Ahmed Chadli

Research output

Research output per year 1992 2020

• 1551 Citations
• 18 h-Index
• 34 Article
• 1 Comment/debate
• 1 Review article

Research output per year

Research output per year

Search results

• Article

  Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms

  Pye, C., Elsherbiny, N. M., Ibrahim, A. S., Liou, G. I., Chadli, A., Al-Shabrawey, M. & Elmarakby, A. A., Jul 2014, In: Pharmacological Research. 85, p. 45-54 10 p.

  Research output: Contribution to journal › Article › peer-review

  • ABT 702
  • Adenosine Kinase
  • Experimental Diabetes Mellitus
  • Antioxidants
  • Anti-Inflammatory Agents
  16 Scopus citations

• Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition

  Chadli, A., Bruinsma, E. S., Stensgard, B. & Toft, D., Mar 4 2008, In: Biochemistry. 47, 9, p. 2850-2857 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Tetratricopeptide Repeat
  • Progesterone Receptors
  • tacrolimus binding protein 4
  • Proteins
  • Conformations
  22 Scopus citations

• Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity

  Kabbaj, F. Z., Lu, S., Faouzi, M. E. A., Meddah, B., Proksch, P., Cherrah, Y., Altenbach, H. J., Aly, A. H., Chadli, A. & Debbab, A., Jan 1 2015, In: Bioorganic and Medicinal Chemistry. 23, 1, p. 126-131 6 p.

  Research output: Contribution to journal › Article › peer-review

  • sclerotiorin
  • Chaetomium
  • Metabolites
  • Cells
  • Endophytes
  8 Scopus citations

• Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

  Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In: Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

  Research output: Contribution to journal › Article › peer-review

  • tripterine
  • Steroid Receptors
  • Molecules
  • Adenosine Triphosphate
  • Dissection
  64 Scopus citations

• Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium

  Okoye, F. B. C., Lu, S., Nworu, C. S., Esimone, C. O., Proksch, P., Chadli, A. & Debbab, A., Aug 7 2013, In: Tetrahedron Letters. 54, 32, p. 4210-4214 5 p.

  Research output: Contribution to journal › Article › peer-review

  • depsidone
  • Endophytes
  • Apocynaceae
  • Nuclear magnetic resonance spectroscopy
  • Fungi
  14 Scopus citations

• Development of screening methods for detection of carbohydrate-binding proteins by use of soluble glycosylated polyacrylamide-based copolymers

  Chadli, A., Caron, M., Tichá, M., Joubert, R., Bladier, D. & Kocourek, J., Jul 1992, In: Analytical Biochemistry. 204, 1, p. 198-203 6 p.

  Research output: Contribution to journal › Article › peer-review

  • saccharide-binding proteins
  • polyacrylamide
  • Copolymers
  • Lectins
  • Screening
  11 Scopus citations

• Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

  Chadli, A., Bouhouche, I., Sullivan, W., Stensgard, B., McMahon, N., Catelli, M. G. & Toft, D. O., Nov 7 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12524-12529 6 p.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • Molecular Chaperones
  • Dimerization
  • Glutathione Transferase
  • Adenosine Triphosphate
  132 Scopus citations

• GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway

  Chadli, A., Graham, J. D., Abel, M. G., Jackson, T. A., Gordon, D. F., Wood, W. M., Felts, S. J., Horwitz, K. B. & Toft, D., Mar 2006, In: Molecular and Cellular Biology. 26, 5, p. 1722-1730 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Progesterone Receptors
  • tacrolimus binding protein 4
  • progesterone receptor A
  • progesterone receptor B
  • Myosins
  48 Scopus citations

• GCUNC45 is the first Hsp90 Co-chaperone to show α/β isoform specificity

  Chadli, A., Felts, S. J. & Toft, D. O., Apr 11 2008, In: Journal of Biological Chemistry. 283, 15, p. 9509-9512 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Isoforms
  • Molecular Chaperones
  • Normal Distribution
  • Eukaryotic Cells
  • Progesterone Receptors
  35 Scopus citations

• Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis

  Patwardhan, C. A., Fauq, A., Peterson, L. B., Miller, C., Blagg, B. S. J. & Chadli, A., Mar 8 2013, In: Journal of Biological Chemistry. 288, 10, p. 7313-7325 13 p.

