Chad E. Stephens

Associate Professor

  • 2012 Citations
  • 27 h-Index
19962019
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Research Output 1996 2019

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Article
2005
11 Citations (Scopus)

Inhibitory effect of dicationic diphenylfurans on production of type I collagen by human fibroblasts and activated hepatic stellate cells

Stefanovic, L., Stephens, C. E., Boykin, D. & Stefanovic, B., Mar 11 2005, In : Life Sciences. 76, 17, p. 2011-2026 16 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Fibroblasts
Protein Sorting Signals
Collagen Type I
Procollagen
58 Citations (Scopus)

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs

Arafa, R. K., Brun, R., Wenzler, T., Tanious, F. A., Wilson, W. D., Stephens, C. E. & Boykin, D. W., Aug 25 2005, In : Journal of Medicinal Chemistry. 48, 17, p. 5480-5488 9 p.

Research output: Contribution to journalArticle

Prodrugs
Carbamates
DNA
Guanidine
Fluorenes
39 Citations (Scopus)

Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase

Saulter, J. Y., Kurian, J. R., Trepanier, L. A., Tidwell, R. R., Bridges, A. S., Boykin, D. W., Stephens, C. E., Anbazhagan, M. & Hall, J. E., Dec 1 2005, In : Drug Metabolism and Disposition. 33, 12, p. 1886-1893 8 p.

Research output: Contribution to journalArticle

Cytochrome-B(5) Reductase
Cytochromes b5
Prodrugs
Oxidoreductases
Liver Microsomes
2004
10 Citations (Scopus)

Activities of dicationic compounds against Trichomonas vaginalis

Crowell, A. L., Stephens, C. E., Kumar, A., Boykin, D. W. & Secor, W. E., Sep 1 2004, In : Antimicrobial Agents and Chemotherapy. 48, 9, p. 3602-3605 4 p.

Research output: Contribution to journalArticle

Trichomonas vaginalis
Metronidazole
Inhibitory Concentration 50
Parasites
4-nitroimidazole
17 Citations (Scopus)

Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®

Stephens, C. E. & Blake, J. A., Dec 1 2004, In : Journal of Fluorine Chemistry. 125, 12, p. 1939-1945 7 p.

Research output: Contribution to journalArticle

Fluorination
fluorination
Halogenation
Temperature
acetonitrile
3 Citations (Scopus)

Synthesis of Benzyloxybromobenzonitriles

Ismail, M. A., Anbazhagan, M., Stephens, C. E. & Boykin, D. W., Mar 31 2004, In : Synthetic Communications. 34, 5, p. 751-758 8 p.

Research output: Contribution to journalArticle

2-bromobenzonitrile
2003
33 Citations (Scopus)

Convenient and improved halogenation of 3,5-diarylisoxazoles using N-halosuccinimides

Day, R. A., Blake, J. A. & Stephens, C. E., Jan 1 2003, In : Synthesis. 10, p. 1586-1590 5 p.

Research output: Contribution to journalArticle

Halogenation
Isoxazoles
Acetic acid
Acetic Acid
Heating
43 Citations (Scopus)

Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules

Givens, M. D., Dykstra, C. C., Brock, K. V., Stringfellow, D. A., Kumar, A., Stephens, C. E., Goker, H. & Boykin, D. W., Jul 1 2003, In : Antimicrobial Agents and Chemotherapy. 47, 7, p. 2223-2230 8 p.

Research output: Contribution to journalArticle

Bovine Viral Diarrhea Viruses
Hepacivirus
RNA Viruses
Drug Discovery
Cell Culture Techniques
13 Citations (Scopus)

Direct Conversion of Amidoximes to Amidines via Transfer Hydrogenation

Anbazhagan, M., Boykin, D. W. & Stephens, C. E., Jan 1 2003, In : Synthesis. 16, p. 2467-2469 3 p.

Research output: Contribution to journalArticle

formic acid
Amidines
Acetic acid
Acetic Acid
Hydrogenation
10 Citations (Scopus)

Inhibition of In Vitro Intracellular Growth of Trypanosoma cruzi by Dicationic Compounds

Rowland, E. C., Moore-Lai, D., Seed, J. R., Stephens, C. E. & Boykin, D. W., Oct 1 2003, In : Journal of Parasitology. 89, 5, p. 1078-1080 3 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
parasite
Parasites
parasites
drug
66 Citations (Scopus)

The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Stephens, C. E., Brun, R., Salem, M. M., Werbovetz, K. A., Tanious, F., Wilson, W. D. & Boykin, D. W., Jun 16 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 12, p. 2065-2069 5 p.

Research output: Contribution to journalArticle

Amidines
Leishmania donovani
Trypanosoma cruzi
Inhibitory Concentration 50
Molecules
2002
15 Citations (Scopus)

Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry

Zhou, L., Voyksner, R. D., Thakker, D. R., Stephens, C. E., Anbazhagan, M., Boykin, D. W., Hall, J. E. & Tidwell, R. R., Jun 5 2002, In : Rapid Communications in Mass Spectrometry. 16, 11, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

Metabolites
Mass spectrometry
Ions
Deuterium Oxide
Electrospray ionization
64 Citations (Scopus)

Distribution of furamidine analogues in tumor cells: Influence of the number of positive charges

Lansiaux, A., Dassonneville, L., Facompré, M., Kumar, A., Stephens, C. E., Bajic, M., Tanious, F., Wilson, D. W., Boykin, D. W. & Bailly, C., May 9 2002, In : Journal of Medicinal Chemistry. 45, 10, p. 1994-2002 9 p.

