Chunhong Yan

Associate Professor

  • 2092 Citations
  • 23 h-Index
19982019
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Research Output 1998 2019

  • 2092 Citations
  • 23 h-Index
  • 59 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
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Article
2019

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

Wang, L., Liu, Y., Du, T., Yang, H., Lei, L., Guo, M., Ding, H., Zhang, J., Wang, H., Chen, X. & Yan, C., Jan 1 2019, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
Activating Transcription Factor 3
Antiporters
Lipid Peroxidation
Glutathione
Cell Death

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

Xue, N., Lai, F., Du, T., Ji, M., Liu, D., Yan, C., Zhang, S., Yu, X., Jin, J. & Chen, X., Sep 1 2019, In : Cellular and Molecular Life Sciences. 76, 17, p. 3433-3447 15 p.

Research output: Contribution to journalArticle

Autophagy
Pancreatic Neoplasms
HSP90 Heat-Shock Proteins
Proteasome Endopeptidase Complex
Lysosomes

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

Ji, Y., Liu, Y., Xue, N., Du, T., Wang, L., Huang, R., Li, L., Yan, C. & Chen, X., Jan 1 2019, In : OncoTargets and Therapy. 12, p. 883-896 14 p.

Research output: Contribution to journalArticle

Open Access
Esophageal Neoplasms
Interleukin-6
Janus Kinase 2
Apoptosis
Salvia miltiorrhiza
5 Citations (Scopus)

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

Fusidic Acid
Hydroxyl Radical
Tumors
Derivatives
Neoplasms

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

Histone Demethylases
Neuroblastoma
Epigenomics
Cell Differentiation
Histones
2018
6 Citations (Scopus)

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

Wang, Z., He, Y., Deng, W., Lang, L., Yang, H., Jin, B., Kolhe, R. B., Ding, H., Zhang, J., Hai, T. & Yan, C., Jan 4 2018, In : Oncogene. 37, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Genomic Instability
Carcinogenesis
Neoplasms
DNA Damage
27 Citations (Scopus)

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

Yang, Y., Guan, D., Lei, L., Lu, J., Liu, J. Q., Yang, G., Yan, C., Zhai, R., Tian, J., Bi, Y., Fu, F. & Wang, H., Feb 15 2018, In : Toxicology and Applied Pharmacology. 341, p. 98-105 8 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
P-Glycoprotein
Paclitaxel
Derivatives
Rhodamine 123
8 Citations (Scopus)

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer

Ding, M., Wang, H., Qu, C., Xu, F., Zhu, Y., Lv, G., Lu, Y., Zhou, Q., Zhou, H., Zeng, X., Zhang, J., Yan, C., Lin, J., Luo, H. R., Deng, Z., Xiao, Y., Tian, J., Zhu, M. X. & Hong, X., Sep 28 2018, In : Cancer Letters. 432, p. 47-55 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Inhibitory Concentration 50
HEK293 Cells
Heterografts
Nude Mice
2 Citations (Scopus)

Rnf126 as a biomarker of a poor prognosis in invasive breast cancer and chek1 inhibitor efficacy in breast cancer cells

Yang, X., Pan, Y., Qiu, Z., Du, Z., Zhang, Y., Fa, P., Gorityala, S., Ma, S., Li, S., Chen, C., Wang, H., Xu, Y., Yan, C., Ruth, K., Ma, Z. & Zhang, J., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1629-1643 15 p.

Research output: Contribution to journalArticle

Biomarkers
Breast Neoplasms
Proteins
Staining and Labeling
Ubiquitin-Protein Ligases
2017
1 Citation (Scopus)

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Zhang, J., Wang, N., Xie, X., Yan, C., Fu, F., Yao, J. & Wang, H., Jun 1 2017, In : Wuhan University Journal of Natural Sciences. 22, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

Quinazolines
Cytotoxicity
Bioactivity
Antineoplastic Agents
Cells
27 Citations (Scopus)

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lv, G., Sun, D., Zhang, J., Xie, X., Wu, X., Fang, W., Tian, J., Yan, C., Wang, H. & Fu, F., Jan 1 2017, In : Acta Pharmaceutica Sinica B. 7, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Tubulin
Cytotoxins
docetaxel
Cell Line
5 Citations (Scopus)

Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage

Cui, H., Gu, X., Chen, J., Xie, Y., Ke, S., Wu, J., Golovko, A., Morpurgo, B., Yan, C., Phillips, T. D., Xie, W., Luo, J., Zhou, Z. & Tian, Y., Jun 5 2017, In : Toxicology Letters. 275, p. 67-76 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Liver
DNA Damage
DNA
Assays
2016
11 Citations (Scopus)

Emerging roles of ATF3 in the suppression of prostate cancer

Wang, Z. & Yan, C., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1010948.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Prostatic Neoplasms
Androgen Receptors
Down-Regulation
Neoplasms
27 Citations (Scopus)

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

Zhao, E., Ding, J., Xia, Y., Liu, M., Ye, B., Choi, J. H., Yan, C., Dong, Z., Huang, S., Zha, Y., Yang, L., Cui, H. & Ding, H. F., Jan 26 2016, In : Cell Reports. 14, 3, p. 506-519 14 p.

Research output: Contribution to journalArticle

Metabolism
Amino Acids
Serine
Transcriptional Activation
Cell proliferation
5 Citations (Scopus)

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In : Oncogene. 35, 27, p. 3555-3564 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Prostate
Carcinogenesis
Epithelial Cells
Hormones
11 Citations (Scopus)

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

Wang, Y., Deng, O., Feng, Z., Du, Z., Xiong, X., Lai, J., Yang, X., Xu, M., Wang, H., Taylor, D., Yan, C., Chen, C., Difeo, A., Ma, Z. & Zhang, J., Mar 17 2016, In : Oncogene. 35, 11, p. 1363-1372 10 p.

Research output: Contribution to journalArticle

Homologous Recombination
Ubiquitin-Protein Ligases
Neoplasms
Transcriptional Activation
Recombinational DNA Repair
11 Citations (Scopus)

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

Zhang, Y., Lai, J., Du, Z., Gao, J., Yang, S., Gorityala, S., Xiong, X., Deng, O., Ma, Z., Yan, C., Susana, G., Xu, Y. & Zhang, J., Jun 7 2016, In : Oncotarget. 7, 23, p. 34688-34702 15 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Oncogenes
Radiotherapy
myc Genes
Homologous Recombination
20 Citations (Scopus)

The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation

Zhao, J., Li, X., Guo, M., Yu, J. & Yan, C., May 4 2016, In : BMC Genomics. 17, 1, 335.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
DNA Damage
Gene Expression
Genes
Camptothecin
4 Citations (Scopus)

The stress-responsive gene ATF3 mediates dichotomous UV responses by regulating the Tip60 and p53 proteins

Cui, H., Li, X., Han, C., Wang, Q. E., Wang, H., Ding, H., Zhang, J. & Yan, C., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10847-10857 11 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Genes
Proteins
Irradiation
DNA Repair
14 Citations (Scopus)

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Liu, M., Xia, Y., Ding, J., Ye, B., Zhao, E., Choi, J. H., Alptekin, A., Yan, C., Dong, Z., Huang, S., Yang, L., Cui, H., Zha, Y. & Ding, H. F., Oct 4 2016, In : Cell Reports. 17, 2, p. 609-623 15 p.

Research output: Contribution to journalArticle

Neuroblastoma
Sterols
Glycine
Serine
Amplification
2015
20 Citations (Scopus)

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Fan, P., Yan, C., Willers, H. & Zhang, J., Jan 1 2015, In : Nucleic Acids Research. 43, 3, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

G1 Phase
Double-Stranded DNA Breaks
Sequence Deletion
Genomic Instability
Homologous Recombination
3 Citations (Scopus)

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds

Lang, L., Ding, H., Chen, X., Sun, S. Y., Liu, G. & Yan, C., Jul 24 2015, In : Chemistry and Biology. 22, 7, p. 957-964 8 p., 3080.

