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Research Output

25-Hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth

Breen, M. E., Laing, E. M., Hall, D. B., Hausman, D. B., Taylor, R. G., Isales, C. M., Ding, K., Pollock, N. K., Hamrick, M. W., Baile, C. A. & Lewis, R. D., Jan 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 1

Research output: Contribution to journalArticle

34 Scopus citations
27 Scopus citations

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

3 Scopus citations
60 Scopus citations

ACTH is a novel regulator of bone mass

Isales, C. M., Zaidi, M. & Blair, H. C., Jan 1 2010, Skeletal Biology and Medicine. Blackwell Publishing Inc., p. 110-116 7 p. (Annals of the New York Academy of Sciences; vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

44 Scopus citations

ACTH protects against glucocorticoid-induced osteonecrosis of bone

Zaidi, M., Sun, L., Robinson, L. J., Tourkova, I. L., Liu, L., Wang, Y., Zhu, L. L., Liu, X., Li, J., Peng, Y., Yang, G., Shi, X. M., Levine, A., Iqbal, J., Yaroslavskiy, B. B., Isales, C. M. & Blair, H. C., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8782-8787 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Acute cholecystitis. Hepatobiliary study (99mTc disofenin).

González, Y., Isales, C. M. & Rivera, J. V., Aug 1 1983, In : Boletin de la Asociacion Medica de Puerto Rico. 75, 8, p. 353-354 2 p.

Research output: Contribution to journalArticle

Adenosine stimulation of Na+ transport is mediated by an A1 receptor and a [Ca2+]i-dependent mechanism

Hayslett, J. P., Macala, L. J., Smallwood, J. I., Kalghatgi, L., Gasalla-Herraiz, J. & Isales, C., Jun 1995, In : Kidney International. 47, 6, p. 1576-1584 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells

Zhang, W., Ou, G., Hamrick, M. W., Hill, W. D., Borke, J., Wenger, K., Chutkan, N., Yu, J. C., Mi, Q. S., Isales, C. M. & Shi, X. M., Jul 1 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1118-1128 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access

Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin

Hamrick, M. W., Ding, K. H., Pennington, C., Chao, Y. J., Wu, Y. D., Howard, B., Immel, D., Borlongan, C., McNeil, P. L., Bollag, W. B., Curl, W. W., Yu, J. & Isales, C. M., Oct 1 2006, In : Bone. 39, 4, p. 845-853 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line

Orloff, J. J., Ganz, M. B., Nathanson, M. H., Moyer, M. S., Kats, Y., Mitnick, M., Behal, A., Gasalla-Herraiz, J. & Isales, C. M., Jan 1 1996, In : Endocrinology. 137, 12, p. 5376-5385 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Amino acids as signaling molecules modulating bone turnover

Ding, K., Cain, M., Davis, M., Bergson, C. M., McGee Lawrence, M. E., Perkins, C., Hardigan, T., Shi, X. M., Zhong, Q., Xu, J., Bollag, W. B., Hill, W. D., Elsalanty, M. E., Hunter, D. M., Isales, M. C., Lopez, P., Hamrick, M. W. & Isales, C. M., Oct 2018, In : Bone. 115, p. 15-24 10 p.

Research output: Contribution to journalReview article

7 Scopus citations

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

Arounleut, P., Bialek, P., Liang, L. F., Upadhyay, S., Fulzele, S., Johnson, M., Elsalanty, M., Isales, C. M. & Hamrick, M. W., Sep 1 2013, In : Experimental Gerontology. 48, 9, p. 898-904 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Angiotensin-ii-induced changes in diacylglycerol levels and their potential role in modulating the steroidogenic response

Bollag, W. B., Barrett, P. Q., Isales, C. M. & Rasmussen, H., Jan 1991, In : Endocrinology. 128, 1, p. 231-241 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Angiotensin II priming of aldosterone secretion with agents that enhance Ca2+ influx

Betancourt-Calle, S., Mann-Blakeney, R. S., Isales, C. M., Calle, R. A. & Bollinger Bollag, W., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 61-70 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

A novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III

Monticone, S., Hattangady, N. G., Penton, D., Isales, C. M., Edwards, M. A., Williams, T. A., Sterner, C., Warth, R., Mulatero, P. & Rainey, W. E., Nov 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 11, p. E1861-E1865

Research output: Contribution to journalArticle

63 Scopus citations

ANP-(7-23) stimulates a DHP-sensitive Ca2+ conductance and reduces cellular cAMP via a cGMP-independent mechanism

Isales, C. M., Lewicki, J. A., Nee, J. J. & Barrett, P. Q., Jan 1 1992, In : American Journal of Physiology - Cell Physiology. 263, 2 32-2, p. C334-C342

Research output: Contribution to journalArticle

28 Scopus citations

A patient with concurrent primary hyperaldosteronism and adrenal insufficiency

Puentes, F., Jackson, T. W. & Isales, C. M., Dec 2004, In : American Journal of the Medical Sciences. 328, 6, p. 344-347 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

A potential role for phospholipase-D in the angiotensin II-induced stimulation of aldosterone secretion from bovine adrenal glomerulosa cells

Bollag, W. B., Barrett, P. Q., Isales, C. M., Liscovitch, M. & Rasmussen, H., Jan 1 1990, In : Endocrinology. 127, 3, p. 1436-1443 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension

Refaey, M. E., Zhong, Q., Hill, W. D., Shi, X. M., Hamrick, M. W., Bailey, L., Johnson, M., Xu, J., Bollag, W. B., Chutkan, N. & Isales, C. M., Apr 11 2014, In : PloS one. 9, 4, e91108.

