
Progesterone Receptors
Assays
Screening
17
Citations
(Scopus)
Purification and characterization of a human brain galectin-1 ligand
Chadli, A., LeCaer, J. P., Bladier, D., Joubert-Caron, R. & Caron, M., Jan 1 1997, In : Journal of Neurochemistry. 68, 4, p. 1640-1647 8 p.Research output: Contribution to journal › Article
Galectin 1
Purification
Brain
Ligands
HSP90 Heat-Shock Proteins
12
Citations
(Scopus)
Study of lectin-ganglioside interactions by high-performance liquid affinity chromatography
Caron, M., Joubert-Caron, R., Cartier, J. R., Chadli, A. & Bladier, D., Sep 3 1993, In : Journal of Chromatography A. 646, 2, p. 327-333 7 p.Research output: Contribution to journal › Article
Affinity chromatography
Gangliosides
Liquid chromatography
Affinity Chromatography
Lectins
1
Citation
(Scopus)
Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor
Pinkerton, D. M., Chow, S., Eisa, N. H., Kainth, K., Vanden Berg, T. J., Burns, J. M., Guddat, L. W., Savage, G. P., Chadli, A. & Williams, C. M., Jan 28 2019, In : Chemistry - A European Journal. 25, 6, p. 1451-1455 5 p.Research output: Contribution to journal › Article
Limonins
Enzyme inhibition
Machinery
Assays
Enzymes
2
Citations
(Scopus)
Targeting the MYC oncogene in burkitt lymphoma through HSP90 inhibition
Poole, C. J., Zheng, W., Lee, H., Young, D., Lodh, A., Chadli, A. & van Riggelen, J., Nov 16 2018, In : Cancers. 10, 11, 448.Research output: Contribution to journal › Article
Burkitt Lymphoma
Oncogenes
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
tanespimycin
Proteins
18
Citations
(Scopus)
The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors
Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A. & Cox, M. B., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15297-15308 12 p.Research output: Contribution to journal › Article
Steroid hormones
Steroid Receptors
Glucocorticoid Receptors
Androgen Receptors
Progestins
1
Citation
(Scopus)
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis
Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R. J., Maihle, N. J., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, , Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.Research output: Contribution to journal › Article
Myosins
Carcinogenesis
Phosphotransferases
Cell proliferation
Cells
397
Citations
(Scopus)
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
Marcu, M. G., Chadli, A., Bouhouche, I., Catelli, M. & Neckers, L. M., Nov 24 2000, In : Journal of Biological Chemistry. 275, 47, p. 37181-37186 6 p.Research output: Contribution to journal › Article
Novobiocin
HSP90 Heat-Shock Proteins
Adenosine Triphosphate
Steroid hormones
Binding Sites
69
Citations
(Scopus)
The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter
Kang, K. I., Meng, X., Devin-Leclerc, J., Bouhouche, I., Chadli, A., Cadepond, F., Baulieu, E. E. & Catelli, M. G., Feb 16 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 4, p. 1439-1444 6 p.Research output: Contribution to journal › Article
Molecular Chaperones
Ligands
Hormones
Steroid Receptors
Poisons
8
Citations
(Scopus)
The N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptor
Bouhouche-Chatelier, I., Chadli, A. & Catelli, M. G., Dec 19 2001, In : Cell Stress and Chaperones. 6, 4, p. 297-305 9 p.Research output: Contribution to journal › Article
Estrogen Receptors
Adenosine Triphosphate
Sepharose
Bearings (structural)
Fusion reactions
4
Citations
(Scopus)
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.Research output: Contribution to journal › Article
Breast Neoplasms
Cell Death
Triple Negative Breast Neoplasms
Heterografts
Cell Line
7
Citations
(Scopus)
UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation
Jilani, Y., Lu, S., Huang, L., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.Research output: Contribution to journal › Article
Centrosome
Cell Proliferation
Neoplasms
Aptitude
Myosins
Comment/debate
Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)
Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In : Oncogene. 38, 28, 1 p.Research output: Contribution to journal › Comment/debate
Open Access
Financial Management
Oncogenes
Breast Neoplasms
Laboratory Animals
Genomics
Review article
1
Citation
(Scopus)
Glycobiology and bioaffinity chromatography
Caron, M., Chadli, A., Seve, A. P., Lutomski, D., Bladier, D. & Joubert-Caron, R., Jan 1 1997, In : International Journal of Bio-Chromatography. 3, 2, p. 111-121 11 p.Research output: Contribution to journal › Review article
Glycosylation
Affinity chromatography
Chromatography
Lectins
Glycoproteins