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2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

3 Scopus citations

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D. Y., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W. D., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

6 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

1 Scopus citations

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W. D., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M. E., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

1 Scopus citations

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw

Elsayed, R., Kurago, Z., Cutler, C. W., Arce, R. M., Gerber, J., Celis, E., Sultan, H., Elashiry, M., Meghil, M., Sun, C., Auersvald, C. M., Awad, M. E., Zeitoun, R., Elsayed, R., Eldin M. Elshikh, M., Isales, C. & Elsalanty, M. E., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2595-2608 14 p.

Research output: Contribution to journalArticle

Open Access
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Association of Dietary Niacin Intake With Incident Hip Fracture, BMD, and Body Composition: The Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Raiford, M., Le, B., Isales, C. M., Shikany, J. M., Coughlin, S. S. & Robbins, J. A., Apr 2019, In : Journal of Bone and Mineral Research. 34, 4, p. 643-652 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss

Singleton, Q., Vaibhav, K., Braun, M., Patel, C., Khayrullin, A., Mendhe, B., Lee, B. R., Kolhe, R., Kaiser, H., Awad, M. E., Fariyike, T., Elsayed, R., Elsalanty, M., Isales, C. M., Liu, Y., Hamrick, M. W., Dhandapani, K. M. & Fulzele, S., Jan 17 2019, In : Fuel Cells. 8, 1

Research output: Contribution to journalArticle

Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

Kim, B. J., Lee, J. Y., Park, S. J., Lee, S. H., Kim, S. J., Yoo, H. J., De Pena, S. I. R., McGee-Lawrence, M., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jan 1 2019, In : Aging. 11, 21, p. 9388-9404 17 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
4 Scopus citations

Lower hand grip strength in older adults with non-alcoholic fatty liver disease: A nationwide population-based study

Kim, B. J., Ahn, S. H., Lee, S. H., Hong, S., Hamrick, M. W., Isales, C. M. & Koh, J. M., Jul 1 2019, In : Aging. 11, 13, p. 4547-4560 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Meta-analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair: Methodological guidelines and quality assessment

Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D. & Fulzele, S., 2019, In : Stem Cells International. 2019, 3826054.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Phosphatidylglycerol Inhibits Toll-Like Receptor–Mediated Inflammation by Danger-Associated Molecular Patterns

Choudhary, V., Uaratanawong, R., Patel, R. R., Patel, H., Bao, W., Hartney, B., Cohen, E., Chen, X., Zhong, Q., Isales, C. M. & Bollag, W. B., Apr 2019, In : Journal of Investigative Dermatology. 139, 4, p. 868-877 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study

Le, B., Bůžková, P., Robbins, J. A., Fink, H. A., Raiford, M., Isales, C. M., Shikany, J. M., Coughlin, S. S. & Carbone, L. D., Aug 15 2019, In : Calcified Tissue International. 105, 2, p. 161-172 12 p.

Research output: Contribution to journalArticle

The detrimental effects of kynurenine, a tryptophan metabolite, on human bone metabolism

Kim, B. J., Hamrick, M. W., Yoo, H. J., Lee, S. H., Kim, S. J., Koh, J. M. & Isales, C. M., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2334-2342 9 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In : Pharmacology and Therapeutics. 198, p. 90-108 19 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly

Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: A nationwide population-based study

Kim, B. J., Lee, S. H., Kwak, M. K., Isales, C. M., Koh, J. M. & Hamrick, M. W., Aug 1 2018, In : Aging. 10, 8, p. 2051-2061 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

Yang, G., Pillich, H., White, R., Czikora, I., Pochic, I., Yue, Q., Hudel, M., Gorshkov, B. A., Verin, A. D., Sridhar, S., Isales, C. M., Eaton, D. C., Hamacher, J., Chakraborty, T. & Lucas, R., Feb 11 2018, In : Toxins. 10, 2, 79.

Research output: Contribution to journalArticle

1 Scopus citations

Modulation of miRNAS by vitamin C in human bone marrow stromal cells

Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In : Nutrients. 10, 2, 186.

Research output: Contribution to journalArticle

4 Scopus citations

Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy

Bollag, W. B., Ding, K., Choudhary, V., Xu, J., Zhong, Q., Elsayed, R., Bailey, L. J., Elsalanty, M. E., Yu, K., Johnson, M. H., McGee Lawrence, M. E. & Isales, C. M., Oct 15 2018, In : Molecular and Cellular Endocrinology. 474, p. 176-183 8 p.

Research output: Contribution to journalArticle

The positive association of total protein intake with femoral neck strength (KNHANES IV)

Kim, B. J., Lee, S. H., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jun 1 2018, In : Osteoporosis International. 29, 6, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Isales, C. M. & Hill, W. D., May 1 2017, In : Osteoporosis International. 28, 5, p. 1631-1640 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific reports. 7, 1, 2029.

