Chad E. Stephens

Associate Professor

  • 2012 Citations
  • 27 h-Index
19962019
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Research Output 1996 2019

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1996
9 Citations (Scopus)

Synthesis of Substituted Pyrrolo[2,3-e][1,3,4]thiadiazine 4,4-Dioxides

Stephens, C. E. & Sowell, J. W., Jan 1 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1615-1617 3 p.

Research output: Contribution to journalArticle

Thiadiazines
1997
4 Citations (Scopus)

Synthesis of Novel Heterocycles from 2-Amino-3-cyanomethyl-sulfonyl-4,5-dimethylfuran

Stephens, C. E. & Sowell, J. W., Jan 1 1997, In : Journal of Heterocyclic Chemistry. 34, 3, p. 857-860 4 p.

Research output: Contribution to journalArticle

Cyclization
Thiazines
Pyrroles
quinoline
furan
1998
4 Citations (Scopus)

Synthesis and Cyclization Reactions of 2-Amino-3-[(methoxycarbonyl)methylsulfonyl]pyrroles and Thiophene

Stephens, C. E. & Walter Sowell, J., Jan 1 1998, In : Journal of Heterocyclic Chemistry. 35, 4, p. 933-938 6 p.

Research output: Contribution to journalArticle

Thiophenes
Pyrroles
Cyclization
Esters
Amines
10 Citations (Scopus)

Synthesis of Novel Heterocycles from 2-Amino-3-(cyanomethylsulfonyl)thiophene

Stephens, C. E. & Sowell, J. W., Jan 1 1998, In : Journal of Heterocyclic Chemistry. 35, 4, p. 927-931 5 p.

Research output: Contribution to journalArticle

Thiazines
Thiophenes
hydrazine
Thiadiazines
Sulfones
1999
17 Citations (Scopus)

Palladium catalyzed cross-coupling reactions for the synthesis of 2,5-disubstitutedfurans

Kumar, A., Stephens, C. E. & Boykin, D. W., Jan 1 1999, In : Heterocyclic Communications. 5, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

Palladium
furan
12 Citations (Scopus)

Synthesis of methyl 3-amino-4-aryl(or methyl)sulfonyl-2- thiophenecarboxylates from 3-alkoxy-2-aryl(or methyl)-sulfonylacrylonitriles

Stephens, C. E., Price, M. B. & Sowell, J. W., Jan 1 1999, In : Journal of Heterocyclic Chemistry. 36, 3, p. 659-665 7 p.

Research output: Contribution to journalArticle

Acylation
Amines
Hydrolysis
Esters
alkoxyl radical
2000
5 Citations (Scopus)
Thiadiazines
Thiadiazoles
Carboxylic Acids
Hydrolysis
Esters
2001
129 Citations (Scopus)

Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents

Stephens, C. E., Tanious, F., Kim, S., Wilson, W. D., Schell, W. A., Perfect, J. R., Franzblau, S. G. & Boykin, D. W., May 24 2001, In : Journal of Medicinal Chemistry. 44, 11, p. 1741-1748 8 p.

Research output: Contribution to journalArticle

Furans
Anti-Infective Agents
Rhizopus
Cryptococcus neoformans
Aspergillus fumigatus
67 Citations (Scopus)

Evaluation of the influence of compound structure on stacked-dimer formation in the DNA minor groove

Wang, L., Carrasco, C., Kumar, A., Stephens, C. E., Bailly, C., Boykin, D. W. & Wilson, W. D., Feb 27 2001, In : Biochemistry. 40, 8, p. 2511-2521 11 p.

Research output: Contribution to journalArticle

Amidines
Dimers
DNA
Human Genome Project
Nucleotide Motifs
55 Citations (Scopus)

Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones

Stephens, C. E., Felder, T. M., Sowell, J. W., Andrei, G., Balzarini, J., Snoeck, R. & De Clercq, E., May 1 2001, In : Bioorganic and Medicinal Chemistry. 9, 5, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

Thiophenes
Cytomegalovirus
Antiviral Agents
Human Herpesvirus 3
Viruses
15 Citations (Scopus)

Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

Stephens, C. E., Patrick, D. A., Chen, H., Tidwell, R. R. & Boykin, D. W., Mar 19 2001, In : Journal of Labelled Compounds and Radiopharmaceuticals. 44, 3, p. 197-208 12 p.

