Chad E. Stephens

Associate Professor

  • 2091 Citations
  • 27 h-Index
19962019

Research output per year

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Research Output

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Article
2019

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

Depauw, S., Lambert, M., Jambon, S., Paul, A., Peixoto, P., Nhili, R., Marongiu, L., Figeac, M., Dassi, C., Paul-Constant, C., Billoré, B., Kumar, A., Farahat, A. A., Ismail, M. A., Mineva, E., Sweat, D. P., Stephens, C. E., Boykin, D. W., Wilson, W. D. & David-Cordonnier, M. H., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1306-1329 24 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

Simone, R., Balendra, R., Moens, T. G., Preza, E., Wilson, K. M., Heslegrave, A., Woodling, N. S., Niccoli, T., Gilbert-Jaramillo, J., Abdelkarim, S., Clayton, E. L., Clarke, M., Konrad, M. T., Nicoll, A. J., Mitchell, J. S., Calvo, A., Chio, A., Houlden, H., Polke, J. M., Ismail, M. A. & 13 others, Stephens, C. E., Vo, T., Farahat, A. A., Wilson, W. D., Boykin, D. W., Zetterberg, H., Partridge, L., Wray, S., Parkinson, G., Neidle, S., Patani, R., Fratta, P. & Isaacs, A. M., Jan 2018, In : EMBO Molecular Medicine. 10, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Isolation of 5-Hydroxy-γ-lactams from a Classical 2-Aminopyrrole Synthesis

Suthiwangcharoen, N., Bean, A. C., Hassan, M., Eidell, C. K. & Stephens, C. E., May 1 2018, In : Journal of Heterocyclic Chemistry. 55, 5, p. 1219-1222 4 p.

Research output: Contribution to journalArticle

2017

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

da Silva, C. F., Batista, D. D. G. J., de Araújo, J. S., Cunha-Junior, E. F., Stephens, C. E., Banerjee, M., Farahat, A. A., Akay, S., Fisher, M. K., Boykin, D. W. & Soeiro, M. D. N. C., Apr 3 2017, In : Drug Design, Development and Therapy. 11, p. 1095-1105 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Wilkerson, P. D., Bean, A. C. & Stephens, C. E., Apr 1 2017, In : Heterocyclic Communications. 23, 2, p. 101-103 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Antiprion activity of DB772 and related monothiophene- and furan-based analogs in a persistently infected ovine microglia culture system

Dinkel, K. D., Stanton, J. B., Boykin, D. W., Stephens, C. E., Madsen-Bouterse, S. A. & Schneider, D. A., Sep 1 2016, In : Antimicrobial agents and chemotherapy. 60, 9, p. 5467-5482 16 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Aerobic aromatization of 1,3,5-triarylpyrazolines in open air and without catalyst

Jenkins, R. N., Hinnant, G. M., Bean, A. C. & Stephens, C. E., Dec 7 2015, In : Arkivoc. 2015, 7, p. 347-353 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and charge density determination of 4,4-difluoro-3,5-diphenyl-4H-pyrazole and a hydrate derivative

Walton, L., Duplain, H. R., Knapp, A. L., Eidell, C. K., Bacsa, J. & Stephens, C. E., May 2015, In : Journal of Fluorine Chemistry. 173, p. 470-480 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts

Hostettler, I., Müller, J., Stephens, C. E., Haynes, R. & Hemphill, A., Dec 1 2014, In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 3, p. 201-209 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement

Ju, W., Yang, S., Ansede, J. H., Stephens, C. E., Bridges, A. S., Voyksner, R. D., Ismail, M. A., Boykin, D. W., Tidwell, R. R., Hall, J. E. & Wang, M. Z., Jan 2014, In : Journal of Pharmaceutical Sciences. 103, 1, p. 337-349 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi

De Araújo, J. S., Da Silva, C. F., Batista, D. G. J., Da Silva, P. B., Meuser, M. B., Aiub, C. A. F., Da Silva, M. F. V., Araújo-Lima, C. F., Banerjee, M., Farahat, A. A., Stephens, C. E., Kumar, A., Boykin, D. W. & Soeiro, M. N. C., Jul 2014, In : Antimicrobial agents and chemotherapy. 58, 7, p. 4191-4195 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

