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Research Output

2008

Phorbol ester increases mitochondrial cholesterol content in NCI H295R cells

Bollag, W. B., Kent, P., White, S., Wilson, M. V., Isales, C. M. & Calle, R. A., Dec 16 2008, In : Molecular and Cellular Endocrinology. 296, 1-2, p. 53-57 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
24 Scopus citations
2007

Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells

Bollag, W. B., Kent, P., White, S., Malinova, M., Isales, C. M. & Calle, R. A., Feb 1 2007, In : Endocrinology. 148, 2, p. 585-593 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of glucose-dependent insulinotropic peptide on osteoclast function

Zhong, Q., Itokawa, T., Sridhar, S., Ding, K., Xie, D., Kang, B., Bollag, W. B., Bollag, R. J., Hamrick, M. W., Insogna, K. & Isales, C. M., Feb 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 2, p. E543-E548

Research output: Contribution to journalArticle

128 Scopus citations
10 Scopus citations

Future developments in therapy

Isales, C. M. & McDonald, J. M., Nov 2007, In : Annals of the New York Academy of Sciences. 1117, p. 258-263 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass

Xie, D., Zhong, Q., Ding, K., Cheng, H., Williams, S., Correa, D., Bollag, W. B., Bollag, R. J., Insogna, K., Troiano, N., Coady, C., Hamrick, M. W. & Isales, C. M., May 1 2007, In : Bone. 40, 5, p. 1352-1360 9 p.

Research output: Contribution to journalArticle

100 Scopus citations

Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading

Hamrick, M. W., Shi, X., Zhang, W., Pennington, C., Thakore, H., Haque, M., Kang, B., Isales, C. M., Fulzele, S. & Wenger, K. H., Jun 1 2007, In : Bone. 40, 6, p. 1544-1553 10 p.

Research output: Contribution to journalArticle

108 Scopus citations

Pituitary glycoprotein hormone receptors in non-endocrine organs

Blair, H. C., Wells, A. & Isales, C. M., Aug 1 2007, In : Trends in Endocrinology and Metabolism. 18, 6, p. 227-233 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
1 Scopus citations
2006

Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin

Hamrick, M. W., Ding, K. H., Pennington, C., Chao, Y. J., Wu, Y. D., Howard, B., Immel, D., Borlongan, C., McNeil, P. L., Bollag, W. B., Curl, W. W., Yu, J. & Isales, C. M., Oct 1 2006, In : Bone. 39, 4, p. 845-853 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss

Ding, K., Wang, Z. Z., Hamrick, M. W., Deng, Z. B., Zhou, L., Kang, B., Yan, S. L., She, J-X., Stern, D. M., Isales, C. M. & Mi, Q. S., Feb 24 2006, In : Biochemical and Biophysical Research Communications. 340, 4, p. 1091-1097 7 p.

Research output: Contribution to journalArticle

87 Scopus citations

Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet

Hamrick, M. W., Pennington, C., Webb, C. N. & Isales, C. M., May 1 2006, In : International Journal of Obesity. 30, 5, p. 868-870 3 p.

Research output: Contribution to journalArticle

38 Scopus citations
2005
1 Scopus citations

Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover

Xie, D., Cheng, H., Hamrick, M., Zhong, Q., Ding, K. H., Correa, D., Williams, S., Mulloy, A., Bollag, W., Bollag, R. J., Runner, R. R., McPherson, J. C., Insogna, K. & Isales, C. M., Dec 1 2005, In : Bone. 37, 6, p. 759-769 11 p.

Research output: Contribution to journalArticle

117 Scopus citations

Multiple melanocortin receptors are expressed in bone cells

Zhong, Q., Sridhar, S., Ruan, L., Ding, K., Xie, D., Insogna, K., Kang, B., Xu, J., Bollag, R. J. & Isales, C. M., May 2005, In : Bone. 36, 5, p. 820-831 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice

Montgomery, E., Pennington, C., Isales, C. M. & Hamrick, M. W., Sep 1 2005, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 286, 1, p. 814-822 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

SUMO wrestling with type 1 diabetes

Li, M., Guo, D., Isales, C. M., Eizirik, D. L., Atkinson, M., She, J. X. & Wang, C. Y., Jul 1 2005, In : Journal of Molecular Medicine. 83, 7, p. 504-513 10 p.

