• 5103 Citations
  • 38 h-Index
1983 …2019
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Research Output 1983 2019

  • 5103 Citations
  • 38 h-Index
  • 62 Article
  • 2 Chapter
  • 2 Comment/debate
  • 1 Review article
2019
1 Citation (Scopus)
Molecular Chaperones
HSP70 Heat-Shock Proteins
Extracellular Signal-Regulated MAP Kinases
Liver Neoplasms
Mitogen-Activated Protein Kinases
2018
1 Citation (Scopus)
Insulin Resistance
Shock
Obesity
Hot Temperature
Phosphorylation
1 Citation (Scopus)

Targeted deletion of Hsf1, 2, and 4 genes in mice

Jin, X., Eroglu, B., Moskofidis, D. & Mivechi, N. F., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 1-22 22 p. (Methods in Molecular Biology; vol. 1709).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genes
Knockout Mice
Heat-Shock Proteins
Shock
Plasmids
2017
11 Citations (Scopus)

The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis

Qiao, A., Jin, X., Pang, J., Moskofidis, D. & Mivechi, N. F., Mar 6 2017, In : The Journal of cell biology. 216, 3, p. 723-741 19 p.

Research output: Contribution to journalArticle

Heat-Shock Response
NAD
Energy Metabolism
Shock
Homeostasis
2014
11 Citations (Scopus)

An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development

Eroglu, B., Min, J. N., Zhang, Y., Szurek, E., Moskofidis, D., Eroglu, A. & Mivechi, N. F., Feb 15 2014, In : Developmental Biology. 386, 2, p. 448-460 13 p.

Research output: Contribution to journalArticle

Embryonic Development
Carrier Proteins
Zebrafish
Embryoid Bodies
Shock
21 Citations (Scopus)

Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury

Eroglu, B., Kimbler, D. E., Pang, J., Choi, J., Moskofidis, D., Yanasak, N. E., Dhandapani, K. M. & Mivechi, N. F., Jan 1 2014, In : Journal of Neurochemistry. 130, 5, p. 626-641 16 p.

Research output: Contribution to journalArticle

Brain
Therapeutics
Cell death
p53 Genes
Cell Death
2012
47 Citations (Scopus)

Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis

Xi, C., Hu, Y., Buckhaults, P., Moskophidis, D. & Mivechi, N. F., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35646-35657 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Shock
Carcinogenesis
Breast
Hot Temperature
9 Citations (Scopus)

Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis In Vivo

Jin, X., Eroglu, B., Cho, W., Yamaguchi, Y., Moskofidis, D. & Mivechi, N. F., Apr 1 2012, In : Molecular Cancer Research. 10, 4, p. 523-534 12 p.

Research output: Contribution to journalArticle

Cell Aging
Shock
Carcinogenesis
Hot Temperature
Galactosidases
2011
69 Citations (Scopus)
Hepatocellular Carcinoma
Liver
Insulin Resistance
Carcinogens
Lipids
6 Citations (Scopus)

Targeted deletion of Hsf1, 2, and 4 genes in mice

Jin, X., Eroglu, B., Moskofidis, D. & Mivechi, N. F., Oct 25 2011, Molecular Chaperones: Methods and Protocols. Calderwood, S. K. & Prince, T. L. (eds.). p. 1-20 20 p. (Methods in Molecular Biology; vol. 787).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genes
Heat-Shock Proteins
Knockout Mice
Shock
Plasmids
2010
38 Citations (Scopus)
Amyloid
Protein Phosphatase 2
Tauopathies
Amyloid beta-Protein Precursor
Heat-Shock Proteins
2009
21 Citations (Scopus)

Heat shock factor 1 deficiency via its downstream target gene αB-crystallin (Hspb5) impairs p53 degradation

Jin, X., Moskofidis, D., Hu, Y., Phillips, A. & Mivechi, N. F., Jun 1 2009, In : Journal of Cellular Biochemistry. 107, 3, p. 504-515 12 p.

Research output: Contribution to journalArticle

Crystallins
Shock
Hot Temperature
Genes
Degradation
2008
22 Citations (Scopus)

Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection

Ou, R., Zhang, M., Huang, L. & Moskofidis, D., Apr 1 2008, In : Journal of Virology. 82, 7, p. 3353-3368 16 p.

