Chad E. Stephens

Associate Professor

  • 2012 Citations
  • 27 h-Index
19962019
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Research Output 1996 2019

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Article
2019
1 Citation (Scopus)

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

Depauw, S., Lambert, M., Jambon, S., Paul, A., Peixoto, P., Nhili, R., Marongiu, L., Figeac, M., Dassi, C., Paul-Constant, C., Billoré, B., Kumar, A., Farahat, A. A., Ismail, M. A., Mineva, E., Sweat, D. P., Stephens, C. E., Boykin, D. W., Wilson, W. D. & David-Cordonnier, M. H., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1306-1329 24 p.

Research output: Contribution to journalArticle

Pentamidine
Leukemia
Transcription Factors
Ligands
DNA
2018
34 Citations (Scopus)

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

Simone, R., Balendra, R., Moens, T. G., Preza, E., Wilson, K. M., Heslegrave, A., Woodling, N. S., Niccoli, T., Gilbert-Jaramillo, J., Abdelkarim, S., Clayton, E. L., Clarke, M., Konrad, M. T., Nicoll, A. J., Mitchell, J. S., Calvo, A., Chio, A., Houlden, H., Polke, J. M., Ismail, M. A. & 13 others, Stephens, C. E., Vo, T., Farahat, A. A., Wilson, W. D., Boykin, D. W., Zetterberg, H., Partridge, L., Wray, S., Parkinson, G., Neidle, S., Patani, R., Fratta, P. & Isaacs, A. M., Jan 2018, In : EMBO Molecular Medicine. 10, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Dipeptides
Pathology
Motor Neurons
RNA

Isolation of 5-Hydroxy-γ-lactams from a Classical 2-Aminopyrrole Synthesis

Suthiwangcharoen, N., Bean, A. C., Hassan, M., Eidell, C. K. & Stephens, C. E., May 1 2018, In : Journal of Heterocyclic Chemistry. 55, 5, p. 1219-1222 4 p.

Research output: Contribution to journalArticle

Lactams
Byproducts
Condensation
2017
3 Citations (Scopus)

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

da Silva, C. F., Batista, D. D. G. J., de Araújo, J. S., Cunha-Junior, E. F., Stephens, C. E., Banerjee, M., Farahat, A. A., Akay, S., Fisher, M. K., Boykin, D. W. & Soeiro, M. D. N. C., Apr 3 2017, In : Drug Design, Development and Therapy. 11, p. 1095-1105 11 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Computer Simulation
Parasites
Salts
Amidines
1 Citation (Scopus)

Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Wilkerson, P. D., Bean, A. C. & Stephens, C. E., Apr 1 2017, In : Heterocyclic Communications. 23, 2, p. 101-103 3 p.

Research output: Contribution to journalArticle

Sulfones
Ketones
Antiviral Agents
Byproducts
1,4-benzothiazine
2016
3 Citations (Scopus)

Antiprion activity of DB772 and related monothiophene- and furan-based analogs in a persistently infected ovine microglia culture system

Dinkel, K. D., Stanton, J. B., Boykin, D. W., Stephens, C. E., Madsen-Bouterse, S. A. & Schneider, D. A., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5467-5482 16 p.

Research output: Contribution to journalArticle

Microglia
Sheep
Prions
Structure-Activity Relationship
Library Surveys
2015
1 Citation (Scopus)

Aerobic aromatization of 1,3,5-triarylpyrazolines in open air and without catalyst

Jenkins, R. N., Hinnant, G. M., Bean, A. C. & Stephens, C. E., Dec 7 2015, In : Arkivoc. 2015, 7, p. 347-353 7 p.

Research output: Contribution to journalArticle

Pyrazoles
Aromatization
Dimethyl Sulfoxide
Heating
Catalysts
1 Citation (Scopus)

Synthesis and charge density determination of 4,4-difluoro-3,5-diphenyl-4H-pyrazole and a hydrate derivative

Walton, L., Duplain, H. R., Knapp, A. L., Eidell, C. K., Bacsa, J. & Stephens, C. E., Jan 1 2015, In : Journal of Fluorine Chemistry. 173, p. 470-480 11 p.