Research output: Contribution to journalArticle

Lead compounds
Transcription
Reporter Genes
Assays
Genes
27 Citations (Scopus)

Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

Wang, Z., Xu, D., Ding, H., Kim, J., Zhang, J., Hai, T. & Yan, C., Sep 17 2015, In : Oncogene. 34, 38, p. 4975-4984 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Knockout Mice
Prostatic Neoplasms
Prostate
Prostatic Intraepithelial Neoplasia
13 Citations (Scopus)

The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

Cui, H., Guo, M., Xu, D., Ding, Z-C., Zhou, G., Ding, H., Zhang, J., Tang, Y. & Yan, C., Apr 13 2015, In : Nature Communications. 6, 6752.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
tat Gene Products
Histone Acetyltransferases
genes
Genes
2014
9 Citations (Scopus)

A synthetic manassantin a derivative inhibits hypoxia-inducible factor 1 and tumor growth

Lang, L., Liu, X., Li, Y., Zhou, Q., Xie, P., Yan, C. & Chen, X., Jun 12 2014, In : PloS one. 9, 6, e99584.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Tumors
chemical derivatives
Derivatives
neoplasms
8 Citations (Scopus)

Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors

Li, N., Chen, M., Truong, S., Yan, C. & Buttyan, R., Jan 1 2014, In : Prostate. 74, 14, p. 1400-1410 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgens
Chromatin Immunoprecipitation
Response Elements
16 Citations (Scopus)

MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

Zha, Y., Xia, Y., Ding, J., Choi, J. H., Yang, L., Dong, Z., Yan, C., Huang, S. & Ding, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 9, e1417.

Research output: Contribution to journalArticle

Neuroblastoma
Cell Division
Cell Survival
Cell Proliferation
cdc Genes
29 Citations (Scopus)

The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins

Wei, S., Wang, H., Lu, C., Malmut, S., Zhang, J., Ren, S., Yu, G., Wang, W., Tang, D. D. & Yan, C., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8947-8959 13 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Mutant Proteins
Proteins
Cells
Neoplasms
2013
19 Citations (Scopus)

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Lu, C., Liu, D., Jin, J., Deokar, H., Zhang, Y., Buolamwini, J. K., Yu, X., Yan, C. & Chen, X., May 1 2013, In : Biochemical Pharmacology. 85, 9, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Tumors
Stomach
Cells
Growth
2012
24 Citations (Scopus)

The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor

Wang, H., Jiang, M., Cui, H., Chen, M., Buttyan, R., Hayward, S. W., Hai, T., Wang, Z. & Yan, C., Aug 1 2012, In : Molecular and Cellular Biology. 32, 16, p. 3190-3202 13 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Androgen Receptors
Androgens
Prostate
Prostatic Neoplasms
2011
79 Citations (Scopus)

A small-molecule inhibitor of MDMX activates p53 and induces apoptosis

Wang, H., Ma, X., Ren, S., Buolamwini, J. K. & Yan, C., Jan 1 2011, In : Molecular cancer therapeutics. 10, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
MCF-7 Cells
Preclinical Drug Evaluations
Cell Survival
31 Citations (Scopus)

A small-molecule p53 activato induces apoptosis through inhibiting MDMX expression in breast cancer cells1,2

Wang, H. & Yan, C., Jan 1 2011, In : Neoplasia. 13, 7, p. 611-619 9 p.

Research output: Contribution to journalArticle

(10-methyl-9-anthryl)methyl imidothiocarbamate
Apoptosis
Breast Neoplasms
pseudourea
Growth
2010
39 Citations (Scopus)

Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6

Wang, H., Mo, P., Ren, S. & Yan, C., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13201-13210 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Protein Binding
Uterine Cervical Neoplasms
Proteins
Ubiquitin
30 Citations (Scopus)

MDM2 mediates ubiquitination and degradation of activating transcription factor 3

Mo, P., Wang, H., Lu, H., Boyd, D. D. & Yan, C., Aug 27 2010, In : Journal of Biological Chemistry. 285, 35, p. 26908-26915 8 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Ubiquitination
Degradation
DNA Damage
Proteolysis
2008
17 Citations (Scopus)