Research output: Contribution to journalArticle

ubiquitin-protein ligase
Ubiquitin-Protein Ligases
Virus Diseases
T-lymphocytes
Pathology
8 Citations (Scopus)

Genomic and biological characterization of aggressive and docile strains of lymphocytic choriomeningitis virus rescued from a plasmid-based reverse-genetics system

Chen, M., Lan, S., Ou, R., Price, G. E., Jiang, H., de la Torre, J. C. & Moskofidis, D., Jun 1 2008, In : Journal of General Virology. 89, 6, p. 1421-1433 13 p.

Research output: Contribution to journalArticle

Arenavirus
Lymphocytic choriomeningitis virus
Reverse Genetics
Plasmids
Viruses
19 Citations (Scopus)

Regulation of immune response and inflammatory reactions against viral infection by VCAM-1

Ou, R., Zhang, M., Huang, L., Flavell, R. A., Koni, P. & Moskofidis, D., Mar 1 2008, In : Journal of Virology. 82, 6, p. 2952-2965 14 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Virus Diseases
cell adhesion
blood vessels
immune response
2007
68 Citations (Scopus)

Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption

Huang, L., Min, J. N., Masters, S., Mivechi, N. F. & Moskofidis, D., Aug 1 2007, In : Genesis. 45, 8, p. 487-501 15 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Genes
Myocardium
Molecular Chaperones
Lac Operon
109 Citations (Scopus)

Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors

Min, J. N., Huang, L., Zimonjic, D. B., Moskophidis, D. & Mivechi, N. F., Aug 2 2007, In : Oncogene. 26, 35, p. 5086-5097 12 p.

Research output: Contribution to journalArticle

Lymphoma
Neoplasms
Heat-Shock Proteins
heat shock transcription factor
Molecular Chaperones
2005
18 Citations (Scopus)

Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus

Price, G. E., Huang, L., Ou, R., Zhang, M. & Moskofidis, D., Jul 1 2005, In : Journal of Virology. 79, 13, p. 8545-8559 15 p.

Research output: Contribution to journalArticle

Perforin
Orthomyxoviridae
T-lymphocytes
T-Lymphocytes
mice
2004
72 Citations (Scopus)

Differential Tissue-Specific Regulation of Antiviral CD8+ T-Cell Immune Responses during Chronic Viral Infection

Zhou, S., Ou, R., Huang, L., Price, G. E. & Moskophidis, D., Apr 1 2004, In : Journal of Virology. 78, 7, p. 3578-3600 23 p.

Research output: Contribution to journalArticle

cytotoxic T-lymphocytes
Cytotoxic T-Lymphocytes
Virus Diseases
Antiviral Agents
T-lymphocytes
76 Citations (Scopus)

Essential Requirement for Both hsf1 and hsf2 Transcriptional Activity in Spermatogenesis and Male Fertility

Wang, G., Ying, Z., Jin, X., Tu, N., Zhang, Y., Phillips, M., Moskophidis, D. & Mivechi, N. F., Feb 1 2004, In : Genesis. 38, 2, p. 66-80 15 p.

Research output: Contribution to journalArticle

Spermatogenesis
Fertility
Germ Cells
Pachytene Stage
Prophase
121 Citations (Scopus)

TCR affinity and negative regulation limit autoimmunity

Gronski, M. A., Boulter, J. M., Moskofidis, D., Nguyen, L. T., Holmberg, K., Elford, A. R., Deenick, E. K., Kim, H. O., Penninger, J. M., Odermatt, B., Gallimore, A., Gascoigne, N. R. J. & Ohashi, P. S., Nov 1 2004, In : Nature Medicine. 10, 11, p. 1234-1239 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Autoimmunity
T-cells
Ligands
Autoimmune Diseases
87 Citations (Scopus)

Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation

Min, J. N., Zhang, Y., Moskofidis, D. & Mivechi, N. F., Dec 1 2004, In : Genesis. 40, 4, p. 205-217 13 p.

Research output: Contribution to journalArticle

Crystalline Lens
Lenses
Cell Differentiation
Cataract
Crystallins
2003
101 Citations (Scopus)
Spermatogenesis
Heat-Shock Proteins
Trans-Activators
Lateral Ventricles
Embryonic Development
2002
80 Citations (Scopus)
Perforin
tumor necrosis factors
Tumor Necrosis Factor Receptors
Virus Diseases
Down-Regulation
109 Citations (Scopus)
Molecular Chaperones
Heat-Shock Proteins
Tissue
Hot Temperature
Caspases
2001
154 Citations (Scopus)

Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells

Ou, R., Zhou, S., Huang, L. & Moskophidis, D., Aug 31 2001, In : Journal of Virology. 75, 18, p. 8407-8423 17 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Interferon-beta
interferon-gamma
Interferon-alpha
Interferon-gamma
111 Citations (Scopus)
Molecular Chaperones
HSP70 Heat-Shock Proteins
Genes
Hot Temperature
Proteins
193 Citations (Scopus)
Sodium-Calcium Exchanger
Embryonic and Fetal Development
Myocardial Contraction
Gene Targeting
gene targeting
2000
141 Citations (Scopus)

The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice

Price, G. E., Gaszewska-Mastarlarz, A. & Moskophidis, D., May 2 2000, In : Journal of Virology. 74, 9, p. 3996-4003 8 p.

