David C Hess

EVP, Med Affairs & Dean, MCG

  • 11106 Citations
  • 58 h-Index
1989 …2020

Research output per year

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Research Output

2007

Transplantation of bone marrow-derived stem cells: A promising therapy for stroke

Tang, Y., Yasuhara, T., Hara, K., Matsukawa, N., Maki, M., Yu, G., Xu, L., Hess, D. C. & Borlongan, C. V., May 4 2007, In : Cell Transplantation. 16, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: In vitro evidence of expedited neuronal differentiation and GDNF secretion

Hara, K., Matsukawa, N., Yasuhara, T., Xu, L., Yu, G., Maki, M., Kawase, T., Hess, D. C., Kim, S. U. & Borlongan, C. V., May 1 2007, In : Journal of Neuroscience Research. 85, 6, p. 1240-1251 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Using tPA for acute stroke in a rural setting [6]

Gross, H., Hall, C., Switzer, J. A., Adams, R. J., Wang, S., Hess, D. C., Nichols, F. T. & Pardue, C., May 1 2007, In : Neurology. 68, 22, p. 1957-1958 2 p.

Research output: Contribution to journalLetter

10 Scopus citations
2006

Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury

Yasuhara, T., Matsukawa, N., Yu, G., Xu, L., Mays, R. W., Kovach, J., Deans, R. J., Hess, D. C., Carroll, J. E. & Borlongan, C. V., May 22 2006, In : Cell Transplantation. 15, 3, p. 231-238 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke

Machado, L. S., Kozak, A., Ergul, A., Hess, D. C., Borlongan, C. V. & Fagan, S. C., Jul 17 2006, In : BMC Neuroscience. 7, 56.

Research output: Contribution to journalArticle

153 Scopus citations

Drs. Borlongan and Hess respond [4]

Borlongan, C. V. & Hess, D. C., Oct 24 2006, In : CMAJ. 175, 9, 1 p.

Research output: Contribution to journalLetter

1 Scopus citations

Gene therapy, cell transplantation and stroke

Borlongan, C. V., Fournier, C., Stahl, C. E., Yu, G., Xu, L., Matsukawa, N., Newman, M., Yasuhara, T., Hara, K., Hess, D. C. & Sanberg, P. R., Feb 23 2006, In : Frontiers in Bioscience. 11, 1 P.889-1198, p. 1090-1100 11 p.

Research output: Contribution to journalReview article

17 Scopus citations

Hypertension after experimental cerebral ischemia: Candesartan provides neurovascular protection

Fagan, S. C., Kozak, A., Hill, W. D., Pollock, D. M., Xu, L., Johnson, M. H., Ergul, A. & Hess, D. C., Mar 2006, In : Journal of hypertension. 24, 3, p. 535-539 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Minocycline for short-term neuroprotection

Elewa, H. F., Hilali, R., Hess, D. C., Machado, L. S. & Fagan, S. C., Apr 1 2006, In : Pharmacotherapy. 26, 4, p. 515-521 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

New hope for stroke patients: Mobilization of endogenous stem cells

Borlongan, C. V. & Hess, D. C., Mar 28 2006, In : CMAJ. 174, 7, p. 954-955 2 p.

Research output: Contribution to journalComment/debate

36 Scopus citations

NXY-059: A hopeful sign in the treatment of stroke

Hess, D. C., Oct 1 2006, In : Stroke. 37, 10, p. 2649-2650 2 p.

Research output: Contribution to journalShort survey

17 Scopus citations

Pathophysiology and treatment of stroke in sickle-cell disease: present and future

Switzer, J. A., Hess, D. C., Nichols, F. T. & Adams, R. J., Jun 1 2006, In : Lancet Neurology. 5, 6, p. 501-512 12 p.

Research output: Contribution to journalReview article

159 Scopus citations

Prospective reliability of the STRokE DOC wireless/site independent telemedicine system [10]

Gross, H., Hall, C. E., Wang, S., Pardue, C., Hess, D. C., Nichols, F. T. & Adams, R. J., Feb 1 2006, In : Neurology. 66, 3, 1 p.

Research output: Contribution to journalLetter

6 Scopus citations

Statins in stroke: Prevention, protection and recovery

Switzer, J. A. & Hess, D. C., Feb 1 2006, In : Expert Review of Neurotherapeutics. 6, 2, p. 195-202 8 p.

Research output: Contribution to journalReview article

26 Scopus citations

Statin therapy for coronary heart disease and its effect on stroke

Switzer, J. A. & Hess, D. C., Jul 1 2006, In : Current Atherosclerosis Reports. 8, 4, p. 337-342 6 p.

