Biaoru Li

Senior Research Scientist

  • 567 Citations
  • 16 h-Index
19942019
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Research Output 1994 2019

2019
1 Citation (Scopus)

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice

Oseghale, A. R., Zhu, X., Li, B., Peterson, K. R., Nudelman, A., Rephaeli, A., Xu, H. & Pace, B. S., Nov 1 2019, In : Blood Cells, Molecules, and Diseases. 79, 102345.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Prodrugs
Transgenic Mice
Sickle Cell Anemia
2 Citations (Scopus)

Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease

Zhu, X., Oseghale, A. R., Nicole, L. H., Li, B. & Pace, B. S., Feb 1 2019, In : Experimental Biology and Medicine. 244, 2, p. 171-182 12 p.

Research output: Contribution to journalReview article

Fetal Hemoglobin
Oxidative stress
Sickle Cell Anemia
Oxidative Stress
Sickle Hemoglobin
8 Citations (Scopus)

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Gene Silencing
MicroRNAs
1 Citation (Scopus)

MIR29B mediates epigenetic mechanisms of HBG gene activation

Starlard-Davenport, A., Smith, A., Vu, L., Li, B. & Pace, B. S., Jul 2019, In : British Journal of Haematology. 186, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Epigenomics
Transcriptional Activation
Methyltransferases
Cytidine Deaminase
2018
3 Citations (Scopus)

Fetal hemoglobin induction in sickle erythroid progenitors using a synthetic zinc finger DNA-binding domain

Li, B., Zhu, X., Hossain, M. A., Guy, C. R., Xu, H., Bungert, J. & Pace, B. S., Aug 31 2018, In : Haematologica. 103, 9, p. e384-e387

Research output: Contribution to journalLetter

Fetal Hemoglobin
Zinc Fingers
DNA
2017
8 Citations (Scopus)

NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors

Zhu, X., Li, B. & Pace, B. S., Jul 31 2017, In : Haematologica. 102, 8, p. e285-e288

Research output: Contribution to journalLetter

gamma-Globins
Fetal Hemoglobin
Genes
2016
7 Citations (Scopus)

Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells

Ward, C. M., Li, B. & Pace, B. S., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 719-729 11 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
K562 Cells
Genes
Histone Deacetylase 1

Personalized chemotherapy of tumor disease based on system modeling

Li, B., Jan 1 2016, Frontiers in Drug Design and Discovery. 1 ed. Bentham Science Publishers B.V., p. 223-247 25 p. (Frontiers in Drug Design and Discovery; vol. 7, no. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Therapy
Precision Medicine
Neoplasms
Drug Discovery
Therapeutics
2015
13 Citations (Scopus)

Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease

Pace, B. S., Liu, L., Li, B. & Makala, L. H., Jan 1 2015, In : Experimental Biology and Medicine. 240, 8, p. 1050-1064 15 p.

Research output: Contribution to journalArticle

Cell signaling
Fetal Hemoglobin
Sickle Cell Anemia
Globins
Sickle Hemoglobin
7 Citations (Scopus)

Novel inducers of fetal globin identified through high throughput screening (HTS) are active in vivo in anemic baboons and transgenic mice

Boosalis, M. S., Sangerman, J. I., White, G. L., Wolf, R. F., Shen, L., Dai, Y., White, E., Makala, L. H., Li, B., Pace, B. S., Nouraie, M., Faller, D. V. & Perrine, S. P., Dec 1 2015, In : PloS one. 10, 12, 0144660.

Research output: Contribution to journalArticle

Globins
Papio
Transgenic Mice
Screening
promoter regions

Single-cell next-generation sequencing and its applications in cancer biology

Li, B., Zhang, X. & Zheng, J., Jan 1 2015, Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides. Springer International Publishing, p. 1-18 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumors
Genes
Neoplasms
Tissue
Microarrays
2014
17 Citations (Scopus)

A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies

Peterson, K. R., Costa, F. C., Fedosyuk, H., Neades, R. Y., Chazelle, A. M., Zelenchuk, L., Fonteles, A. H., Dalal, P., Roy, A., Chaguturu, R., Li, B. & Pace, B. S., Sep 16 2014, In : PloS one. 9, 9, e107006.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Hemoglobinopathies
Globins
hemoglobin
luciferase
3 Citations (Scopus)

Characterization of transcription factor networks involved in umbilical cord blood CD34+ stem cells-derived erythropoiesis

Li, B., Ding, L., Yang, C., Kang, B., Liu, L., Story, M. D. & Pace, B. S., Sep 2014, In : PloS one. 9, 9, e0107133.