Munde, M., Wang, S., Kumar, A., Stephens, C. E., Farahat, A. A., Boykin, D. W., Wilson, W. D. & Poon, G. M. K., Feb 10 2014, In : Nucleic Acids Research. 42, 2, p. 1379-1390 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013
2 Scopus citations

In Vitro and in vivo activities of dicationic diguanidino compounds against echinococcus multilocularis metacestodes

Küster, T., Kriegel, N., Boykin, D. W., Stephens, C. E. & Hemphill, A., Aug 1 2013, In : Antimicrobial agents and chemotherapy. 57, 8, p. 3829-3835 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mono- and trifluorination of the thiazole ring of 2,5-diarylthiazoles using N-fluorobenzenesulfonimide (NFSI)

Hatfield, J. M., Eidell, C. K. & Stephens, C. E., Feb 20 2013, In : Tetrahedron Letters. 54, 8, p. 1025-1028 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

Nhili, R., Peixoto, P., Depauw, S., Flajollet, S., Dezitter, X., Munde, M. M., Ismail, M. A., Kumar, A., Farahat, A. A., Stephens, C. E., Duterque-Coquillaud, M., David Wilson, W., Boykin, D. W. & David-Cordonnier, M. H., Jan 1 2013, In : Nucleic Acids Research. 41, 1, p. 125-138 14 p.

Research output: Contribution to journalArticle

46 Scopus citations
2012

Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice

Schorer, M., Debache, K., Barna, F., Monney, T., Müller, J., Boykin, D. W., Stephens, C. E. & Hemphill, A., Dec 1 2012, In : International Journal for Parasitology: Drugs and Drug Resistance. 2, p. 109-120 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: In vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies

Zhu, X., Liu, Q., Yang, S., Parman, T., Green, C. E., Mirsalis, J. C., Soeiro, M. D. N. C., De Souza, E. M., Da Silva, C. F., Batista, D. D. G. J., Stephens, C. E., Banerjee, M., Farahat, A. A., Munde, M., Wilson, W. D., Boykin, D. W., Wang, M. Z. & Werbovetz, K. A., Jul 1 2012, In : Antimicrobial agents and chemotherapy. 56, 7, p. 3690-3699 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

The adaptive potential of a survival artist: Characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures

Kropf, C., Debache, K., Rampa, C., Barna, F., Schorer, M., Stephens, C. E., Ismail, M. A., Boykin, D. W. & Hemphill, A., Feb 1 2012, In : Parasitology. 139, 2, p. 208-220 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011

An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines

Suthiwangcharoen, N., Pochini, S. M., Sweat, D. P. & Stephens, C. E., May 1 2011, In : Journal of Heterocyclic Chemistry. 48, 3, p. 706-709 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo

da Gama Jaén Batista, D., Batista, M. M., de Oliveira, G. M., Britto, C. C., Rodrigues, A. C. M., Stephens, C. E., Boykin, D. W. & de Nazaré Correia Soeiro, M., Aug 1 2011, In : PloS one. 6, 7, e22155.

Research output: Contribution to journalArticle

19 Scopus citations

Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide

Debache, K., Guionaud, C., Kropf, C., Boykin, D., Stephens, C. E. & Hemphill, A., Oct 1 2011, In : Experimental Parasitology. 129, 2, p. 95-100 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

In vitro effects of arylimidamides against Besnoitia besnoiti infection in Vero cells.

Cortes, H. C., Muller, N., Boykin, D., Stephens, C. E. & Hemphill, A., Apr 1 2011, In : Parasitology. 138, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes

Stadelmann, B., Küster, T., Scholl, S., Barna, F., Kropf, C., Keiser, J., Boykin, D. W., Stephens, C. E. & Hemphill, A., Oct 1 2011, In : Antimicrobial agents and chemotherapy. 55, 10, p. 4866-4872 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi

da Silva, C. F., Junqueira, A., Lima, M. M., Romanha, A. J., Sales Junior, P. A., Stephens, C. E., Som, P., Boykin, D. W. & de Nazaré Correia Soeiro, M., Jun 1 2011, In : Journal of Antimicrobial Chemotherapy. 66, 6, p. 1295-1297 3 p., dkr140.

