David C Hess

EVP, Med Affairs & Dean, MCG

  • 11106 Citations
  • 58 h-Index
1989 …2020

Research output per year

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Research Output

2012

Minocycline Prevents IL-6 Increase after Acute Ischemic Stroke

Switzer, J. A., Sikora, A., Ergul, A., Waller, J. L., Hess, D. C. & Fagan, S. C., Sep 1 2012, In : Translational Stroke Research. 3, 3, p. 364-368 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Permeating the blood brain barrier and Abrogating the inflammation in stroke: Implications for stroke therapy

Borlongan, C. V., Glover, L. E., Sanberg, P. R. & Hess, D. C., Oct 22 2012, In : Current Pharmaceutical Design. 18, 25, p. 3670-3676 7 p.

Research output: Contribution to journalReview article

37 Scopus citations

Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke

Hoda, M. N., Siddiqui, S., Herberg, S., Periyasamy-Thandavan, S., Bhatia, K., Hafez, S. S., Johnson, M. H., Hill, W. D., Ergul, A., Fagan, S. C. & Hess, D. C., Oct 1 2012, In : Stroke. 43, 10, p. 2794-2799 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
2011

Cell therapy for ischaemic stroke

Hess, D. C. & Hill, W. D., Apr 1 2011, In : Cell Proliferation. 44, SUPPL. 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
15 Scopus citations

Impact of systems of care and blood pressure management on stroke outcomes

Shulkin, D. J., Jewell, K. E., Alexandrov, A. W., Bernard, D. B., Brophy, G. M., Hess, D. C., Kohlbrenner, J., Martin-Schild, S., Mayer, S. A., Peacock, W. F., Qureshi, A. I., Sung, G. Y. & Lyles, A., Dec 1 2011, In : Population Health Management. 14, 6, p. 267-275 9 p.

Research output: Contribution to journalArticle

Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke

Switzer, J. A., Hess, D. C., Ergul, A., Waller, J. L., MacHado, L. S., Portik-Dobos, V., Pettigrew, L. C., Clark, W. M. & Fagan, S. C., Sep 1 2011, In : Stroke. 42, 9, p. 2633-2635 3 p.

Research output: Contribution to journalArticle

73 Scopus citations

Minocycline Development for Acute Ischemic Stroke

Fagan, S. C., Cronic, L. E. & Hess, D. C., Jun 1 2011, In : Translational Stroke Research. 2, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

Recent advances in basic and translational stroke research

Boltze, J., Kranz, A., Wagner, D. C., Reymann, K., Reiser, G. & Hess, D. C., Feb 1 2011, In : Expert Review of Neurotherapeutics. 11, 2, p. 199-202 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke

Hoda, M. N., Li, W., Ahmad, A., Ogbi, S., Zemskova, M. A., Johnson, M. H., Ergul, A., Hill, W. D., Hess, D. C. & Sazonova, I. Y., Dec 16 2011, In : Experimental and Translational Stroke Medicine. 3, 1, 16.

Research output: Contribution to journalArticle

42 Scopus citations

Simplified modified rankin scale questionnaire: Reproducibility over the telephone and validation with quality of life

Bruno, A., Akinwuntan, A. E., Lin, C., Close, B., Davis, K., Baute, V., Aryal, T., Brooks, D., Hess, D. C., Switzer, J. A. & Nichols, F. T., Aug 1 2011, In : Stroke. 42, 8, p. 2276-2279 4 p.

Research output: Contribution to journalArticle

104 Scopus citations

Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II

Savitz, S. I., Chopp, M., Deans, R., Carmichael, S. T., Phinney, D., Wechsler, L., Aronowski, J., Bednar, M., Boltze, J., Borlongan, C., Chase, T., Corbett, D., Cox, C. S., Cramer, S., Fischkoff, S., Frank, J., Greenberg, D., Hess, D., Hong, K., Koga, M. & 15 others, Jones, T., Keating, A., Kokaia, Z., Mays, R., Mora, K., Pittenger, M., Sanberg, P., Schallert, T., Sinden, J., Snyder, E., Steinberg, G., Victor, S., Willing, A., Yankee, E. & Yavagal, D., Mar 1 2011, In : Stroke. 42, 3, p. 825-829 5 p.

Research output: Contribution to journalReview article

179 Scopus citations

Stroke telepresence: Removing all geographic barriers

Hess, D. C. & Switzer, J. A., Mar 29 2011, In : Neurology. 76, 13, p. 1121-1123 3 p.

Research output: Contribution to journalEditorial

10 Scopus citations

Stroke treatment academic industry roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies

Albers, G. W., Goldstein, L. B., Hess, D. C., Wechsler, L. R., Furie, K. L., Gorelick, P. B., Hurn, P., Liebeskind, D. S., Nogueira, R. G. & Saver, J. L., Sep 1 2011, In : Stroke. 42, 9, p. 2645-2650 6 p.

Research output: Contribution to journalReview article

131 Scopus citations

Treatment of fever after stroke: Conflicting evidence

Wrotek, S. E., Kozak, W. E., Hess, D. C. & Fagan, S. C., Nov 1 2011, In : Pharmacotherapy. 31, 11, p. 1085-1091 7 p.