Research output: Contribution to journalArticle

erythropoiesis
umbilical cord
Globins
Erythropoiesis
blood cells
19 Citations (Scopus)
Fetal Hemoglobin
Erythroid Cells
Retinal Pigments
Globins
Retina
2012
12 Citations (Scopus)

Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation

Li, B., Ding, L., Li, W., Story, M. D. & Pace, B. S., Apr 26 2012, In : BMC Genomics. 13, 1, 153.

Research output: Contribution to journalArticle

Globins
Transcriptome
Genes
Gene Expression Profiling
Ataxia Telangiectasia Mutated Proteins
2011

Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting

Wang, Z., Hu, H., Zheng, J. & Li, B., Dec 27 2011, Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. p. 72-77 6 p. 6089810. (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

T-cells
Gene expression
Liver
Tumors
Blood
2009
4 Citations (Scopus)

Genomic expression analysis by single-cell mRNA differential display of quiescent CD8 T cells from tumour-infiltrating lymphocytes obtained from in vivo liver tumours

Zhang, W., Ding, J., Qu, Y., Hu, H., Lin, M., Datta, A., Larson, A., Liu, G. E. & Li, B., May 1 2009, In : Immunology. 127, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Tumor-Infiltrating Lymphocytes
Gene Expression Profiling
T-Lymphocytes
Liver
2006
17 Citations (Scopus)

Regulation of sexual dimorphism: Mutational and chemogenetic analysis of the doublesex DM domain

Zhang, W., Li, B., Singh, R., Narendra, U., Zhu, L. & Weiss, M. A., Jan 1 2006, In : Molecular and Cellular Biology. 26, 2, p. 535-547 13 p.

Research output: Contribution to journalArticle

Sex Characteristics
DNA
Drosophila
Zinc
Sex Factors
16 Citations (Scopus)

SRY-directed DNA Bending and Human Sex Reversal: Reassessment of a Clinical Mutation Uncovers a Global Coupling between the HMG Box and its Tail

Li, B., Phillips, N. B., Jancso-Radek, A., Ittah, V., Singh, R., Jones, D. N., Haas, E. & Weiss, M. A., Jul 7 2006, In : Journal of Molecular Biology. 360, 2, p. 310-328 19 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Tail
Mutation
DNA
Transcriptional Activation
2005
5 Citations (Scopus)

A strategy to identify genomic expression at single-cell level or a small number of cells

Li, B., Apr 15 2005, In : Electronic Journal of Biotechnology. 8, 1, p. 71-81 11 p.

Research output: Contribution to journalReview article

Cell Count
Carcinogenesis
Single-Cell Analysis
Gene Expression
Electrophoresis, Gel, Two-Dimensional
2004
27 Citations (Scopus)

Enhancing the activity of insulin at the receptor interface: Crystal structure and photo-cross-linking of A8 analogues

Wan, Z., Xu, B., Huang, K., Chu, Y. C., Li, B., Nakagawa, S. H., Qu, Y., Hu, S. Q., Katsoyannis, P. G. & Weiss, M. A., Dec 28 2004, In : Biochemistry. 43, 51, p. 16119-16133 15 p.

Research output: Contribution to journalArticle

Insulin Receptor
Crystal structure
Insulin
Substitution reactions
Hormones
2 Citations (Scopus)

Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex

Bayrer, J., Wan, Z., Li, B. & Weiss, M. A., Jul 1 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 7, p. 1328-1330 3 p.