Research output: Contribution to journalArticle

Cell Count
Cell Nucleus
Amidines
DNA
Neoplasms
61 Citations (Scopus)

Distribution of furamidine analogues in tumor cells: Targeting of the nucleus or mitochondria depending on the amidine substitution

Lansiaux, A., Tanious, F., Mishal, Z., Dassonneville, L., Kumar, A., Stephens, C. E., Hu, Q., Wilson, W. D., Boykin, D. W. & Bailly, C., Dec 15 2002, In : Cancer Research. 62, 24, p. 7219-7229 11 p.

Research output: Contribution to journalArticle

Amidines
Cell Nucleus
Mitochondria
DNA
Pentamidine
26 Citations (Scopus)

Palladium-catalyzed N-arylation of O-methylamidoximes

Anbazhagan, M., Stephens, C. E. & Boykin, D. W., Jun 3 2002, In : Tetrahedron Letters. 43, 23, p. 4221-4224 4 p.

Research output: Contribution to journalArticle

Palladium
Electrons
Oxadiazoles
Cyclization
benzamidoxime
12 Citations (Scopus)

Regioselective cleavage of O-benzyl-N-arylamidoximes: Synthesis of N-aryl amidines and amidoximes

Anbazhagan, M., Boykin, D. W. & Stephens, C. E., Dec 9 2002, In : Tetrahedron Letters. 43, 50, p. 9089-9092 4 p.

Research output: Contribution to journalArticle

Amidines
Palladium
amidoxime
2001
129 Citations (Scopus)

Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents

Stephens, C. E., Tanious, F., Kim, S., Wilson, W. D., Schell, W. A., Perfect, J. R., Franzblau, S. G. & Boykin, D. W., May 24 2001, In : Journal of Medicinal Chemistry. 44, 11, p. 1741-1748 8 p.

Research output: Contribution to journalArticle

Furans
Anti-Infective Agents
Rhizopus
Cryptococcus neoformans
Aspergillus fumigatus
67 Citations (Scopus)

Evaluation of the influence of compound structure on stacked-dimer formation in the DNA minor groove

Wang, L., Carrasco, C., Kumar, A., Stephens, C. E., Bailly, C., Boykin, D. W. & Wilson, W. D., Feb 27 2001, In : Biochemistry. 40, 8, p. 2511-2521 11 p.

Research output: Contribution to journalArticle

Amidines
Dimers
DNA
Human Genome Project
Nucleotide Motifs
55 Citations (Scopus)

Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones

Stephens, C. E., Felder, T. M., Sowell, J. W., Andrei, G., Balzarini, J., Snoeck, R. & De Clercq, E., May 1 2001, In : Bioorganic and Medicinal Chemistry. 9, 5, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

Thiophenes
Cytomegalovirus
Antiviral Agents
Human Herpesvirus 3
Viruses
15 Citations (Scopus)

Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

Stephens, C. E., Patrick, D. A., Chen, H., Tidwell, R. R. & Boykin, D. W., Mar 19 2001, In : Journal of Labelled Compounds and Radiopharmaceuticals. 44, 3, p. 197-208 12 p.

Research output: Contribution to journalArticle

Deuterium
furamidine
furan
diphenyl
bromobenzene
2000
5 Citations (Scopus)
Thiadiazines
Thiadiazoles
Carboxylic Acids
Hydrolysis
Esters
1999
17 Citations (Scopus)

Palladium catalyzed cross-coupling reactions for the synthesis of 2,5-disubstitutedfurans

Kumar, A., Stephens, C. E. & Boykin, D. W., Jan 1 1999, In : Heterocyclic Communications. 5, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

Palladium
furan
12 Citations (Scopus)

Synthesis of methyl 3-amino-4-aryl(or methyl)sulfonyl-2- thiophenecarboxylates from 3-alkoxy-2-aryl(or methyl)-sulfonylacrylonitriles

Stephens, C. E., Price, M. B. & Sowell, J. W., Jan 1 1999, In : Journal of Heterocyclic Chemistry. 36, 3, p. 659-665 7 p.

Research output: Contribution to journalArticle

Acylation
Amines
Hydrolysis
Esters
alkoxyl radical
1998
4 Citations (Scopus)

Synthesis and Cyclization Reactions of 2-Amino-3-[(methoxycarbonyl)methylsulfonyl]pyrroles and Thiophene

Stephens, C. E. & Walter Sowell, J., Jan 1 1998, In : Journal of Heterocyclic Chemistry. 35, 4, p. 933-938 6 p.

Research output: Contribution to journalArticle

Thiophenes
Pyrroles
Cyclization
Esters
Amines
10 Citations (Scopus)

Synthesis of Novel Heterocycles from 2-Amino-3-(cyanomethylsulfonyl)thiophene

Stephens, C. E. & Sowell, J. W., Jan 1 1998, In : Journal of Heterocyclic Chemistry. 35, 4, p. 927-931 5 p.

Research output: Contribution to journalArticle

Thiazines
Thiophenes
hydrazine
Thiadiazines
Sulfones
1997
4 Citations (Scopus)

Synthesis of Novel Heterocycles from 2-Amino-3-cyanomethyl-sulfonyl-4,5-dimethylfuran

Stephens, C. E. & Sowell, J. W., Jan 1 1997, In : Journal of Heterocyclic Chemistry. 34, 3, p. 857-860 4 p.

Research output: Contribution to journalArticle

Cyclization
Thiazines
Pyrroles
quinoline
furan
1996
9 Citations (Scopus)

Synthesis of Substituted Pyrrolo[2,3-e][1,3,4]thiadiazine 4,4-Dioxides

Stephens, C. E. & Sowell, J. W., Jan 1 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1615-1617 3 p.

Research output: Contribution to journalArticle

Thiadiazines