  Research output: Contribution to journal › Article › peer-review

  • gedunin
  • protein p23
  • Cell death
  • Cell Death
  • Apoptosis
  81 Scopus citations

• Heat-induced oligomerization of the molecular chaperone Hsp90: Inhibition by ATP and geldanamycin and activation by transition metal oxyanions

  Chadli, A., Ladjimi, M. M., Baulieu, E. E. & Catelli, M. G., Feb 12 1999, In: Journal of Biological Chemistry. 274, 7, p. 4133-4139 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomerization
  • geldanamycin
  • Transition metals
  • HSP90 Heat-Shock Proteins
  • Molecular Chaperones
  39 Scopus citations

• HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor

  Patricia Hernández, M., Chadli, A. & Toft, D. O., Apr 5 2002, In: Journal of Biological Chemistry. 277, 14, p. 11873-11881 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Progesterone Receptors
  • HSP40 Heat-Shock Proteins
  • Adenosine Triphosphate
  • Hormones
  • Stoichiometry
  114 Scopus citations

• Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains

  Johnson, B. D., Chadli, A., Felts, S. J., Bouhouche, I., Catelli, M. G. & Toft, D. O., Oct 20 2000, In: Journal of Biological Chemistry. 275, 42, p. 32499-32507 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Citrate (si)-Synthase
  • Humulus
  • Firefly Luciferases
  • Peptides
  • Molecular Chaperones
  42 Scopus citations

• Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production

  Chen, F., Pandey, D., Chadli, A., Catravas, J. D., Chen, T. & Fulton, D. J. R., Jun 1 2011, In: Antioxidants and Redox Signaling. 14, 11, p. 2107-2119 13 p.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • NADPH Oxidases
  • Hydrogen Peroxide
  • Superoxides
  • Enzymes
  63 Scopus citations

• Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

  Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., 2017, In: Nature communications. 8, 14979.

  Research output: Contribution to journal › Article › peer-review

  • suppressors
  • Myeloid-Derived Suppressor Cells
  • Tumors
  • tumors
  • Plasticity
  125 Scopus citations

• Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones

  Chen, F., Haigh, S., Yu, Y., Benson, T., Wang, Y., Li, X., Dou, H., Bagi, Z., Verin, A. D., Stepp, D. W., Csanyi, G., Chadli, A., Weintraub, N. L., Smith, S. M. E. & Fulton, D. J. R., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 793-805 13 p.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • Carbon Monoxide
  • Superoxides
  • Enzyme activity
  • Assays
  27 Scopus citations

• Oligoclonal β-galactoside-binding immunoglobulins antigenically related to 14kda lectin in human serum and cerebrospinal fluid: Purification and characterization

  Joubert-Caron, R., Caron, M., Bochet, P., Chadli, A., Delaporte, P., Schuller, E. & Bladier, D., Jun 1994, In: International Journal of Biochemistry. 26, 6, p. 813-823 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Galactosides
  • Cerebrospinal fluid
  • Purification
  • Lectins
  • Immunoglobulins
  8 Scopus citations

• Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production

  Chen, F., Yu, Y., Qian, J., Wang, Y., Cheng, B., Dimitropoulou, C., Patel, V., Chadli, A., Rudic, R. D., Stepp, D. W., Catravas, J. D. & Fulton, D. J. R., Dec 2012, In: Arteriosclerosis, thrombosis, and vascular biology. 32, 12, p. 2989-2999 11 p.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins
  • NADP
  • Oxidoreductases
  • NADPH Oxidases
  61 Scopus citations

• Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity

  Lemos, H., Ou, R., McCardle, C., Lin, Y., Calver, J., Minett, J., Chadli, A., Huang, L. & Mellor, A. L., Aug 26 2020, In: Journal for ImmunoTherapy of Cancer. 8, 2, e001182.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Therapy
  • Interferons
  • Immunity
  • Lewis Lung Carcinoma
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  2 Scopus citations

• Presence of an aromatase inhibitor, possibly heat shock protein 90, in dominant follicles of cattle

  Driancourt, M. A., Guet, P., Reynaud, K., Chadli, A. & Catelli, M. G., Jan 1999, In: Journal of Reproduction and Fertility. 115, 1, p. 45-58 14 p.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • Aromatase Inhibitors
  • Aromatase
  • Follicular Fluid
  • Cattle
  19 Scopus citations

• Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

  Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In: Nature communications. 10, 1, 1430.

  Research output: Contribution to journal › Article › peer-review

  • immunity
  • mice
  • Tumors
  • Cells
  • tumors
  19 Scopus citations

• Production and characterization of a monoclonal antibody able to discriminate galectin-1 from galectin-2 and galectin-3

  Cornillot, J. D., Pontet, M., Dupuy, C., Chadli, A., Caron, M., Joubert-Caron, R., Bourin, P. & Bladier, D., May 1998, In: Glycobiology. 8, 5, p. 425-432 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Galectin 2
  • Galectin 1
  • Galectin 3
  • Monoclonal Antibodies
  • human LGALS1 protein
  5 Scopus citations

• Progesterone receptor chaperone complex-based high-throughput screening assay: Identification of capsaicin as an inhibitor of the Hsp90 machine

  Patwardhan, C. A., Alfa, E., Lu, S. & Chadli, A., Feb 24 2015, In: Journal of Biomolecular Screening. 20, 2, p. 223-229 7 p.

