Chunwan Lu

Assistant Research Scientist

  • 368 Citations
  • 11 h-Index
20132019
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Research Output 2013 2019

  • 368 Citations
  • 11 h-Index
  • 23 Article
  • 1 Editorial
  • 1 Letter
  • 1 Review article
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Article
2013
19 Citations (Scopus)

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Lu, C., Liu, D., Jin, J., Deokar, H., Zhang, Y., Buolamwini, J. K., Yu, X., Yan, C. & Chen, X., May 1 2013, In : Biochemical Pharmacology. 85, 9, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Tumors
Stomach
Cells
Growth
2014
29 Citations (Scopus)

The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins

Wei, S., Wang, H., Lu, C., Malmut, S., Zhang, J., Ren, S., Yu, G., Wang, W., Tang, D. D. & Yan, C., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8947-8959 13 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Mutant Proteins
Proteins
Cells
Neoplasms
2015
37 Citations (Scopus)

H3K9 trimethylation silences fas expression to confer colon carcinoma immune escape and 5-fluorouracil chemoresistance

Paschall, A. V., Yang, D., Lu, C., Choi, J-H., Li, X., Liu, F., Figueroa, M., Oberlies, N. H., Pearce, C., Bollag, W. B., Nayak, A. & Liu, K., Aug 15 2015, In : Journal of Immunology. 195, 4, p. 1868-1882 15 p.

Research output: Contribution to journalArticle

Fluorouracil
Colon
Carcinoma
Immune Evasion
decitabine
5 Citations (Scopus)

Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in Chinese Holstein

Huang, P., Lu, C., Li, J., Xu, J., Liu, Z., Wang, Q., Wang, Z., Huo, J., Li, H., Teng, Y. & Cai, Y., Mar 15 2015, In : Gene. 559, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

Mastitis
Mutation
Single Nucleotide Polymorphism
Genes
Secondary Protein Structure
19 Citations (Scopus)

The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

Simon, P. S., Sharman, S. K., Lu, C., Yang, D., Paschall, A. V., Tulachan, S. S. & Liu, K., Oct 23 2015, In : BMC Cancer. 15, 1, 770.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Myeloid Cells
Colon
Tumor Microenvironment
Carcinoma
40 Citations (Scopus)

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development

Cai, Y., Pi, W., Sivaprakasam, S., Zhu, X., Zhang, M., Chen, J., Makala, L. H., Lu, C., Wu, J., Teng, Y., Pace, B. S., Tuan Lo, D., Singh, N. & Li, H., Nov 1 2015, In : PLoS Genetics. 11, 11, e1005643.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
endoplasmic reticulum
Embryonic Development
Hematopoiesis
Hematopoietic Stem Cells
2016
12 Citations (Scopus)

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

Paschall, A. V., Yang, D., Lu, C., Redd, P. S., Choi, J-H., Heaton, C. M., Lee, J. R., Nayak, A. & Liu, K., Jan 1 2016, In : Oncotarget. 7, 48, p. 78698-78712 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Fluorouracil
Colonic Neoplasms
Phenotype
Gene Expression
25 Citations (Scopus)

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloidderived suppressor cells

Liu, F., Li, X., Lu, C., Bai, A., Bielawski, J., Bielawska, A., Marshall, B., Schoenlein, P. V., Lebedyeva, I. O. & Liu, K., Jan 1 2016, In : Oncotarget. 7, 51, p. 83907-83925 19 p.

Research output: Contribution to journalArticle

Cathepsin B
Cathepsin D
Ceramides
Autophagy
Apoptosis
8 Citations (Scopus)

Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

Coe, G. L., Redd, P. S., Paschall, A. V., Lu, C., Gu, L., Cai, H., Albers, T., Lebedyeva, I. O. & Liu, K., Aug 4 2016, In : Scientific Reports. 6, 30816.

Research output: Contribution to journalArticle

Caspase 8
Ceramides
Cytotoxic T-Lymphocytes
Colon
Carcinoma
5 Citations (Scopus)

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression

Simon, P. S., Bardhan, K., Chen, M. R., Paschall, A. V., Lu, C., Bollag, R. J., Kong, F. C., Jin, J. Y., Kong, F. M., Waller, J. L., Pollock, R. E. & Liu, K., Apr 26 2016, In : Oncotarget. 7, 17, p. 23395-23415 21 p.

