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Research Output 1983 2019

2014
15 Citations (Scopus)

Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition

Pan, G., Cao, J., Yang, N., Ding, K., Fan, C., Xiong, W., Hamrick, M. W., Isales, C. M. & Shi, X. M., Jul 11 2014, In : Journal of Biological Chemistry. 289, 28, p. 19373-19382 10 p.

Research output: Contribution to journalArticle

Leucine Zippers
Glucocorticoids
Bone
Bone and Bones
Peroxisome Proliferator-Activated Receptors
6 Citations (Scopus)

Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation

Herberg, S., Kondrikova, G., Hussein, K. A., Periyasamy-Thandavan, S., Johnson, M. H., Elsalanty, M. E., Shi, X. M., Hamrick, M. W., Isales, C. M. & Hill, W. D., Jan 1 2014, In : Tissue Engineering - Part A. 20, 23-24, p. 3212-3227 16 p.

Research output: Contribution to journalArticle

Whole-Body Irradiation
Stem cells
Mesenchymal Stromal Cells
Osteogenesis
Bone
2013
24 Citations (Scopus)
Leptin Receptors
muscular atrophy
myoblasts
Muscular Atrophy
Myoblasts
35 Citations (Scopus)
Myostatin
Bone Density
Muscle
Bone
Bone and Bones
56 Citations (Scopus)

A novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III

Monticone, S., Hattangady, N. G., Penton, D., Isales, C. M., Edwards, M. A., Williams, T. A., Sterner, C., Warth, R., Mulatero, P. & Rainey, W. E., Nov 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 11, p. E1861-E1865

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Inwardly Rectifying Potassium Channel
Gene expression
Mutation
Hyperaldosteronism
40 Citations (Scopus)

Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells

Bowser, M., Herberg, S., Arounleut, P., Shi, X. M., Fulzele, S. T., Hill, W. D., Isales, C. M. & Hamrick, M. W., Feb 1 2013, In : Experimental Gerontology. 48, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

Myostatin
Follistatin
Muscle Cells
Muscle
Bone
1 Citation (Scopus)
Leptin Receptors
Muscle
Protein Isoforms
2 Citations (Scopus)

GRowing an epidermal tumor

Bollag, W. B. & Isales, C. M., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2659-2662 4 p.

Research output: Contribution to journalComment/debate

Glucocorticoid Receptors
Tumors
Skin
Physiological Phenomena
Neoplasms
6 Citations (Scopus)

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M. W., Isales, C. M., Elsalanty, M. E., Smith, S. B., Liou, G. I. & Fulzele, S. T., Jan 1 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Bone
Bone Marrow
Bone and Bones
Oxidative Stress
9 Citations (Scopus)

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Intervertebral Disc
Ascorbic Acid
Somatomedins
Dexamethasone
17 Citations (Scopus)

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P., Sangani, R., Chutkan, N., Hamrick, M., Bhattacharyya, M., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. & Ganapathy, V., Jan 1 2013, In : Stem Cell Research. 10, 1, p. 36-47 12 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Mesenchymal Stromal Cells
Osteogenesis
Ascorbic Acid
Bone and Bones
41 Citations (Scopus)
Chemokine CXCL12
autophagy
Autophagy
stromal cells
Stem cells
25 Citations (Scopus)

Stromal Cell-derived Factor-1β potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro

Herberg, S., Fulzele, S. T., Yang, N., Shi, X. M., Hess, M., Periyasamy Thandavan, S., Hamrick, M. W., Isales, C. M. & Hill, W. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 1-2, p. 1-13 13 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Bone Morphogenetic Protein 2
Stem cells
Mesenchymal Stromal Cells
Bone
2012
15 Citations (Scopus)

Cadmium intake and systemic exposure in postmenopausal women and age-matched men who smoke cigarettes

Ebert-McNeill, A., Clark, S. P., Miller, J. J., Birdsall, P., Chandar, M., Wu, L., Cerny, E. A., Hall, P. H., Johnson, M. H., Isales, C. M., Chutkan, N. & Bhattacharyya, M. H., Nov 1 2012, In : Toxicological Sciences. 130, 1, p. 191-204 14 p., kfs226.

Research output: Contribution to journalArticle

Cadmium
Smoke
Tobacco Products
Blood
Nutrition
92 Citations (Scopus)

Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells

Monticone, S., Hattangady, N. G., Nishimoto, K., Mantero, F., Rubin, B., Cicala, M. V., Pezzani, R., Auchus, R. J., Ghayee, H. K., Shibata, H., Kurihara, I., Williams, T. A., Giri, J. G., Bollag, R. J., Edwards, M. A., Isales, C. M. & Rainey, W. E., Aug 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 8, p. E1567-E1572

Research output: Contribution to journalArticle

Adrenocortical Adenoma
Aldosterone
Gene expression
Adenoma
Gene Expression
56 Citations (Scopus)

GIP-Overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis

Kim, S. J., Nian, C., Karunakaran, S., Clee, S. M., Isales, C. M. & McIntosh, C. H. S., Jul 3 2012, In : PloS one. 7, 7, e40156.