Research output: Contribution to journalArticle

Deuterium
furamidine
furan
diphenyl
bromobenzene
2002
15 Citations (Scopus)

Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry

Zhou, L., Voyksner, R. D., Thakker, D. R., Stephens, C. E., Anbazhagan, M., Boykin, D. W., Hall, J. E. & Tidwell, R. R., Jun 5 2002, In : Rapid Communications in Mass Spectrometry. 16, 11, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

Metabolites
Mass spectrometry
Ions
Deuterium Oxide
Electrospray ionization
64 Citations (Scopus)

Distribution of furamidine analogues in tumor cells: Influence of the number of positive charges

Lansiaux, A., Dassonneville, L., Facompré, M., Kumar, A., Stephens, C. E., Bajic, M., Tanious, F., Wilson, D. W., Boykin, D. W. & Bailly, C., May 9 2002, In : Journal of Medicinal Chemistry. 45, 10, p. 1994-2002 9 p.

Research output: Contribution to journalArticle

Cell Count
Cell Nucleus
Amidines
DNA
Neoplasms
61 Citations (Scopus)

Distribution of furamidine analogues in tumor cells: Targeting of the nucleus or mitochondria depending on the amidine substitution

Lansiaux, A., Tanious, F., Mishal, Z., Dassonneville, L., Kumar, A., Stephens, C. E., Hu, Q., Wilson, W. D., Boykin, D. W. & Bailly, C., Dec 15 2002, In : Cancer Research. 62, 24, p. 7219-7229 11 p.

Research output: Contribution to journalArticle

Amidines
Cell Nucleus
Mitochondria
DNA
Pentamidine
26 Citations (Scopus)

Palladium-catalyzed N-arylation of O-methylamidoximes

Anbazhagan, M., Stephens, C. E. & Boykin, D. W., Jun 3 2002, In : Tetrahedron Letters. 43, 23, p. 4221-4224 4 p.

Research output: Contribution to journalArticle

Palladium
Electrons
Oxadiazoles
Cyclization
benzamidoxime
12 Citations (Scopus)

Regioselective cleavage of O-benzyl-N-arylamidoximes: Synthesis of N-aryl amidines and amidoximes

Anbazhagan, M., Boykin, D. W. & Stephens, C. E., Dec 9 2002, In : Tetrahedron Letters. 43, 50, p. 9089-9092 4 p.

Research output: Contribution to journalArticle

Amidines
Palladium
amidoxime
2003
33 Citations (Scopus)

Convenient and improved halogenation of 3,5-diarylisoxazoles using N-halosuccinimides

Day, R. A., Blake, J. A. & Stephens, C. E., Jan 1 2003, In : Synthesis. 10, p. 1586-1590 5 p.

Research output: Contribution to journalArticle

Halogenation
Isoxazoles
Acetic acid
Acetic Acid
Heating
43 Citations (Scopus)

Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules

Givens, M. D., Dykstra, C. C., Brock, K. V., Stringfellow, D. A., Kumar, A., Stephens, C. E., Goker, H. & Boykin, D. W., Jul 1 2003, In : Antimicrobial Agents and Chemotherapy. 47, 7, p. 2223-2230 8 p.

Research output: Contribution to journalArticle

Bovine Viral Diarrhea Viruses
Hepacivirus
RNA Viruses
Drug Discovery
Cell Culture Techniques
13 Citations (Scopus)

Direct Conversion of Amidoximes to Amidines via Transfer Hydrogenation

Anbazhagan, M., Boykin, D. W. & Stephens, C. E., Jan 1 2003, In : Synthesis. 16, p. 2467-2469 3 p.

Research output: Contribution to journalArticle

formic acid
Amidines
Acetic acid
Acetic Acid
Hydrogenation
10 Citations (Scopus)

Inhibition of In Vitro Intracellular Growth of Trypanosoma cruzi by Dicationic Compounds

Rowland, E. C., Moore-Lai, D., Seed, J. R., Stephens, C. E. & Boykin, D. W., Oct 1 2003, In : Journal of Parasitology. 89, 5, p. 1078-1080 3 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
parasite
Parasites
parasites
drug
66 Citations (Scopus)

The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Stephens, C. E., Brun, R., Salem, M. M., Werbovetz, K. A., Tanious, F., Wilson, W. D. & Boykin, D. W., Jun 16 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 12, p. 2065-2069 5 p.

Research output: Contribution to journalArticle

Amidines
Leishmania donovani
Trypanosoma cruzi
Inhibitory Concentration 50
Molecules
2004
10 Citations (Scopus)

Activities of dicationic compounds against Trichomonas vaginalis

Crowell, A. L., Stephens, C. E., Kumar, A., Boykin, D. W. & Secor, W. E., Sep 1 2004, In : Antimicrobial Agents and Chemotherapy. 48, 9, p. 3602-3605 4 p.

