• 1328 Citations
  • 17 h-Index
1992 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1992 2019

  • 1328 Citations
  • 17 h-Index
  • 33 Article
  • 1 Comment/debate
  • 1 Review article
Filter
Article
2019

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature Communications. 10, 1, 1430.

Research output: Contribution to journalArticle

immunity
mice
Tumors
Immunity
tumors
1 Citation (Scopus)

Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor

Pinkerton, D. M., Chow, S., Eisa, N. H., Kainth, K., Vanden Berg, T. J., Burns, J. M., Guddat, L. W., Savage, G. P., Chadli, A. & Williams, C. M., Jan 28 2019, In : Chemistry - A European Journal. 25, 6, p. 1451-1455 5 p.

Research output: Contribution to journalArticle

Limonins
Enzyme inhibition
Machinery
Assays
Enzymes
1 Citation (Scopus)

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R. J., Maihle, N. J., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

Myosins
Carcinogenesis
Phosphotransferases
Cell proliferation
Cells
4 Citations (Scopus)

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Death
Triple Negative Breast Neoplasms
Heterografts
Cell Line
2018
2 Citations (Scopus)

Targeting the MYC oncogene in burkitt lymphoma through HSP90 inhibition

Poole, C. J., Zheng, W., Lee, H., Young, D., Lodh, A., Chadli, A. & van Riggelen, J., Nov 16 2018, In : Cancers. 10, 11, 448.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Oncogenes
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
tanespimycin
Proteins
2017
56 Citations (Scopus)

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature Communications. 8, 14979.

Research output: Contribution to journalArticle

suppressors
plastic properties
Plasticity
Tumors
cascades
2015
6 Citations (Scopus)

Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity

Kabbaj, F. Z., Lu, S., Faouzi, M. E. A., Meddah, B., Proksch, P., Cherrah, Y., Altenbach, H. J., Aly, A. H., Chadli, A. & Debbab, A., Jan 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 1, p. 126-131 6 p.

Research output: Contribution to journalArticle

Chaetomium
Metabolites
Cells
Endophytes
Cell Line
16 Citations (Scopus)

Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones

Chen, F., Haigh, S., Yu, Y., Benson, T., Wang, Y., Li, X., Dou, H., Bagi, Z., Verin, A. D., Stepp, D. W., Csanyi, G., Chadli, A., Weintraub, N. L., Smith, S. M. E. & Fulton, D. J., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 793-805 13 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Carbon Monoxide
Superoxides
Enzyme activity
Protein Binding
4 Citations (Scopus)

Progesterone receptor chaperone complex-based high-throughput screening assay: Identification of capsaicin as an inhibitor of the Hsp90 machine

Patwardhan, C. A., Alfa, E., Lu, S. & Chadli, A., Feb 24 2015, In : Journal of Biomolecular Screening. 20, 2, p. 223-229 7 p.

Research output: Contribution to journalArticle

High-Throughput Screening Assays
Capsaicin
Progesterone Receptors
Assays
Screening
7 Citations (Scopus)

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

Jilani, Y., Lu, S., Huang, L., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

Centrosome
Cell Proliferation
Neoplasms
Aptitude
Myosins
2014
15 Citations (Scopus)

Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms

Pye, C., Elsherbiny, N. M., Ibrahim, A. S., Liou, G. I., Chadli, A., Al-Shabrawey, M. & Elmarakby, A. A., Jan 1 2014, In : Pharmacological Research. 85, p. 45-54 10 p.

Research output: Contribution to journalArticle

Adenosine Kinase
Experimental Diabetes Mellitus
Oxidants
Anti-Inflammatory Agents
Kidney
17 Citations (Scopus)

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A. & Cox, M. B., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15297-15308 12 p.

Research output: Contribution to journalArticle

Steroid hormones
Steroid Receptors
Glucocorticoid Receptors
Androgen Receptors
Progestins
2013
11 Citations (Scopus)

Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium

Okoye, F. B. C., Lu, S., Nworu, C. S., Esimone, C. O., Proksch, P., Chadli, A. & Debbab, A., Aug 7 2013, In : Tetrahedron Letters. 54, 32, p. 4210-4214 5 p.