Research output: Contribution to journalArticle

Selenomethionine
Crystallization
Drosophila
Transcription Factors
X-Rays
68 Citations (Scopus)

How insulin binds: The B-chain α-helix contacts the L1 β-helix of the insulin receptor

Huang, K., Xu, B., Hu, S. Q., Chu, Y. C., Hua, Q. X., Qu, Y., Li, B., Wang, S., Wang, R. Y., Nakagawa, S. H., Theede, A. M., Whittaker, J., De Meyts, P., Katsoyannis, P. G. & Weiss, M. A., Aug 6 2004, In : Journal of Molecular Biology. 341, 2, p. 529-550 22 p.

Research output: Contribution to journalArticle

Insulin Receptor
Alanine
Insulin
Aminobutyrates
Threonine
2003
31 Citations (Scopus)

DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction

Luo, L., Li, B. & Pretlow, T. P., Oct 1 2003, In : Cancer Research. 63, 19, p. 6166-6169 4 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
DNA Fingerprinting
Genomic Instability
Colonic Neoplasms
Polymerase Chain Reaction
7 Citations (Scopus)

The effects of the farnesyl transferase inhibitor FTI L-778,123 on normal, myelodysplastic, and myeloid leukemia bone marrow progenitor proliferation in vitro

Huang, X. K., Meyer, P., Li, B., Raza, A. & Preisler, H. D., Jan 1 2003, In : Leukemia and Lymphoma. 44, 1, p. 157-164 8 p.

Research output: Contribution to journalReview article

Myeloid Leukemia
Proxy
Transferases
Stem Cells
Bone Marrow
2002
10 Citations (Scopus)

Experimental and bioinformatics comparison of gene expression between T cells from TIL of liver cancer and T cells from UniGene

Li, B., Perabekam, S., Liu, G., Yin, M., Song, S. & Larson, A., May 21 2002, In : Journal of Gastroenterology. 37, 4, p. 275-282 8 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Liver Neoplasms
Computational Biology
T-Lymphocytes
Gene Expression
22 Citations (Scopus)

Sex-specific gene regulation: The doublesex DM motif is a bipartite DNA-binding domain

Narendra, U., Zhu, L., Li, B., Wilken, J. & Weiss, M. A., Nov 8 2002, In : Journal of Biological Chemistry. 277, 45, p. 43463-43473 11 p.

Research output: Contribution to journalArticle

Gene expression
Tail
DNA
Zinc
Genes
2001
17 Citations (Scopus)

Alterations in IRF1/IRF2 expression in acute myelogenous leukemia

Preisler, H. D., Perambakam, S., Li, B., Hsu, W. T., Venugopal, P., Creech, S., Sivaraman, S. & Tanaka, N., Aug 23 2001, In : American Journal of Hematology. 68, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Bone Marrow
Gene Expression
Mutation
p53 Genes
41 Citations (Scopus)

Human sex reversal due to impaired nuclear localization of SRY: A clinical correlation

Li, B., Zhang, W., Chan, G., Jancso-Radek, A., Liu, S. & Weiss, M. A., Dec 7 2001, In : Journal of Biological Chemistry. 276, 49, p. 46480-46484 5 p.

Research output: Contribution to journalArticle

46,XY Gonadal Dysgenesis
Nuclear Localization Signals
Mutation
DNA
Chromosomes
17 Citations (Scopus)

In vivo effects of IL-4, IL-10, and amifostine on cytokine production in patients with acute myelogenous leukemia

Tao, M., Li, B., Nayini, J., Sivaraman, S., Song, S., Larson, A., Toofanfard, M., Chen, H., Venugopal, P. & Preisler, H. D., Jan 1 2001, In : Leukemia and Lymphoma. 41, 1-2, p. 161-168 8 p.

Research output: Contribution to journalArticle

Amifostine
Acute Myeloid Leukemia
Interleukin-4
Interleukin-10
Cytokines
37 Citations (Scopus)

P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients

Preisler, H. D., Li, B., Chen, H., Fisher, L., Nayini, J., Raza, A., Creech, S. & Venugopal, P., Jan 1 2001, In : Leukemia. 15, 10, p. 1589-1595 7 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Methylation
Lymphoma
Bone Marrow
Gene Expression
9 Citations (Scopus)

Poor prognosis acute myelogenous leukemia: 3 - Biological and molecular biological changes during remission induction therapy

Devemy, E., Li, B., Tao, M., Horvath, E., Chopra, H., Fisher, L., Nayini, J., Creech, S., Venugopal, P., Yang, J., Kaspar, C., Hsu, W. T. & Preisler, H. D., Jan 1 2001, In : Leukemia Research. 25, 9, p. 783-791 9 p.