Research output: Contribution to journalArticle

Trichomonas vaginalis
Metronidazole
Inhibitory Concentration 50
Parasites
4-nitroimidazole
17 Citations (Scopus)

Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®

Stephens, C. E. & Blake, J. A., Dec 1 2004, In : Journal of Fluorine Chemistry. 125, 12, p. 1939-1945 7 p.

Research output: Contribution to journalArticle

Fluorination
fluorination
Halogenation
Temperature
acetonitrile
3 Citations (Scopus)

Synthesis of Benzyloxybromobenzonitriles

Ismail, M. A., Anbazhagan, M., Stephens, C. E. & Boykin, D. W., Mar 31 2004, In : Synthetic Communications. 34, 5, p. 751-758 8 p.

Research output: Contribution to journalArticle

2-bromobenzonitrile
2005
135 Citations (Scopus)

Dications that target the DNA minor groove: Compound design and preparation, DNA interactions, cellular distribution and biological activity

Wilson, W. D., Nguyen, B., Tanious, F. A., Mathis, A., Hall, J. E., Stephens, C. E. & Boykin, D. W., Jul 1 2005, In : Current Medicinal Chemistry - Anti-Cancer Agents. 5, 4, p. 389-408 20 p.

Research output: Contribution to journalArticle

Pentamidine
Kinetoplast DNA
DNA
Circular DNA
Thiophenes
11 Citations (Scopus)

Inhibitory effect of dicationic diphenylfurans on production of type I collagen by human fibroblasts and activated hepatic stellate cells

Stefanovic, L., Stephens, C. E., Boykin, D. & Stefanovic, B., Mar 11 2005, In : Life Sciences. 76, 17, p. 2011-2026 16 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Fibroblasts
Protein Sorting Signals
Collagen Type I
Procollagen
58 Citations (Scopus)

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs

Arafa, R. K., Brun, R., Wenzler, T., Tanious, F. A., Wilson, W. D., Stephens, C. E. & Boykin, D. W., Aug 25 2005, In : Journal of Medicinal Chemistry. 48, 17, p. 5480-5488 9 p.

Research output: Contribution to journalArticle

Prodrugs
Carbamates
DNA
Guanidine
Fluorenes
39 Citations (Scopus)

Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase

Saulter, J. Y., Kurian, J. R., Trepanier, L. A., Tidwell, R. R., Bridges, A. S., Boykin, D. W., Stephens, C. E., Anbazhagan, M. & Hall, J. E., Dec 1 2005, In : Drug Metabolism and Disposition. 33, 12, p. 1886-1893 8 p.

Research output: Contribution to journalArticle

Cytochrome-B(5) Reductase
Cytochromes b5
Prodrugs
Oxidoreductases
Liver Microsomes
2006
12 Citations (Scopus)

3,5-diarylisoxazoles: Individualized three-step synthesis and isomer determination using 13C NMR or mass spectroscopy

Stephens, C. E. & Arafa, R. K., Sep 1 2006, In : Journal of Chemical Education. 83, 9, p. 1336-1340 5 p.

Research output: Contribution to journalArticle

Chalcone
Isomers
fragmentation
Isoxazoles
Nuclear magnetic resonance
27 Citations (Scopus)

An efficient synthesis of 5,5′-diaryl-2,2′-bichalcophenes

Ismail, M. A., Boykin, D. W. & Stephens, C. E., Jan 30 2006, In : Tetrahedron Letters. 47, 5, p. 795-797 3 p.

Research output: Contribution to journalArticle

Furans
Thiophenes
Light
27 Citations (Scopus)

Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses

Naesens, L., Stephens, C. E., Andrei, G., Loregian, A., De Bolle, L., Snoeck, R., Sowell, J. W. & De Clercq, E., Oct 1 2006, In : Antiviral Research. 72, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 6
Benzene Derivatives
Cytomegalovirus
Human Activities
Foscarnet
69 Citations (Scopus)

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4- amidinophenyl)furan-bis-O-methylamidoxime]

Wang, M. Z., Saulter, J. Y., Usuki, E., Cheung, Y. L., Hall, M., Bridges, A. S., Loewen, G., Parkinson, O. T., Stephens, C. E., Allen, J. L., Zeldin, D. C., Boykin, D. W., Tidwell, R. R., Parkinson, A., Paine, M. F. & Hall, J. E., Dec 1 2006, In : Drug Metabolism and Disposition. 34, 12, p. 1985-1994 10 p.

