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Research Output 1983 2019

1999
58 Citations (Scopus)
Hydroxybutyrates
Ketone Bodies
Diabetic Ketoacidosis
Endothelin-1
Vascular Endothelial Growth Factor A
2000
35 Citations (Scopus)

Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line

Isales, C. M., Sumpio, B., Bollag, R. J., Zhong, Q., Ding, K., Du, W., Rodriguez-Commes, J., Lopez, R., Rosales, O. R., Gasalla-Herraiz, J., McCarthy, R. & Barrett, P. Q., Oct 4 2000, In : American Journal of Physiology - Endocrinology and Metabolism. 279, 3 42-3, p. E654-E662

Research output: Contribution to journalArticle

Parathyroid Hormone Receptors
Umbilical Veins
Parathyroid Hormone
Endothelial Cells
Cell Line
39 Citations (Scopus)

Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

Zhong, Q., Bollag, R. J., Dransfield, D. T., Gasalla-Herraiz, J., Ding, K. H., Min, L. & Isales, C. M., Nov 8 2000, In : Peptides. 21, 9, p. 1427-1432 6 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Endothelial cells
Endothelial Cells
Peptide Receptors
Calcium Signaling
170 Citations (Scopus)

Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors

Bollag, R. J., Zhong, Q., Phillips, P., Min, L., Zhong, L., Cameron, R., Mulloy, A. L., Rasmussen, H., Qin, F., Ding, K. H. & Isales, C. M., Jan 1 2000, In : Endocrinology. 141, 3, p. 1228-1235 8 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Peptide Receptors
Osteoblasts
Incretins
Bone and Bones
2001
9 Citations (Scopus)

Angiotensin II priming of aldosterone secretion with agents that enhance Ca2+ influx

Betancourt-Calle, S., Mann-Blakeney, R. S., Isales, C. M., Calle, R. A. & Bollag, W. B., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 61-70 10 p.

Research output: Contribution to journalArticle

Aldosterone
Angiotensin II
Phosphorylation
Saralasin
Protein Kinase C
35 Citations (Scopus)

Differential effects of agonists of aldosterone secretion on steroidogenic acute regulatory phosphorylation

Betancourt-Calle, S., Calle, R. A., Isales, C. M., White, S., Rasmussen, H. & Bollag, W. B., Feb 22 2001, In : Molecular and Cellular Endocrinology. 173, 1-2, p. 87-94 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Aldosterone
Tetradecanoylphorbol Acetate
Angiotensin II
Adrenocorticotropic Hormone

Functional analysis of glucose-dependent insulinotropic polypeptide fusion proteins

Ding, K., Isales, C. M., Zhong, Q. & Bollag, R. J., Apr 30 2001, In : Peptides. 22, 4, p. 575-582 8 p.

Research output: Contribution to journalArticle

Functional analysis
Fusion reactions
Glucose
Peptides
Green Fluorescent Proteins
101 Citations (Scopus)

Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects

Bollag, R. J., Zhong, Q., Ding, K. H., Phillips, P., Zhong, L., Qin, F., Cranford, J., Mulloy, A. L., Cameron, R. & Isales, C. M., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 35-41 7 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Hormones
Bone
Nutrients
Bone and Bones
44 Citations (Scopus)

Microarray analysis of Tbx2-directed gene expression: A possible role in osteogenesis

Chen, J. R., Zhong, Q., Wang, J., Cameron, R. S., Borke, J. L., Isales, C. M. & Bollag, R. J., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 43-54 12 p.

Research output: Contribution to journalArticle

Microarray Analysis
Microarrays
Osteogenesis
Gene expression
Genes
2002
10 Citations (Scopus)

Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration

Throckmorton, D., Kurscheid-Reich, D., Rosales, O. R., Rodriguez-Commes, J., Lopez, R., Sumpio, B., Zhong, Q., Ding, K., McCarthy, R., Barrett, P. Q. & Isales, C. M., Feb 11 2002, In : Peptides. 23, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

Endothelial cells
Parathyroid Hormone
Endothelial Cells
Protein Kinase C
Peptides
2003
14 Citations (Scopus)
Gastric Inhibitory Polypeptide
Transforming Growth Factor beta
Cell proliferation
Thymidine
Cell Proliferation
17 Citations (Scopus)
Gastric Inhibitory Polypeptide
Endothelial cells
Human Umbilical Vein Endothelial Cells
Endothelin-1
Thymidine
65 Citations (Scopus)

High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway

Shaw, S., Wang, X., Redd, H., Alexander, G. D., Isales, C. M. & Marrero, M. B., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 30634-30641 8 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Muscle
15 Citations (Scopus)

Negative transcriptional regulation of connexin 43 by Tbx2 in rat immature coronal sutures and ROS 17/2.8 cells in culture

Borke, J. L., Chen, J. R., Yu, J. C., Bollag, R. J., Orellana, M. F. & Isales, C. M., May 1 2003, In : Cleft Palate-Craniofacial Journal. 40, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

Connexin 43
Sutures
Cell Culture Techniques
Proteins
Cranial Sutures
6 Citations (Scopus)

Primary ovarian lymphoma manifesting with severe hypercalcemia

Rizvi, A. A., Bowman, M. A., Vaughters, R. B., Isales, C. & Mulloy, A. L., Sep 1 2003, In : Endocrine Practice. 9, 5, p. 389-393 5 p.

