David C Hess

EVP, Med Affairs & Dean, MCG

  • 10663 Citations
  • 57 h-Index
1989 …2019
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Research Output 1989 2019

2011
57 Citations (Scopus)

Minocycline Development for Acute Ischemic Stroke

Fagan, S. C., Cronic, L. E. & Hess, D. C., Jun 1 2011, In : Translational Stroke Research. 2, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

Minocycline
Stroke
Clinical Trials
Neuroprotective Agents
Tissue Plasminogen Activator
4 Citations (Scopus)

Recent advances in basic and translational stroke research

Boltze, J., Kranz, A., Wagner, D. C., Reymann, K., Reiser, G. & Hess, D. C., Feb 1 2011, In : Expert Review of Neurotherapeutics. 11, 2, p. 199-202 4 p.

Research output: Contribution to journalArticle

Translational Medical Research
Stroke
Cell- and Tissue-Based Therapy
Regeneration
Research
Minocycline
Matrix Metalloproteinase 9
Stroke
41 Citations (Scopus)

Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke

Hoda, MD. N., Li, W., Ahmad, A., Ogbi, S., Zemskova, M. A., Johnson, M. H., Ergul, A., Hill, W. D., Hess, D. C. & Sazonova, I. Y., Dec 16 2011, In : Experimental and Translational Stroke Medicine. 3, 1, 16.

Research output: Contribution to journalArticle

Minocycline
Stroke
Matrix Metalloproteinases
Cerebrovascular Circulation
Neuroprotection
92 Citations (Scopus)

Simplified modified rankin scale questionnaire: Reproducibility over the telephone and validation with quality of life

Bruno, A., Akinwuntan, A. E., Lin, C., Close, B., Davis, K., Baute, V., Aryal, T., Brooks, D., Hess, D. C., Switzer, J. A. & Nichols, F. T., Aug 1 2011, In : Stroke. 42, 8, p. 2276-2279 4 p.

Research output: Contribution to journalArticle

Telephone
Quality of Life
Stroke
Neurology
Reproducibility of Results
176 Citations (Scopus)

Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II

Savitz, S. I., Chopp, M., Deans, R., Carmichael, S. T., Phinney, D., Wechsler, L., Aronowski, J., Bednar, M., Boltze, J., Borlongan, C., Chase, T., Corbett, D., Cox, C. S., Cramer, S., Fischkoff, S., Frank, J., Greenberg, D., Hess, D., Hong, K., Koga, M. & 15 others, Jones, T., Keating, A., Kokaia, Z., Mays, R., Mora, K., Pittenger, M., Sanberg, P., Schallert, T., Sinden, J., Snyder, E., Steinberg, G., Victor, S., Willing, A., Yankee, E. & Yavagal, D., Mar 1 2011, In : Stroke. 42, 3, p. 825-829 5 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Stem Cells
Stroke
Industry
National Institutes of Health (U.S.)
10 Citations (Scopus)

Stroke telepresence: Removing all geographic barriers

Hess, D. C. & Switzer, J. A., Mar 29 2011, In : Neurology. 76, 13, p. 1121-1123 3 p.

Research output: Contribution to journalEditorial

Stroke
131 Citations (Scopus)

Stroke treatment academic industry roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies

Albers, G. W., Goldstein, L. B., Hess, D. C., Wechsler, L. R., Furie, K. L., Gorelick, P. B., Hurn, P., Liebeskind, D. S., Nogueira, R. G. & Saver, J. L., Sep 1 2011, In : Stroke. 42, 9, p. 2645-2650 6 p.

Research output: Contribution to journalReview article

Industry
Stroke
Therapeutics
Reperfusion
Thrombolytic Therapy
21 Citations (Scopus)

Treatment of fever after stroke: Conflicting evidence

Wrotek, S. E., Kozak, W. E., Hess, D. C. & Fagan, S. C., Nov 1 2011, In : Pharmacotherapy. 31, 11, p. 1085-1091 7 p.

