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Ahmed Chadli

Associate Professor

  • 1413 Citations
  • 17 h-Index
1992 …2019

Research output per year

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Research Output

  • 1413 Citations
  • 17 h-Index
  • 33 Article
  • 1 Comment/debate
  • 1 Review article
Article

Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms

Pye, C., Elsherbiny, N. M., Ibrahim, A. S., Liou, G. I., Chadli, A., Al-Shabrawey, M. & Elmarakby, A. A., Jul 2014, In : Pharmacological Research. 85, p. 45-54 10 p.

Research output: Contribution to journal › Article

16 Scopus citations

Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition

Chadli, A., Bruinsma, E. S., Stensgard, B. & Toft, D., Mar 4 2008, In : Biochemistry. 47, 9, p. 2850-2857 8 p.

Research output: Contribution to journal › Article

22 Scopus citations

Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity

Kabbaj, F. Z., Lu, S., Faouzi, M. E. A., Meddah, B., Proksch, P., Cherrah, Y., Altenbach, H. J., Aly, A. H., Chadli, A. & Debbab, A., Jan 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 1, p. 126-131 6 p.

Research output: Contribution to journal › Article

7 Scopus citations

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

Research output: Contribution to journal › Article

59 Scopus citations

Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium

Okoye, F. B. C., Lu, S., Nworu, C. S., Esimone, C. O., Proksch, P., Chadli, A. & Debbab, A., Aug 7 2013, In : Tetrahedron Letters. 54, 32, p. 4210-4214 5 p.

Research output: Contribution to journal › Article

13 Scopus citations

Development of screening methods for detection of carbohydrate-binding proteins by use of soluble glycosylated polyacrylamide-based copolymers

Chadli, A., Caron, M., Tichá, M., Joubert, R., Bladier, D. & Kocourek, J., Jul 1992, In : Analytical Biochemistry. 204, 1, p. 198-203 6 p.

Research output: Contribution to journal › Article

11 Scopus citations

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

Chadli, A., Bouhouche, I., Sullivan, W., Stensgard, B., McMahon, N., Catelli, M. G. & Toft, D. O., Nov 7 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12524-12529 6 p.

Research output: Contribution to journal › Article

132 Scopus citations

GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway

Chadli, A., Graham, J. D., Abel, M. G., Jackson, T. A., Gordon, D. F., Wood, W. M., Felts, S. J., Horwitz, K. B. & Toft, D., Mar 1 2006, In : Molecular and Cellular Biology. 26, 5, p. 1722-1730 9 p.

Research output: Contribution to journal › Article

47 Scopus citations

GCUNC45 is the first Hsp90 Co-chaperone to show α/β isoform specificity

Chadli, A., Felts, S. J. & Toft, D. O., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 9509-9512 4 p.

Research output: Contribution to journal › Article

34 Scopus citations

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis

Patwardhan, C. A., Fauq, A., Peterson, L. B., Miller, C., Blagg, B. S. J. & Chadli, A., Mar 8 2013, In : Journal of Biological Chemistry. 288, 10, p. 7313-7325 13 p.

Research output: Contribution to journal › Article

70 Scopus citations

Heat-induced oligomerization of the molecular chaperone Hsp90: Inhibition by ATP and geldanamycin and activation by transition metal oxyanions

Chadli, A., Ladjimi, M. M., Baulieu, E. E. & Catelli, M. G., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 4133-4139 7 p.

Research output: Contribution to journal › Article

39 Scopus citations

HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor

Patricia Hernández, M., Chadli, A. & Toft, D. O., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11873-11881 9 p.

Research output: Contribution to journal › Article

114 Scopus citations

Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains

Johnson, B. D., Chadli, A., Felts, S. J., Bouhouche, I., Catelli, M. G. & Toft, D. O., Oct 20 2000, In : Journal of Biological Chemistry. 275, 42, p. 32499-32507 9 p.

Research output: Contribution to journal › Article

42 Scopus citations

Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production

Chen, F., Pandey, D., Chadli, A., Catravas, J. D., Chen, T. & Fulton, D. J. R., Jun 1 2011, In : Antioxidants and Redox Signaling. 14, 11, p. 2107-2119 13 p.

Research output: Contribution to journal › Article

57 Scopus citations

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature Communications. 8, 14979.

Research output: Contribution to journal › Article

82 Scopus citations

Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones

Chen, F., Haigh, S., Yu, Y., Benson, T., Wang, Y., Li, X., Dou, H., Bagi, Z., Verin, A. D., Stepp, D. W., Csanyi, G., Chadli, A., Weintraub, N. L., Smith, S. M. E. & Fulton, D. J., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 793-805 13 p.

Research output: Contribution to journal › Article

21 Scopus citations

Oligoclonal β-galactoside-binding immunoglobulins antigenically related to 14kda lectin in human serum and cerebrospinal fluid: Purification and characterization

Joubert-Caron, R., Caron, M., Bochet, P., Chadli, A., Delaporte, P., Schuller, E. & Bladier, D., Jun 1994, In : International Journal of Biochemistry. 26, 6, p. 813-823 11 p.