Research output: Contribution to journalReview article

1 Scopus citations

Telestroke: Extending stroke expertise into underserved areas

Hess, D. C., Wang, S., Gross, H., Nichols, F. T., Hall, C. E. & Adams, R. J., Mar 1 2006, In : Lancet Neurology. 5, 3, p. 275-278 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Transplantation of Cryopreserved Human Bone Marrow-derived Multipotent Adult Progenitor Cells for Neonatal Hypoxic-Ischemic Injury: Targeting the Hippocampus

Yasuhara, T., Matsukawa, N., Yu, G., Xu, L., Mays, R. W., Kovach, J., Deans, R., Hess, D. C., Carroll, J. E. & Borlongan, C. V., Jan 1 2006, In : Reviews in the Neurosciences. 17, 1-2, p. 215-226 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Acute functional effects of cyclosporine-A and methylprednisolone treatment in adult rats exposed to transient ischemic stroke

Borlongan, C. V., Yu, G., Matsukawa, N., Xu, L., Hess, D. C., Sanberg, P. R. & Wang, Y., Feb 11 2005, In : Life sciences. 76, 13, p. 1503-1512 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

BrdU-positive cells in the neonatal mouse hippocampus following hypoxic-ischemic brain injury

Bartley, J., Soltau, T., Wimborne, H., Kim, S., Martin-Studdard, A., Hess, D. C., Hill, W. D., Waller, J. L. & Carroll, J. E., Mar 2 2005, In : BMC Neuroscience. 6, 15.

Research output: Contribution to journalArticle

50 Scopus citations

Carotid endarterectomy - An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

Chaturvedi, S., Bruno, A., Feasby, T., Holloway, R., Benavente, O., Cohen, S. N., Cote, R., Hess, D., Saver, J., Spence, J. D., Stern, B. & Wilterdink, J., Sep 27 2005, In : Neurology. 65, 6, p. 794-801 8 p.

Research output: Contribution to journalArticle

401 Scopus citations

Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats

Borlongan, C. V., Evans, A., Yu, G. & Hess, D. C., Jun 28 2005, In : Brain Research. 1048, 1-2, p. 116-122 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Multiple sclerosis: When to suspect - Keys to diagnosis

Hess, D. C. & Hughes, M. D., Jul 1 2005, In : Consultant. 45, 8, p. 844-852 9 p.

Research output: Contribution to journalReview article

Multiple sclerosis: New help, new hope

Hess, D. C. & Hughes, M. D., Sep 1 2005, In : Consultant. 45, 10, p. 1144-1148 5 p.

Research output: Contribution to journalReview article

REACH: Clinical feasibility of a rural telestroke network

Hess, D. C., Wang, S., Hamilton, W. B., Lee, S., Pardue, C., Waller, J. L., Gross, H., Nichols, F. T., Hall, C. & Adams, R. J., Sep 1 2005, In : Stroke. 36, 9, p. 2018-2020 3 p.

Research output: Contribution to journalArticle

134 Scopus citations

Statins and stroke prevention

Shaltoni, H. M., Yatsu, F. M. & Hess, D. C., Jul 2005, In : Current Atherosclerosis Reports. 7, 4, p. 313-318 6 p.

Research output: Contribution to journalReview article

4 Scopus citations

Tactics for vascular protection after acute ischemic stroke

Fagan, S. C., Hess, D. C., Machado, L. S., Hohnadel, E. J., Pollock, D. M. & Ergul, A., Mar 1 2005, In : Pharmacotherapy. 25, 3, p. 387-395 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury

Miller, J. T., Bartley, J. H., Wimborne, H. J. C., Walker, A. L., Hess, D. C., Hill, W. D. & Carroll, J. E., Oct 31 2005, In : BMC Neuroscience. 6, 63.

Research output: Contribution to journalArticle

110 Scopus citations

Transplantation of carotid body cells in the treatment of neurological disorders

Yu, G., Fournier, C., Hess, D. C. & Borlongan, C. V., Jan 1 2005, In : Neuroscience and Biobehavioral Reviews. 28, 8, p. 803-810 8 p.

Research output: Contribution to journalReview article

10 Scopus citations
2004

Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats

Borlongan, C. V., Lind, J. G., Dillon-Carter, O., Yu, G., Hadman, M., Cheng, C., Carroll, J. & Hess, D. C., Jun 4 2004, In : Brain Research. 1010, 1-2, p. 108-116 9 p.

Research output: Contribution to journalArticle

144 Scopus citations

Botulinum toxin treatment of painful tonic spasms in multiple sclerosis [1] (multiple letters)

Morgan, J. C., Hess, D. C., Sethi, K. D., Restivo, D. A., Tinazzi, M., Patti, F., Palmeri, A. & Maimone, D., Jun 8 2004, In : Neurology. 62, 11, 1 p.

