David C Hess

EVP, Med Affairs & Dean, MCG

  • 11153 Citations
  • 58 h-Index
1989 …2020

Research output per year

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Research Output

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Article
2009

Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Yamashima, T., Buccafusco, J. J., Kawase, T., Hess, D. C. & Borlongan, C. V., Aug 25 2009, In : Brain Research. 1286, p. 185-191 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
76 Scopus citations

Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential.

Machado, L. S., Sazonova, I. Y., Kozak, A., Wiley, D. C., El-Remessy, A. B., Ergul, A., Hess, D. C., Waller, J. L. & Fagan, S. C., Sep 2009, In : Stroke; a journal of cerebral circulation. 40, 9, p. 3028-3033 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

Matsukawa, N., Yasuhara, T., Hara, K., Xu, L., Maki, M., Yu, G., Kaneko, Y., Ojika, K., Hess, D. C. & Borlongan, C. V., Oct 6 2009, In : BMC Neuroscience. 10, 1 p., 1471.

Research output: Contribution to journalArticle

102 Scopus citations
2008

Carotid endarterectomy - An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

Chaturvedi, S., Bruno, A., Feasby, T., Holloway, R., Benavente, O., Cohen, S. N., Cote, R., Hess, D., Saver, J., Spence, J. D., Stern, B. & Wilterdink, J., Feb 1 2008, In : CONTINUUM Lifelong Learning in Neurology. 14, 1, p. 197-204 8 p.

Research output: Contribution to journalArticle

Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats

Yasuhara, T., Hara, K., Maki, M., Mays, R. W., Deans, R. J., Hess, D. C., Carroll, J. E. & Borlongan, C. V., Nov 1 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 11, p. 1804-1810 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Stem cells and neurological diseases

Hess, D. C. & Borlongan, C. V., Feb 1 2008, In : Cell Proliferation. 41, S1, p. 94-114 21 p.

Research output: Contribution to journalArticle

179 Scopus citations
2007

An analysis of business issues in a telestroke project

Cho, S., Khasanshina, E. V., Mathiassen, L., Hess, D. C., Wang, S. & Stachura, M. E., Jul 1 2007, In : Journal of Telemedicine and Telecare. 13, 5, p. 257-262 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: A pilot study

Hara, K., Yasuhara, T., Matsukawa, N., Maki, M., Masuda, T., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Kawase, T., Yamashima, T., Buccafusco, J. J., Hess, D. C. & Borlongan, C. V., Sep 14 2007, In : Brain Research Bulletin. 74, 1-3, p. 164-171 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Transplantation of bone marrow-derived stem cells: A promising therapy for stroke

Tang, Y., Yasuhara, T., Hara, K., Matsukawa, N., Maki, M., Yu, G., Xu, L., Hess, D. C. & Borlongan, C. V., May 4 2007, In : Cell Transplantation. 16, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: In vitro evidence of expedited neuronal differentiation and GDNF secretion

Hara, K., Matsukawa, N., Yasuhara, T., Xu, L., Yu, G., Maki, M., Kawase, T., Hess, D. C., Kim, S. U. & Borlongan, C. V., May 1 2007, In : Journal of Neuroscience Research. 85, 6, p. 1240-1251 12 p.

Research output: Contribution to journalArticle

35 Scopus citations
2006

Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury

Yasuhara, T., Matsukawa, N., Yu, G., Xu, L., Mays, R. W., Kovach, J., Deans, R. J., Hess, D. C., Carroll, J. E. & Borlongan, C. V., May 22 2006, In : Cell Transplantation. 15, 3, p. 231-238 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke

Machado, L. S., Kozak, A., Ergul, A., Hess, D. C., Borlongan, C. V. & Fagan, S. C., Jul 17 2006, In : BMC Neuroscience. 7, 56.

Research output: Contribution to journalArticle

153 Scopus citations

Hypertension after experimental cerebral ischemia: Candesartan provides neurovascular protection

Fagan, S. C., Kozak, A., Hill, W. D., Pollock, D. M., Xu, L., Johnson, M. H., Ergul, A. & Hess, D. C., Mar 2006, In : Journal of hypertension. 24, 3, p. 535-539 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Minocycline for short-term neuroprotection

Elewa, H. F., Hilali, R., Hess, D. C., Machado, L. S. & Fagan, S. C., Apr 1 2006, In : Pharmacotherapy. 26, 4, p. 515-521 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Telestroke: Extending stroke expertise into underserved areas

Hess, D. C., Wang, S., Gross, H., Nichols, F. T., Hall, C. E. & Adams, R. J., Mar 1 2006, In : Lancet Neurology. 5, 3, p. 275-278 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Transplantation of Cryopreserved Human Bone Marrow-derived Multipotent Adult Progenitor Cells for Neonatal Hypoxic-Ischemic Injury: Targeting the Hippocampus