Research output: Contribution to journalArticle

Interferon-beta
Influenza A virus
interferon-gamma
Orthomyxoviridae
Interferon-alpha
74 Citations (Scopus)

Viral escape by selection of cytotoxic T cell-resistant variants in influenza a virus pneumonia

Price, G. E., Ou, R., Jiang, H., Huang, L. & Moskofidis, D., Jun 5 2000, In : Journal of Experimental Medicine. 191, 11, p. 1853-1867 15 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Orthomyxoviridae
Pneumonia
T-Lymphocytes
Nucleoproteins
1998
147 Citations (Scopus)
Cytotoxic T-Lymphocytes
Virus Diseases
T-Cell Antigen Receptor
Orthomyxoviridae
Transgenic Mice
19 Citations (Scopus)

Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic mice

Tarazona, R., Williams, O., Moskofidis, D., Smyth, L. A., Tanaka, Y., Murdjeva, M., Wack, A., Mamalaki, C. & Kioussis, D., Jun 1 1998, In : Journal of Immunology. 160, 11, p. 5397-5403 7 p.

Research output: Contribution to journalArticle

Thymocytes
Thymus Gland
Transgenic Mice
Apoptosis
Antigens
1997
11 Citations (Scopus)

Virus-Specific IgD in Acute Viral Infection of Mice

Moskofidis, D., Moskophidis, M. & Löhler, J., Feb 1 1997, In : Journal of Immunology. 158, 3, p. 1254-1261 8 p.

Research output: Contribution to journalArticle

Immunoglobulin D
Virus Diseases
Viruses
B-Lymphocytes
Lymphocytic choriomeningitis virus
1996
9 Citations (Scopus)

Immunobiology of cytotoxic T-cell resistant virus variants: Studies on lymphocytic choriomeningitis virus (LCMV)

Moskofidis, D. & Zinkernagel, R. M., Jan 1 1996, In : Seminars in Virology. 7, 1, p. 3-11 9 p.

Research output: Contribution to journalReview article

Lymphocytic choriomeningitis virus
Viruses
T-Lymphocytes
T-Lymphocyte Epitopes
Virus Diseases
1995
76 Citations (Scopus)

Immumobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

Moskofidis, D. & Zinkernagel, R. M., Apr 1 1995, In : Journal of Virology. 69, 4, p. 2187-2193 7 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
T-lymphocytes
epitopes
T-Lymphocytes
mutants
65 Citations (Scopus)

Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus

Moskophidis, D., Battegay, M., Van den Broek, M., Laine, E., Hoffmann-Rohrer, U. & Zinkernagel, R. M., Jan 1 1995, In : Journal of General Virology. 76, 2, p. 381-391 11 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Viruses
T-Lymphocytes
T-Lymphocyte Epitopes
Inbred C57BL Mouse
1994
256 Citations (Scopus)

Enhanced establishment of a virus carrier state in adult CD4+ T-cell- deficient mice

Battegay, M., Moskophidis, D., Rahemtulla, A., Hengartner, H., Mak, T. W. & Zinkernagel, R. M., Jan 1 1994, In : Journal of Virology. 68, 7, p. 4700-4704 5 p.

