Bobby Thomas

Associate Professor

  • 4573 Citations
  • 30 h-Index
20002018
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Parkinson Disease Medicine & Life Sciences
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Medicine & Life Sciences
NF-E2-Related Factor 2 Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Corpus Striatum Medicine & Life Sciences
Neuroprotective Agents Medicine & Life Sciences
Antioxidant Response Elements Medicine & Life Sciences
Knockout Mice Medicine & Life Sciences

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Projects 2008 2015

Activators of Nrf2/ARE pathway as therapeutic target for Parkinson's Disease

Thomas, B.

National Institutes of Health

6/1/099/30/11

Project: Research projectExploratory/Developmental Grants

NF-E2-Related Factor 2
Antioxidant Response Elements
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Synucleins

Role of MyD88-5 in the pathogenesis of Parkinson's disease

Thomas, B.

National Institutes of Health

7/16/086/30/15

Project: Research projectResearch Project

Parkinson Disease
Synucleins
Mitogen-Activated Protein Kinase 10
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Knockout Mice

Research Output 2000 2018

  • 4573 Citations
  • 30 h-Index
  • 43 Article
  • 8 Review article
  • 2 Chapter
1 Citations

Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors

Gaisina, I. N., Lee, S. H., Kaidery, N. A., Ben Aissa, M., Ahuja, M., Smirnova, N. N., Wakade, S., Gaisin, A., Bourassa, M. W., Ratan, R. R., Nikulin, S. V., Poloznikov, A. A., Thomas, B., Thatcher, G. R. J. & Gazaryan, I. G., May 16 2018, In : ACS Chemical Neuroscience. 9, 5, p. 894-900 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Chemical activation
Prolyl Hydroxylases
Acids
Aptitude

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A. A., Bettendorff, L., Hushpulian, D. M., Smirnova, N. A., Gazaryan, I. G., Kaidery, N. A., Wakade, S., Calingasan, N. Y., Thomas, B., Gibson, G. E., Dumont, M. & 1 othersBeal, M. F., Jan 1 2018, In : Human Molecular Genetics. 27, 16, p. 2874-2892 19 p.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Tauopathies
Transgenic Mice
Thiamine
Neurofibrillary Tangles
5 Citations

Current perspective of mitochondrial biology in Parkinson's disease

Ammal Kaidery, N. & Thomas, B., Jul 1 2018, In : Neurochemistry International. 117, p. 91-113 23 p.

Research output: Contribution to journalReview article

Parkinson Disease
Movement Disorders
Neurodegenerative Diseases
Homeostasis
Mitochondrial Dynamics

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 1 2018, (Accepted/In press) In : Experimental eye research.

Research output: Contribution to journalArticle

Homocysteine
Neuroglia
Up-Regulation
Antioxidants
Oxidative Stress

Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease

Rane, A., Rajagopalan, S., Ahuja, M., Thomas, B., Chinta, S. J. & Andersen, J. K., Mar 1 2018, In : NeuroToxicology. 65, p. 166-173 8 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Parkinson Disease
Stabilization
Neurons
1-Methyl-4-phenylpyridinium