Research output: Contribution to journalArticle

Hypercalcemia
Lymphoma
Serum
Calcium
Confusion
17 Citations (Scopus)

Tension-Induced Reduction in Connexin 43 Expression in Cranial Sutures is Linked to Transcriptional Regulation by TBX2

Borke, J. L., Yu, J. C., Isales, C. M., Wagle, N., Do, N. N., Chen, J. R. & Bollag, R. J., Nov 1 2003, In : Annals of Plastic Surgery. 51, 5, p. 499-504 6 p.

Research output: Contribution to journalArticle

Cranial Sutures
Connexin 43
Bone and Bones
Green Fluorescent Proteins
Osteogenesis
2004
1 Citation (Scopus)

A patient with concurrent primary hyperaldosteronism and adrenal insufficiency

Puentes, F., Jackson, T. W. & Isales, C. M., Dec 2004, In : American Journal of the Medical Sciences. 328, 6, p. 344-347 4 p.

Research output: Contribution to journalArticle

Cosyntropin
Addison Disease
Hyperaldosteronism
Aortic Rupture
Adrenal Insufficiency
30 Citations (Scopus)
Gastric Inhibitory Polypeptide
Hepatic Artery
Endothelial cells
Portal Vein
Endothelial Cells
268 Citations (Scopus)

Leptin deficiency produces contrasting phenotypes in bones of the limb and spine

Hamrick, M. W., Pennington, C., Newton, D., Xie, D. & Isales, C., Mar 1 2004, In : Bone. 34, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

Leptin
Spine
Extremities
Phenotype
Bone and Bones
25 Citations (Scopus)

Tbx2 represses expression of Connexin43 in osteoblastic-like cells

Chen, J. R., Chatterjee, B., Meyer, R., Yu, J. C., Borke, J. L., Isales, C. M., Kirby, M. L., Lo, C. W. & Bollag, R. J., Jun 1 2004, In : Calcified Tissue International. 74, 6, p. 561-573 13 p.

Research output: Contribution to journalArticle

Connexin 43
Osteoblasts
Gap Junctions
Binding Sites
Down-Regulation
29 Citations (Scopus)

The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans

Pi, W., Yang, Z., Wang, J., Ruan, L., Yu, X., Ling, J., Krantz, S., Isales, C. M., Conway, S. J., Lin, S. & Tuan Lo, D., Jan 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 3, p. 805-810 6 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Zebrafish
Oocytes
Stem Cells
Globins
2005
1 Citation (Scopus)
Endothelial cells
Human Umbilical Vein Endothelial Cells
Thymidine
Endothelial Cells
Molecules
111 Citations (Scopus)

Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover

Xie, D., Cheng, H., Hamrick, M., Zhong, Q., Ding, K. H., Correa, D., Williams, S., Mulloy, A., Bollag, W., Bollag, R. J., Runner, R. R., McPherson, J. C., Insogna, K. & Isales, C. M., Dec 1 2005, In : Bone. 37, 6, p. 759-769 11 p.

Research output: Contribution to journalArticle

Bone Remodeling
Knockout Mice
Bone and Bones
Glucose
Peptides
49 Citations (Scopus)

Multiple melanocortin receptors are expressed in bone cells

Zhong, Q., Sridhar, S., Ruan, L., Ding, K., Xie, D., Insogna, K., Kang, B., Xu, J., Bollag, R. J. & Isales, C. M., May 2005, In : Bone. 36, 5, p. 820-831 12 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Pro-Opiomelanocortin
Bone and Bones
Bone Remodeling
Hormones
37 Citations (Scopus)

Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice

Montgomery, E., Pennington, C., Isales, C. M. & Hamrick, M. W., Sep 1 2005, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 286, 1, p. 814-822 9 p.

Research output: Contribution to journalArticle

Myostatin
dystrophin
myostatin
Dystrophin
bones
69 Citations (Scopus)

SUMO wrestling with type 1 diabetes

Li, M., Guo, D., Isales, C. M., Eizirik, D. L., Atkinson, M., She, J-X. & Wang, C. Y., Jul 1 2005, In : Journal of Molecular Medicine. 83, 7, p. 504-513 10 p.