Research output: Contribution to journalReview article

Fever
Stroke
Body Temperature
Therapeutics
Patient Harm
13 Citations (Scopus)
Aircraft
Telemedicine
Stroke
X Ray Tomography
Therapeutics
2 Citations (Scopus)

Wisdom and determination in the ongoing pursuit of the ever-elusive neuroprotective agent

Howard, G., Hess, D. C. & Howard, V. J., Jun 1 2011, In : Stroke. 42, 6, p. 1505-1506 2 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Stroke
2010
38 Citations (Scopus)

A telestroke network enhances recruitment into acute stroke clinical trials

Switzer, J. A., Hall, C. E., Close, B., Nichols, F. T., Gross, H., Bruno, A. & Hess, D. C., Mar 1 2010, In : Stroke. 41, 3, p. 566-569 4 p.

Research output: Contribution to journalArticle

Telemedicine
Stroke
Clinical Trials
Referral and Consultation
Pharmaceutical Preparations
26 Citations (Scopus)

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Mays, R. W., Borlongan, C. V., Yasuhara, T., Hara, K., Maki, M., Carroll, J. E., Deans, R. J. & Hess, D. C., 2010, In : Journal of Experimental Stroke and Translational Medicine. 3, 1, p. 34-46 13 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem Cells
Stroke
Wounds and Injuries
Therapeutics
75 Citations (Scopus)

Improving modified rankin scale assessment with a simplified questionnaire

Bruno, A., Shah, N., Lin, C., Close, B., Hess, D. C., Davis, K., Baute, V., Switzer, J. A., Waller, J. L. & Nichols, F. T., May 1 2010, In : Stroke. 41, 5, p. 1048-1050 3 p.

Research output: Contribution to journalArticle

Stroke
Ambulatory Care Facilities
Outcome Assessment (Health Care)
Interviews
Surveys and Questionnaires
145 Citations (Scopus)

Minocycline to Improve Neurologic Outcome in Stroke (MINOS): A dose-finding study

Fagan, S. C., Waller, J. L., Nichols, F. T., Edwards, D. J., Pettigrew, L. C., Clark, W. M., Hall, C. E., Switzer, J. A., Ergul, A. & Hess, D. C., Oct 1 2010, In : Stroke. 41, 10, p. 2283-2287 5 p.

Research output: Contribution to journalArticle

Minocycline
Nervous System
Stroke
Tissue Plasminogen Activator
Half-Life
9 Citations (Scopus)

Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse

Masuda, T., Maki, M., Hara, K., Yasuhara, T., Matsukawa, N., Yu, S., Bae, E. C., Tajiri, N., Chheda, S. H., Solomita, M. A., Weinbren, N., Kaneko, Y., Kirov, S. A., Hess, D. C., Hida, H. & Borlongan, C. V., Oct 8 2010, In : Brain Research. 1355, p. 228-239 12 p.

Research output: Contribution to journalArticle

Collagenases
Hemorrhage
Cerebral Hemorrhage
Wounds and Injuries
Neurons
15 Citations (Scopus)

Repurposing an old drug to improve the use and safety of tissue plasminogen activator for acute ischemic stroke: Minocycline

Hess, D. C. & Fagan, S. C., Jul 1 2010, In : Pharmacotherapy. 30, 7 PART 2, p. 55S-61S

Research output: Contribution to journalReview article

Drug Repositioning
Minocycline
Tissue Plasminogen Activator
Stroke
Cerebral Hemorrhage
4 Citations (Scopus)
Drug Repositioning
Minocycline
Tissue Plasminogen Activator
Cerebral Hemorrhage
Stroke
105 Citations (Scopus)

Toward cell therapy using placenta-derived cells: Disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table

Parolini, O., Alviano, F., Bergwerf, I., Boraschi, D., De Bari, C., De Waele, P., Dominici, M., Evangelista, M., Falk, W., Hennerbichler, S., Hess, D. C., Lanzoni, G., Liu, B., Marongiu, F., McGuckin, C., Mohr, S., Nolli, M. L., Ofir, R., Ponsaerts, P., Romagnoli, L. & 10 others, Solomon, A., Soncini, M., Strom, S., Surbek, D., Venkatachalam, S., Wolbank, S., Zeisberger, S., Zeitlin, A., Zisch, A. & Borlongan, C. V., Feb 1 2010, In : Stem Cells and Development. 19, 2, p. 143-154 12 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Placenta
Cell Biology
Stem Cells
Regenerative Medicine
2009
68 Citations (Scopus)

Amnion: A potent graft source for cell therapy in stroke

Seong, J. Y., Soncini, M., Kaneko, Y., Hess, D. C., Parolini, O. & Borlongan, C. V., Jun 16 2009, In : Cell Transplantation. 18, 2, p. 111-118 8 p.