Research output: Contribution to journalArticle

Remission Induction
Acute Myeloid Leukemia
Leukemia
Telomerase
Drug Therapy
2 Citations (Scopus)

Quantitation of interferon regulatory factor transcripts in patients with acute myeloid leukemia

Perambakam, S., Li, B. & Preisler, H., Jun 21 2001, In : Cancer Investigation. 19, 4, p. 346-351 6 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Acute Myeloid Leukemia
Amifostine
Bone Marrow
Interleukin-4
28 Citations (Scopus)

SRY and architectural gene regulation: The kinetic stability of a bent protein-DNA complex can regulate its transcriptional potency

Ukiyama, E., Jancso-Radek, A., Li, B., Milos, L., Zhang, W., Phillips, N. B., Morikawa, N., King, C. Y., Chan, G., Haqq, C. M., Radek, J. T., Poulat, F., Donahoe, P. K. & Weiss, M. A., Jan 1 2001, In : Molecular Endocrinology. 15, 3, p. 363-377 15 p.

Research output: Contribution to journalArticle

DNA
Genes
Proteins
Base Pairing
Sex-Determining Region Y Protein
2000
7 Citations (Scopus)

Identification of mRNAs expressed in tumor-infiltrating lymphocytes by a strategy for rapid and high throughput screening

Li, B., Chang, T., Larson, A. & Ding, J., Sep 19 2000, In : Gene. 255, 2, p. 273-279 7 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Gene Expression
Messenger RNA
Liver Neoplasms
Complementary DNA

Immunologic character of tumor infiltrating lymphocytes in ovarian carcinoma

Wang, J. H., Tong, S. Q., Li, B., Ding, J. Q., Hu, B. Y., Zhu, Y. M., Lu, D. Y., Hua, Z. D. & Lu, J., Jan 1 2000, In : Chinese Journal of Cancer Research. 12, 2, p. 99-104 6 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Carcinoma
Aptitude
Cytokines
Neoplasms
3 Citations (Scopus)

Poor prognosis acute myelogenous leukemia 2 - Biological and molecular biological characteristics and treatment outcome

Li, B., Yang, J., Tao, M., Nayini, J., Horvath, E., Chopra, H., Meyer, P., Venugopal, P. & Preisler, H. D., Sep 1 2000, In : Leukemia Research. 24, 9, p. 777-789 13 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Amifostine
Bone Marrow
Telomerase
Leukemia

Regulation of serum cytokines following IL-4 and IL-10 therapy in patients with acute myelogenous leukemia

Tao, M., Li, B., Nayini, J., Sivaraman, S., Song, S., Larson, A., Toofanfard, M., Chen, H., Venugopal, P. & Preisler, H. D., Dec 1 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Interleukin-4
Interleukin-10
Cytokines
Interleukin-1
21 Citations (Scopus)

SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients

Tao, M., Li, B., Nayini, J., Andrews, C. B., Huang, R. W., Devemy, E., Song, S., Venugopal, P. & Preisler, H. D., Jun 2000, In : Cytokine. 12, 6, p. 699-707 9 p.