Research output: Contribution to journalArticle

Apocynaceae
Endophytes
Lactones
Metabolites
Fungi
62 Citations (Scopus)

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis

Patwardhan, C. A., Fauq, A., Peterson, L. B., Miller, C., Blagg, B. S. J. & Chadli, A., Mar 8 2013, In : Journal of Biological Chemistry. 288, 10, p. 7313-7325 13 p.

Research output: Contribution to journalArticle

Cell death
Cell Death
Apoptosis
Caspase 7
Neoplasms
2012
49 Citations (Scopus)

Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production

Chen, F., Yu, Y., Qian, J., Wang, Y., Cheng, B., Dimitropoulou, C., Patel, V. S., Chadli, A., Rudic, R. D., Stepp, D. W., Catravas, J. D. & Fulton, D. J., Dec 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 12, p. 2989-2999 11 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
NADP
Reactive Oxygen Species
Oxidoreductases
2011
54 Citations (Scopus)

Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production

Chen, F., Pandey, D., Chadli, A., Catravas, J. D., Chen, T. & Fulton, D. J. R., Jun 1 2011, In : Antioxidants and Redox Signaling. 14, 11, p. 2107-2119 13 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
NADPH Oxidase
Superoxides
Hydrogen Peroxide
Enzymes
2010
54 Citations (Scopus)

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

Steroid Receptors
Adenosine Triphosphate
Dissection
Molecules
Molecular Chaperones
2008
21 Citations (Scopus)

Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition

Chadli, A., Bruinsma, E. S., Stensgard, B. & Toft, D., Mar 4 2008, In : Biochemistry. 47, 9, p. 2850-2857 8 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Proteins
Conformations
Nucleotides
Adenosine Triphosphate
34 Citations (Scopus)

GCUNC45 is the first Hsp90 Co-chaperone to show α/β isoform specificity

Chadli, A., Felts, S. J. & Toft, D. O., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 9509-9512 4 p.

Research output: Contribution to journalArticle

Protein Isoforms
Molecular Chaperones
Normal Distribution
Eukaryotic Cells
Progesterone Receptors
2006
47 Citations (Scopus)

GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway

Chadli, A., Graham, J. D., Abel, M. G., Jackson, T. A., Gordon, D. F., Wood, W. M., Felts, S. J., Horwitz, K. B. & Toft, D., Mar 1 2006, In : Molecular and Cellular Biology. 26, 5, p. 1722-1730 9 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Myosins
Adenosine Triphosphatases
Adenosine Triphosphate
Binding Sites
2002
113 Citations (Scopus)

HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor

Patricia Hernández, M., Chadli, A. & Toft, D. O., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11873-11881 9 p.

Research output: Contribution to journalArticle

Progesterone Receptors
HSP40 Heat-Shock Proteins
Adenosine Triphosphate
Hormones
Stoichiometry
2001
8 Citations (Scopus)

The N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptor

Bouhouche-Chatelier, I., Chadli, A. & Catelli, M. G., Dec 19 2001, In : Cell Stress and Chaperones. 6, 4, p. 297-305 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Adenosine Triphosphate
Sepharose
Bearings (structural)
Fusion reactions
2000
132 Citations (Scopus)

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

Chadli, A., Bouhouche, I., Sullivan, W., Stensgard, B., McMahon, N., Catelli, M. G. & Toft, D. O., Nov 7 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12524-12529 6 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Molecular Chaperones
Dimerization
Glutathione Transferase
Adenosine Triphosphate
41 Citations (Scopus)

Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains

Johnson, B. D., Chadli, A., Felts, S. J., Bouhouche, I., Catelli, M. G. & Toft, D. O., Oct 20 2000, In : Journal of Biological Chemistry. 275, 42, p. 32499-32507 9 p.