Research output: Contribution to journalReview article

Amnion
Cell- and Tissue-Based Therapy
Stem cells
Grafts
Stroke
4 Citations (Scopus)

Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Yamashima, T., Buccafusco, J. J., Kawase, T., Hess, D. C. & Borlongan, C. V., Aug 25 2009, In : Brain Research. 1286, p. 185-191 7 p.

Research output: Contribution to journalArticle

Macaca mulatta
Thoracic Aorta
Ischemia
Arteries
Brachiocephalic Trunk
74 Citations (Scopus)
Hospital Emergency Service
Stroke
Thrombolytic Therapy
Tissue Plasminogen Activator
Rural Population
73 Citations (Scopus)

Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential.

Machado, L. S., Sazonova, I. Y., Kozak, A., Wiley, D. C., El-Remessy, A. B., Ergul, A., Hess, D. C., Waller, J. L. & Fagan, S. C., Sep 2009, In : Stroke; a journal of cerebral circulation. 40, 9, p. 3028-3033 6 p.

Research output: Contribution to journalArticle

Minocycline
Tissue Plasminogen Activator
Plasminogen Activators
Stroke
Hemorrhage
26 Citations (Scopus)

Systemic delivery of umbilical cord blood cells for stroke therapy: A review

Yu, G., Borlongan, C. V., Stahl, C. E., Hess, D. C., Ou, Y., Kaneko, Y., Yu, S. J., Yang, T., Fang, L. & Xie, X., Feb 20 2009, In : Restorative Neurology and Neuroscience. 27, 1, p. 41-54 14 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Fetal Blood
Blood Cells
Stroke
Transplantation
26 Citations (Scopus)

Telestroke 10 years later - 'telestroke 2.0'

Switzer, J. A., Levine, S. R. & Hess, D. C., Sep 1 2009, In : Cerebrovascular Diseases. 28, 4, p. 323-330 8 p.

Research output: Contribution to journalReview article

Stroke
Occupational Health Physicians
Teleradiology
Videoconferencing
Physicians
95 Citations (Scopus)

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

Matsukawa, N., Yasuhara, T., Hara, K., Xu, L., Maki, M., Yu, G., Kaneko, Y., Ojika, K., Hess, D. C. & Borlongan, C. V., Oct 6 2009, In : BMC Neuroscience. 10, 1 p., 1471.

Research output: Contribution to journalArticle

Minocycline
Stroke
Cell Death
Neurological Models
Therapeutics
39 Citations (Scopus)

Who's in favor of translational cell therapy for stroke: STEPS forward please?

Chopp, M., Steinberg, G. K., Kondziolka, D., Lu, M., Bliss, T. M., Li, Y., Hess, D. C. & Borlongan, C. V., Nov 9 2009, In : Cell Transplantation. 18, 7, p. 691-693 3 p.

Research output: Contribution to journalComment/debate

Biotechnology
Cell- and Tissue-Based Therapy
Stem cells
Stroke
Industry
2008

Carotid endarterectomy - An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

Chaturvedi, S., Bruno, A., Feasby, T., Holloway, R., Benavente, O., Cohen, S. N., Cote, R., Hess, D. C., Saver, J., Spence, J. D., Stern, B. & Wilterdink, J., Feb 1 2008, In : CONTINUUM Lifelong Learning in Neurology. 14, 1, p. 197-204 8 p.

Research output: Contribution to journalArticle

Biomedical Technology Assessment
Carotid Endarterectomy
Pathologic Constriction
Endarterectomy
Stroke
83 Citations (Scopus)

Cell-based therapy in ischemic stroke

Hess, D. C. & Borlongan, C. V., Aug 1 2008, In : Expert Review of Neurotherapeutics. 8, 8, p. 1193-1201 9 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Stroke
Brain Injuries
Transplantation
Bone Marrow
15 Citations (Scopus)

Development of regional programs to speed treatment of stroke

Switzer, J. A. & Hess, D. C., Jan 1 2008, In : Current Neurology and Neuroscience Reports. 8, 1, p. 35-42 8 p.

