Chunhong Yan

Associate Professor

  • 2284 Citations
  • 24 h-Index
19982020

Research output per year

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Research Output

  • 2284 Citations
  • 24 h-Index
  • 61 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
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Article
2020

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

Wang, L., Liu, Y., Du, T., Yang, H., Lei, L., Guo, M., Ding, H., Zhang, J., Wang, H., Chen, X. & Yan, C., Feb 1 2020, In : Cell Death and Differentiation. 27, 2, p. 662-675 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Competitive ubiquitination activates the tumor suppressor p53

Li, X., Guo, M., Cai, L., Du, T., Liu, Y., Ding, H. F., Wang, H., Zhang, J., Chen, X. & Yan, C., Jun 1 2020, In : Cell Death and Differentiation. 27, 6, p. 1807-1818 12 p.

Research output: Contribution to journalArticle

Open Access

PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo

Li, F., Liu, Z., Sun, H., Li, C., Wang, W., Ye, L., Yan, C., Tian, J. & Wang, H., Feb 2020, In : Acta Pharmaceutica Sinica B. 10, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades

Huang, Y., Feng, G., Cai, J., Peng, Q., Yang, Z., Yan, C., Yang, L. & Wang, Z., May 1 2020, In : Life sciences. 248, 117449.

Research output: Contribution to journalArticle

2019

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

Xue, N., Lai, F., Du, T., Ji, M., Liu, D., Yan, C., Zhang, S., Yu, X., Jin, J. & Chen, X., Sep 1 2019, In : Cellular and Molecular Life Sciences. 76, 17, p. 3433-3447 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

Ji, Y., Liu, Y., Xue, N., Du, T., Wang, L., Huang, R., Li, L., Yan, C. & Chen, X., Jan 1 2019, In : OncoTargets and Therapy. 12, p. 883-896 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

2 Scopus citations

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2018

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

Wang, Z., He, Y., Deng, W., Lang, L., Yang, H., Jin, B., Kolhe, R. B., Ding, H., Zhang, J., Hai, T. & Yan, C., Jan 4 2018, In : Oncogene. 37, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

Yang, Y., Guan, D., Lei, L., Lu, J., Liu, J. Q., Yang, G., Yan, C., Zhai, R., Tian, J., Bi, Y., Fu, F. & Wang, H., Feb 15 2018, In : Toxicology and Applied Pharmacology. 341, p. 98-105 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer

Ding, M., Wang, H., Qu, C., Xu, F., Zhu, Y., Lv, G., Lu, Y., Zhou, Q., Zhou, H., Zeng, X., Zhang, J., Yan, C., Lin, J., Luo, H. R., Deng, Z., Xiao, Y., Tian, J., Zhu, M. X. & Hong, X., Sep 28 2018, In : Cancer Letters. 432, p. 47-55 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rnf126 as a biomarker of a poor prognosis in invasive breast cancer and chek1 inhibitor efficacy in breast cancer cells

Yang, X., Pan, Y., Qiu, Z., Du, Z., Zhang, Y., Fa, P., Gorityala, S., Ma, S., Li, S., Chen, C., Wang, H., Xu, Y., Yan, C., Ruth, K., Ma, Z. & Zhang, J., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1629-1643 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Zhang, J., Wang, N., Xie, X., Yan, C., Fu, F., Yao, J. & Wang, H., Jun 1 2017, In : Wuhan University Journal of Natural Sciences. 22, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lv, G., Sun, D., Zhang, J., Xie, X., Wu, X., Fang, W., Tian, J., Yan, C., Wang, H. & Fu, F., Jan 1 2017, In : Acta Pharmaceutica Sinica B. 7, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage

Cui, H., Gu, X., Chen, J., Xie, Y., Ke, S., Wu, J., Golovko, A., Morpurgo, B., Yan, C., Phillips, T. D., Xie, W., Luo, J., Zhou, Z. & Tian, Y., Jun 5 2017, In : Toxicology Letters. 275, p. 67-76 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Emerging roles of ATF3 in the suppression of prostate cancer

Wang, Z. & Yan, C., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1010948.

Research output: Contribution to journalArticle

13 Scopus citations

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

Zhao, E., Ding, J., Xia, Y., Liu, M., Ye, B., Choi, J. H., Yan, C., Dong, Z., Huang, S., Zha, Y., Yang, L., Cui, H. & Ding, H. F., Jan 26 2016, In : Cell Reports. 14, 3, p. 506-519 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In : Oncogene. 35, 27, p. 3555-3564 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

Wang, Y., Deng, O., Feng, Z., Du, Z., Xiong, X., Lai, J., Yang, X., Xu, M., Wang, H., Taylor, D., Yan, C., Chen, C., Difeo, A., Ma, Z. & Zhang, J., Mar 17 2016, In : Oncogene. 35, 11, p. 1363-1372 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

Zhang, Y., Lai, J., Du, Z., Gao, J., Yang, S., Gorityala, S., Xiong, X., Deng, O., Ma, Z., Yan, C., Susana, G., Xu, Y. & Zhang, J., Jun 7 2016, In : Oncotarget. 7, 23, p. 34688-34702 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation

Zhao, J., Li, X., Guo, M., Yu, J. & Yan, C., May 4 2016, In : BMC Genomics. 17, 1, 335.

