Chunhong Yan

Associate Professor

  • 2175 Citations
  • 24 h-Index
19982020
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Research Output 1998 2020

  • 2175 Citations
  • 24 h-Index
  • 62 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
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Article
22 Citations (Scopus)

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Fan, P., Yan, C., Willers, H. & Zhang, J., Jan 1 2015, In : Nucleic Acids Research. 43, 3, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

G1 Phase
Double-Stranded DNA Breaks
Sequence Deletion
Genomic Instability
Homologous Recombination
138 Citations (Scopus)

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Yan, C., Lu, D., Hai, T. & Boyd, D. D., Jul 6 2005, In : EMBO Journal. 24, 13, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Ubiquitination
Sensors
DNA Damage
Null Lymphocytes
39 Citations (Scopus)

Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6

Wang, H., Mo, P., Ren, S. & Yan, C., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13201-13210 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Protein Binding
Uterine Cervical Neoplasms
Proteins
Ubiquitin

Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells

Tian, F., Yan, C., Xue, H. & Xiao, F. J., Dec 2002, In : Chinese Journal of Cancer Research. 14, 4, p. 251-253 3 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Ovarian Neoplasms
Gene Expression
Matrix Metalloproteinases
Fibronectins
1 Citation (Scopus)

Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells

Yan, C., Tian, F., Xiao, F., Li, K. & Li, C., Jan 1 2002, In : Zhonghua zhong liu za zhi [Chinese journal of oncology]. 24, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Ovarian Neoplasms
Gene Expression
Matrix Metalloproteinases
Fibronectins
122 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Phosphotransferases
DNA
Collagenases
17 Citations (Scopus)

A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression

Nair, R. R., Avila, H., Ma, X., Wang, Z., Lennartz, M., Darnay, B. G., Boyd, D. D. & Yan, C., Mar 1 2008, In : Molecular Pharmacology. 73, 3, p. 919-929 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Gene Expression
Homologous Recombination
Reporter Genes
Small Molecule Libraries
39 Citations (Scopus)
NF-kappa B
Homologous Recombination
Matrix Metalloproteinase 9
Transcription
Matrix Metalloproteinases
80 Citations (Scopus)

A small-molecule inhibitor of MDMX activates p53 and induces apoptosis

Wang, H., Ma, X., Ren, S., Buolamwini, J. K. & Yan, C., Jan 1 2011, In : Molecular cancer therapeutics. 10, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
MCF-7 Cells
Preclinical Drug Evaluations
Cell Survival
32 Citations (Scopus)

A small-molecule p53 activato induces apoptosis through inhibiting MDMX expression in breast cancer cells1,2

Wang, H. & Yan, C., Jul 2011, In : Neoplasia. 13, 7, p. 611-619 9 p.

Research output: Contribution to journalArticle

(10-methyl-9-anthryl)methyl imidothiocarbamate
Apoptosis
Breast Neoplasms
pseudourea
Growth
10 Citations (Scopus)

A synthetic manassantin a derivative inhibits hypoxia-inducible factor 1 and tumor growth

Lang, L., Liu, X., Li, Y., Zhou, Q., Xie, P., Yan, C. & Chen, X., Jun 12 2014, In : PloS one. 9, 6, e99584.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Tumors
chemical derivatives
Derivatives
neoplasms
8 Citations (Scopus)

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

Wang, Z., He, Y., Deng, W., Lang, L., Yang, H., Jin, B., Kolhe, R. B., Ding, H., Zhang, J., Hai, T. & Yan, C., Jan 4 2018, In : Oncogene. 37, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Genomic Instability
Carcinogenesis
Neoplasms
DNA Damage
2 Citations (Scopus)

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

Wang, L., Liu, Y., Du, T., Yang, H., Lei, L., Guo, M., Ding, H., Zhang, J., Wang, H., Chen, X. & Yan, C., Feb 1 2020, In : Cell Death and Differentiation. 27, 2, p. 662-675 14 p.