Research output: Contribution to journalArticle

gastric inhibitory polypeptide
Nutrition
homeostasis
obesity
Homeostasis
18 Citations (Scopus)

Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation

He, L., Yang, N., Isales, C. M. & Shi, X. M., Mar 2 2012, In : PloS one. 7, 3, e31717.

Research output: Contribution to journalArticle

Leucine Zippers
leucine zipper
glucocorticoids
Stem cells
Mesenchymal Stromal Cells
2011
32 Citations (Scopus)

25-Hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth

Breen, M. E., Laing, E. M., Hall, D. B., Hausman, D. B., Taylor, R. G., Isales, C. M., Ding, K., Pollock, N. K., Hamrick, M. W., Baile, C. A. & Lewis, R. D., Jan 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 1

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Minerals
Bone
Bone Density
Bone and Bones
20 Citations (Scopus)

Skeletal receptors for steroid-family regulating glycoprotein hormones: A multilevel, integrated physiological control system Skeletal receptors for pituitary hormones Blair et al.

Blair, H. C., Robinson, L. J., Sun, L., Isales, C. M., Davies, T. F. & Zaidi, M., Jan 1 2011, In : Annals of the New York Academy of Sciences. 1240, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

Pituitary Hormone Receptors
Steroid Receptors
Glycoproteins
Bone
Hormones
2010
40 Citations (Scopus)

ACTH is a novel regulator of bone mass

Isales, C. M., Zaidi, M. & Blair, H. C., Jan 1 2010, Skeletal Biology and Medicine. Blackwell Publishing Inc., p. 110-116 7 p. (Annals of the New York Academy of Sciences; vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Adrenocorticotropic Hormone
Bone
Bone and Bones
Osteoblasts
Melanocortin Receptors
82 Citations (Scopus)

ACTH protects against glucocorticoid-induced osteonecrosis of bone

Zaidi, M., Sun, L., Robinson, L. J., Tourkova, I. L., Liu, L., Wang, Y., Zhu, L. L., Liu, X., Li, J., Peng, Y., Yang, G., Shi, X. M., Levine, A., Iqbal, J., Yaroslavskiy, B. B., Isales, C. M. & Blair, H. C., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8782-8787 6 p.

Research output: Contribution to journalArticle

Osteonecrosis
Adrenocorticotropic Hormone
Glucocorticoids
Bone and Bones
Bone Remodeling
37 Citations (Scopus)

Effect of whole-body vibration on bone properties in aging mice

Wenger, K. H., Freeman, J. D., Fulzele, S. T., Immel, D. M., Powell, B. D., Molitor, P., Chao, Y. J., Gao, H. S., Elsalanty, M. E., Hamrick, M. W., Isales, C. M. & Yu, J. C., Oct 1 2010, In : Bone. 47, 4, p. 746-755 10 p.

Research output: Contribution to journalArticle

Vibration
Bone and Bones
Bone Density
Femur
Independent Living
13 Citations (Scopus)

MicroRNA deficiency in pancreatic islet cells exacerbates streptozotocin-induced murine autoimmune diabetes

Mi, Q. S., He, H. Z., Dong, Z., Isales, C. M. & Zhou, L., Aug 1 2010, In : Cell Cycle. 9, 15, p. 3127-3129 3 p.

Research output: Contribution to journalArticle

Streptozocin
MicroRNAs
Type 1 Diabetes Mellitus
Islets of Langerhans
Biological Phenomena
44 Citations (Scopus)

Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF

Wahl, E. C., Aronson, J., Liu, L., Fowlkes, J. L., Thrailkill, K. M., Bunn, R. C., Skinner, R. A., Miller, M. J., Cockrell, G. E., Clark, L. M., Ou, Y., Isales, C. M., Badger, T. M., Ronis, M. J., Sims, J. & Lumpkin, C. K., Jan 1 2010, In : Journal of Bone and Mineral Research. 25, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

Bone Regeneration
Cyclin-Dependent Kinase Inhibitor p21
Anabolic Agents
Fracture Healing
Osteogenesis
82 Citations (Scopus)

The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

Hamrick, M. W., Herberg, S., Arounleut, P., He, H. Z., Shiver, A. L., Qi, R. Q., Zhou, L., Isales, C. M. & Mi, Q. S., Sep 1 2010, In : Biochemical and Biophysical Research Communications. 400, 3, p. 379-383 5 p.