Research output: Contribution to journalArticle

Antiparasitic Agents
Prodrugs
Liver Microsomes
Enzymes
Cytochrome-B(5) Reductase
12 Citations (Scopus)

Nuclear fluorination of 2,4-diarylthiazoles with Accufluor®

Campbell, T. F. & Stephens, C. E., Dec 1 2006, In : Journal of Fluorine Chemistry. 127, 12, p. 1591-1594 4 p.

Research output: Contribution to journalArticle

Thiazoles
Fluorination
fluorination
Halogenation
chromatography
14 Citations (Scopus)

Oxidative ring opening of 2,5-diarylfurans by Selectfluor®

Blank, S. J. & Stephens, C. E., Sep 18 2006, In : Tetrahedron Letters. 47, 38, p. 6849-6850 2 p.

Research output: Contribution to journalArticle

Fluorination
Halogenation
Isomers
furan
selectfluor
2007
48 Citations (Scopus)

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro"

Silva, C. F., Batista, M. M., Mota, R. A., de Souza, E. M., Stephens, C. E., Som, P., Boykin, D. W. & Soeiro, M. D. N. C., Jun 15 2007, In : Biochemical Pharmacology. 73, 12, p. 1939-1946 8 p.

Research output: Contribution to journalArticle

Pentamidine
Trypanosoma cruzi
Toxicity
Nifurtimox
Cells
46 Citations (Scopus)

Cellular effects of reversed amidines on Trypanosoma cruzi

Silva, C. F., Meuser, M. B., De Souza, E. M., Meirelles, M. N. L., Stephens, C. E., Som, P., Boykin, D. W. & Soeiro, M. N. C., Nov 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 11, p. 3803-3809 7 p.

Research output: Contribution to journalArticle

Amidines
Trypanosoma cruzi
Pentamidine
Chagas Disease
Parasites
12 Citations (Scopus)

In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum

Rosypal, A. C., Hall, J. E., Bakunova, S., Patrick, D. A., Bakunov, S., Stephens, C. E., Kumar, A., Boykin, D. W. & Tidwell, R. R., Apr 30 2007, In : Veterinary Parasitology. 145, 3-4, p. 207-216 10 p.

Research output: Contribution to journalArticle

Leishmania infantum
Pentamidine
leishmaniasis
amidines
Leishmaniasis
51 Citations (Scopus)

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

Gonzalez, J. L., Stephens, C. E., Wenzler, T., Brun, R., Tanious, F. A., Wilson, W. D., Barszcz, T., Werbovetz, K. A. & Boykin, D. W., Apr 1 2007, In : European Journal of Medicinal Chemistry. 42, 4, p. 552-557 6 p.

Research output: Contribution to journalArticle

Antiparasitic Agents
Thiophenes
Trypanosoma brucei rhodesiense
Pentamidine
Plasmodium falciparum
2008
18 Citations (Scopus)

Heterocyclic diamidine interactions at AT base Pairs in the DNA minor groove: Effects of heterocycle differences, DNA AT sequence and length

Liu, Y., Collar, C. J., Kumar, A., Stephens, C. E., Boykin, D. W. & Wilson, W. D., Sep 18 2008, In : Journal of Physical Chemistry B. 112, 37, p. 11809-11818 10 p.

Research output: Contribution to journalArticle

Pentamidine
DNA sequences
Amidines
grooves
DNA
30 Citations (Scopus)

Host cells participate in the in vitro effects of novel diamidine analogues against tachyzoites of the intracellular apicomplexan parasites Neospora caninum and Toxoplasma gondii

Leepin, A., Stüdli, A., Brun, R., Stephens, C. E., Boykin, D. W. & Hemphill, A., Jun 1 2008, In : Antimicrobial Agents and Chemotherapy. 52, 6, p. 1999-2008 10 p.

Research output: Contribution to journalArticle

Neospora
Pentamidine
Toxoplasma
Parasites
Pharmaceutical Preparations
16 Citations (Scopus)

Inhibition by dications of in vitro growth of Leishmania major and Leishmania tropica: Causative agents of old world cutaneous leishmaniasis

Rosypal, A. C., Werbovetz, K. A., Salem, M., Stephens, C. E., Kumar, A., Boykin, D. W., Hall, J. E. & Tidwell, R. R., Jun 1 2008, In : Journal of Parasitology. 94, 3, p. 743-749 7 p.