Research output: Contribution to journalArticle

Citrate (si)-Synthase
Firefly Luciferases
Humulus
Peptides
Molecular Chaperones
395 Citations (Scopus)

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

Marcu, M. G., Chadli, A., Bouhouche, I., Catelli, M. & Neckers, L. M., Nov 24 2000, In : Journal of Biological Chemistry. 275, 47, p. 37181-37186 6 p.

Research output: Contribution to journalArticle

Novobiocin
HSP90 Heat-Shock Proteins
Adenosine Triphosphate
Steroid hormones
Binding Sites
1999
38 Citations (Scopus)

Heat-induced oligomerization of the molecular chaperone Hsp90: Inhibition by ATP and geldanamycin and activation by transition metal oxyanions

Chadli, A., Ladjimi, M. M., Baulieu, E. E. & Catelli, M. G., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 4133-4139 7 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Oligomerization
Molecular Chaperones
Transition metals
Hot Temperature
17 Citations (Scopus)

Presence of an aromatase inhibitor, possibly heat shock protein 90, in dominant follicles of cattle

Driancourt, M. A., Guet, P., Reynaud, K., Chadli, A. & Catelli, M. G., Jan 1999, In : Journal of Reproduction and Fertility. 115, 1, p. 45-58 14 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Aromatase Inhibitors
Aromatase
Follicular Fluid
Proteins
69 Citations (Scopus)

The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter

Kang, K. I., Meng, X., Devin-Leclerc, J., Bouhouche, I., Chadli, A., Cadepond, F., Baulieu, E. E. & Catelli, M. G., Feb 16 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 4, p. 1439-1444 6 p.

Research output: Contribution to journalArticle

Molecular Chaperones
Ligands
Hormones
Steroid Receptors
Poisons
1998
5 Citations (Scopus)

Production and characterization of a monoclonal antibody able to discriminate galectin-1 from galectin-2 and galectin-3

Cornillot, J. D., Pontet, M., Dupuy, C., Chadli, A., Caron, M., Joubert-Caron, R., Bourin, P. & Bladier, D., May 1 1998, In : Glycobiology. 8, 5, p. 425-432 8 p.

Research output: Contribution to journalArticle

Galectin 2
Galectin 1
Galectin 3
Monoclonal Antibodies
Brain
1997
17 Citations (Scopus)

Purification and characterization of a human brain galectin-1 ligand

Chadli, A., LeCaer, J. P., Bladier, D., Joubert-Caron, R. & Caron, M., Jan 1 1997, In : Journal of Neurochemistry. 68, 4, p. 1640-1647 8 p.

Research output: Contribution to journalArticle

Galectin 1
Purification
Brain
Ligands
HSP90 Heat-Shock Proteins
1994
8 Citations (Scopus)

Oligoclonal β-galactoside-binding immunoglobulins antigenically related to 14kda lectin in human serum and cerebrospinal fluid: Purification and characterization

Joubert-Caron, R., Caron, M., Bochet, P., Chadli, A., Delaporte, P., Schuller, E. & Bladier, D., Jan 1 1994, In : International Journal of Biochemistry. 26, 6, p. 813-823 11 p.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Galactosides
Lectins
Purification
Cerebrospinal Fluid
1993
12 Citations (Scopus)

Study of lectin-ganglioside interactions by high-performance liquid affinity chromatography

Caron, M., Joubert-Caron, R., Cartier, J. R., Chadli, A. & Bladier, D., Sep 3 1993, In : Journal of Chromatography A. 646, 2, p. 327-333 7 p.

Research output: Contribution to journalArticle

Affinity chromatography
Gangliosides
Liquid chromatography
Affinity Chromatography
Lectins
1992
11 Citations (Scopus)

Development of screening methods for detection of carbohydrate-binding proteins by use of soluble glycosylated polyacrylamide-based copolymers

Chadli, A., Caron, M., Tichá, M., Joubert, R., Bladier, D. & Kocourek, J., Jan 1 1992, In : Analytical Biochemistry. 204, 1, p. 198-203 6 p.

Research output: Contribution to journalArticle

Lectins
Screening
Copolymers
Assays
Polymers