Research output: Contribution to journalLetter

6 Scopus citations

Combined cyclosporine-A and methylprednisolone treatment exerts partial and transient neuroprotection against ischemic stroke

Yu, G., Hess, D. C. & Borlongan, C. V., Aug 20 2004, In : Brain Research. 1018, 1, p. 32-37 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Do bone marrow cells generate neurons?

Hess, D. C., Hill, W. D., Carroll, J. E. & Borlongan, C. V., Apr 1 2004, In : Archives of Neurology. 61, 4, p. 483-485 3 p.

Research output: Contribution to journalReview article

28 Scopus citations

Healing a broken heart with stem cells

Stern, D. M., Hess, D. C. & Borlongan, C. V., Jan 1 2004, In : Cell Transplantation. 13, 7-8, p. 725-727 3 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Hematopoietic origin of microglial and perivascular cells in brain

Hess, D. C., Abe, T., Hill, W. D., Studdard, A. M., Carothers, J., Masuya, M., Fleming, P. A., Drake, C. J. & Ogawa, M., Apr 1 2004, In : Experimental Neurology. 186, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

219 Scopus citations

Intracerebral transplantation of carotid body in rats with transient middle cerebral artery occlusion

Yu, G., Xu, L., Hadman, M., Hess, D. C. & Borlongan, C. V., Jul 23 2004, In : Brain Research. 1015, 1-2, p. 50-56 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood-brain barrier

Borlongan, C. V., Lind, J. G., Dillon-Carter, O., Yu, G., Hadman, M., Cheng, C., Carroll, J. & Hess, D. C., May 29 2004, In : Brain Research. 1009, 1-2, p. 26-33 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Intracerebral Xenotransplantation of GFP Mouse Bone Marrow Stromal Cells in Intact and Stroke Rat Brain: Graft Survival and Immunologic Response

Irons, H., Lind, J. G., Wakade, C. G., Yu, G., Hadman, M., Carroll, J. E., Hess, D. C. & Borlongan, C. V., Jan 1 2004, In : Cell Transplantation. 13, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

Xu, L., Fagan, S. C., Waller, J. L., Edwards, D., Borlongan, C. V., Zheng, J., Hill, W. D., Feurstein, G. & Hess, D. C., Apr 26 2004, In : BMC Neurology. 4, 7.

Research output: Contribution to journalArticle

128 Scopus citations

Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria

Wang, J., Wei, Q., Wang, C. Y., Hill, W. D., Hess, D. C. & Dong, Z., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19948-19954 7 p.

Research output: Contribution to journalArticle

218 Scopus citations

Optimal delivery of minocycline to the brain: Implication for human studies of acute neuroprotection

Fagan, S. C., Edwards, D. J., Borlongan, C. V., Xu, L., Arora, A., Feuerstein, G. & Hess, D. C., Apr 1 2004, In : Experimental Neurology. 186, 2, p. 248-251 4 p.

Research output: Contribution to journalArticle

106 Scopus citations

Remote evaluation of acute ischemic stroke in rural community hospitals in Georgia

Wang, S., Gross, H., Lee, S. B., Pardue, C., Waller, J. L., Nichols, F. T., Adams, R. J. & Hess, D. C., Jul 1 2004, In : Stroke. 35, 7, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

SDF-1 (CXCL12) Is Upregulated in the Ischemic Penumbra Following Stroke: Association with Bone Marrow Cell Homing to Injury

Hill, W. D., Hess, D. C., Martin-Studdard, A., Carothers, J. J., Zheng, J., Hale, D., Maeda, M., Fagan, S. C., Carroll, J. E. & Conway, S. J., Jan 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 1, p. 84-96 13 p.

Research output: Contribution to journalArticle

316 Scopus citations

Targets for vascular protection after acute ischemic stroke

Fagan, S. C., Hess, D. C., Hohnadel, E. J., Pollock, D. M. & Ergul, A., Sep 1 2004, In : Stroke. 35, 9, p. 2220-2225 6 p.