Research output: Contribution to journalArticle

Cyclopropanes
Gems
Charge density
Hydrates
crystal structure
2014
9 Citations (Scopus)

A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts

Hostettler, I., Müller, J., Stephens, C. E., Haynes, R. & Hemphill, A., Dec 1 2014, In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 3, p. 201-209 9 p.

Research output: Contribution to journalArticle

Theileria annulata
Schizonts
Reverse Transcriptase Polymerase Chain Reaction
Theileria
Parasites
6 Citations (Scopus)

CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement

Ju, W., Yang, S., Ansede, J. H., Stephens, C. E., Bridges, A. S., Voyksner, R. D., Ismail, M. A., Boykin, D. W., Tidwell, R. R., Hall, J. E. & Wang, M. Z., Jan 2014, In : Journal of Pharmaceutical Sciences. 103, 1, p. 337-349 13 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A1
Prodrugs
Biotransformation
Nitric Oxide
Amidines
5 Citations (Scopus)

In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi

De Araújo, J. S., Da Silva, C. F., Batista, D. G. J., Da Silva, P. B., Meuser, M. B., Aiub, C. A. F., Da Silva, M. F. V., Araújo-Lima, C. F., Banerjee, M., Farahat, A. A., Stephens, C. E., Kumar, A., Boykin, D. W. & Soeiro, M. N. C., Jul 2014, In : Antimicrobial Agents and Chemotherapy. 58, 7, p. 4191-4195 5 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Parasitemia
Mortality
In Vitro Techniques
31 Citations (Scopus)

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

Munde, M., Wang, S., Kumar, A., Stephens, C. E., Farahat, A. A., Boykin, D. W., Wilson, W. D. & Poon, G. M. K., Feb 10 2014, In : Nucleic Acids Research. 42, 2, p. 1379-1390 12 p.

Research output: Contribution to journalArticle

Pentamidine
Consensus
AT Rich Sequence
Nucleic Acid Conformation
Cell Nucleus
2013
1 Citation (Scopus)
Pyrroles
Carboxylic Acids
Acetic Acid
Acids
phenylacetic acid
17 Citations (Scopus)

In Vitro and in vivo activities of dicationic diguanidino compounds against echinococcus multilocularis metacestodes

Küster, T., Kriegel, N., Boykin, D. W., Stephens, C. E. & Hemphill, A., Aug 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 8, p. 3829-3835 7 p.

Research output: Contribution to journalArticle

Echinococcus multilocularis
Benzimidazoles
Thiophenes
Mebendazole
Furans
4 Citations (Scopus)

Mono- and trifluorination of the thiazole ring of 2,5-diarylthiazoles using N-fluorobenzenesulfonimide (NFSI)

Hatfield, J. M., Eidell, C. K. & Stephens, C. E., Feb 20 2013, In : Tetrahedron Letters. 54, 8, p. 1025-1028 4 p.

Research output: Contribution to journalArticle

Thiazoles
Fluorination
Halogenation
Crystal structure
X-Rays
42 Citations (Scopus)

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

Nhili, R., Peixoto, P., Depauw, S., Flajollet, S., Dezitter, X., Munde, M. M., Ismail, M. A., Kumar, A., Farahat, A. A., Stephens, C. E., Duterque-Coquillaud, M., David Wilson, W., Boykin, D. W. & David-Cordonnier, M. H., Jan 1 2013, In : Nucleic Acids Research. 41, 1, p. 125-138 14 p.

Research output: Contribution to journalArticle

Pentamidine
Human Activities
Transcription Factors
DNA
Electrophoretic Mobility Shift Assay
2012
24 Citations (Scopus)

Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice

Schorer, M., Debache, K., Barna, F., Monney, T., Müller, J., Boykin, D. W., Stephens, C. E. & Hemphill, A., Dec 1 2012, In : International Journal for Parasitology: Drugs and Drug Resistance. 2, p. 109-120 12 p.