Research output: Contribution to journalArticle

24 Scopus citations

The stress-responsive gene ATF3 mediates dichotomous UV responses by regulating the Tip60 and p53 proteins

Cui, H., Li, X., Han, C., Wang, Q. E., Wang, H., Ding, H. F., Zhang, J. & Yan, C., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10847-10857 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Liu, M., Xia, Y., Ding, J., Ye, B., Zhao, E., Choi, J. H., Alptekin, A., Yan, C., Dong, Z., Huang, S., Yang, L., Cui, H., Zha, Y. & Ding, H. F., Oct 4 2016, In : Cell Reports. 17, 2, p. 609-623 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Fan, P., Yan, C., Willers, H. & Zhang, J., Jan 1 2015, In : Nucleic Acids Research. 43, 3, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds

Lang, L., Ding, H., Chen, X., Sun, S. Y., Liu, G. & Yan, C., Jul 24 2015, In : Chemistry and Biology. 22, 7, p. 957-964 8 p., 3080.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

Wang, Z., Xu, D., Ding, H., Kim, J., Zhang, J., Hai, T. & Yan, C., Sep 17 2015, In : Oncogene. 34, 38, p. 4975-4984 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

Cui, H., Guo, M., Xu, D., Ding, Z-C., Zhou, G., Ding, H., Zhang, J., Tang, Y. & Yan, C., Apr 13 2015, In : Nature communications. 6, 6752.

Research output: Contribution to journalArticle

15 Scopus citations
2014

A synthetic manassantin a derivative inhibits hypoxia-inducible factor 1 and tumor growth

Lang, L., Liu, X., Li, Y., Zhou, Q., Xie, P., Yan, C. & Chen, X., Jun 12 2014, In : PloS one. 9, 6, e99584.

Research output: Contribution to journalArticle

10 Scopus citations

Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors

Li, N., Chen, M., Truong, S., Yan, C. & Buttyan, R., Oct 2014, In : Prostate. 74, 14, p. 1400-1410 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

Zha, Y., Xia, Y., Ding, J., Choi, J. H., Yang, L., Dong, Z., Yan, C., Huang, S. & Ding, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 9, e1417.

Research output: Contribution to journalArticle

21 Scopus citations

The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins

Wei, S., Wang, H., Lu, C., Malmut, S., Zhang, J., Ren, S., Yu, G., Wang, W., Tang, D. D. & Yan, C., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8947-8959 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Lu, C., Liu, D., Jin, J., Deokar, H., Zhang, Y., Buolamwini, J. K., Yu, X., Yan, C. & Chen, X., May 1 2013, In : Biochemical Pharmacology. 85, 9, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2012

The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor

Wang, H., Jiang, M., Cui, H., Chen, M., Buttyan, R., Hayward, S. W., Hai, T., Wang, Z. & Yan, C., Aug 1 2012, In : Molecular and Cellular Biology. 32, 16, p. 3190-3202 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

A small-molecule inhibitor of MDMX activates p53 and induces apoptosis

Wang, H., Ma, X., Ren, S., Buolamwini, J. K. & Yan, C., Jan 1 2011, In : Molecular cancer therapeutics. 10, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

A small-molecule p53 activato induces apoptosis through inhibiting MDMX expression in breast cancer cells1,2

Wang, H. & Yan, C., Jul 2011, In : Neoplasia. 13, 7, p. 611-619 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6

Wang, H., Mo, P., Ren, S. & Yan, C., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13201-13210 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

MDM2 mediates ubiquitination and degradation of activating transcription factor 3

Mo, P., Wang, H., Lu, H., Boyd, D. D. & Yan, C., Aug 27 2010, In : Journal of Biological Chemistry. 285, 35, p. 26908-26915 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2008

A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression

Nair, R. R., Avila, H., Ma, X., Wang, Z., Lennartz, M., Darnay, B. G., Boyd, D. D. & Yan, C., Mar 1 2008, In : Molecular Pharmacology. 73, 3, p. 919-929 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Identification of an histone H3 acetylated/K4-methylated-bound intragenic enhancer regulatory for urokinase receptor expression

Wang, H., Yan, C., Asangani, I., Allgayer, H. & Boyd, D. D., Mar 29 2007, In : Oncogene. 26, 14, p. 2058-2070 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2006

Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression

Yan, C. & Boyd, D. D., Sep 1 2006, In : Molecular and Cellular Biology. 26, 17, p. 6357-6371 15 p.

Research output: Contribution to journalArticle

117 Scopus citations
2005

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Yan, C., Lu, D., Hai, T. & Boyd, D. D., Jul 6 2005, In : EMBO Journal. 24, 13, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

139 Scopus citations

Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin

Yan, C., Jamaluddin, M. S., Aggarwal, B., Myers, J. & Boyd, D. D., Feb 1 2005, In : Molecular cancer therapeutics. 4, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

103 Scopus citations
2004
39 Scopus citations
2003
61 Scopus citations

Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene

Wang, H., Hicks, J., Khanbolooki, P., Kim, S. J., Yan, C., Wang, Y. & Boyd, D., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 453-464 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2002

Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells

Yan, C., Tian, F., Xiao, F., Li, K. & Li, C., Jan 1 2002, In : Zhonghua zhong liu za zhi [Chinese journal of oncology]. 24, 1, p. 251-253 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
122 Scopus citations

ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter

Yan, C., Wang, H. & Boyd, D. D., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 10804-10812 9 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A

Li, H. Y., Li, Y., Yan, C., Li, L. N. & Chen, X. G., Dec 1 2002, In : Journal of Asian Natural Products Research. 4, 4, p. 271-280 10 p.

Research output: Contribution to journalArticle

24 Scopus citations