Research output: Contribution to journalArticle

Th1 Cells
Tumor Microenvironment
Radiation
T-Lymphocytes
Neoplasms
45 Citations (Scopus)

The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells

Lu, C., Redd, P. S., Lee, J. R., Savage, N. M. & Liu, K., Dec 1 2016, In : OncoImmunology. 5, 12, e1247135.

Research output: Contribution to journalArticle

Ligands
Neoplasms
Tumor Microenvironment
Myeloid-Derived Suppressor Cells
Microsatellite Repeats
2017
26 Citations (Scopus)
Cytotoxic T-Lymphocytes
Lymphocyte Activation
Pancreatic Neoplasms
Immunotherapy
Inflammation
40 Citations (Scopus)

The MLL1-H3K4me3 axis-mediated PD-L1 expression and pancreatic cancer immune evasion

Lu, C., Paschall, A. V., Shi, H., Savage, N., Waller, J. L., Sabbatini, M. E., Oberlies, N. H., Pearce, C. & Liu, K., Jan 1 2017, In : Journal of the National Cancer Institute. 109, 6, djw283.

Research output: Contribution to journalArticle

Immune Evasion
Pancreatic Neoplasms
Cytotoxic T-Lymphocytes
Immunotherapy
Neoplasms
2018
5 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
5 Citations (Scopus)

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

Tumor Escape
Osteopontin
T-Lymphocytes
Immunotherapy
Colon
11 Citations (Scopus)
3 Citations (Scopus)

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

Redd, P. S., Lu, C., Klement, J. D., Ibrahim, M. L., Zhou, G., Kumai, T., Celis, E. & Liu, K., Sep 2 2018, In : OncoImmunology. 7, 9, e1483302.

Research output: Contribution to journalArticle

T-Lymphocytes
CD8 Antigens
Immunologic Monitoring
CD4 Antigens
T-Cell Antigen Receptor
5 Citations (Scopus)

IFNAR1 controls autocrine type I IFN regulation of PD-L1 expression in myeloid-derived suppressor cells

Xiao, W., Klement, J. D., Lu, C., Ibrahim, M. L. & Liu, K., Jul 1 2018, In : Journal of Immunology. 201, 1, p. 264-277 14 p.

Research output: Contribution to journalArticle

Ligands
Tumor Microenvironment
Myeloid-Derived Suppressor Cells
Neoplasms
Up-Regulation
4 Citations (Scopus)

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

Ibrahim, M. L., Klement, J. D., Lu, C., Redd, P. S., Xiao, W., Yang, D., Browning, D. D., Savage, N. M., Buckhaults, P. J., Morse, H. C. & Liu, K., Dec 11 2018, In : Cell Reports. 25, 11, p. 3036-3046.e6

Research output: Contribution to journalArticle

Colitis
Interleukin-10
Colon
Carcinogenesis
Inflammation
2019
2 Citations (Scopus)

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., Browning, D. D., Liu, K., Blumberg, R., Singh, N. & Li, H., Dec 1 2019, In : Cell Discovery. 5, 1, 7.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Paneth Cells
Ubiquitin
Homeostasis
Inflammation
2 Citations (Scopus)

Loss of fas expression and function is coupled with colon cancer resistance to immune checkpoint inhibitor immunotherapy

Xiao, W., Ibrahim, M. L., Redd, P. S., Klement, J. D., Lu, C., Yang, D., Savage, N. M. & Liu, K., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 420-430 11 p.

Research output: Contribution to journalArticle

Immunotherapy
Colonic Neoplasms
Microsatellite Repeats
Neoplastic Stem Cells
Apoptosis
1 Citation (Scopus)

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 1 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

Tumor Escape
Cytotoxic T-Lymphocytes
Colon
Tumor Microenvironment
Microsatellite Repeats

Type i interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Lu, C., Klement, J. D., Ibrahim, M. L., Xiao, W., Redd, P. S., Nayak, A., Zhou, G. & Liu, K., Jun 22 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 157.

Research output: Contribution to journalArticle

Open Access
Granzymes
Cytotoxic T-Lymphocytes
Interferons
Growth
Neoplasms