Research output: Contribution to journalReview article

Wrestling
Sumoylation
Ubiquitin
Type 1 Diabetes Mellitus
Ubiquitins
2006
92 Citations (Scopus)

Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin

Hamrick, M. W., Ding, K. H., Pennington, C., Chao, Y. J., Wu, Y. D., Howard, B., Immel, D., Borlongan, C., McNeil, P. L., Bollag, W. B., Curl, W. W., Yu, J. & Isales, C. M., Oct 1 2006, In : Bone. 39, 4, p. 845-853 9 p.

Research output: Contribution to journalArticle

Leptin
Bone and Bones
Muscles
Serum
Adipose Tissue
80 Citations (Scopus)

Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss

Ding, K., Wang, Z. Z., Hamrick, M. W., Deng, Z. B., Zhou, L., Kang, B., Yan, S. L., She, J-X., Stern, D. M., Isales, C. M. & Mi, Q. S., Feb 24 2006, In : Biochemical and Biophysical Research Communications. 340, 4, p. 1091-1097 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Medical problems
Bone
Bone and Bones
Advanced Glycosylation End Product-Specific Receptor
36 Citations (Scopus)

Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet

Hamrick, M. W., Pennington, C., Webb, C. N. & Isales, C. M., May 1 2006, In : International Journal of Obesity. 30, 5, p. 868-870 3 p.

Research output: Contribution to journalArticle

High Fat Diet
Adipose Tissue
Myostatin
Fats
Leptin
2007
8 Citations (Scopus)

Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells

Bollag, W. B., Kent, P., White, S., Malinova, M., Isales, C. M. & Calle, R. A., Feb 1 2007, In : Endocrinology. 148, 2, p. 585-593 9 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Phospholipase D
Angiotensin II
Phorbol 12,13-Dibutyrate
Diglycerides
123 Citations (Scopus)

Effects of glucose-dependent insulinotropic peptide on osteoclast function

Zhong, Q., Itokawa, T., Sridhar, S., Ding, K., Xie, D., Kang, B., Bollag, W. B., Bollag, R. J., Hamrick, M. W., Insogna, K. & Isales, C. M., Feb 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 2, p. E543-E548

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Osteoclasts
Peptide Receptors
Bone Resorption
Bone and Bones
10 Citations (Scopus)
Myostatin
Peroxisome Proliferator-Activated Receptors
Adipocytes
Bone and Bones
Mesenchymal Stromal Cells
1 Citation (Scopus)

Future developments in therapy

Isales, C. M. & McDonald, J. M., Jan 1 2007, In : Annals of the New York Academy of Sciences. 1117, p. 258-263 6 p.

Research output: Contribution to journalArticle

Bone
Bone and Bones
Osteoporosis
Therapeutics
Minerals
95 Citations (Scopus)

Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass

Xie, D., Zhong, Q., Ding, K., Cheng, H., Williams, S., Correa, D., Bollag, W. B., Bollag, R. J., Insogna, K., Troiano, N., Coady, C., Hamrick, M. W. & Isales, C. M., May 1 2007, In : Bone. 40, 5, p. 1352-1360 9 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Transgenic Mice
Bone and Bones
Peptide Receptors
Osteogenesis
100 Citations (Scopus)

Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading

Hamrick, M. W., Shi, X., Zhang, W., Pennington, C., Thakore, H., Haque, M., Kang, B., Isales, C. M., Fulzele, S. & Wenger, K. H., Jun 1 2007, In : Bone. 40, 6, p. 1544-1553 10 p.

Research output: Contribution to journalArticle

Myostatin
Mesenchymal Stromal Cells
Bone Marrow
Hindlimb Suspension
Bone and Bones
11 Citations (Scopus)

Pituitary glycoprotein hormone receptors in non-endocrine organs

Blair, H. C., Wells, A. & Isales, C. M., Aug 1 2007, In : Trends in Endocrinology and Metabolism. 18, 6, p. 227-233 7 p.

Research output: Contribution to journalArticle

Pituitary Hormone Receptors
Glycoproteins
Hormones
Fishes
Therapeutics
1 Citation (Scopus)
Osteoporosis
Bisphosphonate-Associated Osteonecrosis of the Jaw
Therapeutics
Tooth Loss
Health
2008
72 Citations (Scopus)

Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells

Zhang, W., Ou, G., Hamrick, M. W., Hill, W. D., Borke, J., Wenger, K., Chutkan, N., Yu, J. C., Mi, Q. S., Isales, C. M. & Shi, X. M., Jul 1 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1118-1128 11 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Cell Count
Stem Cells
Inbred C57BL Mouse
Cell Differentiation
85 Citations (Scopus)
Caloric Restriction
Skeleton
Body Weight
Leptin
Bone and Bones
10 Citations (Scopus)