Research output: Contribution to journalArticle

Open Access
Activating Transcription Factor 3
Antiporters
Lipid Peroxidation
Glutathione
Cell Death
82 Citations (Scopus)

ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter

Yan, C., Wang, H. & Boyd, D. D., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 10804-10812 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 8
Matrix Metalloproteinase 2
Collagenases
Matrix Metalloproteinases
Chemical activation
11 Citations (Scopus)

Cancer chemopreventive activities of S-3-1, a synthetic derivative of Danshinone

Chen, X. G., Li, Y., Yan, C., Li, L. N. & Han, R., Jan 1 2001, In : Journal of Asian Natural Products Research. 3, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

Croton Oil
Salvia miltiorrhiza
Derivatives
Tumors
Skin
2 Citations (Scopus)

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

Xue, N., Lai, F., Du, T., Ji, M., Liu, D., Yan, C., Zhang, S., Yu, X., Jin, J. & Chen, X., Sep 1 2019, In : Cellular and Molecular Life Sciences. 76, 17, p. 3433-3447 15 p.

Research output: Contribution to journalArticle

Autophagy
Pancreatic Neoplasms
HSP90 Heat-Shock Proteins
Proteasome Endopeptidase Complex
Lysosomes

Competitive ubiquitination activates the tumor suppressor p53

Li, X., Guo, M., Cai, L., Du, T., Liu, Y., Ding, H. F., Wang, H., Zhang, J., Chen, X. & Yan, C., Jan 1 2019, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
Ubiquitination
Ubiquitin
Neoplasms
Activating Transcription Factor 3
Ubiquitin-Protein Ligases
1 Citation (Scopus)

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

Ji, Y., Liu, Y., Xue, N., Du, T., Wang, L., Huang, R., Li, L., Yan, C. & Chen, X., Jan 1 2019, In : OncoTargets and Therapy. 12, p. 883-896 14 p.

Research output: Contribution to journalArticle

Open Access
Esophageal Neoplasms
Interleukin-6
Janus Kinase 2
Apoptosis
Salvia miltiorrhiza
1 Citation (Scopus)

Cytoskeleton-associated protein tyrosine phosphorylation involved in induction of differentiation in mouse melanoma cells

Yan, C. & Han, R., Jan 1 1999, In : Chinese Science Bulletin. 44, 4, p. 335-339 5 p.

Research output: Contribution to journalArticle

Cytoskeleton
Tyrosine
Melanoma
Phosphorylation
Phosphotyrosine
1 Citation (Scopus)

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Zhang, J., Wang, N., Xie, X., Yan, C., Fu, F., Yao, J. & Wang, H., Jun 1 2017, In : Wuhan University Journal of Natural Sciences. 22, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

Quinazolines
Cytotoxicity
Bioactivity
Antineoplastic Agents
Cells
9 Citations (Scopus)

Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors

Li, N., Chen, M., Truong, S., Yan, C. & Buttyan, R., Oct 2014, In : Prostate. 74, 14, p. 1400-1410 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgens
Chromatin Immunoprecipitation
Response Elements
6 Citations (Scopus)

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

Fusidic Acid
Hydroxyl Radical
Tumors
Derivatives
Neoplasms
24 Citations (Scopus)

Effects of genistein, a soybean-derived isoflavone, on proliferation and differentiation of B16-BL6 mouse melanoma cells

Yan, C., Chen, X. G., Li, Y. & Han, R., Jan 1 1999, In : Journal of Asian Natural Products Research. 1, 4, p. 285-299 15 p.

Research output: Contribution to journalArticle

Isoflavones
Genistein
Soybeans
Melanoma
Cytoskeleton
1 Citation (Scopus)

Effects of genistein on experimental metastasis of B16-BL6 mouse melanoma cells

Yan, C. & Han, R., Nov 1 1999, In : Yaoxue Xuebao. 34, 11, p. 814-817 4 p.