Research output: Contribution to journalComment/debate

carrier state
Carrier State
T-lymphocytes
Viruses
Lymphocytic choriomeningitis virus
71 Citations (Scopus)

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

Corbella, P., Moskofidis, D., Spanopoulou, E., Mamalaki, C., Tolaini, M., Itano, A., Lans, D., Baltimore, D., Robeyj, E. & Kioussis, D., Jan 1 1994, In : Immunity. 1, 4, p. 269-276 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Cell Lineage
Helper-Inducer T-Lymphocytes
Thymocytes
T-Cell Antigen Receptor
50 Citations (Scopus)

MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice

Moskofidis, D., Lechner, F., Hengartner, H. & Zinkernagel, R. M., Jan 1 1994, In : Journal of Immunology. 152, 10, p. 4976-4983 8 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Viruses
MHC Class I Genes
T-Lymphocytes
Carrier State
81 Citations (Scopus)

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

Moskofidis, D., Battegay, M., Bruendler, M. A., Laine, E., Gresser, I. & Zinkernagel, R. M., Mar 1 1994, In : Journal of Virology. 68, 3, p. 1951-1955 5 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
interferon-beta
Interferon-beta
interferon-gamma
Interferon-alpha
1993
76 Citations (Scopus)

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

Zinkernagel, R. M., Moskofidis, D., Kündig, T., Oehen, S., Pircher, H. & Hengartner, H., Jan 1 1993, In : Immunological Reviews. 133, 1, p. 199-223 25 p.

Research output: Contribution to journalArticle

Lymphocytic Choriomeningitis
Viral Antibodies
Immunologic Memory
Lymphocytic choriomeningitis virus
Viral Antigens
4 Citations (Scopus)

Erratum: Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells (Nature (1993) 362 (758-761))

Moskophldis, D., Lechner, F., Plrcher, H. & Zinkernagel, R. M., Jan 1 1993, In : Nature. 364, 6434, 1 p.

Research output: Contribution to journalComment/debate

101 Citations (Scopus)

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells

Battegay, M., Moskofidis, D., Waldner, H., Brundler, M. A., Fung-Leung, W. P., Mak, T. W., Hengartner, H. & Zinkernagel, R. M., Jan 1 1993, In : Journal of Immunology. 151, 10, p. 5408-5415 8 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Neutralizing Antibodies
Antibody Formation
Antiviral Agents
Viruses
77 Citations (Scopus)

Peripheral clonal deletion of antiviral memory CD8+ T cells

Moskofidis, D., Laine, E. & Zinkernagel, R. M., Jan 1 1993, In : European Journal of Immunology. 23, 12, p. 3306-3311 6 p.

Research output: Contribution to journalArticle

Clonal Deletion
Antiviral Agents
T-Lymphocytes
Lymphocytic choriomeningitis virus
Adoptive Immunotherapy
897 Citations (Scopus)

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

Moskofidis, D., Lechner, F., Pircher, H. & Zinkernagel, R. M., Jan 1 1993, In : Nature. 362, 6422, p. 758-761 4 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Antiviral Agents
Viruses
T-Lymphocytes
Immunity
1992
50 Citations (Scopus)

Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation

Althage, A., Odermatt, B., Moskofidis, D., Kündig, T., Hengartner, U. HR. H. & Zinkernagel, R. M., Jan 1 1992, In : European Journal of Immunology. 22, 7, p. 1803-1812 10 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
B-Lymphocyte Subsets
Antigen Presentation
Virus Diseases
Immunosuppression
21 Citations (Scopus)

Suppression of virus-specific antibody production by CD8+ class I- restricted antiviral cytotoxic T cells in vivo

Moskofidis, D., Pircher, H., Ciernik, I., Odermatt, B., Hengartner, H. & Zinkernagel, R. M., Jan 1 1992, In : Journal of Virology. 66, 6, p. 3661-3668 8 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
antibody formation
Antibody Formation
Antiviral Agents
T-lymphocytes
1991
71 Citations (Scopus)

In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes

Aebischer, T., Moskophidis, D., Rohrer, U. H., Zinkernagel, R. M. & Hengartner, H., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 24, p. 11047-11051 5 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Cytotoxic T-Lymphocytes
Aspartic Acid
T-Lymphocyte Epitopes
T-Cell Antigen Receptor
248 Citations (Scopus)

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

Pircher, H., Rohrer, U. H., Moskofidis, D., Zinkernagel, R. M. & Hengartner, H., Jan 1 1991, In : Nature. 351, 6326, p. 482-485 4 p.

Research output: Contribution to journalArticle

Clonal Deletion
Lymphocytic choriomeningitis virus
T-Lymphocytes
Thymus Gland
T-Cell Antigen Receptor Specificity
27 Citations (Scopus)

Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon

Moskofidis, D., Frei, K., Lohler, J., Fontana, A. & Zinkernagel, R. M., Jan 1 1991, In : Journal of Virology. 65, 3, p. 1364-1369 6 p.

Research output: Contribution to journalArticle

interleukin-5
Immunoglobulin Isotypes
Interleukin-5
Virus Diseases
interleukin-4