  Research output: Contribution to journal › Article › peer-review

  • High-Throughput Screening Assays
  • Assays
  • Capsaicin
  • Progesterone Receptors
  • Screening
  7 Scopus citations

• Purification and characterization of a human brain galectin-1 ligand

  Chadli, A., LeCaer, J. P., Bladier, D., Joubert-Caron, R. & Caron, M., Apr 1997, In: Journal of Neurochemistry. 68, 4, p. 1640-1647 8 p.

  Research output: Contribution to journal › Article › peer-review

  • human LGALS1 protein
  • Galectin 1
  • Purification
  • Brain
  • Ligands
  17 Scopus citations

• Study of lectin-ganglioside interactions by high-performance liquid affinity chromatography

  Caron, M., Joubert-Caron, R., Cartier, J. R., Chadli, A. & Bladier, D., Sep 3 1993, In: Journal of Chromatography A. 646, 2, p. 327-333 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Affinity chromatography
  • saccharide-binding proteins
  • Liquid chromatography
  • Gangliosides
  • lysoGM1 ganglioside
  14 Scopus citations

• Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor

  Pinkerton, D. M., Chow, S., Eisa, N. H., Kainth, K., Vanden Berg, T. J., Burns, J. M., Guddat, L. W., Savage, G. P., Chadli, A. & Williams, C. M., Jan 28 2019, In: Chemistry - A European Journal. 25, 6, p. 1451-1455 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Enzyme inhibition
  • Limonins
  • gedunin
  • Assays
  • Enzymes
  6 Scopus citations

• Targeting the MYC oncogene in burkitt lymphoma through HSP90 inhibition

  Poole, C. J., Zheng, W., Lee, H., Young, D., Lodh, A., Chadli, A. & van Riggelen, J., Nov 16 2018, In: Cancers. 10, 11, 448.

  Research output: Contribution to journal › Article › peer-review

  • Burkitt Lymphoma
  • Oncogenes
  • 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
  • tanespimycin
  • benzyloxycarbonylleucyl-leucyl-leucine aldehyde
  7 Scopus citations

• The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

  Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A. & Cox, M. B., May 30 2014, In: Journal of Biological Chemistry. 289, 22, p. 15297-15308 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Steroid hormones
  • Tetratricopeptide Repeat
  • Steroid Receptors
  • Glucocorticoid Receptors
  • Progestins
  21 Scopus citations

• The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

  Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In: Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

  Research output: Contribution to journal › Article › peer-review

  • NIMA-Related Kinases
  • Myosins
  • Phosphotransferases
  • Carcinogenesis
  • Cell proliferation
  7 Scopus citations

• The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

  Marcu, M. G., Chadli, A., Bouhouche, I., Catelli, M. & Neckers, L. M., Nov 24 2000, In: Journal of Biological Chemistry. 275, 47, p. 37181-37186 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Novobiocin
  • HSP90 Heat-Shock Proteins
  • Adenosine Triphosphate
  • monorden
  • geldanamycin
  416 Scopus citations

• The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter

  Kang, K. I., Meng, X., Devin-Leclerc, J., Bouhouche, I., Chadli, A., Cadepond, F., Baulieu, E. E. & Catelli, M. G., Feb 16 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 4, p. 1439-1444 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Chaperones
  • Ligands
  • Hormones
  • Steroid Receptors
  • DNA
  70 Scopus citations

• The N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptor

  Bouhouche-Chatelier, I., Chadli, A. & Catelli, M. G., 2001, In: Cell Stress and Chaperones. 6, 4, p. 297-305 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Adenosine Triphosphate
  • Sepharose
  • molybdate
  • Fusion reactions
  8 Scopus citations

• The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

  Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In: Oncogene. 38, 4, p. 469-482 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Cell Death
  • Triple Negative Breast Neoplasms
  • Heterografts
  • Cell Line
  13 Scopus citations

• UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

  Jilani, Y., Lu, S., Lei, H., Karnitz, L. M. & Chadli, A., Feb 1 2015, In: Cancer Letters. 357, 1, p. 114-120 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Centrosome
  • Cell Proliferation
  • Neoplasms
  • Myosins
  • Carcinogenesis
  9 Scopus citations
• Comment/debate

  Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)

  Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In: Oncogene. 38, 28, p. 5749 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Financial Management
  • Oncogenes
  • Breast Neoplasms
  • Laboratory Animals
  • Genomics
• Review article

  Glycobiology and bioaffinity chromatography

  Caron, M., Chadli, A., Seve, A. P., Lutomski, D., Bladier, D. & Joubert-Caron, R., Jan 1 1997, In: International Journal of Bio-Chromatography. 3, 2, p. 111-121 11 p.

  Research output: Contribution to journal › Review article › peer-review
  1 Scopus citations