Research output: Contribution to journalReview article

Program Development
Stroke
Thrombolytic Therapy
Therapeutics
Community Hospital
98 Citations (Scopus)

Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats

Yasuhara, T., Hara, K., Maki, M., Mays, R. W., Deans, R. J., Hess, D. C., Carroll, J. E. & Borlongan, C. V., Nov 1 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 11, p. 1804-1810 7 p.

Research output: Contribution to journalArticle

Stem Cells
Transplants
Transplantation
Wounds and Injuries
Cell- and Tissue-Based Therapy
70 Citations (Scopus)

Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Masuda, T., Yu, S. J., Ali, M., Yu, G., Xu, L., Kim, S. U., Hess, D. C. & Borlongan, C. V., Jul 1 2008, In : Progress in Neurobiology. 85, 3, p. 318-334 17 p.

Research output: Contribution to journalReview article

Teratocarcinoma
Stem Cells
Transplantation
Stroke
Cell Line
60 Citations (Scopus)

Potential of stem/progenitor cells in treating stroke: The missing steps in translating cell therapy from laboratory to clinic

Borlongan, C. V., Chopp, M., Steinberg, G. K., Bliss, T. M., Li, Y., Lu, M., Hess, D. C. & Kondziolka, D., Dec 1 2008, In : Regenerative Medicine. 3, 3, p. 249-250 2 p.

Research output: Contribution to journalEditorial

Stem Cell Transplantation
Cell- and Tissue-Based Therapy
Stem cells
Rats
Cell Differentiation
1 Citation (Scopus)
Geography
Fibrinolytic Agents
Tissue Plasminogen Activator
Rural Population
Neurology
72 Citations (Scopus)

Rural-urban differences in acute stroke management practices: A modifiable disparity

Leira, E. C., Hess, D. C., Torner, J. C. & Adams, H. P., Jul 1 2008, In : Archives of Neurology. 65, 7, p. 887-891 5 p.

Research output: Contribution to journalReview article

Practice Management
Stroke
Tertiary Healthcare
Emergency Medical Technicians
Patient Transfer
173 Citations (Scopus)

Stem cells and neurological diseases

Hess, D. C. & Borlongan, C. V., Feb 1 2008, In : Cell Proliferation. 41, S1, p. 94-114 21 p.

Research output: Contribution to journalArticle

Stem Cells
Cell- and Tissue-Based Therapy
Neural Stem Cells
Brain-Derived Neurotrophic Factor
Brain
2007
16 Citations (Scopus)

An analysis of business issues in a telestroke project

Cho, S., Khasanshina, E. V., Mathiassen, L., Hess, D. C., Wang, S. & Stachura, M. E., Jul 1 2007, In : Journal of Telemedicine and Telecare. 13, 5, p. 257-262 6 p.

Research output: Contribution to journalArticle

Rural Hospitals
Telemedicine
Negotiating
Tissue Plasminogen Activator
Stroke
1 Citation (Scopus)

Carotid stenosis: Endarterectomy or angioplasty and stenting?

Switzer, J. A. & Hess, D. C., Nov 1 2007, In : Current Treatment Options in Neurology. 9, 6, p. 451-462 12 p.

Research output: Contribution to journalReview article

Carotid Endarterectomy
Carotid Stenosis
Angioplasty
Pathologic Constriction
Endarterectomy
15 Citations (Scopus)

Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: A pilot study

Hara, K., Yasuhara, T., Matsukawa, N., Maki, M., Masuda, T., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Kawase, T., Yamashima, T., Buccafusco, J. J., Hess, D. C. & Borlongan, C. V., Sep 14 2007, In : Brain Research Bulletin. 74, 1-3, p. 164-171 8 p.