Research output: Contribution to journalArticle

Neospora
Membranes
Infection
Parasites
Pentamidine
16 Citations (Scopus)

Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: In vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies

Zhu, X., Liu, Q., Yang, S., Parman, T., Green, C. E., Mirsalis, J. C., Soeiro, M. D. N. C., De Souza, E. M., Da Silva, C. F., Batista, D. D. G. J., Stephens, C. E., Banerjee, M., Farahat, A. A., Munde, M., Wilson, W. D., Boykin, D. W., Wang, M. Z. & Werbovetz, K. A., Jul 1 2012, In : Antimicrobial Agents and Chemotherapy. 56, 7, p. 3690-3699 10 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Parasitemia
Chagas Disease
Toxicology
Pharmacokinetics
19 Citations (Scopus)

The adaptive potential of a survival artist: Characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures

Kropf, C., Debache, K., Rampa, C., Barna, F., Schorer, M., Stephens, C. E., Ismail, M. A., Boykin, D. W. & Hemphill, A., Feb 1 2012, In : Parasitology. 139, 2, p. 208-220 13 p.

Research output: Contribution to journalArticle

tachyzoites
Toxoplasma
Toxoplasma gondii
fibroblasts
cell culture
2011
4 Citations (Scopus)

An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines

Suthiwangcharoen, N., Pochini, S. M., Sweat, D. P. & Stephens, C. E., May 1 2011, In : Journal of Heterocyclic Chemistry. 48, 3, p. 706-709 4 p.

Research output: Contribution to journalArticle

Quinazolines
phosphine
Ligands
Palladium
Electrons
16 Citations (Scopus)

Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo

da Gama Jaén Batista, D., Batista, M. M., de Oliveira, G. M., Britto, C. C., Rodrigues, A. C. M., Stephens, C. E., Boykin, D. W. & de Nazaré Correia Soeiro, M., Aug 1 2011, In : PloS one. 6, 7, e22155.

Research output: Contribution to journalArticle

Trypanosoma cruzi
parasitemia
mice
therapeutics
Chagas disease
23 Citations (Scopus)

Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide

Debache, K., Guionaud, C., Kropf, C., Boykin, D., Stephens, C. E. & Hemphill, A., Oct 1 2011, In : Experimental Parasitology. 129, 2, p. 95-100 6 p.

Research output: Contribution to journalArticle

nitazoxanide
Neospora
Infection
Intraperitoneal Injections
Therapeutics
19 Citations (Scopus)

In vitro effects of arylimidamides against Besnoitia besnoiti infection in Vero cells.

Cortes, H. C., Muller, N., Boykin, D., Stephens, C. E. & Hemphill, A., Apr 1 2011, In : Parasitology. 138, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

Sarcocystidae
Besnoitia besnoiti
Vero Cells
tachyzoites
Real-Time Polymerase Chain Reaction
27 Citations (Scopus)

In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes

Stadelmann, B., Küster, T., Scholl, S., Barna, F., Kropf, C., Keiser, J., Boykin, D. W., Stephens, C. E. & Hemphill, A., Oct 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 10, p. 4866-4872 7 p.

Research output: Contribution to journalArticle

Echinococcus multilocularis
Mefloquine
nitazoxanide
Benzimidazoles
Glucose-6-Phosphate Isomerase
13 Citations (Scopus)

In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi

da Silva, C. F., Junqueira, A., Lima, M. M., Romanha, A. J., Sales Junior, P. A., Stephens, C. E., Som, P., Boykin, D. W. & de Nazaré Correia Soeiro, M., Jun 1 2011, In : Journal of Antimicrobial Chemotherapy. 66, 6, p. 1295-1297 3 p., dkr140.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Inhibitory Concentration 50
Trypanocidal Agents
Gentian Violet
Blood Banks
1 Citation (Scopus)

Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Griswold, C. P., Suthiwangcharoen, N., Pochini, S. M. & Stephens, C. E., May 11 2011, In : Synthetic Communications. 41, 11, p. 1672-1681 10 p.

