• 2136 Citations
  • 21 h-Index
1988 …2019
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Research Output 1988 2019

  • 2136 Citations
  • 21 h-Index
  • 32 Article
  • 3 Review article
  • 1 Comment/debate
2019

Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin

Folk, W. P., Kumari, A., Iwasaki, T., Pyndiah, S., Johnson, J. C., Cassimere, E. K., Abdulovic-Cui, A. L. & Sakamuro, D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5700-5719 20 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Nuclear Proteins
Cisplatin
Tumors
Phosphotransferases
2018
2 Citations (Scopus)

Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells

Prusinski Fernung, L., Yang, Q., Sakamuro, D., Kumari, A., Mas, A. & Al-Hendy, A., Oct 1 2018, In : Biology of reproduction. 99, 4, p. 735-748 14 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Leiomyoma
DNA Repair
Stem Cells
Incidence
2017
5 Citations (Scopus)

The dual roles of MYC in genomic instability and cancer chemoresistance

Kumari, A., Folk, W. P. & Sakamuro, D., Jun 7 2017, In : Genes. 8, 6, 158.

Research output: Contribution to journalReview article

Genomic Instability
Neoplasms
Double-Stranded DNA Breaks
Histones
Cytoprotection
2015
14 Citations (Scopus)

Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation

Kumari, A., Iwasaki, T., Pyndiah, S., Cassimere, E. K., Palani, C. D. & Sakamuro, D., Feb 1 2015, In : Cell Death and Differentiation. 22, 2, p. 311-322 12 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Apoptosis
Starvation
Serum
DNA Damage

Restoration of tumor suppressor functions by small-molecule inhibitors

Pyndiah, S. & Sakamuro, D., Jul 3 2015, In : Molecular and Cellular Oncology. 2, 3, e991225.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
Neoplasms
Therapeutics
2 Citations (Scopus)

To die, or not to die: E2F1 never decides by itself during serum starvation

Sakamuro, D., Folk, W. P. & Kumari, A., Apr 3 2015, In : Molecular and Cellular Oncology. 2, 2, e981447.

Research output: Contribution to journalArticle

Starvation
Apoptosis
DNA Damage
Serum
Ataxia Telangiectasia
2013
5 Citations (Scopus)

Un trio de choc pour pallier la chimiorésistance des cancers c-MYC, PARP1, BIN1

Translated title of the contribution: C-MYC, PARP1 and BIN1 as targets for therapy of cancer cell resistancePyndiah, S. & Sakamuro, D., Feb 1 2013, In : Medecine/Sciences. 29, 2, p. 133-135 3 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Proto-Oncogene Proteins c-myc
Tumor Suppressor Proteins
Poly(ADP-ribose) Polymerases
Nuclear Proteins
2012
43 Citations (Scopus)

Mechanisms of cisplatin-induced apoptosis and of cisplatin sensitivity: Potential of BIN1 to act as a potent predictor of cisplatin sensitivity in gastric cancer treatment

Tanida, S., Mizoshita, T., Ozeki, K., Tsukamoto, H., Kamiya, T., Kataoka, H., Sakamuro, D. & Joh, T., Sep 18 2012, In : International Journal of Surgical Oncology. 2012, 862879.

Research output: Contribution to journalReview article

Cisplatin
Stomach Neoplasms
Apoptosis
DNA Damage
DNA Repair
2011
55 Citations (Scopus)

c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: A mechanism by which cancer cells acquire cisplatin resistance

Pyndiah, S., Tanida, S., Ahmed, K. M., Cassimere, E. K., Choe, C. & Sakamuro, D., Mar 29 2011, In : Science Signaling. 4, 166, ra19.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Cisplatin
Cells
Neoplasms
Genes
8 Citations (Scopus)

Identification of a novel effector domain of BIN1 for cancer suppression

Lundgaard, G. L., Daniels, N. E., Pyndiah, S., Cassimere, E. K., Ahmed, K. M., Rodrigue, A., Kihara, D., Post, C. B. & Sakamuro, D., Oct 1 2011, In : Journal of cellular biochemistry. 112, 10, p. 2992-3001 10 p.

Research output: Contribution to journalArticle

Peptides
Trypsin
Neoplasms
Tumor Suppressor Proteins
Proteins
2009
22 Citations (Scopus)

The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage

Cassimere, E. K., Pyndiah, S. & Sakamuro, D., Jul 27 2009, In : Cell Death and Differentiation. 16, 12, p. 1641-1653 13 p.