Yasuhara, T., Matsukawa, N., Yu, G., Xu, L., Mays, R. W., Kovach, J., Deans, R., Hess, D. C., Carroll, J. E. & Borlongan, C. V., Jan 1 2006, In : Reviews in the Neurosciences. 17, 1-2, p. 215-226 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Acute functional effects of cyclosporine-A and methylprednisolone treatment in adult rats exposed to transient ischemic stroke

Borlongan, C. V., Yu, G., Matsukawa, N., Xu, L., Hess, D. C., Sanberg, P. R. & Wang, Y., Feb 11 2005, In : Life sciences. 76, 13, p. 1503-1512 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

BrdU-positive cells in the neonatal mouse hippocampus following hypoxic-ischemic brain injury

Bartley, J., Soltau, T., Wimborne, H., Kim, S., Martin-Studdard, A., Hess, D. C., Hill, W. D., Waller, J. L. & Carroll, J. E., Mar 2 2005, In : BMC Neuroscience. 6, 15.

Research output: Contribution to journalArticle

50 Scopus citations

Carotid endarterectomy - An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

Chaturvedi, S., Bruno, A., Feasby, T., Holloway, R., Benavente, O., Cohen, S. N., Cote, R., Hess, D., Saver, J., Spence, J. D., Stern, B. & Wilterdink, J., Sep 27 2005, In : Neurology. 65, 6, p. 794-801 8 p.

Research output: Contribution to journalArticle

401 Scopus citations

Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats

Borlongan, C. V., Evans, A., Yu, G. & Hess, D. C., Jun 28 2005, In : Brain Research. 1048, 1-2, p. 116-122 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

REACH: Clinical feasibility of a rural telestroke network

Hess, D. C., Wang, S., Hamilton, W. B., Lee, S., Pardue, C., Waller, J. L., Gross, H., Nichols, F. T., Hall, C. & Adams, R. J., Sep 2005, In : Stroke. 36, 9, p. 2018-2020 3 p.

Research output: Contribution to journalArticle

134 Scopus citations

The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury

Miller, J. T., Bartley, J. H., Wimborne, H. J. C., Walker, A. L., Hess, D. C., Hill, W. D. & Carroll, J. E., Oct 31 2005, In : BMC Neuroscience. 6, 63.

Research output: Contribution to journalArticle

110 Scopus citations
2004

Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats

Borlongan, C. V., Lind, J. G., Dillon-Carter, O., Yu, G., Hadman, M., Cheng, C., Carroll, J. & Hess, D. C., Jun 4 2004, In : Brain Research. 1010, 1-2, p. 108-116 9 p.

Research output: Contribution to journalArticle

145 Scopus citations

Combined cyclosporine-A and methylprednisolone treatment exerts partial and transient neuroprotection against ischemic stroke

Yu, G., Hess, D. C. & Borlongan, C. V., Aug 20 2004, In : Brain Research. 1018, 1, p. 32-37 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hematopoietic origin of microglial and perivascular cells in brain

Hess, D. C., Abe, T., Hill, W. D., Studdard, A. M., Carothers, J., Masuya, M., Fleming, P. A., Drake, C. J. & Ogawa, M., Apr 1 2004, In : Experimental Neurology. 186, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

219 Scopus citations

Intracerebral transplantation of carotid body in rats with transient middle cerebral artery occlusion

Yu, G., Xu, L., Hadman, M., Hess, D. C. & Borlongan, C. V., Jul 23 2004, In : Brain Research. 1015, 1-2, p. 50-56 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood-brain barrier

Borlongan, C. V., Lind, J. G., Dillon-Carter, O., Yu, G., Hadman, M., Cheng, C., Carroll, J. & Hess, D. C., May 29 2004, In : Brain Research. 1009, 1-2, p. 26-33 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Intracerebral Xenotransplantation of GFP Mouse Bone Marrow Stromal Cells in Intact and Stroke Rat Brain: Graft Survival and Immunologic Response

Irons, H., Lind, J. G., Wakade, C. G., Yu, G., Hadman, M., Carroll, J. E., Hess, D. C. & Borlongan, C. V., 2004, In : Cell Transplantation. 13, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

Xu, L., Fagan, S. C., Waller, J. L., Edwards, D., Borlongan, C. V., Zheng, J., Hill, W. D., Feurstein, G. & Hess, D. C., Apr 26 2004, In : BMC Neurology. 4, 7.

Research output: Contribution to journalArticle

128 Scopus citations

Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria

Wang, J., Wei, Q., Wang, C. Y., Hill, W. D., Hess, D. C. & Dong, Z., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19948-19954 7 p.