Research output: Contribution to journalArticle

Pyrimidinones
Palladium
Amines
Electrons
6 Citations (Scopus)

The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro

Da Silva, C. F., Daliry, A., Da Silva, P. B., Akay, S., Banerjee, M., Farahat, A. A., Fisher, M. K., Hu, L., Kumar, A., Liu, Z., Stephens, C. E., Boykin, D. W. & Correia Soeiro, M. D. N., Dec 1 2011, In : Parasitology. 138, 14, p. 1863-1869 7 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Parasites
parasites
blood flow
blood
16 Citations (Scopus)

The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA

Daliry, A., Pires, M. Q., Silva, C. F., Pacheco, R. S., Munde, M., Stephens, C. E., Kumar, A., Ismail, M. A., Liu, Z., Farahat, A. A., Akay, S., Som, P., Hu, Q., Boykin, D. W., Wilson, W. D., De Castro, S. L. & Soeiro, M. N. C., Oct 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 10, p. 4765-4773 9 p.

Research output: Contribution to journalArticle

Kinetoplast DNA
Amidines
Trypanosoma cruzi
Circular Dichroism
Pentamidine
2010
4 Citations (Scopus)

Aerobic epoxidation and hydroxylation of a pyrrolo[2,1-b]quinazoline under ambient conditions

Hawkins, R. A. & Stephens, C. E., Nov 24 2010, In : Tetrahedron Letters. 51, 47, p. 6129-6131 3 p.

Research output: Contribution to journalArticle

Quinazolines
Hydroxylation
Pyrroles
Oxygenation
Epoxidation
56 Citations (Scopus)

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment

Batista, D. D. G. J., Batista, M. M., De Oliveira, G. M., Do Amaral, P. B., Lannes-Vieira, J., Britto, C. C., Junqueira, A., Lima, M. M., Romanha, A. J., Sales, P. A., Stephens, C. E., Boykin, D. W. & Soeiro, M. D. N. C., Jul 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2940-2952 13 p.

Research output: Contribution to journalArticle

Chagas Disease
Trypanosoma cruzi
Parasites
Parasite Load
Parasitic Diseases
29 Citations (Scopus)

DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity, and Specificity for a TTAA Site

Munde, M., Kumar, A., Nhili, R., Depauw, S., David-Cordonnier, M. H., Ismail, M. A., Stephens, C. E., Farahat, A. A., Batista-Parra, A., Boykin, D. W. & Wilson, W. D., Oct 8 2010, In : Journal of Molecular Biology. 402, 5, p. 847-864 18 p.

Research output: Contribution to journalArticle

Heterocyclic Compounds
Dimerization
Pentamidine
Cations
CD-I
12 Citations (Scopus)

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi

Gillingwater, K., Kumar, A., Ismail, M. A., Arafa, R. K., Stephens, C. E., Boykin, D. W., Tidwell, R. R. & Brun, R., May 1 2010, In : Veterinary Parasitology. 169, 3-4, p. 264-272 9 p.

Research output: Contribution to journalArticle

Pentamidine
Trypanosoma
Trypanosoma evansi
toxicity
Trypanosoma rhodesiense
51 Citations (Scopus)

Novel arylimidamides for treatment of visceral leishmaniasis

Wang, M. Z., Zhu, X., Srivastava, A., Liu, Q., Sweat, J. M., Pandharkar, T., Stephens, C. E., Riccio, E., Parman, T., Munde, M., Mandal, S., Madhubala, R., Tidwell, R. R., Wilson, W. D., Boykin, D. W., Hall, J. E., Kyle, D. E. & Werbovetz, K. A., Jun 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 6, p. 2507-2516 10 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania donovani
Parasitemia
Cricetinae
Inhibitory Concentration 50
2009
28 Citations (Scopus)

Large, sequence-dependent effects on DNA conformation by minor groove binding compounds

Tevis, D. S., Kumar, A., Stephens, C. E., Boykin, D. W. & Wilson, W. D., Jul 3 2009, In : Nucleic Acids Research. 37, 16, p. 5550-5558 9 p., gkp558.