Research output: Contribution to journalArticle

56 Scopus citations

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years

Kindler, J. M., Pollock, N. K., Laing, E. M., Oshri, A., Jenkins, N. T., Isales, C. M., Hamrick, M. W., Ding, K. H., Hausman, D. B., McCabe, G. P., Martin, B. R., Hill Gallant, K. M., Warden, S. J., Weaver, C. M., Peacock, M. & Lewis, R. D., Jul 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1537-1545 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
47 Scopus citations

Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss

Yang, N., Baban, B., Isales, C. M. & Shi, X. M., Aug 2017, In : PloS one. 12, 8, e0181133.

Research output: Contribution to journalArticle

4 Scopus citations

Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor-deficient mice

McGee-Lawrence, M. E., Wenger, K. H., Misra, S., Davis, C. L., Pollock, N. K., Elsalanty, M., Ding, K., Isales, C. M., Hamrick, M. W., Wosiski-Kuhn, M., Arounleut, P., Mattson, M. P., Cutler, R. G., Yu, J. C. & Stranahan, A. M., May 1 2017, In : Endocrinology. 158, 5, p. 1160-1171 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Chemically defined and xeno-free cryopreservation of human adipose-derived stem cells

López, M., Bollag, R. J., Yu, J. C., Isales, C. M. & Eroglu, A., Mar 1 2016, In : PloS one. 11, 3, e0152161.

Research output: Contribution to journalArticle

12 Scopus citations

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Insulin resistance negatively influences the muscle- dependent igf-1-bone mass relationship in premenarcheal girls

Kindler, J. M., Pollock, N. K., Laing, E. M., Jenkins, N. T., Oshri, A., Isales, C., Hamrick, M. & Lewis, R. D., Jan 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 1, p. 199-205 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015
15 Scopus citations

Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy

Herberg, S., Kondrikova, G., Hussein, K. A., Johnson, M. H., Elsalanty, M. E., Shi, X., Hamrick, M. W., Isales, C. M. & Hill, W. D., Feb 1 2015, In : Journal of Orthopaedic Research. 33, 2, p. 174-184 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells

Sangani, R., Periyasamy-Thandavan, S., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Isales, C., Hamrick, M., Hill, W. D. & Fulzele, S., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 19-26 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Removal of pamidronate from bone in rats using systemic and local chelation

Howie, R. N., Bhattacharyya, M., Salama, M. E., Refaey, M. E., Isales, C. M., Borke, J., Daoudi, A., Medani, F. & Elsalanty, M. E., Dec 1 2015, In : Archives of Oral Biology. 60, 12, p. 1699-1707 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

Hamrick, M. W., Dukes, A., Arounleut, P., Davis, C., Periyasamy-Thandavan, S., Mork, S., Herberg, S., Johnson, M. H., Isales, C. M., Hill, W. D., Otvos, L. & Belin de Chantemèle, E. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 92-96 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro

Dukes, A., Davis, C. M., El Refaey, M., Upadhyay, S., Mork, S., Arounleut, P., Johnson, M. H., Hill, W. D., Isales, C. M. & Hamrick, M. W., Jan 1 2015, In : Nutrition. 31, 7-8, p. 1018-1024 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis

Sangani, R., Periyasamy-Thandavan, S., Pathania, R., Ahmad, S., Kutiyanawalla, A., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Sep 1 2015, In : Stem Cell Research. 15, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Zinc supplementation increases procollagen type 1 amino-terminal propeptide in premenarcheal girls: A randomized controlled trial

Berger, P. K., Pollock, N. K., Laing, E. M., Chertin, V., Bernard, P. J., Grider, A., Shapses, S. A., Ding, K. H., Isales, C. M. & Lewis, R. D., Jan 1 2015, In : Journal of Nutrition. 145, 12, p. 2699-2704 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension

Refaey, M. E., Zhong, Q., Hill, W. D., Shi, X. M., Hamrick, M. W., Bailey, L., Johnson, M., Xu, J., Bollag, W. B., Chutkan, N. & Isales, C. M., Apr 11 2014, In : PloS one. 9, 4, e91108.

Research output: Contribution to journalArticle

9 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of dietary aromatic amino acids on osteoclastic activity

Refaey, M. E., Zhong, Q., Ding, K. H., Shi, X. M., Xu, J., Bollag, W. B., Hill, W. D., Chutkan, N., Robbins, R., Nadeau, H., Johnson, M., Hamrick, M. W. & Isales, C. M., Aug 2014, In : Calcified Tissue International. 95, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

8 Scopus citations