Research output: Contribution to journalArticle

amidines
Leishmania tropica
Amidines
leishmaniasis
Leishmania major
2009
28 Citations (Scopus)

Large, sequence-dependent effects on DNA conformation by minor groove binding compounds

Tevis, D. S., Kumar, A., Stephens, C. E., Boykin, D. W. & Wilson, W. D., Jul 3 2009, In : Nucleic Acids Research. 37, 16, p. 5550-5558 9 p., gkp558.

Research output: Contribution to journalArticle

Nucleic Acid Conformation
Netropsin
Kinetoplast DNA
Amidines
Pentamidine
21 Citations (Scopus)

Synthesis and stille cross-coupling reactions of 2-(tributylstannyl)-and 2,5-bis(trimethylstannyl)tellurophene

Sweat, D. P. & Stephens, C. E., Nov 18 2009, In : Synthesis. 19, p. 3214-3218 5 p.

Research output: Contribution to journalArticle

Dimethylformamide
Palladium
Cesium
Iodides
Copper
20 Citations (Scopus)

Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro

Pacheco, M. G. D. O., Silva, C. F. D., Souza, E. M. D., Batista, M. M., Silva, P. B. D., Kumar, A., Stephens, C. E., Boykin, D. W. & Soeiro, M. D. N. C., Sep 1 2009, In : Experimental Parasitology. 123, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Pentamidine
Parasites
Chagas Disease
Heterocyclic Compounds
2010
4 Citations (Scopus)

Aerobic epoxidation and hydroxylation of a pyrrolo[2,1-b]quinazoline under ambient conditions

Hawkins, R. A. & Stephens, C. E., Nov 24 2010, In : Tetrahedron Letters. 51, 47, p. 6129-6131 3 p.

Research output: Contribution to journalArticle

Quinazolines
Hydroxylation
Pyrroles
Oxygenation
Epoxidation
56 Citations (Scopus)

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment

Batista, D. D. G. J., Batista, M. M., De Oliveira, G. M., Do Amaral, P. B., Lannes-Vieira, J., Britto, C. C., Junqueira, A., Lima, M. M., Romanha, A. J., Sales, P. A., Stephens, C. E., Boykin, D. W. & Soeiro, M. D. N. C., Jul 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2940-2952 13 p.

Research output: Contribution to journalArticle

Chagas Disease
Trypanosoma cruzi
Parasites
Parasite Load
Parasitic Diseases
29 Citations (Scopus)

DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity, and Specificity for a TTAA Site

Munde, M., Kumar, A., Nhili, R., Depauw, S., David-Cordonnier, M. H., Ismail, M. A., Stephens, C. E., Farahat, A. A., Batista-Parra, A., Boykin, D. W. & Wilson, W. D., Oct 8 2010, In : Journal of Molecular Biology. 402, 5, p. 847-864 18 p.

Research output: Contribution to journalArticle

Heterocyclic Compounds
Dimerization
Pentamidine
Cations
CD-I
12 Citations (Scopus)

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi

Gillingwater, K., Kumar, A., Ismail, M. A., Arafa, R. K., Stephens, C. E., Boykin, D. W., Tidwell, R. R. & Brun, R., May 1 2010, In : Veterinary Parasitology. 169, 3-4, p. 264-272 9 p.

Research output: Contribution to journalArticle

Pentamidine
Trypanosoma
Trypanosoma evansi
toxicity
Trypanosoma rhodesiense
51 Citations (Scopus)

Novel arylimidamides for treatment of visceral leishmaniasis

Wang, M. Z., Zhu, X., Srivastava, A., Liu, Q., Sweat, J. M., Pandharkar, T., Stephens, C. E., Riccio, E., Parman, T., Munde, M., Mandal, S., Madhubala, R., Tidwell, R. R., Wilson, W. D., Boykin, D. W., Hall, J. E., Kyle, D. E. & Werbovetz, K. A., Jun 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 6, p. 2507-2516 10 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania donovani
Parasitemia
Cricetinae
Inhibitory Concentration 50
2011
4 Citations (Scopus)

An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines

Suthiwangcharoen, N., Pochini, S. M., Sweat, D. P. & Stephens, C. E., May 1 2011, In : Journal of Heterocyclic Chemistry. 48, 3, p. 706-709 4 p.

Research output: Contribution to journalArticle

Quinazolines
phosphine
Ligands
Palladium
Electrons