Research output: Contribution to journalArticle

13 Scopus citations

Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Griswold, C. P., Suthiwangcharoen, N., Pochini, S. M. & Stephens, C. E., May 11 2011, In : Synthetic Communications. 41, 11, p. 1672-1681 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro

Da Silva, C. F., Daliry, A., Da Silva, P. B., Akay, S., Banerjee, M., Farahat, A. A., Fisher, M. K., Hu, L., Kumar, A., Liu, Z., Stephens, C. E., Boykin, D. W. & Correia Soeiro, M. D. N., Dec 1 2011, In : Parasitology. 138, 14, p. 1863-1869 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA

Daliry, A., Pires, M. Q., Silva, C. F., Pacheco, R. S., Munde, M., Stephens, C. E., Kumar, A., Ismail, M. A., Liu, Z., Farahat, A. A., Akay, S., Som, P., Hu, Q., Boykin, D. W., Wilson, W. D., De Castro, S. L. & Soeiro, M. N. C., Oct 1 2011, In : Antimicrobial agents and chemotherapy. 55, 10, p. 4765-4773 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Aerobic epoxidation and hydroxylation of a pyrrolo[2,1-b]quinazoline under ambient conditions

Hawkins, R. A. & Stephens, C. E., Nov 24 2010, In : Tetrahedron Letters. 51, 47, p. 6129-6131 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment

Batista, D. D. G. J., Batista, M. M., De Oliveira, G. M., Do Amaral, P. B., Lannes-Vieira, J., Britto, C. C., Junqueira, A., Lima, M. M., Romanha, A. J., Sales, P. A., Stephens, C. E., Boykin, D. W. & Soeiro, M. D. N. C., Jul 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2940-2952 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity, and Specificity for a TTAA Site

Munde, M., Kumar, A., Nhili, R., Depauw, S., David-Cordonnier, M. H., Ismail, M. A., Stephens, C. E., Farahat, A. A., Batista-Parra, A., Boykin, D. W. & Wilson, W. D., Oct 8 2010, In : Journal of Molecular Biology. 402, 5, p. 847-864 18 p.

Research output: Contribution to journalArticle

30 Scopus citations

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi

Gillingwater, K., Kumar, A., Ismail, M. A., Arafa, R. K., Stephens, C. E., Boykin, D. W., Tidwell, R. R. & Brun, R., May 1 2010, In : Veterinary Parasitology. 169, 3-4, p. 264-272 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Novel arylimidamides for treatment of visceral leishmaniasis

Wang, M. Z., Zhu, X., Srivastava, A., Liu, Q., Sweat, J. M., Pandharkar, T., Stephens, C. E., Riccio, E., Parman, T., Munde, M., Mandal, S., Madhubala, R., Tidwell, R. R., Wilson, W. D., Boykin, D. W., Hall, J. E., Kyle, D. E. & Werbovetz, K. A., Jun 1 2010, In : Antimicrobial agents and chemotherapy. 54, 6, p. 2507-2516 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2009

Large, sequence-dependent effects on DNA conformation by minor groove binding compounds

Tevis, D. S., Kumar, A., Stephens, C. E., Boykin, D. W. & Wilson, W. D., Jul 3 2009, In : Nucleic Acids Research. 37, 16, p. 5550-5558 9 p., gkp558.

Research output: Contribution to journalArticle

28 Scopus citations

Synthesis and stille cross-coupling reactions of 2-(tributylstannyl)-and 2,5-bis(trimethylstannyl)tellurophene

Sweat, D. P. & Stephens, C. E., Nov 18 2009, In : Synthesis. 19, p. 3214-3218 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro

Pacheco, M. G. D. O., Silva, C. F. D., Souza, E. M. D., Batista, M. M., Silva, P. B. D., Kumar, A., Stephens, C. E., Boykin, D. W. & Soeiro, M. D. N. C., Sep 1 2009, In : Experimental Parasitology. 123, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2008

Heterocyclic diamidine interactions at AT base Pairs in the DNA minor groove: Effects of heterocycle differences, DNA AT sequence and length

Liu, Y., Collar, C. J., Kumar, A., Stephens, C. E., Boykin, D. W. & Wilson, W. D., Sep 18 2008, In : Journal of Physical Chemistry B. 112, 37, p. 11809-11818 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Host cells participate in the in vitro effects of novel diamidine analogues against tachyzoites of the intracellular apicomplexan parasites Neospora caninum and Toxoplasma gondii