Research output: Contribution to journalArticle

Nucleic Acid Conformation
Netropsin
Kinetoplast DNA
Amidines
Pentamidine
21 Citations (Scopus)

Synthesis and stille cross-coupling reactions of 2-(tributylstannyl)-and 2,5-bis(trimethylstannyl)tellurophene

Sweat, D. P. & Stephens, C. E., Nov 18 2009, In : Synthesis. 19, p. 3214-3218 5 p.

Research output: Contribution to journalArticle

Dimethylformamide
Palladium
Cesium
Iodides
Copper
20 Citations (Scopus)

Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro

Pacheco, M. G. D. O., Silva, C. F. D., Souza, E. M. D., Batista, M. M., Silva, P. B. D., Kumar, A., Stephens, C. E., Boykin, D. W. & Soeiro, M. D. N. C., Sep 1 2009, In : Experimental Parasitology. 123, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Pentamidine
Parasites
Chagas Disease
Heterocyclic Compounds
2008
18 Citations (Scopus)

Heterocyclic diamidine interactions at AT base Pairs in the DNA minor groove: Effects of heterocycle differences, DNA AT sequence and length

Liu, Y., Collar, C. J., Kumar, A., Stephens, C. E., Boykin, D. W. & Wilson, W. D., Sep 18 2008, In : Journal of Physical Chemistry B. 112, 37, p. 11809-11818 10 p.

Research output: Contribution to journalArticle

Pentamidine
DNA sequences
Amidines
grooves
DNA
30 Citations (Scopus)

Host cells participate in the in vitro effects of novel diamidine analogues against tachyzoites of the intracellular apicomplexan parasites Neospora caninum and Toxoplasma gondii

Leepin, A., Stüdli, A., Brun, R., Stephens, C. E., Boykin, D. W. & Hemphill, A., Jun 1 2008, In : Antimicrobial Agents and Chemotherapy. 52, 6, p. 1999-2008 10 p.

Research output: Contribution to journalArticle

Neospora
Pentamidine
Toxoplasma
Parasites
Pharmaceutical Preparations
16 Citations (Scopus)

Inhibition by dications of in vitro growth of Leishmania major and Leishmania tropica: Causative agents of old world cutaneous leishmaniasis

Rosypal, A. C., Werbovetz, K. A., Salem, M., Stephens, C. E., Kumar, A., Boykin, D. W., Hall, J. E. & Tidwell, R. R., Jun 1 2008, In : Journal of Parasitology. 94, 3, p. 743-749 7 p.

Research output: Contribution to journalArticle

amidines
Leishmania tropica
Amidines
leishmaniasis
Leishmania major
2007
48 Citations (Scopus)

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro"

Silva, C. F., Batista, M. M., Mota, R. A., de Souza, E. M., Stephens, C. E., Som, P., Boykin, D. W. & Soeiro, M. D. N. C., Jun 15 2007, In : Biochemical Pharmacology. 73, 12, p. 1939-1946 8 p.

Research output: Contribution to journalArticle

Pentamidine
Trypanosoma cruzi
Toxicity
Nifurtimox
Cells
46 Citations (Scopus)

Cellular effects of reversed amidines on Trypanosoma cruzi

Silva, C. F., Meuser, M. B., De Souza, E. M., Meirelles, M. N. L., Stephens, C. E., Som, P., Boykin, D. W. & Soeiro, M. N. C., Nov 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 11, p. 3803-3809 7 p.

Research output: Contribution to journalArticle

Amidines
Trypanosoma cruzi
Pentamidine
Chagas Disease
Parasites
12 Citations (Scopus)

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum

Rosypal, A. C., Hall, J. E., Bakunova, S., Patrick, D. A., Bakunov, S., Stephens, C. E., Kumar, A., Boykin, D. W. & Tidwell, R. R., Apr 30 2007, In : Veterinary Parasitology. 145, 3-4, p. 207-216 10 p.