Research output: Contribution to journal › Article

8 Scopus citations

Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production

Chen, F., Yu, Y., Qian, J., Wang, Y., Cheng, B., Dimitropoulou, C., Patel, V., Chadli, A., Rudic, R. D., Stepp, D. W., Catravas, J. D. & Fulton, D. J. R., Dec 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 12, p. 2989-2999 11 p.

Research output: Contribution to journal › Article

54 Scopus citations

Presence of an aromatase inhibitor, possibly heat shock protein 90, in dominant follicles of cattle

Driancourt, M. A., Guet, P., Reynaud, K., Chadli, A. & Catelli, M. G., Jan 1999, In : Journal of Reproduction and Fertility. 115, 1, p. 45-58 14 p.

Research output: Contribution to journal › Article

19 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journal › Article

5 Scopus citations

Production and characterization of a monoclonal antibody able to discriminate galectin-1 from galectin-2 and galectin-3

Cornillot, J. D., Pontet, M., Dupuy, C., Chadli, A., Caron, M., Joubert-Caron, R., Bourin, P. & Bladier, D., May 1 1998, In : Glycobiology. 8, 5, p. 425-432 8 p.

Research output: Contribution to journal › Article

5 Scopus citations

Progesterone receptor chaperone complex-based high-throughput screening assay: Identification of capsaicin as an inhibitor of the Hsp90 machine

Patwardhan, C. A., Alfa, E., Lu, S. & Chadli, A., Feb 24 2015, In : Journal of Biomolecular Screening. 20, 2, p. 223-229 7 p.

Research output: Contribution to journal › Article

4 Scopus citations

Purification and characterization of a human brain galectin-1 ligand

Chadli, A., LeCaer, J. P., Bladier, D., Joubert-Caron, R. & Caron, M., Jan 1 1997, In : Journal of Neurochemistry. 68, 4, p. 1640-1647 8 p.

Research output: Contribution to journal › Article

17 Scopus citations

Study of lectin-ganglioside interactions by high-performance liquid affinity chromatography

Caron, M., Joubert-Caron, R., Cartier, J. R., Chadli, A. & Bladier, D., Sep 3 1993, In : Journal of Chromatography A. 646, 2, p. 327-333 7 p.

Research output: Contribution to journal › Article

12 Scopus citations

Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor

Pinkerton, D. M., Chow, S., Eisa, N. H., Kainth, K., Vanden Berg, T. J., Burns, J. M., Guddat, L. W., Savage, G. P., Chadli, A. & Williams, C. M., Jan 28 2019, In : Chemistry - A European Journal. 25, 6, p. 1451-1455 5 p.

Research output: Contribution to journal › Article

3 Scopus citations

Targeting the MYC oncogene in burkitt lymphoma through HSP90 inhibition

Poole, C. J., Zheng, W., Lee, H., Young, D., Lodh, A., Chadli, A. & van Riggelen, J., Nov 16 2018, In : Cancers. 10, 11, 448.

Research output: Contribution to journal › Article

4 Scopus citations

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A. & Cox, M. B., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15297-15308 12 p.

Research output: Contribution to journal › Article

18 Scopus citations

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journal › Article

4 Scopus citations

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

Marcu, M. G., Chadli, A., Bouhouche, I., Catelli, M. & Neckers, L. M., Nov 24 2000, In : Journal of Biological Chemistry. 275, 47, p. 37181-37186 6 p.

Research output: Contribution to journal › Article

400 Scopus citations

The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter

Kang, K. I., Meng, X., Devin-Leclerc, J., Bouhouche, I., Chadli, A., Cadepond, F., Baulieu, E. E. & Catelli, M. G., Feb 16 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 4, p. 1439-1444 6 p.

Research output: Contribution to journal › Article

69 Scopus citations

The N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptor

Bouhouche-Chatelier, I., Chadli, A. & Catelli, M. G., Dec 19 2001, In : Cell Stress and Chaperones. 6, 4, p. 297-305 9 p.

Research output: Contribution to journal › Article

8 Scopus citations

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journal › Article

8 Scopus citations

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

Jilani, Y., Lu, S., Lei, H., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.

Research output: Contribution to journal › Article

8 Scopus citations
Comment/debate

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In : Oncogene. 38, 28, 1 p.

Research output: Contribution to journal › Comment/debate

Open Access
Review article

Glycobiology and bioaffinity chromatography

Caron, M., Chadli, A., Seve, A. P., Lutomski, D., Bladier, D. & Joubert-Caron, R., Jan 1 1997, In : International Journal of Bio-Chromatography. 3, 2, p. 111-121 11 p.

Research output: Contribution to journal › Review article

1 Scopus citations