Research output: Contribution to journalReview article

26 Scopus citations
15 Scopus citations

Wisdom and determination in the ongoing pursuit of the ever-elusive neuroprotective agent

Howard, G., Hess, D. C. & Howard, V. J., Jun 1 2011, In : Stroke. 42, 6, p. 1505-1506 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2010

A telestroke network enhances recruitment into acute stroke clinical trials

Switzer, J. A., Hall, C. E., Close, B., Nichols, F. T., Gross, H., Bruno, A. & Hess, D. C., Mar 1 2010, In : Stroke. 41, 3, p. 566-569 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Mays, R. W., Borlongan, C. V., Yasuhara, T., Hara, K., Maki, M., Carroll, J. E., Deans, R. J. & Hess, D. C., 2010, In : Journal of Experimental Stroke and Translational Medicine. 3, 1, p. 34-46 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Improving modified rankin scale assessment with a simplified questionnaire

Bruno, A., Shah, N., Lin, C., Close, B., Hess, D. C., Davis, K., Baute, V., Switzer, J. A., Waller, J. L. & Nichols, F. T., May 1 2010, In : Stroke. 41, 5, p. 1048-1050 3 p.

Research output: Contribution to journalArticle

82 Scopus citations

Minocycline to Improve Neurologic Outcome in Stroke (MINOS): A dose-finding study

Fagan, S. C., Waller, J. L., Nichols, F. T., Edwards, D. J., Pettigrew, L. C., Clark, W. M., Hall, C. E., Switzer, J. A., Ergul, A. & Hess, D. C., Oct 1 2010, In : Stroke. 41, 10, p. 2283-2287 5 p.

Research output: Contribution to journalArticle

155 Scopus citations

Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse

Masuda, T., Maki, M., Hara, K., Yasuhara, T., Matsukawa, N., Yu, S., Bae, E. C., Tajiri, N., Chheda, S. H., Solomita, M. A., Weinbren, N., Kaneko, Y., Kirov, S. A., Hess, D. C., Hida, H. & Borlongan, C. V., Oct 8 2010, In : Brain Research. 1355, p. 228-239 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
4 Scopus citations

Repurposing an old drug to improve the use and safety of tissue plasminogen activator for acute ischemic stroke: Minocycline

Hess, D. C. & Fagan, S. C., Jul 1 2010, In : Pharmacotherapy. 30, 7 PART 2, p. 55S-61S

Research output: Contribution to journalReview article

15 Scopus citations

Toward cell therapy using placenta-derived cells: Disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table

Parolini, O., Alviano, F., Bergwerf, I., Boraschi, D., De Bari, C., De Waele, P., Dominici, M., Evangelista, M., Falk, W., Hennerbichler, S., Hess, D. C., Lanzoni, G., Liu, B., Marongiu, F., McGuckin, C., Mohr, S., Nolli, M. L., Ofir, R., Ponsaerts, P., Romagnoli, L. & 10 others, Solomon, A., Soncini, M., Strom, S., Surbek, D., Venkatachalam, S., Wolbank, S., Zeisberger, S., Zeitlin, A., Zisch, A. & Borlongan, C. V., Feb 1 2010, In : Stem Cells and Development. 19, 2, p. 143-154 12 p.

Research output: Contribution to journalReview article

107 Scopus citations
2009

Amnion: A potent graft source for cell therapy in stroke

Seong, J. Y., Soncini, M., Kaneko, Y., Hess, D. C., Parolini, O. & Borlongan, C. V., Jun 16 2009, In : Cell Transplantation. 18, 2, p. 111-118 8 p.

Research output: Contribution to journalReview article

70 Scopus citations

Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Yamashima, T., Buccafusco, J. J., Kawase, T., Hess, D. C. & Borlongan, C. V., Aug 25 2009, In : Brain Research. 1286, p. 185-191 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
76 Scopus citations

Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential.

Machado, L. S., Sazonova, I. Y., Kozak, A., Wiley, D. C., El-Remessy, A. B., Ergul, A., Hess, D. C., Waller, J. L. & Fagan, S. C., Sep 2009, In : Stroke; a journal of cerebral circulation. 40, 9, p. 3028-3033 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Systemic delivery of umbilical cord blood cells for stroke therapy: A review

Yu, G., Borlongan, C. V., Stahl, C. E., Hess, D. C., Ou, Y., Kaneko, Y., Yu, S. J., Yang, T., Fang, L. & Xie, X., Feb 20 2009, In : Restorative Neurology and Neuroscience. 27, 1, p. 41-54 14 p.

Research output: Contribution to journalReview article

28 Scopus citations

Telestroke 10 years later - 'telestroke 2.0'

Switzer, J. A., Levine, S. R. & Hess, D. C., Sep 1 2009, In : Cerebrovascular Diseases. 28, 4, p. 323-330 8 p.

Research output: Contribution to journalReview article

27 Scopus citations

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

Matsukawa, N., Yasuhara, T., Hara, K., Xu, L., Maki, M., Yu, G., Kaneko, Y., Ojika, K., Hess, D. C. & Borlongan, C. V., Oct 6 2009, In : BMC Neuroscience. 10, 1 p., 1471.