Research output: Contribution to journalArticle

Leishmania infantum
Pentamidine
leishmaniasis
amidines
Leishmaniasis
51 Citations (Scopus)

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

Gonzalez, J. L., Stephens, C. E., Wenzler, T., Brun, R., Tanious, F. A., Wilson, W. D., Barszcz, T., Werbovetz, K. A. & Boykin, D. W., Apr 1 2007, In : European Journal of Medicinal Chemistry. 42, 4, p. 552-557 6 p.

Research output: Contribution to journalArticle

Antiparasitic Agents
Thiophenes
Trypanosoma brucei rhodesiense
Pentamidine
Plasmodium falciparum
2006
12 Citations (Scopus)

3,5-diarylisoxazoles: Individualized three-step synthesis and isomer determination using 13C NMR or mass spectroscopy

Stephens, C. E. & Arafa, R. K., Sep 1 2006, In : Journal of Chemical Education. 83, 9, p. 1336-1340 5 p.

Research output: Contribution to journalArticle

Chalcone
Isomers
fragmentation
Isoxazoles
Nuclear magnetic resonance
27 Citations (Scopus)

An efficient synthesis of 5,5′-diaryl-2,2′-bichalcophenes

Ismail, M. A., Boykin, D. W. & Stephens, C. E., Jan 30 2006, In : Tetrahedron Letters. 47, 5, p. 795-797 3 p.

Research output: Contribution to journalArticle

Furans
Thiophenes
Light
27 Citations (Scopus)

Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses

Naesens, L., Stephens, C. E., Andrei, G., Loregian, A., De Bolle, L., Snoeck, R., Sowell, J. W. & De Clercq, E., Oct 1 2006, In : Antiviral Research. 72, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 6
Benzene Derivatives
Cytomegalovirus
Human Activities
Foscarnet
69 Citations (Scopus)

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4- amidinophenyl)furan-bis-O-methylamidoxime]

Wang, M. Z., Saulter, J. Y., Usuki, E., Cheung, Y. L., Hall, M., Bridges, A. S., Loewen, G., Parkinson, O. T., Stephens, C. E., Allen, J. L., Zeldin, D. C., Boykin, D. W., Tidwell, R. R., Parkinson, A., Paine, M. F. & Hall, J. E., Dec 1 2006, In : Drug Metabolism and Disposition. 34, 12, p. 1985-1994 10 p.

Research output: Contribution to journalArticle

Antiparasitic Agents
Prodrugs
Liver Microsomes
Enzymes
Cytochrome-B(5) Reductase
12 Citations (Scopus)

Nuclear fluorination of 2,4-diarylthiazoles with Accufluor®

Campbell, T. F. & Stephens, C. E., Dec 1 2006, In : Journal of Fluorine Chemistry. 127, 12, p. 1591-1594 4 p.

Research output: Contribution to journalArticle

Thiazoles
Fluorination
fluorination
Halogenation
chromatography
14 Citations (Scopus)

Oxidative ring opening of 2,5-diarylfurans by Selectfluor®

Blank, S. J. & Stephens, C. E., Sep 18 2006, In : Tetrahedron Letters. 47, 38, p. 6849-6850 2 p.

Research output: Contribution to journalArticle

Fluorination
Halogenation
Isomers
furan
selectfluor
2005
135 Citations (Scopus)

Dications that target the DNA minor groove: Compound design and preparation, DNA interactions, cellular distribution and biological activity

Wilson, W. D., Nguyen, B., Tanious, F. A., Mathis, A., Hall, J. E., Stephens, C. E. & Boykin, D. W., Jul 1 2005, In : Current Medicinal Chemistry - Anti-Cancer Agents. 5, 4, p. 389-408 20 p.

Research output: Contribution to journalArticle

Pentamidine
Kinetoplast DNA
DNA
Circular DNA
Thiophenes