Research output: Contribution to journalArticle

218 Scopus citations

Optimal delivery of minocycline to the brain: Implication for human studies of acute neuroprotection

Fagan, S. C., Edwards, D. J., Borlongan, C. V., Xu, L., Arora, A., Feuerstein, G. & Hess, D. C., Apr 1 2004, In : Experimental Neurology. 186, 2, p. 248-251 4 p.

Research output: Contribution to journalArticle

106 Scopus citations

Remote evaluation of acute ischemic stroke in rural community hospitals in Georgia

Wang, S., Gross, H., Lee, S. B., Pardue, C., Waller, J. L., Nichols, F. T., Adams, R. J. & Hess, D. C., Jul 1 2004, In : Stroke. 35, 7, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

SDF-1 (CXCL12) Is Upregulated in the Ischemic Penumbra Following Stroke: Association with Bone Marrow Cell Homing to Injury

Hill, W. D., Hess, D. C., Martin-Studdard, A., Carothers, J. J., Zheng, J., Hale, D., Maeda, M., Fagan, S. C., Carroll, J. E. & Conway, S. J., Jan 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 1, p. 84-96 13 p.

Research output: Contribution to journalArticle

317 Scopus citations

Tracking Trends in Secondary Stroke Prevention Strategies

Carswell, J. L., Beard, K. A., Chevrette, M. M., Pardue, C. N., Hess, D. C. & Fagan, S. C., Feb 1 2004, In : Annals of Pharmacotherapy. 38, 2, p. 215-219 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2003

Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

Sillesen, H., Albers, G., Altafullah, I., Benavente, O., Book, D., Broderick, J., Calder, C., Callahan, A. S., Carlini, W., Chaturvedi, S., Chippendale, T., Clark, W., Collins, G., Coull, B., Davis, P., Devlin, T., Dick, A. R., Dirr-Ledbetter, L. Y., Dooneief, G., Duff, R. S. & 124 others, Estronza, N., Forteza, A., Frankel, M. R., Frey, J. L., Friday, G., Goldstein, J., Goldstein, S., Graham, G., Harper, W., Harris, J., Hendin, B., Hess, D. C., Hinton, R., Hollander, J., Hsu, C. Y., Hughes, R. L., Kasner, S., Kent, T. A., Kim, L., Kirshner, H., LaMonte, M., Levin, K., Libman, R., McDowell, P., McGee, F. E., Meyer, B., Minagar, A., Munschauer, F. E., Munson, R., Nash, M., Orr, S. C., Ratinov, G., Salanga, V., Sen, S., Silliman, S., Singer, R., Smith, D., Sullivan, H., Thaler, D., Tietjen, G., Tuchman, M., Uskavitch, D., Verro, P., Vicari, R., Weinstein, R., Wilterdink, J., Zweifler, R., Beaudry, M., Cote, R., Hoyte, K., Lebrun, L. H., Norris, J., Selchen, D., Shuaib, A., Simard, D., Spence, D., Teal, P., Winger, M., Schmidt, R., Pramsohler, B., Schmidauer, C., Kaste, M., Sivenius, J., Wagner, A., Terent, A., Amarenco, P., Milandre, L., Chollet, F., de Broucker, T., Moulin, T., Roullet, E., Leys, D., Mahagne, M. H., Hennerici, M., Heiss, W. D., Busse, O., Haberl, R., Harms, L., Diener, C., Hamann, G., Ringelstein, E. B., Canal, N., Capurso, A., Mamoli, A., Frattola, L., Gandolfo, C., Senin, U., Zito, M., de Keyser, K., Netherlands, T., Koudstaal, P. J., Haas, J. A., de Jong, G., Bogousslavsky, J., Mattie, H., Baumgartner, R., MacWalter, R. S., Dijkhuizen, R., Ekpo, E. B., Bath, P., Lees, K. R., Ferro, J., Cunha, L., Davalos, A., Chamorro, A., Sabin, A., Jimenez, D., Gonzalez, J. R., Lago, A., Egido, J., Vivancos, J., Guiu, M., Dorman, G., Davis, S., Gilles, D., Frayne, J., Crimmins, D., Dimmit, S., Singh, G. P., Scott, R., Anderson, N. E., Carr, J., Kruger, A. K. & Gardiner, J., 2003, In : Cerebrovascular Diseases. 16, 4, p. 389-395 7 p.

Research output: Contribution to journalArticle

156 Scopus citations

Establishing data elements for the Paul Coverdell National Acute Stroke Registry: Part 1: Proceedings of an expert panel

Wattigney, W. A., Croft, J. B., Mensah, G. A., Alberts, M. J., Shephard, T. J., Gorelick, P. B., Nilasena, D. S., Hess, D. C., Walker, M. D., Hanley, D. F., Shwayder, P., Girgus, M., Neff, L. J., Williams, J. E., LaBarthe, D. R. & Collins, J. L., Jan 1 2003, In : Stroke. 34, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Hematopoietic origin of glomerular mesangial cells

Masuya, M., Drake, C. J., Fleming, P. A., Reilly, C. M., Zeng, H., Hill, W. D., Martin-Studdard, A., Hess, D. C. & Ogawa, M., Mar 15 2003, In : Blood. 101, 6, p. 2215-2218 4 p.