Research output: Contribution to journalArticle

Primates
Ischemia
Calpain
Hippocampus
Cathepsins
1 Citation (Scopus)

Issues pertaining to the critiques of the SAINT-I trial [1]

Fisher, M., Hess, D. C. & Lees, K., Nov 1 2007, In : Stroke. 38, 11, p. e126-e127

Research output: Contribution to journalLetter

Conflict of Interest
Statistical Data Interpretation
Drug Industry
Neuroprotective Agents
Stroke

National rollout of a web based telemedicine stroke care service: REACH 2.0

Hess, D. C. & Agate, S. J., Dec 1 2007, Proceedings of the 3rd IASTED International Conference on Telehealth, Telehealth 2007. p. 188-192 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Telemedicine
stroke
Stroke
evaluation
User interfaces
1 Citation (Scopus)

NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic Factor Therapy and Neuroprotection

Borlongan, C. V., Stahl, C. E., Yu, G., Xu, L., Yasuhara, T., Hara, K., Matsukawa, N., Sanberg, P. R., Wang, Y. & Hess, D. C., Dec 1 2007, Cellular Transplantation. Elsevier Inc., p. 353-371 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glial Cell Line-Derived Neurotrophic Factor
Cell Transplantation
Nerve Growth Factors
Stroke
Gene therapy
1 Citation (Scopus)

Stroke, with or with no ice? Observations on amphetamine for the management of acute stroke

Borlongan, C. V. & Hess, D. C., Aug 1 2007, In : Journal of Human Hypertension. 21, 8, p. 594-597 4 p.

Research output: Contribution to journalComment/debate

Dextroamphetamine
Ice
Acute Disease
Amphetamine
Stroke
92 Citations (Scopus)

Transplantation of bone marrow-derived stem cells: A promising therapy for stroke

Tang, Y., Yasuhara, T., Hara, K., Matsukawa, N., Maki, M., Yu, G., Xu, L., Hess, D. C. & Borlongan, C. V., May 4 2007, In : Cell Transplantation. 16, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

Stem cells
Bone Marrow Transplantation
Bone
Stem Cells
Stroke
34 Citations (Scopus)

Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: In vitro evidence of expedited neuronal differentiation and GDNF secretion

Hara, K., Matsukawa, N., Yasuhara, T., Xu, L., Yu, G., Maki, M., Kawase, T., Hess, D. C., Kim, S. U. & Borlongan, C. V., May 1 2007, In : Journal of Neuroscience Research. 85, 6, p. 1240-1251 12 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Transplantation
Stroke
Therapeutics
Nestin
10 Citations (Scopus)

Using tPA for acute stroke in a rural setting [6]

Gross, H., Hall, C., Switzer, J. A., Adams, R. J., Wang, S., Hess, D. C., Nichols, F. T. & Pardue, C., May 1 2007, In : Neurology. 68, 22, p. 1957-1958 2 p.

Research output: Contribution to journalLetter

Remote Consultation
Rural Hospitals
Fibrinolytic Agents
Acute Disease
Tissue Plasminogen Activator
2006
80 Citations (Scopus)

Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury

Yasuhara, T., Matsukawa, N., Yu, G., Xu, L., Mays, R. W., Kovach, J., Deans, R. J., Hess, D. C., Carroll, J. E. & Borlongan, C. V., May 22 2006, In : Cell Transplantation. 15, 3, p. 231-238 8 p.

Research output: Contribution to journalArticle

Stem cells
Grafts
Rats
Bone
Stem Cells
149 Citations (Scopus)

Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke

Machado, L. S., Kozak, A., Ergul, A., Hess, D. C., Borlongan, C. V. & Fagan, S. C., Jul 17 2006, In : BMC Neuroscience. 7, 56.

Research output: Contribution to journalArticle

Minocycline
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Ischemia
1 Citation (Scopus)

Drs. Borlongan and Hess respond [4]

Borlongan, C. V. & Hess, D. C., Oct 24 2006, In : CMAJ. 175, 9, 1 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

Gene therapy, cell transplantation and stroke

Borlongan, C. V., Fournier, C., Stahl, C. E., Yu, G., Xu, L., Matsukawa, N., Newman, M., Yasuhara, T., Hara, K., Hess, D. C. & Sanberg, P. R., Feb 23 2006, In : Frontiers in Bioscience. 11, 1 P.889-1198, p. 1090-1100 11 p.

Research output: Contribution to journalReview article

Gene therapy
Cell Transplantation
Grafts
Genetic Therapy
Stroke