Research output: Contribution to journalArticle

Genistein
Melanoma
Neoplasm Metastasis
Cyclophosphamide
Lung

Effects of genistein on growth and differentiation of NB4 human acute promyelocytic leukemia cells

Yan, C., Xiaoguang, C., Shoujun, Y., Yan, L. & Rui, H., Apr 1 2000, In : Yaoxue Xuebao. 35, 4, 1 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Genistein
Growth
Type II DNA Topoisomerase
Apoptosis
14 Citations (Scopus)
Genistein
Fibrosarcoma
Matrix Metalloproteinases
Human Activities
Tissue Inhibitor of Metalloproteinase-1
12 Citations (Scopus)

Emerging roles of ATF3 in the suppression of prostate cancer

Wang, Z. & Yan, C., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1010948.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Prostatic Neoplasms
Androgen Receptors
Down-Regulation
Neoplasms
1 Citation (Scopus)

Fibronectin induces matrix metalloproteinase-2 expression in ovarian cancer cells

Yan, C., Li, C. & Tian, F., Jan 1 2000, In : Zhonghua zhong liu za zhi [Chinese journal of oncology]. 22, 2, p. 109-112 4 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Fibronectins
Ovarian Neoplasms
Luciferases
Transcription Factor AP-1
103 Citations (Scopus)

Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin

Yan, C., Jamaluddin, M. S., Aggarwal, B., Myers, J. & Boyd, D. D., Feb 1 2005, In : Molecular cancer therapeutics. 4, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Curcumin
Gene Expression Profiling
E2F5 Transcription Factor
Phosphotransferases
26 Citations (Scopus)

Genistein suppresses adhesion-induced protein tyrosine phosphorylation and invasion of B16-BL6 melanoma cells

Yan, C. & Han, R., Jul 3 1998, In : Cancer Letters. 129, 1, p. 117-124 8 p.

Research output: Contribution to journalArticle

Experimental Melanomas
Genistein
Tyrosine
Phosphorylation
Extracellular Matrix
34 Citations (Scopus)

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

Yang, Y., Guan, D., Lei, L., Lu, J., Liu, J. Q., Yang, G., Yan, C., Zhai, R., Tian, J., Bi, Y., Fu, F. & Wang, H., Feb 15 2018, In : Toxicology and Applied Pharmacology. 341, p. 98-105 8 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
P-Glycoprotein
Paclitaxel
Derivatives
Rhodamine 123
1 Citation (Scopus)

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

Histone Demethylases
Neuroblastoma
Epigenomics
Cell Differentiation
Histones
113 Citations (Scopus)

Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression

Yan, C. & Boyd, D. D., Sep 1 2006, In : Molecular and Cellular Biology. 26, 17, p. 6357-6371 15 p.

Research output: Contribution to journalArticle

Acetylation
Transgenes
Histones
Methylation
Chromatin
6 Citations (Scopus)

Identification of an histone H3 acetylated/K4-methylated-bound intragenic enhancer regulatory for urokinase receptor expression

Wang, H., Yan, C., Asangani, I., Allgayer, H. & Boyd, D. D., Mar 29 2007, In : Oncogene. 26, 14, p. 2058-2070 13 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Urokinase-Type Plasminogen Activator
Histones
Chromatin Immunoprecipitation
Deoxyribonuclease I
20 Citations (Scopus)

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Lu, C., Liu, D., Jin, J., Deokar, H., Zhang, Y., Buolamwini, J. K., Yu, X., Yan, C. & Chen, X., May 1 2013, In : Biochemical Pharmacology. 85, 9, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Tumors
Stomach
Cells
Growth
24 Citations (Scopus)

Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A

Li, H. Y., Li, Y., Yan, C., Li, L. N. & Chen, X. G., Dec 1 2002, In : Journal of Asian Natural Products Research. 4, 4, p. 271-280 10 p.

Research output: Contribution to journalArticle

Tumors
Gap Junctions
Growth
myc Genes
Genes
3 Citations (Scopus)

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds

Lang, L., Ding, H., Chen, X., Sun, S. Y., Liu, G. & Yan, C., Jul 24 2015, In : Chemistry and Biology. 22, 7, p. 957-964 8 p., 3080.

Research output: Contribution to journalArticle

Lead compounds
Transcription
Reporter Genes
Assays
Genes
28 Citations (Scopus)

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

Zhao, E., Ding, J., Xia, Y., Liu, M., Ye, B., Choi, J. H., Yan, C., Dong, Z., Huang, S., Zha, Y., Yang, L., Cui, H. & Ding, H. F., Jan 26 2016, In : Cell Reports. 14, 3, p. 506-519 14 p.