Research output: Contribution to journalArticle

Adipokines
Leptin
MicroRNAs
Muscle
Skeletal Muscle
2009
6 Citations (Scopus)

Diagnosis of pheochromocytoma in the setting of Parkinson disease

Mehta, S. H., Prakash, R., Prisant, L. M., Isales, C. M., Morgan, J. C., Williams, H. T. & Sethi, K. D., Oct 23 2009, In : Nature Reviews Neurology. 5, 6, p. 343-347 5 p.

Research output: Contribution to journalArticle

Pheochromocytoma
Parkinson Disease
Hyperplasia
Pallor
Sweating
1 Citation (Scopus)

Regulation of Aldosterone Production

Rainey, W. E., Bollag, W. B. & Isales, C. M., Jan 1 2009, Textbook of Nephro-Endocrinology. Elsevier Inc., p. 361-381 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aldosterone
Cytochrome P-450 CYP11B2
Hypertension
Congenital Adrenal Hyperplasia
Water-Electrolyte Balance
1 Citation (Scopus)

Spontaneous bone loss in RIP-iNoS transgenic mouse: A mouse model for diabetes-mediated osteopenia/osteoporosis

Mi, Q. S., Yan, S. L., Wang, Z. Z., Ding, K., Li, C., Wang, L., Zhou, L., Yamamoto, Y., Yamamoto, H., Okamoto, H. & Isales, C. M., Dec 15 2009, In : Cell Cycle. 8, 24, p. 4179-4181 3 p.

Research output: Contribution to journalLetter

Metabolic Bone Diseases
Type 1 Diabetes Mellitus
Transgenic Mice
Osteoporosis
Bone and Bones
8 Citations (Scopus)

The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells

Qin, H., Kent, P., Isales, C. M., Parker, P. M., Wilson, M. V. & Bollag, W. B., Oct 5 2009, In : Journal of Endocrinology. 202, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Phospholipase D
Calcium
Angiotensin II
Aldosterone
2008
72 Citations (Scopus)

Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells

Zhang, W., Ou, G., Hamrick, M. W., Hill, W. D., Borke, J., Wenger, K., Chutkan, N., Yu, J. C., Mi, Q. S., Isales, C. M. & Shi, X. M., Jul 1 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1118-1128 11 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Cell Count
Stem Cells
Inbred C57BL Mouse
Cell Differentiation
85 Citations (Scopus)
Caloric Restriction
Skeleton
Body Weight
Leptin
Bone and Bones
10 Citations (Scopus)

CART deficiency increases body weight but does not alter bone strength

Bartell, S. M., Isales, C. M., Baile, C. A., Kuhar, M. J. & Hamrick, M. W., Jun 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 2, p. 146-153 8 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Body Weight
Bone and Bones
Femur
51 Citations (Scopus)

Impact of glucose-dependent insulinotropic peptide on age-induced bone loss

Ding, K., Shi, X. M., Zhong, Q., Kang, B., Xie, D., Bollag, W. B., Bollag, R. J., Hill, W. D., Washington, W., Mi, Q. S., Insogna, K., Chutkan, N., Hamrick, M. W. & Isales, C. M., Apr 1 2008, In : Journal of Bone and Mineral Research. 23, 4, p. 536-543 8 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Bone and Bones
Mesenchymal Stromal Cells
Peptide Receptors
Osteoblasts
2 Citations (Scopus)

Nutritional hormones and the entero-osseous axis

Isales, C. M. & Hamrick, M. W., Dec 1 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 4, p. 348-350 3 p.

Research output: Contribution to journalArticle

Gastrointestinal Hormones
Incretins
Bone Remodeling
Osteoclasts
Nutritional Status
8 Citations (Scopus)

Phorbol ester increases mitochondrial cholesterol content in NCI H295R cells

Bollag, W. B., Kent, P., White, S., Wilson, M. V., Isales, C. M. & Calle, R. A., Dec 16 2008, In : Molecular and Cellular Endocrinology. 296, 1-2, p. 53-57 5 p.

Research output: Contribution to journalArticle

Phorbol Esters
Cholesterol
Angiotensin II
Protein Kinase C
Atrial Natriuretic Factor
22 Citations (Scopus)
LIM Domain Proteins
src Homology Domains
Histamine
Stomach
Genes
2007
8 Citations (Scopus)

Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells

Bollag, W. B., Kent, P., White, S., Malinova, M., Isales, C. M. & Calle, R. A., Feb 1 2007, In : Endocrinology. 148, 2, p. 585-593 9 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Phospholipase D
Angiotensin II
Phorbol 12,13-Dibutyrate
Diglycerides
122 Citations (Scopus)

Effects of glucose-dependent insulinotropic peptide on osteoclast function

Zhong, Q., Itokawa, T., Sridhar, S., Ding, K., Xie, D., Kang, B., Bollag, W. B., Bollag, R. J., Hamrick, M. W., Insogna, K. & Isales, C. M., Feb 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 2, p. E543-E548

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Osteoclasts
Peptide Receptors
Bone Resorption
Bone and Bones
10 Citations (Scopus)
Myostatin
Peroxisome Proliferator-Activated Receptors
Adipocytes
Bone and Bones
Mesenchymal Stromal Cells
1 Citation (Scopus)

Future developments in therapy

Isales, C. M. & McDonald, J. M., Jan 1 2007, In : Annals of the New York Academy of Sciences. 1117, p. 258-263 6 p.