Leepin, A., Stüdli, A., Brun, R., Stephens, C. E., Boykin, D. W. & Hemphill, A., Jun 1 2008, In : Antimicrobial Agents and Chemotherapy. 52, 6, p. 1999-2008 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Inhibition by dications of in vitro growth of Leishmania major and Leishmania tropica: Causative agents of old world cutaneous leishmaniasis

Rosypal, A. C., Werbovetz, K. A., Salem, M., Stephens, C. E., Kumar, A., Boykin, D. W., Hall, J. E. & Tidwell, R. R., Jun 1 2008, In : Journal of Parasitology. 94, 3, p. 743-749 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro"

Silva, C. F., Batista, M. M., Mota, R. A., de Souza, E. M., Stephens, C. E., Som, P., Boykin, D. W. & Soeiro, M. D. N. C., Jun 15 2007, In : Biochemical Pharmacology. 73, 12, p. 1939-1946 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Cellular effects of reversed amidines on Trypanosoma cruzi

Silva, C. F., Meuser, M. B., De Souza, E. M., Meirelles, M. N. L., Stephens, C. E., Som, P., Boykin, D. W. & Soeiro, M. N. C., Nov 1 2007, In : Antimicrobial agents and chemotherapy. 51, 11, p. 3803-3809 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum

Rosypal, A. C., Hall, J. E., Bakunova, S., Patrick, D. A., Bakunov, S., Stephens, C. E., Kumar, A., Boykin, D. W. & Tidwell, R. R., Apr 30 2007, In : Veterinary Parasitology. 145, 3-4, p. 207-216 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

Gonzalez, J. L., Stephens, C. E., Wenzler, T., Brun, R., Tanious, F. A., Wilson, W. D., Barszcz, T., Werbovetz, K. A. & Boykin, D. W., Apr 1 2007, In : European Journal of Medicinal Chemistry. 42, 4, p. 552-557 6 p.

Research output: Contribution to journalArticle

52 Scopus citations
2006

3,5-diarylisoxazoles: Individualized three-step synthesis and isomer determination using 13C NMR or mass spectroscopy

Stephens, C. E. & Arafa, R. K., Sep 1 2006, In : Journal of Chemical Education. 83, 9, p. 1336-1340 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

An efficient synthesis of 5,5′-diaryl-2,2′-bichalcophenes

Ismail, M. A., Boykin, D. W. & Stephens, C. E., Jan 30 2006, In : Tetrahedron Letters. 47, 5, p. 795-797 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses

Naesens, L., Stephens, C. E., Andrei, G., Loregian, A., De Bolle, L., Snoeck, R., Sowell, J. W. & De Clercq, E., Oct 1 2006, In : Antiviral Research. 72, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4- amidinophenyl)furan-bis-O-methylamidoxime]

Wang, M. Z., Saulter, J. Y., Usuki, E., Cheung, Y. L., Hall, M., Bridges, A. S., Loewen, G., Parkinson, O. T., Stephens, C. E., Allen, J. L., Zeldin, D. C., Boykin, D. W., Tidwell, R. R., Parkinson, A., Paine, M. F. & Hall, J. E., Dec 1 2006, In : Drug Metabolism and Disposition. 34, 12, p. 1985-1994 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Nuclear fluorination of 2,4-diarylthiazoles with Accufluor®

Campbell, T. F. & Stephens, C. E., Dec 1 2006, In : Journal of Fluorine Chemistry. 127, 12, p. 1591-1594 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Oxidative ring opening of 2,5-diarylfurans by Selectfluor®

Blank, S. J. & Stephens, C. E., Sep 18 2006, In : Tetrahedron Letters. 47, 38, p. 6849-6850 2 p.

Research output: Contribution to journalArticle

14 Scopus citations
2005

Dications that target the DNA minor groove: Compound design and preparation, DNA interactions, cellular distribution and biological activity

Wilson, W. D., Nguyen, B., Tanious, F. A., Mathis, A., Hall, J. E., Stephens, C. E. & Boykin, D. W., Jul 1 2005, In : Current Medicinal Chemistry - Anti-Cancer Agents. 5, 4, p. 389-408 20 p.

Research output: Contribution to journalArticle

141 Scopus citations