Research output: Contribution to journalArticle

Interleukin 1 Receptor Antagonist Protein
Emitter coupled logic circuits
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Bone
12 Citations (Scopus)

Signal antonymy unique to myelodysplastic marrows correlates with altered expression of E2F1

Mundle, S. D., Mativi, B. Y., Cartlidge, J. D., Dangerfield, B., Broady-Robinson, L. T., Li, B., Shetty, V., Venugopal, P., Gregory, S. A., Preisler, H. D. & Raza, A., Jun 24 2000, In : British Journal of Haematology. 109, 2, p. 376-381 6 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Bone Marrow
Retinoblastoma
Non-Hodgkin's Lymphoma
Retinoblastoma Binding Proteins
14 Citations (Scopus)

Suppression of telomerase activity and cytokine messenger RNA levels in acute myelogenous leukemia cells in vivo in patients by amifostine and interleukin 4

Preisler, H. D., Li, B., Yang, J., Huang, R. W., Devemy, E., Venugopal, P., Tao, M., Chopra, H., Gregory, S. A., Adler, S., Sivaraman, S., Toofanfard, P., Jajeh, A., Galvez, A. & Robin, E., Mar 1 2000, In : Clinical Cancer Research. 6, 3, p. 807-812 6 p.

Research output: Contribution to journalArticle

Amifostine
Telomerase
Acute Myeloid Leukemia
Interleukin-4
Leukemia
23 Citations (Scopus)

Telomerase activity in preleukemia and acute myelogenous leukemia

Li, B., Yang, J., Andrews, C., Chen, Y. X., Toofanfard, P., Huang, R. W., Horvath, E., Chopra, H., Raza, A. & Preisler, H. D., Jan 1 2000, In : Leukemia and Lymphoma. 36, 5-6, p. 579-587 9 p.

Research output: Contribution to journalArticle

Preleukemia
Telomerase
Acute Myeloid Leukemia
Bone Marrow
X Chromosome Inactivation
1999
1 Citation (Scopus)

Marrow cytokine transcripts and the secondary hematologic disorders

Preisler, H. D., Gao, X. Z., Ming, T., Li, B., Bi, S., Devemy, E., Loew, J. & Raza, A., Jan 1 1999, In : Leukemia and Lymphoma. 35, 3-4, p. 297-302 6 p.

Research output: Contribution to journalArticle

Bone Marrow
Cytokines
Apoptosis
4 Citations (Scopus)

Tumor tissue recycling - A new combination treatment for solid tumors: Experimental and preliminarily clinical research

Li, B., Ding, J., Larson, A. & Song, S., Sep 1 1999, In : In Vivo. 13, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

Recycling
Tumors
Tissue
Research
Cancer Vaccines

Tyrosine phosphorylation of Shc proteins in normal CD34+ progenitor cells and leukemic cells [2]

Yang, J., Li, B., Nayini, J., Venugopal, P., Tao, M., Andrews, C. B. & Preisler, H. D., Jul 1 1999, In : Blood. 94, 1, p. 373-374 2 p.

Research output: Contribution to journalLetter

Signal Transducing Adaptor Proteins
CD34 Antigens
Vesicular Transport Adaptor Proteins
Phosphorylation
Hematopoietic Stem Cells
1998
17 Citations (Scopus)

Cytokine gene activity in AML cells in vivo in patients

Gao, X. Z., Bi, S., Copra, H., Devemy, E., Venugopal, P., Li, B., Hsu, W. T., Loew, J., Galvez, A., Gregory, S., Yang, J., Horvath, E. & Preisler, H. D., May 1 1998, In : Leukemia Research. 22, 5, p. 429-438 10 p.

Research output: Contribution to journalArticle

Cytokines
Leukemia
Genes
Remission Induction
Interleukin-6
1994
2 Citations (Scopus)

A new experimental and clinical approach of combining usage of highly active tumor-infiltrating lymphocytes and highly sensitive antitumor drugs for the advanced malignant tumor

Li, B., Tong, S., Zhang, X., Lu, J., Gu, Q. & Lu, D., Dec 1 1994, In : Chinese Medical Journal. 107, 11, p. 803-807 5 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Antineoplastic Agents
Neoplasms
Interleukin-2
Poisons
2 Citations (Scopus)

Study on the influence of enzymatic digestion upon tumor-infiltrating lymphocytes

Li, B., Tong, S. Q., Hu, B. Y., Zhu, Y. M., Zhang, X. H., Wu, J. H., Lu, J. & Lu, D. Y., Mar 1 1994, In : Shi yan sheng wu xue bao = Journal of experimental biology. 27, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Digestion
Collagenases
Hyaluronoglucosaminidase
Trypsin