Research output: Contribution to journalArticle

9 Scopus citations

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Association of Dietary Niacin Intake With Incident Hip Fracture, BMD, and Body Composition: The Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Raiford, M., Le, B., Isales, C. M., Shikany, J. M., Coughlin, S. S. & Robbins, J. A., Apr 2019, In : Journal of Bone and Mineral Research. 34, 4, p. 643-652 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Isales, C. M. & Hill, W. D., May 1 2017, In : Osteoporosis International. 28, 5, p. 1631-1640 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly

Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Atrial natriuretic peptide differentially modulates T- and L-type calcium channels

McCarthy, R. T., Isales, C. M., Bollag, W. B., Rasmussen, H. & Barrett, P. Q., 1990, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 258, 3 27-3, p. F473-F478

Research output: Contribution to journalArticle

34 Scopus citations

Atrial natriuretic peptide enhances activity of potassium conductance in adrenal glomerulosa cells

Ganz, M. B., Nee, J. J., Isales, C. M. & Barrett, P. Q., May 13 1994, In : AM.J.PHYSIOL.. 266, 5 part 1, p. 1357-1365 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
13 Scopus citations

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss

Singleton, Q., Vaibhav, K., Braun, M., Patel, C., Khayrullin, A., Mendhe, B., Lee, B. R., Kolhe, R., Kaiser, H., Awad, M. E., Fariyike, T., Elsayed, R., Elsalanty, M., Isales, C. M., Liu, Y., Hamrick, M. W., Dhandapani, K. M. & Fulzele, S., Jan 17 2019, In : Fuel Cells. 8, 1

Research output: Contribution to journalArticle

Ca(2+)-cyclic AMP interactions in sustained cellular responses.

Rasmussen, H., Isales, C. M., Ganesan, S., Calle, R. & Zawalich, W., Jan 1 1992, In : Ciba Foundation symposium. 164

Research output: Contribution to journalReview article

14 Scopus citations

Ca2+ channels and aldosterone secretion: Modulation by K+ and atrial natriuretic peptide

Barrett, P. Q., Isales, C. M., Bollag, W. B. & McCarthy, R. T., 1991, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261, 4 30-4, p. F706-F719

Research output: Contribution to journalArticle

52 Scopus citations

Cadmium intake and systemic exposure in postmenopausal women and age-matched men who smoke cigarettes

Ebert-McNeill, A., Clark, S. P., Miller, J. J., Birdsall, P., Chandar, M., Wu, L., Cerny, E. A., Hall, P. H., Johnson, M. H., Isales, C. M., Chutkan, N. & Bhattacharyya, M. H., Nov 1 2012, In : Toxicological Sciences. 130, 1, p. 191-204 14 p., kfs226.

Research output: Contribution to journalArticle

16 Scopus citations

Calcium ion as intracellular messenger and cellular toxin

Rasmussen, H., Barrett, P., Smallwood, J., Bollag, W. & Isales, C., Jan 1 1990, In : Environmental Health Perspectives. 84, p. 17-25 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Calcium Sensitive Probes for the Measurement of Intracellular Calcium: Effects of Buffer System and Magnesium Concentration

Gasalla-Herraiz, J., Rhee, S. & Isales, C. M., Jan 1 1995, In : Biochemical and Biophysical Research Communications. 214, 2, p. 373-388 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells

Periyasamy Thandavan, S., Herberg, S., Arounleut, P., Upadhyay, S., Dukes, A., Davis, C. M., Johnson, M. H., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Hill, W. D., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 64-72 9 p.

Research output: Contribution to journalReview article

7 Scopus citations
87 Scopus citations
15 Scopus citations
1 Scopus citations

CART deficiency increases body weight but does not alter bone strength

Bartell, S. M., Isales, C. M., Baile, C. A., Kuhar, M. J. & Hamrick, M. W., Jun 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 2, p. 146-153 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells

Bollag, W. B., Kent, P., White, S., Malinova, M., Isales, C. M. & Calle, R. A., Feb 1 2007, In : Endocrinology. 148, 2, p. 585-593 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Chemically defined and xeno-free cryopreservation of human adipose-derived stem cells

López, M., Bollag, R. J., Yu, J. C., Isales, C. M. & Eroglu, A., Mar 1 2016, In : PloS one. 11, 3, e0152161.

Research output: Contribution to journalArticle

12 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations
15 Scopus citations

Cycling of Ca2+ across the Plasma Membrane as a Mechanism for Generating a Ca2+ Signal for Cell Activation

RASMUSSEN, HOWARD., BARRETT, PAULA., ZAWALICH, WALTER., ISALES, CARLOS., STEIN, PETER., SMALLWOOD, JOAN., MCCARTHY, RICHARD. & BOLLAG, WENDY., Dec 1989, In : Annals of the New York Academy of Sciences. 568, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Diacylglycerol production, ca2+ influx, and proteinkinase c activation in sustained cellular responses

Rasmussen, H., Isales, C. M., Calle, R., Throckmorton, D., Gasalla-Herraiz, J., Anderson, M. & McCARTHY, R., Oct 1995, In : Endocrine Reviews. 16, 5, p. 649-681 33 p.

Research output: Contribution to journalArticle

107 Scopus citations