A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression

Nair, R. R., Avila, H., Ma, X., Wang, Z., Lennartz, M., Darnay, B. G., Boyd, D. D. & Yan, C., Mar 1 2008, In : Molecular Pharmacology. 73, 3, p. 919-929 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Gene Expression
Homologous Recombination
Reporter Genes
Small Molecule Libraries
2007
6 Citations (Scopus)

Identification of an histone H3 acetylated/K4-methylated-bound intragenic enhancer regulatory for urokinase receptor expression

Wang, H., Yan, C., Asangani, I., Allgayer, H. & Boyd, D. D., Mar 29 2007, In : Oncogene. 26, 14, p. 2058-2070 13 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Urokinase-Type Plasminogen Activator
Histones
Chromatin Immunoprecipitation
Deoxyribonuclease I
2006
111 Citations (Scopus)

Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression

Yan, C. & Boyd, D. D., Sep 1 2006, In : Molecular and Cellular Biology. 26, 17, p. 6357-6371 15 p.

Research output: Contribution to journalArticle

Acetylation
Transgenes
Histones
Methylation
Chromatin
2005
137 Citations (Scopus)

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Yan, C., Lu, D., Hai, T. & Boyd, D. D., Jul 6 2005, In : EMBO Journal. 24, 13, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Ubiquitination
Sensors
DNA Damage
Null Lymphocytes
102 Citations (Scopus)

Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin

Yan, C., Jamaluddin, M. S., Aggarwal, B., Myers, J. & Boyd, D. D., Feb 1 2005, In : Molecular cancer therapeutics. 4, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Curcumin
Gene Expression Profiling
E2F5 Transcription Factor
Phosphotransferases
2004
39 Citations (Scopus)
NF-kappa B
Homologous Recombination
Matrix Metalloproteinase 9
Transcription
Matrix Metalloproteinases
2003
59 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Histones
Histone Deacetylase 2
Acetylation
11 Citations (Scopus)

Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene

Wang, H., Hicks, J., Khanbolooki, P., Kim, S. J., Yan, C., Wang, Y. & Boyd, D., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 453-464 12 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Urokinase-Type Plasminogen Activator
Genetic Promoter Regions
Transgenic Mice
Genes
2002

Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells

Tian, F., Yan, C., Xue, H. & Xiao, F. J., Jan 1 2002, In : Chinese Journal of Cancer Research. 14, 4, p. 251-253 3 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Ovarian Neoplasms
Gene Expression
Matrix Metalloproteinases
Fibronectins
1 Citation (Scopus)

Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells

Yan, C., Tian, F., Xiao, F., Li, K. & Li, C., Jan 1 2002, In : Zhonghua zhong liu za zhi [Chinese journal of oncology]. 24, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Ovarian Neoplasms
Gene Expression
Matrix Metalloproteinases
Fibronectins
122 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Phosphotransferases
DNA
Collagenases
82 Citations (Scopus)

ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter

Yan, C., Wang, H. & Boyd, D. D., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 10804-10812 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 8
Matrix Metalloproteinase 2
Collagenases
Matrix Metalloproteinases
Chemical activation
22 Citations (Scopus)

Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A

Li, H. Y., Li, Y., Yan, C., Li, L. N. & Chen, X. G., Dec 1 2002, In : Journal of Asian Natural Products Research. 4, 4, p. 271-280 10 p.

Research output: Contribution to journalArticle

Tumors
Gap Junctions
Growth
myc Genes
Genes
2001
10 Citations (Scopus)

Cancer chemopreventive activities of S-3-1, a synthetic derivative of Danshinone

Chen, X. G., Li, Y., Yan, C., Li, L. N. & Han, R., Jan 1 2001, In : Journal of Asian Natural Products Research. 3, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

Croton Oil
Salvia miltiorrhiza
Derivatives
Tumors
Skin
171 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Enzyme activity
Messenger RNA
Proto-Oncogene Proteins c-ets
2000

Effects of genistein on growth and differentiation of NB4 human acute promyelocytic leukemia cells

Yan, C., Xiaoguang, C., Shoujun, Y., Yan, L. & Rui, H., Apr 1 2000, In : Yaoxue Xuebao. 35, 4, 1 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Genistein
Growth
Type II DNA Topoisomerase
Apoptosis