Research output: Contribution to journalReview article

70 Scopus citations
2004

A patient with concurrent primary hyperaldosteronism and adrenal insufficiency

Puentes, F., Jackson, T. W. & Isales, C. M., Dec 2004, In : American Journal of the Medical Sciences. 328, 6, p. 344-347 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
31 Scopus citations

Leptin deficiency produces contrasting phenotypes in bones of the limb and spine

Hamrick, M. W., Pennington, C., Newton, D., Xie, D. & Isales, C., Mar 1 2004, In : Bone. 34, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

278 Scopus citations

Tbx2 represses expression of Connexin43 in osteoblastic-like cells

Chen, J. R., Chatterjee, B., Meyer, R., Yu, J. C., Borke, J. L., Isales, C. M., Kirby, M. L., Lo, C. W. & Bollag, R. J., Jun 1 2004, In : Calcified Tissue International. 74, 6, p. 561-573 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans

Pi, W., Yang, Z., Wang, J., Ruan, L., Yu, X., Ling, J., Krantz, S., Isales, C. M., Conway, S. J., Lin, S. & Tuan Lo, D., Jan 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 3, p. 805-810 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
2003
15 Scopus citations
18 Scopus citations

High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway

Shaw, S., Wang, X., Redd, H., Alexander, G. D., Isales, C. M. & Marrero, M. B., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 30634-30641 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Negative transcriptional regulation of connexin 43 by Tbx2 in rat immature coronal sutures and ROS 17/2.8 cells in culture

Borke, J. L., Chen, J. R., Yu, J. C., Bollag, R. J., Orellana, M. F. & Isales, C. M., May 1 2003, In : Cleft Palate-Craniofacial Journal. 40, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Primary ovarian lymphoma manifesting with severe hypercalcemia

Rizvi, A. A., Bowman, M. A., Vaughters, R. B., Isales, C. & Mulloy, A. L., 2003, In : Endocrine Practice. 9, 5, p. 389-393 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tension-Induced Reduction in Connexin 43 Expression in Cranial Sutures is Linked to Transcriptional Regulation by TBX2

Borke, J. L., Yu, J. C., Isales, C. M., Wagle, N., Do, N. N., Chen, J. R. & Bollag, R. J., Nov 1 2003, In : Annals of Plastic Surgery. 51, 5, p. 499-504 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration

Throckmorton, D., Kurscheid-Reich, D., Rosales, O. R., Rodriguez-Commes, J., Lopez, R., Sumpio, B., Zhong, Q., Ding, K. H., McCarthy, R., Barrett, P. Q. & Isales, C. M., Feb 11 2002, In : Peptides. 23, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2001

Angiotensin II priming of aldosterone secretion with agents that enhance Ca2+ influx

Betancourt-Calle, S., Mann-Blakeney, R. S., Isales, C. M., Calle, R. A. & Bollinger Bollag, W., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 61-70 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Differential effects of agonists of aldosterone secretion on steroidogenic acute regulatory phosphorylation

Betancourt-Calle, S., Calle, R. A., Isales, C. M., White, S., Rasmussen, H. & Bollag, W. B., Feb 22 2001, In : Molecular and Cellular Endocrinology. 173, 1-2, p. 87-94 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Functional analysis of glucose-dependent insulinotropic polypeptide fusion proteins

Ding, K. H., Isales, C. M., Zhong, Q. & Bollag, R. J., Apr 30 2001, In : Peptides. 22, 4, p. 575-582 8 p.

Research output: Contribution to journalArticle

Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects

Bollag, R. J., Zhong, Q., Ding, K. H., Phillips, P., Zhong, L., Qin, F., Cranford, J., Mulloy, A. L., Cameron, R. & Isales, C. M., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 35-41 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Microarray analysis of Tbx2-directed gene expression: A possible role in osteogenesis

Chen, J. R., Zhong, Q., Wang, J., Cameron, R. S., Borke, J. L., Isales, C. M. & Bollag, R. J., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 43-54 12 p.