Research output: Contribution to journalArticle

159 Scopus citations

Remote evaluation of acute ischemic stroke: reliability of National Institutes of Health Stroke Scale via telestroke.

Wang, S., Lee, S. B., Pardue, C., Ramsingh, D., Waller, J. L., Gross, H., Nichols, F. T., Hess, D. C. & Adams, R. J., Oct 2003, In : Stroke; a journal of cerebral circulation. 34, 10, p. e188-191

Research output: Contribution to journalArticle

149 Scopus citations
2002

Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells

Hoffman, W. H., Cheng, C., Passmore, G. G., Carroll, J. E. & Hess, D., Dec 13 2002, In : Neuroscience Letters. 334, 2, p. 71-74 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke

Hess, D. C., Hill, W. D., Martin-Studdard, A., Carroll, J., Brailer, J. & Carothers, J., May 27 2002, In : Stroke. 33, 5, p. 1362-1368 7 p.

Research output: Contribution to journalArticle

243 Scopus citations

Evaluating the comatose patient: Rapid neurologic assessment is key to appropriate management

Malik, K. & Hess, D. C., Jan 1 2002, In : Postgraduate medicine. 111, 2, p. 38-55 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Orthostatic paroxysmal dystonia

Sethi, K. D., Ki, H. L., Deuskar, V. & Hess, D. C., Jul 1 2002, In : Movement Disorders. 17, 4, p. 841-845 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2001

Pharmacology and clinical experience with simvastatin

Hess, D. C. & Fagan, S. C., May 22 2001, In : Expert Opinion on Pharmacotherapy. 2, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

The NF-κB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia

Hill, W. D., Hess, D. C., Carroll, J. E., Wakade, C. G., Howard, E. F., Chen, Q., Cheng, C., Martin-Studdard, A., Waller, J. L. & Beswick, R. A., Aug 20 2001, In : Brain Research Bulletin. 55, 3, p. 375-386 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Use of anti-ICAM-1 therapy in ischemic stroke: Results of the enlimomab acute stroke trial

Sherman, D., Bes, A., Easton, J. D., Hacke, W., Kaste, M., Polmar, S. H., Zivin, J. A., Clark, W., Schneider, D., Whisnant, J., Fieschi, C., Miller, P., Schoenfeld, D., Street, J., Albers, G., Atkinson, R., Biller, J., Bruno, A., Carpenter, D., DeGraba, T. & 57 others, Driscoll, P., Ellis, J., Greenlee R., J., Hess, D. C., Horowitz, D. R., Davenport, J., Hsu, C., Starkman, S., Madden, K., Pettigrew, C., Rosenbaum, D., Schim, J., Tietjen, G., Mansbach, H., Edwards, K., Webb, R., Crisostomo, E., Wilterdrink, J., Rothrock, J., Zweifler, R., Dexter, J., Horowitz, S., Futrell, N., Alter, M., Ferbert, A., Prange, H., Wiersbitzky, M., Büttner, T., Schwartz, A., Busse, O., Klingelhöfer, J., Kaste, M., Erilä, T., Sivenius, J., Sotaniemi, K., Liukkonen, J., Hedman, C., Muuronen, A., Rissanen, A., Larrue, V., Blard, J. M., Caussanel, J. P., Feve, J. R., Moulin, T., Mahagne, M. H., Rancurel, G., Trouillas, P., Weber, M., Thomassen, L., Rosjø, Johnsen, H. J., Kjällman, L., Petersson, J., Ferrari, G., Lagi, A., Mamoli, A. & Re, G., Oct 23 2001, In : Neurology. 57, 8, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

375 Scopus citations
2000

Hypertonic mannitol loading of NF-κ̄ transcription factor decoys in human brain microvascular endothelial cells blocks upregulation of ICAM-1

Hess, D. C., Howard, E., Cheng, C., Carroll, J. & Hill, D. W., May 2000, In : Stroke. 31, 5, p. 1179-1186 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Limb and hemispatial hypometria

Meador, K. J., Moore, E. E., Martin, R. C., Loring, D. W., Hess, D. C. & Heilman, K. M., Jan 2000, In : Journal of the International Neuropsychological Society. 6, 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
1999

Is cholesterol a risk factor for stroke? Yes

Demchuk, A. M., Hess, D. C., Brass, L. M. & Yatsu, F. M., Jan 1 1999, In : Archives of Neurology. 56, 12, p. 1518-1520 3 p.

Research output: Contribution to journalArticle

46 Scopus citations