Research output: Contribution to journalArticle

Metabolism
Amino Acids
Serine
Transcriptional Activation
Cell proliferation
173 Citations (Scopus)
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Enzyme activity
Messenger RNA
Proto-Oncogene Proteins c-ets
28 Citations (Scopus)

Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

Wang, Z., Xu, D., Ding, H., Kim, J., Zhang, J., Hai, T. & Yan, C., Sep 17 2015, In : Oncogene. 34, 38, p. 4975-4984 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Knockout Mice
Prostatic Neoplasms
Prostate
Prostatic Intraepithelial Neoplasia
5 Citations (Scopus)

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In : Oncogene. 35, 27, p. 3555-3564 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Prostate
Carcinogenesis
Epithelial Cells
Hormones
36 Citations (Scopus)

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lv, G., Sun, D., Zhang, J., Xie, X., Wu, X., Fang, W., Tian, J., Yan, C., Wang, H. & Fu, F., Jan 1 2017, In : Acta Pharmaceutica Sinica B. 7, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Tubulin
Cytotoxins
docetaxel
Cell Line
33 Citations (Scopus)

MDM2 mediates ubiquitination and degradation of activating transcription factor 3

Mo, P., Wang, H., Lu, H., Boyd, D. D. & Yan, C., Aug 27 2010, In : Journal of Biological Chemistry. 285, 35, p. 26908-26915 8 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Ubiquitination
Degradation
DNA Damage
Proteolysis
19 Citations (Scopus)

MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

Zha, Y., Xia, Y., Ding, J., Choi, J. H., Yang, L., Dong, Z., Yan, C., Huang, S. & Ding, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 9, e1417.

Research output: Contribution to journalArticle

Neuroblastoma
Cell Division
Cell Survival
Cell Proliferation
cdc Genes
6 Citations (Scopus)

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
Physiological Stress
Biosynthetic Pathways
Glycine
Serine
Carbon

PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo

Li, F., Liu, Z., Sun, H., Li, C., Wang, W., Ye, L., Yan, C., Tian, J. & Wang, H., Jan 1 2019, (Accepted/In press) In : Acta Pharmaceutica Sinica B.

Research output: Contribution to journalArticle

Open Access
Glioma
Microtubules
Phosphotransferases
M Phase Cell Cycle Checkpoints
G2 Phase
7 Citations (Scopus)

Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage

Cui, H., Gu, X., Chen, J., Xie, Y., Ke, S., Wu, J., Golovko, A., Morpurgo, B., Yan, C., Phillips, T. D., Xie, W., Luo, J., Zhou, Z. & Tian, Y., Jun 5 2017, In : Toxicology Letters. 275, p. 67-76 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Liver
DNA Damage
DNA
Assays

Primary study of expression of matrix metalloproteinase-2 in yeast Pichia pastoris

Ding, X. Y., Li, C. H., Zhu, Y. F., Sun, L. Y., Yan, C., Zhang, L. X., Feng, D. X. & Chen, G. M., Dec 1 1999, In : Progress in Biochemistry and Biophysics. 26, 3, p. 293-294 2 p.

Research output: Contribution to journalArticle

Pichia
Matrix Metalloproteinase 2
Yeast
Yeasts
Gelatin
5 Citations (Scopus)

Protein tyrosine kinase inhibitor genistein suppresses in vitro invasion of HT1080 human fibrosarcoma cells

Yan, C. & Han, R., Jul 3 1999, In : Chinese Journal of Oncology. 21, 3, p. 171-174 4 p.

Research output: Contribution to journalArticle

Genistein
Fibrosarcoma
Protein Kinase Inhibitors
Protein-Tyrosine Kinases
Matrix Metalloproteinases
9 Citations (Scopus)

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer

Ding, M., Wang, H., Qu, C., Xu, F., Zhu, Y., Lv, G., Lu, Y., Zhou, Q., Zhou, H., Zeng, X., Zhang, J., Yan, C., Lin, J., Luo, H. R., Deng, Z., Xiao, Y., Tian, J., Zhu, M. X. & Hong, X., Sep 28 2018, In : Cancer Letters. 432, p. 47-55 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Inhibitory Concentration 50
HEK293 Cells
Heterografts
Nude Mice