CART deficiency increases body weight but does not alter bone strength

Bartell, S. M., Isales, C. M., Baile, C. A., Kuhar, M. J. & Hamrick, M. W., Jun 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 2, p. 146-153 8 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Body Weight
Bone and Bones
Femur
51 Citations (Scopus)

Impact of glucose-dependent insulinotropic peptide on age-induced bone loss

Ding, K. H., Shi, X. M., Zhong, Q., Kang, B., Xie, D., Bollag, W. B., Bollag, R. J., Hill, W., Washington, W., Mi, Q. S., Insogna, K., Chutkan, N., Hamrick, M. & Isales, C. M., Apr 1 2008, In : Journal of Bone and Mineral Research. 23, 4, p. 536-543 8 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Bone and Bones
Mesenchymal Stromal Cells
Peptide Receptors
Osteoblasts
2 Citations (Scopus)

Nutritional hormones and the entero-osseous axis

Isales, C. M. & Hamrick, M., Dec 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 4, p. 348-350 3 p.

Research output: Contribution to journalArticle

Gastrointestinal Hormones
Incretins
Bone Remodeling
Osteoclasts
Nutritional Status
8 Citations (Scopus)

Phorbol ester increases mitochondrial cholesterol content in NCI H295R cells

Bollag, W. B., Kent, P., White, S., Wilson, M. V., Isales, C. M. & Calle, R. A., Dec 16 2008, In : Molecular and Cellular Endocrinology. 296, 1-2, p. 53-57 5 p.

Research output: Contribution to journalArticle

Phorbol Esters
Cholesterol
Angiotensin II
Protein Kinase C
Atrial Natriuretic Factor
22 Citations (Scopus)
LIM Domain Proteins
src Homology Domains
Histamine
Stomach
Genes
2009
6 Citations (Scopus)

Diagnosis of pheochromocytoma in the setting of Parkinson disease

Mehta, S. H., Prakash, R., Prisant, L. M., Isales, C. M., Morgan, J. C., Williams, H. & Sethi, K. D., Oct 23 2009, In : Nature Reviews Neurology. 5, 6, p. 343-347 5 p.

Research output: Contribution to journalArticle

Pheochromocytoma
Parkinson Disease
Hyperplasia
Pallor
Sweating
1 Citation (Scopus)

Regulation of Aldosterone Production

Rainey, W. E., Bollag, W. B. & Isales, C. M., Jan 1 2009, Textbook of Nephro-Endocrinology. Elsevier Inc., p. 361-381 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aldosterone
Cytochrome P-450 CYP11B2
Hypertension
Congenital Adrenal Hyperplasia
Water-Electrolyte Balance
1 Citation (Scopus)

Spontaneous bone loss in RIP-iNoS transgenic mouse: A mouse model for diabetes-mediated osteopenia/osteoporosis

Mi, Q. S., Yan, S. L., Wang, Z. Z., Ding, K., Li, C., Wang, L., Zhou, L., Yamamoto, Y., Yamamoto, H., Okamoto, H. & Isales, C. M., Dec 15 2009, In : Cell Cycle. 8, 24, p. 4179-4181 3 p.

Research output: Contribution to journalLetter

Metabolic Bone Diseases
Type 1 Diabetes Mellitus
Transgenic Mice
Osteoporosis
Bone and Bones
8 Citations (Scopus)

The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells

Qin, H., Kent, P., Isales, C. M., Parker, P. M., Wilson, M. V. & Bollag, W. B., Oct 5 2009, In : Journal of Endocrinology. 202, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Phospholipase D
Calcium
Angiotensin II
Aldosterone
2010
40 Citations (Scopus)

ACTH is a novel regulator of bone mass

Isales, C. M., Zaidi, M. & Blair, H. C., Jan 1 2010, Skeletal Biology and Medicine. Blackwell Publishing Inc., p. 110-116 7 p. (Annals of the New York Academy of Sciences; vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Adrenocorticotropic Hormone
Bone
Bone and Bones
Osteoblasts
Melanocortin Receptors
82 Citations (Scopus)

ACTH protects against glucocorticoid-induced osteonecrosis of bone

Zaidi, M., Sun, L., Robinson, L. J., Tourkova, I. L., Liu, L., Wang, Y., Zhu, L. L., Liu, X., Li, J., Peng, Y., Yang, G., Shi, X. M., Levine, A., Iqbal, J., Yaroslavskiy, B. B., Isales, C. M. & Blair, H. C., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8782-8787 6 p.

Research output: Contribution to journalArticle

Osteonecrosis
Adrenocorticotropic Hormone
Glucocorticoids
Bone and Bones
Bone Remodeling