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Research Output

2015
15 Scopus citations

Impact of targeted PPARγ disruption on bone remodeling

Cao, J., Ou, G., Yang, N., Ding, K., Kream, B. E., Hamrick, M. W., Isales, C. M. & Shi, X. M., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 27-34 8 p.

Research output: Contribution to journalReview article

26 Scopus citations

Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy

Herberg, S., Kondrikova, G., Hussein, K. A., Johnson, M. H., Elsalanty, M. E., Shi, X., Hamrick, M. W., Isales, C. M. & Hill, W. D., Feb 1 2015, In : Journal of Orthopaedic Research. 33, 2, p. 174-184 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells

Sangani, R., Periyasamy-Thandavan, S., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Isales, C., Hamrick, M., Hill, W. D. & Fulzele, S., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 19-26 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells

El Refaey, M., Watkins, C. P., Kennedy, E. J., Chang, A., Zhong, Q., Ding, K., Shi, X. M., Xu, J., Bollag, W. B., Hill, W. D., Johnson, M. H., Hunter, D. M., Hamrick, M. W. & Isales, C. M., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 87-96 10 p.

Research output: Contribution to journalReview article

28 Scopus citations

Removal of pamidronate from bone in rats using systemic and local chelation

Howie, R. N., Bhattacharyya, M., Salama, M. E., Refaey, M. E., Isales, C. M., Borke, J., Daoudi, A., Medani, F. & Elsalanty, M. E., Dec 1 2015, In : Archives of Oral Biology. 60, 12, p. 1699-1707 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

Hamrick, M. W., Dukes, A., Arounleut, P., Davis, C., Periyasamy-Thandavan, S., Mork, S., Herberg, S., Johnson, M. H., Isales, C. M., Hill, W. D., Otvos, L. & Belin de Chantemèle, E. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 92-96 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro

Dukes, A., Davis, C. M., El Refaey, M., Upadhyay, S., Mork, S., Arounleut, P., Johnson, M. H., Hill, W. D., Isales, C. M. & Hamrick, M. W., Jan 1 2015, In : Nutrition. 31, 7-8, p. 1018-1024 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis

Sangani, R., Periyasamy-Thandavan, S., Pathania, R., Ahmad, S., Kutiyanawalla, A., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Sep 1 2015, In : Stem Cell Research. 15, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Zinc supplementation increases procollagen type 1 amino-terminal propeptide in premenarcheal girls: A randomized controlled trial

Berger, P. K., Pollock, N. K., Laing, E. M., Chertin, V., Bernard, P. J., Grider, A., Shapses, S. A., Ding, K. H., Isales, C. M. & Lewis, R. D., Jan 1 2015, In : Journal of Nutrition. 145, 12, p. 2699-2704 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension

Refaey, M. E., Zhong, Q., Hill, W. D., Shi, X. M., Hamrick, M. W., Bailey, L., Johnson, M., Xu, J., Bollag, W. B., Chutkan, N. & Isales, C. M., Apr 11 2014, In : PloS one. 9, 4, e91108.

Research output: Contribution to journalArticle

9 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of dietary aromatic amino acids on osteoclastic activity

Refaey, M. E., Zhong, Q., Ding, K. H., Shi, X. M., Xu, J., Bollag, W. B., Hill, W. D., Chutkan, N., Robbins, R., Nadeau, H., Johnson, M., Hamrick, M. W. & Isales, C. M., Aug 2014, In : Calcified Tissue International. 95, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Knockdown of SVCT2 impairs in-vitro cell attachment, migration and wound healing in bone marrow stromal cells

Sangani, R., Pandya, C. D., Bhattacharyya, M. H., Periyasamy-Thandavan, S., Chutkan, N., Markand, S., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Mar 2014, In : Stem Cell Research. 12, 2, p. 354-363 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects

Herberg, S., Susin, C., Pelaez, M., Howie, R. N., Moreno De Freitas, R., Lee, J., Cray, J. J., Johnson, M. H., Elsalanty, M. E., Hamrick, M. W., Isales, C. M., Wikesjö, U. M. E. & Hill, W. D., May 1 2014, In : Tissue Engineering - Part A. 20, 9-10, p. 1444-1453 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons

Clark, S. P., Bollag, W. B., Westlund, K. N., Ma, F., Falls, G., Xie, D., Johnson, M., Isales, C. M. & Bhattacharyya, M. H., Feb 1 2014, In : Phytotherapy Research. 28, 2, p. 252-260 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition

Pan, G., Cao, J., Yang, N., Ding, K., Fan, C., Xiong, W. C., Hamrick, M., Isales, C. M. & Shi, X. M., Jul 11 2014, In : Journal of Biological Chemistry. 289, 28, p. 19373-19382 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation

Herberg, S., Kondrikova, G., Hussein, K. A., Periyasamy-Thandavan, S., Johnson, M. H., Elsalanty, M. E., Shi, X., Hamrick, M. W., Isales, C. M. & Hill, W. D., Dec 1 2014, In : Tissue Engineering - Part A. 20, 23-24, p. 3212-3227 16 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013
27 Scopus citations

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

Arounleut, P., Bialek, P., Liang, L. F., Upadhyay, S., Fulzele, S., Johnson, M., Elsalanty, M., Isales, C. M. & Hamrick, M. W., Sep 1 2013, In : Experimental Gerontology. 48, 9, p. 898-904 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

A novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III

Monticone, S., Hattangady, N. G., Penton, D., Isales, C. M., Edwards, M. A., Williams, T. A., Sterner, C., Warth, R., Mulatero, P. & Rainey, W. E., Nov 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 11, p. E1861-E1865

Research output: Contribution to journalArticle

63 Scopus citations

Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells

Bowser, M., Herberg, S., Arounleut, P., Shi, X., Fulzele, S., Hill, W. D., Isales, C. M. & Hamrick, M. W., Feb 1 2013, In : Experimental Gerontology. 48, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

GRowing an epidermal tumor

Bollag, W. B. & Isales, C. M., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2659-2662 4 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M., Isales, C., Elsalanty, M., Smith, S., Liou, G. I. & Fulzele, S., Dec 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P., Sangani, R., Chutkan, N., Hamrick, M., Bhattacharyya, M., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. & Ganapathy, V., Jan 1 2013, In : Stem Cell Research. 10, 1, p. 36-47 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
47 Scopus citations

Stromal Cell-derived Factor-1β potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro

Herberg, S., Fulzele, S., Yang, N., Shi, X., Hess, M., Periyasamy-Thandavan, S., Hamrick, M. W., Isales, C. M. & Hill, W. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 1-2, p. 1-13 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Cadmium intake and systemic exposure in postmenopausal women and age-matched men who smoke cigarettes

Ebert-McNeill, A., Clark, S. P., Miller, J. J., Birdsall, P., Chandar, M., Wu, L., Cerny, E. A., Hall, P. H., Johnson, M. H., Isales, C. M., Chutkan, N. & Bhattacharyya, M. H., Nov 1 2012, In : Toxicological Sciences. 130, 1, p. 191-204 14 p., kfs226.

Research output: Contribution to journalArticle

16 Scopus citations

Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells

Monticone, S., Hattangady, N. G., Nishimoto, K., Mantero, F., Rubin, B., Cicala, M. V., Pezzani, R., Auchus, R. J., Ghayee, H. K., Shibata, H., Kurihara, I., Williams, T. A., Giri, J. G., Bollag, R. J., Edwards, M. A., Isales, C. M. & Rainey, W. E., Aug 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 8, p. E1567-E1572

Research output: Contribution to journalArticle

102 Scopus citations

GIP-Overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis

Kim, S. J., Nian, C., Karunakaran, S., Clee, S. M., Isales, C. M. & McIntosh, C. H. S., Jul 3 2012, In : PloS one. 7, 7, e40156.

Research output: Contribution to journalArticle

71 Scopus citations

Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation

He, L., Yang, N., Isales, C. M. & Shi, X. M., Mar 2 2012, In : PloS one. 7, 3, e31717.

Research output: Contribution to journalArticle

18 Scopus citations
2011

25-Hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth

Breen, M. E., Laing, E. M., Hall, D. B., Hausman, D. B., Taylor, R. G., Isales, C. M., Ding, K., Pollock, N. K., Hamrick, M. W., Baile, C. A. & Lewis, R. D., Jan 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 1

Research output: Contribution to journalArticle

34 Scopus citations

Skeletal receptors for steroid-family regulating glycoprotein hormones: A multilevel, integrated physiological control system Skeletal receptors for pituitary hormones Blair et al.