Research output: Contribution to journalArticle

102 Scopus citations

Who's in favor of translational cell therapy for stroke: STEPS forward please?

Chopp, M., Steinberg, G. K., Kondziolka, D., Lu, M., Bliss, T. M., Li, Y., Hess, D. C. & Borlongan, C. V., Nov 9 2009, In : Cell Transplantation. 18, 7, p. 691-693 3 p.

Research output: Contribution to journalComment/debate

39 Scopus citations
2008

Carotid endarterectomy - An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

Chaturvedi, S., Bruno, A., Feasby, T., Holloway, R., Benavente, O., Cohen, S. N., Cote, R., Hess, D., Saver, J., Spence, J. D., Stern, B. & Wilterdink, J., Feb 1 2008, In : CONTINUUM Lifelong Learning in Neurology. 14, 1, p. 197-204 8 p.

Research output: Contribution to journalArticle

Cell-based therapy in ischemic stroke

Hess, D. C. & Borlongan, C. V., Aug 1 2008, In : Expert Review of Neurotherapeutics. 8, 8, p. 1193-1201 9 p.

Research output: Contribution to journalReview article

87 Scopus citations

Development of regional programs to speed treatment of stroke

Switzer, J. A. & Hess, D. C., Jan 1 2008, In : Current Neurology and Neuroscience Reports. 8, 1, p. 35-42 8 p.

Research output: Contribution to journalReview article

15 Scopus citations

Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats

Yasuhara, T., Hara, K., Maki, M., Mays, R. W., Deans, R. J., Hess, D. C., Carroll, J. E. & Borlongan, C. V., Nov 1 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 11, p. 1804-1810 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Masuda, T., Yu, S. J., Ali, M., Yu, G., Xu, L., Kim, S. U., Hess, D. C. & Borlongan, C. V., Jul 1 2008, In : Progress in Neurobiology. 85, 3, p. 318-334 17 p.

Research output: Contribution to journalReview article

78 Scopus citations

Potential of stem/progenitor cells in treating stroke: The missing steps in translating cell therapy from laboratory to clinic

Borlongan, C. V., Chopp, M., Steinberg, G. K., Bliss, T. M., Li, Y., Lu, M., Hess, D. C. & Kondziolka, D., Dec 1 2008, In : Regenerative Medicine. 3, 3, p. 249-250 2 p.

Research output: Contribution to journalEditorial

64 Scopus citations

Rural-urban differences in acute stroke management practices: A modifiable disparity

Leira, E. C., Hess, D. C., Torner, J. C. & Adams, H. P., Jul 1 2008, In : Archives of Neurology. 65, 7, p. 887-891 5 p.

Research output: Contribution to journalReview article

78 Scopus citations

Stem cells and neurological diseases

Hess, D. C. & Borlongan, C. V., Feb 1 2008, In : Cell Proliferation. 41, S1, p. 94-114 21 p.

Research output: Contribution to journalArticle

179 Scopus citations
2007

An analysis of business issues in a telestroke project

Cho, S., Khasanshina, E. V., Mathiassen, L., Hess, D. C., Wang, S. & Stachura, M. E., Jul 1 2007, In : Journal of Telemedicine and Telecare. 13, 5, p. 257-262 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Carotid stenosis: Endarterectomy or angioplasty and stenting?

Switzer, J. A. & Hess, D. C., Nov 1 2007, In : Current Treatment Options in Neurology. 9, 6, p. 451-462 12 p.

Research output: Contribution to journalReview article

1 Scopus citations

Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: A pilot study

Hara, K., Yasuhara, T., Matsukawa, N., Maki, M., Masuda, T., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Kawase, T., Yamashima, T., Buccafusco, J. J., Hess, D. C. & Borlongan, C. V., Sep 14 2007, In : Brain Research Bulletin. 74, 1-3, p. 164-171 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Issues pertaining to the critiques of the SAINT-I trial [1]

Fisher, M., Hess, D. C. & Lees, K., Nov 1 2007, In : Stroke. 38, 11, p. e126-e127

Research output: Contribution to journalLetter

1 Scopus citations

National rollout of a web based telemedicine stroke care service: REACH 2.0

Hess, D. C. & Agate, S. J., Dec 1 2007, Proceedings of the 3rd IASTED International Conference on Telehealth, Telehealth 2007. p. 188-192 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic Factor Therapy and Neuroprotection

Borlongan, C. V., Stahl, C. E., Yu, G., Xu, L., Yasuhara, T., Hara, K., Matsukawa, N., Sanberg, P. R., Wang, Y. & Hess, D. C., Dec 1 2007, Cellular Transplantation. Elsevier Inc., p. 353-371 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Stroke, with or with no ice? Observations on amphetamine for the management of acute stroke

Borlongan, C. V. & Hess, D. C., Aug 1 2007, In : Journal of Human Hypertension. 21, 8, p. 594-597 4 p.

Research output: Contribution to journalComment/debate

1 Scopus citations