Chunwan Lu

Assistant Research Scientist

  • 485 Citations
  • 12 h-Index
20132020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 485 Citations
  • 12 h-Index
  • 25 Article
  • 1 Editorial
  • 1 Letter
  • 1 Review article
Filter
Article
2020

Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells

Ibrahim, M. L., Lu, C., Klement, J. D., Redd, P. S., Yang, D., Smith, A. D. & Liu, K., Jan 1 2020, (Accepted/In press) In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticle

SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth

Lu, C., Klement, J. D., Yang, D., Albers, T., Lebedyeva, I. O., Waller, J. L. & Liu, K., Apr 28 2020, In : Cancer Letters. 476, p. 87-96 10 p.

Research output: Contribution to journalArticle

2019

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., Browning, D. D., Liu, K., Blumberg, R., Singh, N. & Li, H., Dec 1 2019, In : Cell Discovery. 5, 1, 7.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of fas expression and function is coupled with colon cancer resistance to immune checkpoint inhibitor immunotherapy

Xiao, W., Ibrahim, M. L., Redd, P. S., Klement, J. D., Lu, C., Yang, D., Savage, N. M. & Liu, K., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 420-430 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Type i interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Lu, C., Klement, J. D., Ibrahim, M. L., Xiao, W., Redd, P. S., Nayak, A., Zhou, G. & Liu, K., Jun 22 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 157.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

9 Scopus citations

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
16 Scopus citations

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

Redd, P. S., Lu, C., Klement, J. D., Ibrahim, M. L., Zhou, G., Kumai, T., Celis, E. & Liu, K., Sep 2 2018, In : OncoImmunology. 7, 9, e1483302.

Research output: Contribution to journalArticle

5 Scopus citations

IFNAR1 controls autocrine type I IFN regulation of PD-L1 expression in myeloid-derived suppressor cells

Xiao, W., Klement, J. D., Lu, C., Ibrahim, M. L. & Liu, K., Jul 1 2018, In : Journal of Immunology. 201, 1, p. 264-277 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

Ibrahim, M. L., Klement, J. D., Lu, C., Redd, P. S., Xiao, W., Yang, D., Browning, D. D., Savage, N. M., Buckhaults, P. J., Morse, H. C. & Liu, K., Dec 11 2018, In : Cell Reports. 25, 11, p. 3036-3046.e6

Research output: Contribution to journalArticle

8 Scopus citations
2017
38 Scopus citations

The MLL1-H3K4me3 axis-mediated PD-L1 expression and pancreatic cancer immune evasion

Lu, C., Paschall, A. V., Shi, H., Savage, N., Waller, J. L., Sabbatini, M. E., Oberlies, N. H., Pearce, C. & Liu, K., Jan 1 2017, In : Journal of the National Cancer Institute. 109, 6, djw283.

Research output: Contribution to journalArticle

56 Scopus citations
2016

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

Paschall, A. V., Yang, D., Lu, C., Redd, P. S., Choi, J. H., Heaton, C. M., Lee, J. R., Nayak-Kapoor, A. & Liu, K., Jan 1 2016, In : Oncotarget. 7, 48, p. 78698-78712 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloidderived suppressor cells

Liu, F., Li, X., Lu, C., Bai, A., Bielawski, J., Bielawska, A., Marshall, B., Schoenlein, P. V., Lebedyeva, I. O. & Liu, K., 2016, In : Oncotarget. 7, 51, p. 83907-83925 19 p.

Research output: Contribution to journalArticle

31 Scopus citations

Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

Coe, G. L., Redd, P. S., Paschall, A. V., Lu, C., Gu, L., Cai, H., Albers, T., Lebedyeva, I. O. & Liu, K., Aug 4 2016, In : Scientific reports. 6, 30816.

Research output: Contribution to journalArticle

11 Scopus citations

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression

Simon, P. S., Bardhan, K., Chen, M. R., Paschall, A. V., Lu, C., Bollag, R. J., Kong, F. C., Jin, J. Y., Kong, F. M., Waller, J. L., Pollock, R. E. & Liu, K., Apr 26 2016, In : Oncotarget. 7, 17, p. 23395-23415 21 p.

Research output: Contribution to journalArticle

5 Scopus citations

The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells

Lu, C., Redd, P. S., Lee, J. R., Savage, N. & Liu, K., Dec 1 2016, In : OncoImmunology. 5, 12, e1247135.

Research output: Contribution to journalArticle

55 Scopus citations
2015

H3K9 trimethylation silences fas expression to confer colon carcinoma immune escape and 5-fluorouracil chemoresistance

Paschall, A. V., Yang, D., Lu, C., Choi, J-H., Li, X., Liu, F., Figueroa, M., Oberlies, N. H., Pearce, C., Bollag, W. B., Nayak, A. & Liu, K., Aug 15 2015, In : Journal of Immunology. 195, 4, p. 1868-1882 15 p.

Research output: Contribution to journalArticle

42 Scopus citations

Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in Chinese Holstein

Huang, P., Lu, C., Li, J., Xu, J., Liu, Z., Wang, Q., Wang, Z., Huo, J., Li, H., Teng, Y. & Cai, Y., Mar 15 2015, In : Gene. 559, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

Simon, P. S., Sharman, S. K., Lu, C., Yang, D., Paschall, A. V., Tulachan, S. S. & Liu, K., Oct 23 2015, In : BMC Cancer. 15, 1, 770.

Research output: Contribution to journalArticle

25 Scopus citations

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development

Cai, Y., Pi, W., Sivaprakasam, S., Zhu, X., Zhang, M., Chen, J., Makala, L. H., Lu, C., Wu, J., Teng, Y., Pace, B. S., Tuan Lo, D., Singh, N. & Li, H., Nov 2015, In : PLoS Genetics. 11, 11, e1005643.

Research output: Contribution to journalArticle

45 Scopus citations
2014

The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins

Wei, S., Wang, H., Lu, C., Malmut, S., Zhang, J., Ren, S., Yu, G., Wang, W., Tang, D. D. & Yan, C., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8947-8959 13 p.

Research output: Contribution to journalArticle

32 Scopus citations
2013

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Lu, C., Liu, D., Jin, J., Deokar, H., Zhang, Y., Buolamwini, J. K., Yu, X., Yan, C. & Chen, X., May 1 2013, In : Biochemical Pharmacology. 85, 9, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

20 Scopus citations