Research output: Contribution to journalReview article

211 Scopus citations

Tracking Trends in Secondary Stroke Prevention Strategies

Carswell, J. L., Beard, K. A., Chevrette, M. M., Pardue, C. N., Hess, D. C. & Fagan, S. C., Feb 1 2004, In : Annals of Pharmacotherapy. 38, 2, p. 215-219 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2003

Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

Sillesen, H., Albers, G., Altafullah, I., Benavente, O., Book, D., Broderick, J., Calder, C., Callahan, A. S., Carlini, W., Chaturvedi, S., Chippendale, T., Clark, W., Collins, G., Coull, B., Davis, P., Devlin, T., Dick, A. R., Dirr-Ledbetter, L. Y., Dooneief, G., Duff, R. S. & 124 others, Estronza, N., Forteza, A., Frankel, M. R., Frey, J. L., Friday, G., Goldstein, J., Goldstein, S., Graham, G., Harper, W., Harris, J., Hendin, B., Hess, D. C., Hinton, R., Hollander, J., Hsu, C. Y., Hughes, R. L., Kasner, S., Kent, T. A., Kim, L., Kirshner, H., LaMonte, M., Levin, K., Libman, R., McDowell, P., McGee, F. E., Meyer, B., Minagar, A., Munschauer, F. E., Munson, R., Nash, M., Orr, S. C., Ratinov, G., Salanga, V., Sen, S., Silliman, S., Singer, R., Smith, D., Sullivan, H., Thaler, D., Tietjen, G., Tuchman, M., Uskavitch, D., Verro, P., Vicari, R., Weinstein, R., Wilterdink, J., Zweifler, R., Beaudry, M., Cote, R., Hoyte, K., Lebrun, L. H., Norris, J., Selchen, D., Shuaib, A., Simard, D., Spence, D., Teal, P., Winger, M., Schmidt, R., Pramsohler, B., Schmidauer, C., Kaste, M., Sivenius, J., Wagner, A., Terent, A., Amarenco, P., Milandre, L., Chollet, F., de Broucker, T., Moulin, T., Roullet, E., Leys, D., Mahagne, M. H., Hennerici, M., Heiss, W. D., Busse, O., Haberl, R., Harms, L., Diener, C., Hamann, G., Ringelstein, E. B., Canal, N., Capurso, A., Mamoli, A., Frattola, L., Gandolfo, C., Senin, U., Zito, M., de Keyser, K., Netherlands, T., Koudstaal, P. J., Haas, J. A., de Jong, G., Bogousslavsky, J., Mattie, H., Baumgartner, R., MacWalter, R. S., Dijkhuizen, R., Ekpo, E. B., Bath, P., Lees, K. R., Ferro, J., Cunha, L., Davalos, A., Chamorro, A., Sabin, A., Jimenez, D., Gonzalez, J. R., Lago, A., Egido, J., Vivancos, J., Guiu, M., Dorman, G., Davis, S., Gilles, D., Frayne, J., Crimmins, D., Dimmit, S., Singh, G. P., Scott, R., Anderson, N. E., Carr, J., Kruger, A. K. & Gardiner, J., Jan 1 2003, In : Cerebrovascular Diseases. 16, 4, p. 389-395 7 p.

Research output: Contribution to journalArticle

156 Scopus citations

Establishing data elements for the Paul Coverdell National Acute Stroke Registry: Part 1: Proceedings of an expert panel

Wattigney, W. A., Croft, J. B., Mensah, G. A., Alberts, M. J., Shephard, T. J., Gorelick, P. B., Nilasena, D. S., Hess, D. C., Walker, M. D., Hanley, D. F., Shwayder, P., Girgus, M., Neff, L. J., Williams, J. E., LaBarthe, D. R. & Collins, J. L., Jan 1 2003, In : Stroke. 34, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

G-CSF-mobilized human peripheral blood for transplantation therapy in stroke

Borlongan, C. V. & Hess, D. C., Jan 1 2003, In : Cell Transplantation. 12, 4, p. 447-448 2 p.

Research output: Contribution to journalComment/debate

10 Scopus citations

Hematopoietic origin of glomerular mesangial cells

Masuya, M., Drake, C. J., Fleming, P. A., Reilly, C. M., Zeng, H., Hill, W. D., Martin-Studdard, A., Hess, D. C. & Ogawa, M., Mar 15 2003, In : Blood. 101, 6, p. 2215-2218 4 p.

Research output: Contribution to journalArticle

159 Scopus citations

Ischemic stroke

Hess, D. C. & Wheby, M. S., Sep 1 2003, In : Medical Crossfire. 5, 7, p. 17-19 3 p.

Research output: Contribution to journalComment/debate

Remote evaluation of acute ischemic stroke: reliability of National Institutes of Health Stroke Scale via telestroke.

Wang, S., Lee, S. B., Pardue, C., Ramsingh, D., Waller, J. L., Gross, H., Nichols, F. T., Hess, D. C. & Adams, R. J., Oct 2003, In : Stroke; a journal of cerebral circulation. 34, 10, p. e188-191

Research output: Contribution to journalArticle

149 Scopus citations