Research output: Contribution to journalArticle

DNA Damage
Etoposide
Apoptosis
Neoplasms
Cell Death
2008
14 Citations (Scopus)

Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism

Kinney, E. L., Tanida, S., Rodrigue, A. A., Johnson, J. K., Tompkins, V. S. & Sakamuro, D., Sep 1 2008, In : Journal of Cellular Physiology. 216, 3, p. 621-631 11 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Cell proliferation
Fibroblasts
Adenoviridae
Small Interfering RNA
2007
18 Citations (Scopus)

Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival

Ghaneie, A., Zemba-Palko, V., Itoh, H., Itoh, K., Sakamuro, D., Nakamura, S., Soler, A. P. & Prendergast, G. C., Jan 1 2007, In : Cancer Biology and Therapy. 6, 2, p. 192-194 3 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Survival
Neoplastic Cell Transformation
Modifier Genes
7 Citations (Scopus)
Apoptosis
Ligands
Carcinoma
Kidney
CD95 Antigens
2001
64 Citations (Scopus)

Bin1 mediates apoptosis by c-Myc in transformed primary cells

DuHadaway, J. B., Sakamuro, D., Ewert, D. L. & Prendergast, G. C., Apr 1 2001, In : Cancer Research. 61, 7, p. 3151-3156 6 p.

Research output: Contribution to journalArticle

Cell Death
Capital Punishment
Apoptosis
Tumor Suppressor Proteins
Genes
2000
74 Citations (Scopus)

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

Ge, K., Duhadaway, J., Sakamuro, D., Wechsler-Reya, R., Reynolds, C. & Prendergast, G. C., Jan 17 2000, In : International Journal of Cancer. 85, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

Cell Death
Breast Neoplasms
Estrogen Receptors
Breast
Neoplasms
77 Citations (Scopus)

Loss of heterozygosity and tumor suppressor activity of BIN1 in prostate carcinoma

Ge, K., Minhas, F., Duhadaway, J., Mao, N. C., Wilson, D., Buccafusca, R., Sakamuro, D., Nelson, P., Malkowicz, S. B., Tomaszewski, J. & Prendergast, G. C., Apr 12 2000, In : International Journal of Cancer. 86, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Prostate
Carcinoma
Prostatic Neoplasms
Neoplasms
1999
88 Citations (Scopus)

Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms

Elliott, K., Sakamuro, D., Basu, A., Du, W., Wunner, W., Staller, P., Gaubatz, S., Zhang, H., Prochownik, E., Eilers, M. & Prendergast, G. C., Jun 17 1999, In : Oncogene. 18, 24, p. 3564-3573 10 p.

Research output: Contribution to journalArticle

Cell Proliferation
Ornithine Decarboxylase
Growth
Transcriptional Activation
myc Genes
142 Citations (Scopus)

New Myc-interacting proteins: A second Myc network emerges

Sakamuro, D. & Prendergast, G. C., May 13 1999, In : Oncogene. 18, 19, p. 2942-2954 13 p.

Research output: Contribution to journalReview article

Staphylococcal Protein A
Apoptosis
Cell Cycle
Proto-Oncogene Proteins c-myc
Retinoblastoma Protein
1997
174 Citations (Scopus)

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment

Lebowitz, P. F., Sakamuro, D. & Prendergast, G. C., Mar 3 1997, In : Cancer Research. 57, 4, p. 708-713 6 p.

Research output: Contribution to journalArticle

Transferases
Apoptosis
L 739749
Antineoplastic Agents
Neoplasms
104 Citations (Scopus)

Structural analysis of the human BIN1 gene: Evidence for tissue-specific transcriptional regulation and alternate RNA splicing

Wechsler-Reya, R., Sakamuro, D., Zhang, J., Duhadaway, J. & Prendergast, G. C., Dec 12 1997, In : Journal of Biological Chemistry. 272, 50, p. 31453-31458 6 p.

Research output: Contribution to journalArticle

RNA Splicing
Alternative Splicing
Structural analysis
Exons
Genes
232 Citations (Scopus)

The polyproline region of p53 is required to activate apoptosis but not growth arrest

Sakamuro, D., Sabbatini, P., White, E. & Prendergast, G. C., Jan 1 1997, In : Oncogene. 15, 8, p. 887-898 12 p.

Research output: Contribution to journalArticle

Apoptosis
Growth
Transcriptional Activation
polyproline
DNA
1996
270 Citations (Scopus)

BIN1 is a novel MYC-interacting protein with features of a tumour suppressor

Sakamuro, D., Elliott, K. J., Wechsler-Reya, R. & Prendergast, G. C., Sep 1 1996, In : Nature Genetics. 14, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Proteins
Oncogene Proteins
Cell Cycle Checkpoints
46 Citations (Scopus)

Detection of a unique γ-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma

Tsutsumi, M., Sakamuro, D., Takada, A., Zang, S. C., Furukawa, T. & Taniguchi, N., Jan 1 1996, In : Hepatology. 23, 5, p. 1093-1097 5 p.

Research output: Contribution to journalArticle

gamma-Glutamyltransferase
Early Diagnosis
Hepatocellular Carcinoma
Messenger RNA
RNA
22 Citations (Scopus)

The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization

Negorev, D., Riethman, H., Wechsler-Reya, R., Sakamuro, D., Prendergast, G. C. & Simon, D., Apr 15 1996, In : Genomics. 33, 2, p. 329-331 3 p.