Research output: Contribution to journalArticle

Bone
Bone and Bones
Osteoporosis
Therapeutics
Minerals
94 Citations (Scopus)

Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass

Xie, D., Zhong, Q., Ding, K., Cheng, H., Williams, S., Correa, D., Bollag, W. B., Bollag, R. J., Insogna, K., Troiano, N., Coady, C., Hamrick, M. W. & Isales, C. M., May 1 2007, In : Bone. 40, 5, p. 1352-1360 9 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Transgenic Mice
Bone and Bones
Peptide Receptors
Osteogenesis
99 Citations (Scopus)

Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading

Hamrick, M. W., Shi, X., Zhang, W., Pennington, C., Thakore, H., Haque, M., Kang, B., Isales, C. M., Fulzele, S. & Wenger, K. H., Jun 1 2007, In : Bone. 40, 6, p. 1544-1553 10 p.

Research output: Contribution to journalArticle

Myostatin
Mesenchymal Stromal Cells
Bone Marrow
Hindlimb Suspension
Bone and Bones
11 Citations (Scopus)

Pituitary glycoprotein hormone receptors in non-endocrine organs

Blair, H. C., Wells, A. & Isales, C. M., Aug 1 2007, In : Trends in Endocrinology and Metabolism. 18, 6, p. 227-233 7 p.

Research output: Contribution to journalArticle

Pituitary Hormone Receptors
Glycoproteins
Hormones
Fishes
Therapeutics
1 Citation (Scopus)
Osteoporosis
Bisphosphonate-Associated Osteonecrosis of the Jaw
Therapeutics
Tooth Loss
Health
2006
92 Citations (Scopus)

Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin

Hamrick, M. W., Ding, K. H., Pennington, C., Chao, Y. J., Wu, Y. D., Howard, B., Immel, D., Borlongan, C., McNeil, P. L., Bollag, W. B., Curl, W. W., Yu, J. & Isales, C. M., Oct 1 2006, In : Bone. 39, 4, p. 845-853 9 p.

Research output: Contribution to journalArticle

Leptin
Bone and Bones
Muscles
Serum
Adipose Tissue
80 Citations (Scopus)

Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss

Ding, K., Wang, Z. Z., Hamrick, M. W., Deng, Z. B., Zhou, L., Kang, B., Yan, S. L., She, J-X., Stern, D. M., Isales, C. M. & Mi, Q. S., Feb 24 2006, In : Biochemical and Biophysical Research Communications. 340, 4, p. 1091-1097 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Medical problems
Bone
Bone and Bones
Advanced Glycosylation End Product-Specific Receptor
36 Citations (Scopus)

Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet

Hamrick, M. W., Pennington, C., Webb, C. N. & Isales, C. M., May 1 2006, In : International Journal of Obesity. 30, 5, p. 868-870 3 p.

Research output: Contribution to journalArticle

High Fat Diet
Adipose Tissue
Myostatin
Fats
Leptin
2005
1 Citation (Scopus)

Carboxy-terminal PTH fragments stimulate [3H]thymidine incorporation in vascular endothelial cells

Ding, K., Zhong, Q., Xie, D., Xu, J., Bollag, R. J., Bollag, W. B. & Isales, C. M., Jan 1 2005, In : Peptides. 26, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Thymidine
Endothelial Cells
Molecules
109 Citations (Scopus)

Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover

Xie, D., Cheng, H., Hamrick, M., Zhong, Q., Ding, K. H., Correa, D., Williams, S., Mulloy, A., Bollag, W., Bollag, R. J., Runner, R. R., McPherson, J. C., Insogna, K. & Isales, C. M., Dec 1 2005, In : Bone. 37, 6, p. 759-769 11 p.

Research output: Contribution to journalArticle

Bone Remodeling
Knockout Mice
Bone and Bones
Glucose
Peptides
49 Citations (Scopus)

Multiple melanocortin receptors are expressed in bone cells

Zhong, Q., Sridhar, S., Ruan, L., Ding, K., Xie, D., Insogna, K., Kang, B., Xu, J., Bollag, R. J. & Isales, C. M., Jan 1 2005, In : Bone. 36, 5, p. 820-831 12 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Pro-Opiomelanocortin
Bone and Bones
Bone Remodeling
Hormones