Blair, H. C., Robinson, L. J., Sun, L., Isales, C. M., Davies, T. F. & Zaidi, M., Jan 1 2011, In : Annals of the New York Academy of Sciences. 1240, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

ACTH is a novel regulator of bone mass

Isales, C. M., Zaidi, M. & Blair, H. C., Jan 1 2010, Skeletal Biology and Medicine. Blackwell Publishing Inc., p. 110-116 7 p. (Annals of the New York Academy of Sciences; vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

44 Scopus citations

ACTH protects against glucocorticoid-induced osteonecrosis of bone

Zaidi, M., Sun, L., Robinson, L. J., Tourkova, I. L., Liu, L., Wang, Y., Zhu, L. L., Liu, X., Li, J., Peng, Y., Yang, G., Shi, X. M., Levine, A., Iqbal, J., Yaroslavskiy, B. B., Isales, C. M. & Blair, H. C., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8782-8787 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Effect of whole-body vibration on bone properties in aging mice

Wenger, K. H., Freeman, J. D., Fulzele, S., Immel, D. M., Powell, B. D., Molitor, P., Chao, Y. J., Gao, H. S., Elsalanty, M., Hamrick, M. W., Isales, C. M. & Yu, J. C., Oct 1 2010, In : Bone. 47, 4, p. 746-755 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

MicroRNA deficiency in pancreatic islet cells exacerbates streptozotocin-induced murine autoimmune diabetes

Mi, Q. S., He, H. Z., Dong, Z., Isales, C. M. & Zhou, L., Aug 1 2010, In : Cell Cycle. 9, 15, p. 3199-3201 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF

Wahl, E. C., Aronson, J., Liu, L., Fowlkes, J. L., Thrailkill, K. M., Bunn, R. C., Skinner, R. A., Miller, M. J., Cockrell, G. E., Clark, L. M., Ou, Y., Isales, C. M., Badger, T. M., Ronis, M. J., Sims, J. & Lumpkin, C. K., Jan 2010, In : Journal of Bone and Mineral Research. 25, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

Hamrick, M. W., Herberg, S., Arounleut, P., He, H. Z., Shiver, A. L., Qi, R. Q., Zhou, L., Isales, C. M. & Mi, Q. S., Sep 1 2010, In : Biochemical and Biophysical Research Communications. 400, 3, p. 379-383 5 p.

Research output: Contribution to journalArticle

86 Scopus citations
2009

Diagnosis of pheochromocytoma in the setting of Parkinson disease

Mehta, S. H., Prakash, R., Prisant, L. M., Isales, C. M., Morgan, J. C., Williams, H. & Sethi, K. D., Oct 23 2009, In : Nature Reviews Neurology. 5, 6, p. 343-347 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Regulation of Aldosterone Production

Rainey, W. E., Bollag, W. B. & Isales, C. M., Jan 1 2009, Textbook of Nephro-Endocrinology. Elsevier Inc., p. 361-381 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spontaneous bone loss in RIP-iNoS transgenic mouse: A mouse model for diabetes-mediated osteopenia/osteoporosis

Mi, Q. S., Yan, S. L., Wang, Z. Z., Ding, K., Li, C., Wang, L., Zhou, L., Yamamoto, Y., Yamamoto, H., Okamoto, H. & Isales, C. M., Dec 15 2009, In : Cell Cycle. 8, 24, p. 4179-4181 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells

Qin, H., Kent, P., Isales, C. M., Parker, P. M., Wilson, M. V. & Bollag, W. B., Oct 5 2009, In : Journal of Endocrinology. 202, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2008

Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells

Zhang, W., Ou, G., Hamrick, M. W., Hill, W. D., Borke, J., Wenger, K., Chutkan, N., Yu, J. C., Mi, Q. S., Isales, C. M. & Shi, X. M., Jul 1 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1118-1128 11 p.

Research output: Contribution to journalArticle

77 Scopus citations
87 Scopus citations

CART deficiency increases body weight but does not alter bone strength

Bartell, S. M., Isales, C. M., Baile, C. A., Kuhar, M. J. & Hamrick, M. W., Jun 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 2, p. 146-153 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Impact of glucose-dependent insulinotropic peptide on age-induced bone loss

Ding, K. H., Shi, X. M., Zhong, Q., Kang, B., Xie, D., Bollag, W. B., Bollag, R. J., Hill, W., Washington, W., Mi, Q. S., Insogna, K., Chutkan, N., Hamrick, M. & Isales, C. M., Apr 1 2008, In : Journal of Bone and Mineral Research. 23, 4, p. 536-543 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Nutritional hormones and the entero-osseous axis

Isales, C. M. & Hamrick, M., Dec 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 4, p. 348-350 3 p.

Research output: Contribution to journalArticle

2 Scopus citations