Chad E. Stephens

Associate Professor

  • 1987 Citations
  • 26 h-Index
19962019
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Personal profile

Education/Academic qualification

University of South Carolina

Research interests

  • Medicinal Chemistry
  • Fluorination Chemistry
  • Antiprotozoals
  • Prodrugs
  • Heterocyclic Chemistry
  • Antivirals

Fingerprint Dive into the research topics where Chad E. Stephens is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Pentamidine Medicine & Life Sciences
Amidines Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences
Parasites Medicine & Life Sciences
Thiophenes Chemical Compounds
DNA Medicine & Life Sciences
Antiparasitic Agents Medicine & Life Sciences
Palladium Chemical Compounds

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Research Output 1996 2019

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

Depauw, S., Lambert, M., Jambon, S., Paul, A., Peixoto, P., Nhili, R., Marongiu, L., Figeac, M., Dassi, C., Paul-Constant, C., Billoré, B., Kumar, A., Farahat, A. A., Ismail, M. A., Mineva, E., Sweat, D. P., Stephens, C. E., Boykin, D. W., Wilson, W. D. & David-Cordonnier, M. H., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1306-1329 24 p.

Research output: Contribution to journalArticle

Pentamidine
Leukemia
Transcription Factors
Ligands
DNA
30 Citations (Scopus)

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

Simone, R., Balendra, R., Moens, T. G., Preza, E., Wilson, K. M., Heslegrave, A., Woodling, N. S., Niccoli, T., Gilbert-Jaramillo, J., Abdelkarim, S., Clayton, E. L., Clarke, M., Konrad, M. T., Nicoll, A. J., Mitchell, J. S., Calvo, A., Chio, A., Houlden, H., Polke, J. M., Ismail, M. A. & 13 others, Stephens, C. E., Vo, T., Farahat, A. A., Wilson, W. D., Boykin, D. W., Zetterberg, H., Partridge, L., Wray, S., Parkinson, G., Neidle, S., Patani, R., Fratta, P. & Isaacs, A. M., Jan 1 2018, In : EMBO Molecular Medicine. 10, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Dipeptides
Pathology
Motor Neurons
RNA

Isolation of 5-Hydroxy-γ-lactams from a Classical 2-Aminopyrrole Synthesis

Suthiwangcharoen, N., Bean, A. C., Hassan, M., Eidell, C. K. & Stephens, C. E., May 1 2018, In : Journal of Heterocyclic Chemistry. 55, 5, p. 1219-1222 4 p.

Research output: Contribution to journalArticle

Lactams
Byproducts
Condensation
3 Citations (Scopus)

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

da Silva, C. F., Batista, D. D. G. J., de Araújo, J. S., Cunha-Junior, E. F., Stephens, C. E., Banerjee, M., Farahat, A. A., Akay, S., Fisher, M. K., Boykin, D. W. & Soeiro, M. D. N. C., Apr 3 2017, In : Drug Design, Development and Therapy. 11, p. 1095-1105 11 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Computer Simulation
Parasites
Salts
Amidines
1 Citation (Scopus)

Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Wilkerson, P. D., Bean, A. C. & Stephens, C. E., Apr 1 2017, In : Heterocyclic Communications. 23, 2, p. 101-103 3 p.

Research output: Contribution to journalArticle

Sulfones
Ketones
Antiviral Agents
Byproducts
1,4-benzothiazine

Activities 2015 2015

  • 1 Editorial activity

Heterocyclic Communications (Journal)

Chad E. Stephens (Editor)
2015

Activity: Editorial work typesEditorial activity