Research output: Contribution to journalArticle

Hybrid Cells
Human Chromosomes
Fluorescence In Situ Hybridization
Polymerase Chain Reaction
Genes
1995
152 Citations (Scopus)

c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms

Sakamuro, D., Eviner, V., Elliott, K. J., Showe, L., White, E. & Prendergast, G. C., Dec 7 1995, In : Oncogene. 11, 11, p. 2410-2418 9 p.

Research output: Contribution to journalArticle

Epithelial Cells
Apoptosis
Temperature
Cell Death
G1 Phase Cell Cycle Checkpoints
273 Citations (Scopus)

Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells

Sakamuro, D., Furukawa, T. & Takegami, T., Jan 1 1995, In : Journal of Virology. 69, 6, p. 3893-3896 4 p.

Research output: Contribution to journalArticle

NIH 3T3 Cells
Hepatitis C virus
Hepacivirus
Complementary DNA
Genome
36 Citations (Scopus)

Japanese encephalitis virus nonstructural protein NS3 has RNA binding and ATPase activities

Takegami, T., Sakamuro, D. & Furukawa, T., Jan 1 1995, In : Virus Genes. 9, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

Japanese Encephalitis Virus
Adenosine Triphosphatases
RNA
Proteins
Viral RNA
1994
23 Citations (Scopus)

Detection of human cytomegalovirus genome in uterus tissue

Furukawa, T., Jisaki, F., Sakamuro, D., Takegami, T. & Murayama, T., Sep 1 1994, In : Archives of Virology. 135, 3-4, p. 265-277 13 p.

Research output: Contribution to journalArticle

Human Genome
Cytomegalovirus
Uterus
Cytomegalovirus Infections
Antigens
11 Citations (Scopus)

Different antibody response to a neutralizing epitope of human cytomegalovirus glycoprotein B among seropositive individuals

Ayata, M., Sugano, T., Murayama, T., Sakamuro, D., Takegami, T., Matsumoto, YI. I. & Furukawa, T., Jan 1 1994, In : Journal of Medical Virology. 43, 4, p. 386-392 7 p.

Research output: Contribution to journalArticle

Antibody Formation
Epitopes
Monoclonal Antibodies
Viral Fusion Proteins
Passive Immunization
10 Citations (Scopus)

Elevated cytokine levels in synovial fluid of rheumatoid arthritis correlates with the presence of cytomegalovirus genome

Murayama, T., Tsuchiya, N., Jisaki, F., Ozaki, M., Sakamuro, D., Hirai, K., Shimizu, S., Ito, K., Matsushima, K. & Furukawa, T., Jan 1 1994, In : Autoimmunity. 17, 4, p. 333-337 5 p.

Research output: Contribution to journalArticle

Synovial Fluid
Cytomegalovirus
Rheumatoid Arthritis
Genome
Cytokines
57 Citations (Scopus)

Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

Murayama, T., Kuno, K., Jisaki, F., Obuchi, M., Sakamuro, D., Furukawa, T., Mukaida, N. & Matsushima, K., Nov 1 1994, In : Journal of Virology. 68, 11, p. 7582-7585 4 p.

Research output: Contribution to journalComment/debate

Human herpesvirus 5
Cytomegalovirus
interleukin-8
Interleukin-8
fibroblasts
1992
21 Citations (Scopus)

Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients

Murayama, T., Jisaki, F., Ayata, M., Sakamuro, D., Hironaka, T., Hirai, K., Tsuchiya, N., Ito, K. & Furukawa, T., Jan 1 1992, In : Clinical and Experimental Rheumatology. 10, 2, p. 161-164 4 p.

Research output: Contribution to journalArticle

Synovial Fluid
Cytomegalovirus
Rheumatoid Arthritis
Genome
Polymerase Chain Reaction
1990
10 Citations (Scopus)

Synthesis of human gamma-glutamyl transpeptidase (GGT) during the fetal development of liver

Shiozawa, M., Hiraoka, Y., Yasuda, K., Imamura, T., Sakamuro, D., Taniguchi, N., Yamazoe, M. & Yoshikawa, H., Mar 15 1990, In : Gene. 87, 2, p. 299-303 5 p.

Research output: Contribution to journalArticle

gamma-Glutamyltransferase
Fetal Development
Liver
Messenger RNA
Bile Canaliculi
1988
2 Citations (Scopus)

Polymorphonuclear cell factor found in patients with rheumatoid arthritis

Wakitani, S., Sakamuro, D., Ochi, T., Owaki, H., Fujimoto, M. & Ono, K., Jan 1 1988, In : Biomedical Research. 9, 5, p. 395-399 5 p.

Research output: Contribution to journalArticle

Collagenases
Rheumatoid Arthritis
Bone
Blood
Fluids
53 Citations (Scopus)

The primary structure of human gamma-glutamyl transpeptidase

Sakamuro, D., Mitsuyoshi, Y., Yukihiko, M., Kenji, K., Naoyuki, T., Hisayuki, M., Hiroshi, Y. & Naotake, O., Dec 15 1988, In : Gene. 73, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

gamma-Glutamyltransferase
Complementary DNA
Light
Amino Acids
Amino Acid Sequence