Research output: Contribution to journalArticle

46 Scopus citations
2000

Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line

Isales, C. M., Sumpio, B., Bollag, R. J., Zhong, Q., Ding, K., Du, W., Rodriguez-Commes, J., Lopez, R., Rosales, O. R., Gasalla-Herraiz, J., McCarthy, R. & Barrett, P. Q., Jan 1 2000, In : American Journal of Physiology - Endocrinology and Metabolism. 279, 3 42-3, p. E654-E662

Research output: Contribution to journalArticle

35 Scopus citations

Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

Zhong, Q., Bollag, R. J., Dransfield, D. T., Gasalla-Herraiz, J., Ding, K. H., Min, L. & Isales, C. M., Nov 8 2000, In : Peptides. 21, 9, p. 1427-1432 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors

Bollag, R. J., Zhong, Q., Phillips, P., Min, L., Zhong, L., Cameron, R., Mulloy, A. L., Rasmussen, H., Qin, F., Ding, K. H. & Isales, C. M., Jan 1 2000, In : Endocrinology. 141, 3, p. 1228-1235 8 p.

Research output: Contribution to journalArticle

177 Scopus citations
1999
60 Scopus citations
1998

Fenfluramine potentiates canine pulmonary vasoreactivity to endothelin-1

Barman, S. A. & Isales, C. M., Apr 1998, In : Pulmonary Pharmacology and Therapeutics. 11, 2-3, p. 183-187 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Overexpression of protein kinase C α and β1 has distinct effects on bovine aortic endothelial cell growth

Rosales, O. R., Isales, C. M. & Bhargava, J., Sep 1 1998, In : Cellular Signalling. 10, 8, p. 589-597 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

pH-dependent fluoride transport in intestinal brush border membrane vesicles

He, H., Ganapathy, V., Isales, C. M. & Whitford, G. M., Jul 17 1998, In : Biochimica et Biophysica Acta - Biomembranes. 1372, 2, p. 244-254 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sustained phospholipase D activation in response to angiotensin II but not carbachol in bovine adrenal glomerulosa cells

Jung, E. M., Betancourt-Calle, S., Mann-Blakeney, R. S., Foushee, T., Isales, C. M. & Bollag, W. B., Feb 15 1998, In : Biochemical Journal. 330, 1, p. 445-451 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Vasopressin-induced activation of protein kinase C in renal epithelial cells

Ali, N., Kantachuvesiri, S., Smallwood, J. I., Macala, L. J., Isales, C., Ji, J., Reilly, R. & Hayslett, J. P., Mar 27 1998, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1402, 2, p. 188-196 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
1997
15 Scopus citations

Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools

Rosales, O. R., Isales, C. M., Barrett, P. Q., Brophy, C. & Sumpio, B. E., Sep 1 1997, In : Biochemical Journal. 326, 2, p. 385-392 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease

Dueñas-Gonzalez, A., Isales, C. M., Del Mar Abad-Hernandez, M., Gonzalez-Sarmiento, R., Sangueza, O. & Rodriguez-Commes, J., Jul 1 1997, In : Modern Pathology. 10, 7, p. 645-649 5 p.

Research output: Contribution to journalArticle

76 Scopus citations

Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents

Ding, K., Husain, S., Akhtar, R. A., Isales, C. M. & Abdel-Latif, A. A., Sep 1 1997, In : Cellular Signalling. 9, 6, p. 411-421 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Molecular cloning of a putative tetrodotoxin-resistant sodium channel from dog nodose ganglion neurons

Chen, J., Ikeda, S. R., Lang, W., Isales, C. M. & Wei, X., Nov 20 1997, In : Gene. 202, 1-2, p. 7-14 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Novel effect of insulin: Insulin-stimulated Na+ transport is mediated by hydrolysis of phosphoinositides

Isales, C., MacAla, L. J., Rodriguez-Commes, J., Gasalla-Herraiz, J. & Hayslett, J. P., Feb 3 1997, In : Biochemical and Biophysical Research Communications. 231, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

1 Scopus citations